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PDBsum entry 1ewq

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protein dna_rna ligands Protein-protein interface(s) links
Replication/DNA PDB id
1ewq
Jmol
Contents
Protein chains
759 a.a. *
DNA/RNA
Ligands
SO4 ×4
EDO ×7
Waters ×814
* Residue conservation analysis
PDB id:
1ewq
Name: Replication/DNA
Title: Crystal structure taq muts complexed with a heteroduplex DNA at 2.2 a resolution
Structure: DNA (5'- d( Gp Cp Gp Ap Cp Gp Cp Tp Ap Gp Cp Gp Tp Gp Cp Gp Gp Cp Tp Cp Gp Tp C)-3'). Chain: c. Engineered: yes. DNA (5'- d( Gp Gp Ap Cp Gp Ap Gp Cp Cp Gp Cp Cp Gp Cp Tp Ap Gp Cp Gp Tp Cp G)-3'). Chain: d.
Source: Synthetic: yes. Thermus aquaticus. Organism_taxid: 271. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.20Å     R-factor:   0.227     R-free:   0.259
Authors: G.Obmolova,C.Ban,P.Hsieh,W.Yang
Key ref:
G.Obmolova et al. (2000). Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA. Nature, 407, 703-710. PubMed id: 11048710 DOI: 10.1038/35037509
Date:
26-Apr-00     Release date:   23-Oct-00    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q56215  (MUTS_THEAQ) -  DNA mismatch repair protein MutS
Seq:
Struc:
 
Seq:
Struc:
811 a.a.
759 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     response to DNA damage stimulus   3 terms 
  Biochemical function     nucleotide binding     5 terms  

 

 
DOI no: 10.1038/35037509 Nature 407:703-710 (2000)
PubMed id: 11048710  
 
 
Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA.
G.Obmolova, C.Ban, P.Hsieh, W.Yang.
 
  ABSTRACT  
 
DNA mismatch repair is critical for increasing replication fidelity in organisms ranging from bacteria to humans. MutS protein, a member of the ABC ATPase superfamily, recognizes mispaired and unpaired bases in duplex DNA and initiates mismatch repair. Mutations in human MutS genes cause a predisposition to hereditary nonpolyposis colorectal cancer as well as sporadic tumours. Here we report the crystal structures of a MutS protein and a complex of MutS with a heteroduplex DNA containing an unpaired base. The structures reveal the general architecture of members of the MutS family, an induced-fit mechanism of recognition between four domains of a MutS dimer and a heteroduplex kinked at the mismatch, a composite ATPase active site composed of residues from both MutS subunits, and a transmitter region connecting the mismatch-binding and ATPase domains. The crystal structures also provide a molecular framework for understanding hereditary nonpolyposis colorectal cancer mutations and for postulating testable roles of MutS.
 
  Selected figure(s)  
 
Figure 1.
Figure 1: Crystal structure of the TAQ MutS-DNA complex. The two protein subunits are represented by ribbon diagrams in blue (A) and green (B). The DNA is shown in a space-filling model, in which the backbone atoms are red and bases are pink. Three orthogonal views from the side, front and top are shown.
Figure 4.
Figure 4: Mismatch recognition by MutS. a, The DNA-binding domains represented by ribbon diagrams are shown with the heteroduplex DNA. Domains I and IV of subunit A are shown in dark blue and orange; the corresponding domains of subunit B are in light blue and yellow. The DNA phosphate backbones are represented by red ribbons and sugars and bases are shown as ball-and-stick. Phe 39 of subunit A is shown in yellow. Structural elements of subunit B are denoted with a prime. b, A view from the top of a. c, A 2F[o]- F[c] electron density map contoured at 1.0 is shown with the refined structure surrounding the unpaired T. The unpaired T and the G 5' to it are labelled. Both Phe 39 and Glu 41 belong to subunit A. The dashed lines represent hydrogen bonds. d, Topology diagram of domains I and IV. Features common between the two domains are boxed and shown in grey. I B is replaced by a 3[10] helix in domain IV. e, A diagram of protein-DNA interactions. Only those base pairs that contact MutS are shown. Phosphate groups are represented by ovals between the sugar pentagons. Interactions made by each protein domain are labelled in the same colour as the ribbon diagram of this domain in a and b. Hydrogen bonds are represented by red arrows and van der Waals contacts by blue arrows.
