PDBsum entry: 1ex0

Transferase

PDB id: 1ex0

Contents

Protein chains

705 a.a. *

Ligands

PO4 ×3

PGO ×6

Metals

_CA ×2

Waters ×1306

* Residue conservation analysis

PDB id:

1ex0

Name:

Transferase

Title:

Human factor xiii, mutant w279f zymogen

Structure:

Coagulation factor xiii a chain. Chain: a, b. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932.

Biol. unit:

Dimer (from PQS)

Resolution:

2.00Å R-factor: 0.187 R-free: 0.234

Authors:

R.J.Garzon,K.P.Pratt,P.D.Bishop,I.Le Trong,R.E.Stenkamp, D.C.Teller

Key ref:

R.J.Garzon et al. Tryptophan 279 is essential for the transglutaminase activity of coagulation factor xiii: functional and structural characterization. To be published,

Date:

28-Apr-00 Release date: 23-Dec-03

Protein chains

P00488  (F13A_HUMAN) -  Coagulation factor XIII A chain

Seq: 732 a.a.

Struc: 705 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.3.2.13 - Protein-glutamine gamma-glutamyltransferase.
• Reaction: Protein glutamine + alkylamine = protein N₅-alkylglutamine + NH₃
• Cofactor: Calcium

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Cellular component: extracellular region (3 terms)
• Biological process: wound healing (5 terms)
• Biochemical function: transferase activity (4 terms)