PDBsum entry: 1f9s

Cytokine

PDB id: 1f9s

Contents

Protein chains

66 a.a. *

62 a.a. *

Waters ×146

* Residue conservation analysis

PDB id:

1f9s

Name:

Cytokine

Title:

Crystal structure of platelet factor 4 mutant 2

Structure:

Platelet factor 4. Chain: a, b, c, d. Synonym: pf-4, oncostatin, iroplact. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Biol. unit:

Tetramer (from PQS)

Resolution:

2.38Å R-factor: 0.228 R-free: 0.288

Authors:

J.Yang,M.Doyle,T.Faulk,G.Visentin,R.Aster,B.Edwards

Key ref:

J.Yang et al. Structure comparison of two platelet factor 4 mutants with the wild-Type reveals the epitopes for the heparin-Induced thrombocytopenia antibodies. To be published,

Date:

11-Jul-00 Release date: 26-Aug-03

Protein chains

P02776  (PLF4_HUMAN) -  Platelet factor 4

Seq: 101 a.a.

Struc: 66 a.a.*

Protein chains

P02776  (PLF4_HUMAN) -  Platelet factor 4

Seq: 101 a.a.

Struc: 62 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 

• Cellular component: extracellular region (2 terms)
• Biological process: immune response (14 terms)
• Biochemical function: cytokine activity (3 terms)