 
  The above figures are reprinted by permission from Macmillan Publishers Ltd: Nature (2000, 407, 703-710) copyright 2000.  
  Figures were selected by an automated process.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
22179786 S.Gupta, M.Gellert, and W.Yang (2012).
Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loops.
  Nat Struct Mol Biol, 19, 72-78.
PDB codes: 3thw 3thx 3thy 3thz
21278758 C.Jeong, W.K.Cho, K.M.Song, C.Cook, T.Y.Yoon, C.Ban, R.Fishel, and J.B.Lee (2011).
MutS switches between two fundamentally distinct clamps during mismatch repair.
  Nat Struct Mol Biol, 18, 379-385.  
20961292 H.Iino, K.Kim, A.Shimada, R.Masui, S.Kuramitsu, and K.Fukui (2011).
Characterization of C- and N-terminal domains of Aquifex aeolicus MutL endonuclease: N-terminal domain stimulates the endonuclease activity of C-terminal domain in a zinc-dependent manner.
  Biosci Rep, 31, 309-322.  
  21366595 K.Osman, J.D.Higgins, E.Sanchez-Moran, S.J.Armstrong, and F.C.Franklin (2011).
Pathways to meiotic recombination in Arabidopsis thaliana.
  New Phytol, 190, 523-544.  
20861000 M.Firczuk, M.Wojciechowski, H.Czapinska, and M.Bochtler (2011).
DNA intercalation without flipping in the specific ThaI-DNA complex.
  Nucleic Acids Res, 39, 744-754.
PDB code: 3ndh
21240268 M.Jaciuk, E.Nowak, K.Skowronek, A.Tańska, and M.Nowotny (2011).
Structure of UvrA nucleotide excision repair protein in complex with modified DNA.
  Nat Struct Mol Biol, 18, 191-197.
PDB code: 3pih
21276852 W.J.Gui, Q.H.Qu, Y.Y.Chen, M.Wang, X.E.Zhang, L.J.Bi, and T.Jiang (2011).
Crystal structure of YdaL, a stand-alone small MutS-related protein from Escherichia coli.
  J Struct Biol, 174, 282-289.
PDB code: 3qd7
20854710 W.Yang (2011).
Nucleases: diversity of structure, function and mechanism.
  Q Rev Biophys, 44, 1.  
20457749 A.Shimada, R.Masui, N.Nakagawa, Y.Takahata, K.Kim, S.Kuramitsu, and K.Fukui (2010).
A novel single-stranded DNA-specific 3'-5' exonuclease, Thermus thermophilus exonuclease I, is involved in several DNA repair pathways.
  Nucleic Acids Res, 38, 5692-5705.  
20453896 C.J.Shih, and M.C.Lai (2010).
Differentially expressed genes after hyper- and hypo-salt stress in the halophilic archaeon Methanohalophilus portucalensis.
  Can J Microbiol, 56, 295-307.  
20140215 C.R.Busch, and J.DiRuggiero (2010).
MutS and MutL are dispensable for maintenance of the genomic mutation rate in the halophilic archaeon Halobacterium salinarum NRC-1.
  PLoS One, 5, e9045.  
20188637 H.Bai, A.Madabushi, X.Guan, and A.L.Lu (2010).
Interaction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1.
  DNA Repair (Amst), 9, 478-487.  
20205420 H.Gu, W.Yang, and N.C.Seeman (2010).
DNA scissors device used to measure MutS binding to DNA mis-pairs.
  J Am Chem Soc, 132, 4352-4357.  
19961540 I.D.Kerr, P.M.Jones, and A.M.George (2010).
Multidrug efflux pumps: the structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues.
  FEBS J, 277, 550-563.  
20167596 J.H.Lebbink, A.Fish, A.Reumer, G.Natrajan, H.H.Winterwerp, and T.K.Sixma (2010).
Magnesium coordination controls the molecular switch function of DNA mismatch repair protein MutS.
  J Biol Chem, 285, 13131-13141.
PDB codes: 2wtu 3k0s
20421420 J.M.Dowen, C.D.Putnam, and R.D.Kolodner (2010).
Functional studies and homology modeling of Msh2-Msh3 predict that mispair recognition involves DNA bending and strand separation.
  Mol Cell Biol, 30, 3321-3328.  
21103398 J.Park, Y.Jeon, D.In, R.Fishel, C.Ban, and J.B.Lee (2010).
Single-molecule analysis reveals the kinetics and physiological relevance of MutL-ssDNA binding.
  PLoS One, 5, e15496.  
20080735 J.Zhai, and M.M.Hingorani (2010).
Saccharomyces cerevisiae Msh2-Msh6 DNA binding kinetics reveal a mechanism of targeting sites for DNA mismatch repair.
  Proc Natl Acad Sci U S A, 107, 680-685.  
  20725617 K.Fukui (2010).
DNA mismatch repair in eukaryotes and bacteria.
  J Nucleic Acids, 2010, 0.  
  20865162 K.T.Nishant, C.Chen, M.Shinohara, A.Shinohara, and E.Alani (2010).
Genetic analysis of baker's yeast Msh4-Msh5 reveals a threshold crossover level for meiotic viability.
  PLoS Genet, 6, 0.  
20180598 L.E.Sass, C.Lanyi, K.Weninger, and D.A.Erie (2010).
Single-molecule FRET TACKLE reveals highly dynamic mismatched DNA-MutS complexes.
  Biochemistry, 49, 3174-3190.  
20097818 M.C.Turrientes, M.R.Baquero, M.B.Sánchez, S.Valdezate, E.Escudero, G.Berg, R.Cantón, F.Baquero, J.C.Galán, and J.L.Martínez (2010).
Polymorphic mutation frequencies of clinical and environmental Stenotrophomonas maltophilia populations.
  Appl Environ Microbiol, 76, 1746-1758.  
20038685 R.Machielsen, I.J.van Alen-Boerrigter, L.A.Koole, R.S.Bongers, M.Kleerebezem, and J.E.Van Hylckama Vlieg (2010).
Indigenous and environmental modulation of frequencies of mutation in Lactobacillus plantarum.
  Appl Environ Microbiol, 76, 1587-1595.  
  20981145 R.Morita, S.Nakane, A.Shimada, M.Inoue, H.Iino, T.Wakamatsu, K.Fukui, N.Nakagawa, R.Masui, and S.Kuramitsu (2010).
Molecular mechanisms of the whole DNA repair system: a comparison of bacterial and eukaryotic systems.
  J Nucleic Acids, 2010, 179594.  
20232326 S.Ahmad (2010).
Platinum-DNA interactions and subsequent cellular processes controlling sensitivity to anticancer platinum complexes.
  Chem Biodivers, 7, 543-566.  
  20844762 S.Feliziani, A.M.Luján, A.J.Moyano, C.Sola, J.L.Bocco, P.Montanaro, L.F.Canigia, C.E.Argaraña, and A.M.Smania (2010).
Mucoidy, quorum sensing, mismatch repair and antibiotic resistance in Pseudomonas aeruginosa from cystic fibrosis chronic airways infections.
  PLoS One, 5, 0.  
20805886 S.M.Offer, Q.Pan-Hammarström, L.Hammarström, and R.S.Harris (2010).
Unique DNA repair gene variations and potential associations with the primary antibody deficiency syndromes IgAD and CVID.
  PLoS One, 5, e12260.  
20953938 T.Zhong, L.Bi, and X.Zhang (2010).
New functional sites in MutS affect DNA mismatch repair.
  Sci China Life Sci, 53, 1170-1173.  
19816584 A.C.Chan, R.H.Borts, and E.Hoffmann (2009).
Temperature-dependent modulation of chromosome segregation in msh4 mutants of budding yeast.
  PLoS One, 4, e7284.  
19237577 A.Mazurek, C.N.Johnson, M.W.Germann, and R.Fishel (2009).
Sequence context effect for hMSH2-hMSH6 mismatch-dependent activation.
  Proc Natl Acad Sci U S A, 106, 4177-4182.  
19282251 A.P.Hayes, L.A.Sevi, M.C.Feldt, M.D.Rose, and A.E.Gammie (2009).
Reciprocal regulation of nuclear import of the yeast MutSalpha DNA mismatch repair proteins Msh2 and Msh6.
  DNA Repair (Amst), 8, 739-751.  
19377479 B.A.Owen, W.H Lang, and C.T.McMurray (2009).
The nucleotide binding dynamics of human MSH2-MSH3 are lesion dependent.
  Nat Struct Mol Biol, 16, 550-557.  
19325619 C.C.Query (2009).
Structural biology: Spliceosome subunit revealed.
  Nature, 458, 418-419.  
19291232 E.M.Garrison, and G.Arrizabalaga (2009).
Disruption of a mitochondrial MutS DNA repair enzyme homologue confers drug resistance in the parasite Toxoplasma gondii.
  Mol Microbiol, 72, 425-441.  
19777055 J.Mauris, and T.C.Evans (2009).
Adenosine triphosphate stimulates Aquifex aeolicus MutL endonuclease activity.
  PLoS One, 4, e7175.  
19775280 L.S.Li, J.C.Morales, M.Veigl, D.Sedwick, S.Greer, M.Meyers, M.Wagner, R.Fishel, and D.A.Boothman (2009).
DNA mismatch repair (MMR)-dependent 5-fluorouracil cytotoxicity and the potential for new therapeutic targets.
  Br J Pharmacol, 158, 679-692.  
19228687 L.Tian, L.Gu, and G.M.Li (2009).
Distinct Nucleotide Binding/Hydrolysis Properties and Molar Ratio of MutS{alpha} and MutS{beta} Determine Their Differential Mismatch Binding Activities.
  J Biol Chem, 284, 11557-11562.  
20080788 M.L.Mendillo, V.V.Hargreaves, J.W.Jamison, A.O.Mo, S.Li, C.D.Putnam, V.L.Woods, and R.D.Kolodner (2009).
A conserved MutS homolog connector domain interface interacts with MutL homologs.
  Proc Natl Acad Sci U S A, 106, 22223-22228.  
19483466 N.Charbonneau, R.Amunugama, C.Schmutte, K.Yoder, and R.Fishel (2009).
Evidence that hMLH3 functions primarily in meiosis and in hMSH2-hMSH3 mismatch repair.
  Cancer Biol Ther, 8, 1411-1420.  
19372559 N.F.Krynetskaia, M.S.Phadke, S.H.Jadhav, and E.Y.Krynetskiy (2009).
Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage.
  Mol Cancer Ther, 8, 864-872.  
19748784 P.M.Jones, M.L.O'Mara, and A.M.George (2009).
ABC transporters: a riddle wrapped in a mystery inside an enigma.
  Trends Biochem Sci, 34, 520-531.  
19690966 S.M.Tam, S.Samipak, A.Britt, and R.T.Chetelat (2009).
Characterization and comparative sequence analysis of the DNA mismatch repair MSH2 and MSH7 genes from tomato.
  Genetica, 137, 341-354.  
19654239 Y.Zhu, Y.Wang, and G.Chen (2009).
Differences in conformational dynamics of [Pt3(HPTAB)]6+-DNA adducts with various cross-linking modes.
  Nucleic Acids Res, 37, 5930-5942.  
18160405 A.Karcher, A.Schele, and K.P.Hopfner (2008).
X-ray structure of the complete ABC enzyme ABCE1 from Pyrococcus abyssi.
  J Biol Chem, 283, 7962-7971.
PDB code: 3bk7
18157157 G.M.Li (2008).
Mechanisms and functions of DNA mismatch repair.
  Cell Res, 18, 85-98.  
18854319 I.Tessmer, Y.Yang, J.Zhai, C.Du, P.Hsieh, M.M.Hingorani, and D.A.Erie (2008).
Mechanism of MutS searching for DNA mismatches and signaling repair.
  J Biol Chem, 283, 36646-36654.  
18679428 J.Gorman, and E.C.Greene (2008).
Visualizing one-dimensional diffusion of proteins along DNA.
  Nat Struct Mol Biol, 15, 768-774.  
18838375 K.Fukui, N.Nakagawa, Y.Kitamura, Y.Nishida, R.Masui, and S.Kuramitsu (2008).
Crystal structure of MutS2 endonuclease domain and the mechanism of homologous recombination suppression.
  J Biol Chem, 283, 33417-33427.
PDB code: 2zqe
18280235 L.A.Simmons, B.W.Davies, A.D.Grossman, and G.C.Walker (2008).
Beta clamp directs localization of mismatch repair in Bacillus subtilis.
  Mol Cell, 29, 291-301.  
18647240 N.D.Thomsen, and J.M.Berger (2008).
Structural frameworks for considering microbial protein- and nucleic acid-dependent motor ATPases.
  Mol Microbiol, 69, 1071-1090.  
18409202 N.Rahner, G.Höefler, C.Högenauer, C.Lackner, V.Steinke, M.Sengteller, W.Friedl, S.Aretz, P.Propping, E.Mangold, and C.Walldorf (2008).
Compound heterozygosity for two MSH6 mutations in a patient with early onset colorectal cancer, vitiligo and systemic lupus erythematosus.
  Am J Med Genet A, 146, 1314-1319.  
18406444 P.Hsieh, and K.Yamane (2008).
DNA mismatch repair: molecular mechanism, cancer, and ageing.
  Mech Ageing Dev, 129, 391-407.  
18673453 S.Acharya (2008).
Mutations in the signature motif in MutS affect ATP-induced clamp formation and mismatch repair.
  Mol Microbiol, 69, 1544-1559.  
18773911 S.N.Huang, and D.M.Crothers (2008).
The role of nucleotide cofactor binding in cooperativity and specificity of MutS recognition.
  J Mol Biol, 384, 31-47.  
18951462 S.Ollila, D.Dermadi Bebek, J.Jiricny, and M.Nyström (2008).
Mechanisms of pathogenicity in human MSH2 missense mutants.
  Hum Mutat, 29, 1355-1363.  
17977839 T.Snowden, K.S.Shim, C.Schmutte, S.Acharya, and R.Fishel (2008).
hMSH4-hMSH5 adenosine nucleotide processing and interactions with homologous recombination machinery.
  J Biol Chem, 283, 145-154.  
18157156 W.Yang (2008).
Structure and mechanism for DNA lesion recognition.
  Cell Res, 18, 184-197.  
18379590 X.Lu, X.Liu, L.An, W.Zhang, J.Sun, H.Pei, H.Meng, Y.Fan, and C.Zhang (2008).
The Arabidopsis MutS homolog AtMSH5 is required for normal meiosis.
  Cell Res, 18, 589-599.  
17567610 A.B.Clark, L.Deterding, K.B.Tomer, and T.A.Kunkel (2007).
Multiple functions for the N-terminal region of Msh6.
  Nucleic Acids Res, 35, 4114-4123.  
17720936 A.E.Gammie, N.Erdeniz, J.Beaver, B.Devlin, A.Nanji, and M.D.Rose (2007).
Functional characterization of pathogenic human MSH2 missense mutations in Saccharomyces cerevisiae.
  Genetics, 177, 707-721.  
17084534 C.A.Rabik, and M.E.Dolan (2007).
Molecular mechanisms of resistance and toxicity associated with platinating agents.
  Cancer Treat Rev, 33, 9.  
18078545 C.D.Putnam, M.Hammel, G.L.Hura, and J.A.Tainer (2007).
X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution.
  Q Rev Biophys, 40, 191-285.  
17207499 E.Jacobs-Palmer, and M.M.Hingorani (2007).
The effects of nucleotides on MutS-DNA binding kinetics clarify the role of MutS ATPase activity in mismatch repair.
  J Mol Biol, 366, 1087-1098.  
17114250 H.Bai, and A.L.Lu (2007).
Physical and functional interactions between Escherichia coli MutY glycosylase and mismatch repair protein MutS.
  J Bacteriol, 189, 902-910.  
17996701 J.Gorman, A.Chowdhury, J.A.Surtees, J.Shimada, D.R.Reichman, E.Alani, and E.C.Greene (2007).
Dynamic basis for one-dimensional DNA scanning by the mismatch repair complex Msh2-Msh6.
  Mol Cell, 28, 359-370.  
17174478 J.J.Perry, L.Fan, and J.A.Tainer (2007).
Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair.
  Neuroscience, 145, 1280-1299.  
17531815 J.J.Warren, T.J.Pohlhaus, A.Changela, R.R.Iyer, P.L.Modrich, and L.S.Beese (2007).
Structure of the human MutSalpha DNA lesion recognition complex.
  Mol Cell, 26, 579-592.
PDB codes: 2o8b 2o8c 2o8d 2o8e 2o8f
17215294 K.Fukui, H.Kosaka, S.Kuramitsu, and R.Masui (2007).
Nuclease activity of the MutS homologue MutS2 from Thermus thermophilus is confined to the Smr domain.
  Nucleic Acids Res, 35, 850-860.  
16937116 K.J.Linton, and C.F.Higgins (2007).
Structure and function of ABC transporters: the ATP switch provides flexible control.
  Pflugers Arch, 453, 555-567.  
16876990 M.Cho, S.Chung, S.D.Heo, J.Ku, and C.Ban (2007).
A simple fluorescent method for detecting mismatched DNAs using a MutS-fluorophore conjugate.
  Biosens Bioelectron, 22, 1376-1381.  
17426027 M.L.Mendillo, C.D.Putnam, and R.D.Kolodner (2007).
Escherichia coli MutS tetramerization domain structure reveals that stable dimers but not tetramers are essential for DNA mismatch repair in vivo.
  J Biol Chem, 282, 16345-16354.
PDB code: 2ok2
18059451 M.M.Hingorani (2007).
TIRF(ing) reveals Msh2-Msh6 surfing on DNA.
  Nat Struct Mol Biol, 14, 1124-1125.  
17333147 M.Masarík, K.Cahová, R.Kizek, E.Palecek, and M.Fojta (2007).
Label-free voltammetric detection of single-nucleotide mismatches recognized by the protein MutS.
  Anal Bioanal Chem, 388, 259-270.  
17238288 M.Milutinovich, E.Unal, C.Ward, R.V.Skibbens, and D.Koshland (2007).
A multi-step pathway for the establishment of sister chromatid cohesion.
  PLoS Genet, 3, e12.  
17626640 M.Z.Zheng, H.D.Qin, X.J.Yu, R.H.Zhang, L.Z.Chen, Q.S.Feng, and Y.X.Zeng (2007).
Haplotype of gene Nedd4 binding protein 2 associated with sporadic nasopharyngeal carcinoma in the Southern Chinese population.
  J Transl Med, 5, 36.  
17255941 O.Koroleva, N.Makharashvili, C.T.Courcelle, J.Courcelle, and S.Korolev (2007).
Structural conservation of RecF and Rad50: implications for DNA recognition and RecF function.
  EMBO J, 26, 867-877.
PDB code: 2o5v
17157869 S.D.Lee, J.A.Surtees, and E.Alani (2007).
Saccharomyces cerevisiae MSH2-MSH3 and MSH2-MSH6 complexes display distinct requirements for DNA binding domain I in mismatch recognition.
  J Mol Biol, 366, 53-66.  
17141577 S.F.Holmes, K.D.Scarpinato, S.D.McCulloch, R.M.Schaaper, and T.A.Kunkel (2007).
Specialized mismatch repair function of Glu339 in the Phe-X-Glu motif of yeast Msh6.
  DNA Repair (Amst), 6, 293-303.  
17573527 S.S.Shell, C.D.Putnam, and R.D.Kolodner (2007).
Chimeric Saccharomyces cerevisiae Msh6 protein with an Msh3 mispair-binding domain combines properties of both proteins.
  Proc Natl Acad Sci U S A, 104, 10956-10961.  
17900616 S.Sharma, P.Gong, B.Temple, D.Bhattacharyya, N.V.Dokholyan, and S.G.Chaney (2007).
Molecular dynamic simulations of cisplatin- and oxaliplatin-d(GG) intrastand cross-links reveal differences in their conformational dynamics.
  J Mol Biol, 373, 1123-1140.  
17513474 T.Davidsen, H.K.Tuven, M.Bjørås, E.A.Rødland, and T.Tønjum (2007).
Genetic interactions of DNA repair pathways in the pathogen Neisseria meningitidis.
  J Bacteriol, 189, 5728-5737.  
17142111 W.Yang (2007).
Human MutLalpha: the jack of all trades in MMR is also an endonuclease.
  DNA Repair (Amst), 6, 135-139.  
17497831 Y.Wu, D.Bhattacharyya, C.L.King, I.Baskerville-Abraham, S.H.Huh, G.Boysen, J.A.Swenberg, B.Temple, S.L.Campbell, and S.G.Chaney (2007).
Solution structures of a DNA dodecamer duplex with and without a cisplatin 1,2-d(GG) intrastrand cross-link: comparison with the same DNA duplex containing an oxaliplatin 1,2-d(GG) intrastrand cross-link.
  Biochemistry, 46, 6477-6487.
PDB codes: 2npw 2nq0 2nq1 2nq4
17965091 Z.Lin, M.Nei, and H.Ma (2007).
The origins and early evolution of DNA mismatch repair genes--multiple horizontal gene transfers and co-evolution.
  Nucleic Acids Res, 35, 7591-7603.  
16541253 C.Oswald, I.B.Holland, and L.Schmitt (2006).
The motor domains of ABC-transporters. What can structures tell us?
  Naunyn Schmiedebergs Arch Pharmacol, 372, 385-399.  
16600868 D.J.Mazur, M.L.Mendillo, and R.D.Kolodner (2006).
Inhibition of Msh6 ATPase activity by mispaired DNA induces a Msh2(ATP)-Msh6(ATP) state capable of hydrolysis-independent movement along DNA.
  Mol Cell, 22, 39-49.  
16546997 F.J.López de Saro, M.G.Marinus, P.Modrich, and M.O'Donnell (2006).
The beta sliding clamp binds to multiple sites within MutL and MutS.
  J Biol Chem, 281, 14340-14349.  
16648361 F.R.Salsbury, J.E.Clodfelter, M.B.Gentry, T.Hollis, and K.D.Scarpinato (2006).
The molecular mechanism of DNA damage recognition by MutS homologs and its consequences for cell death response.
  Nucleic Acids Res, 34, 2173-2185.  
16499625 G.Fichant, M.J.Basse, and Y.Quentin (2006).
ABCdb: an online resource for ABC transporter repertories from sequenced archaeal and bacterial genomes.
  FEMS Microbiol Lett, 256, 333-339.  
16821093 G.Plotz, S.Zeuzem, and J.Raedle (2006).
DNA mismatch repair and Lynch syndrome.
  J Mol Histol, 37, 271-283.  
16407973 J.H.Lebbink, D.Georgijevic, G.Natrajan, A.Fish, H.H.Winterwerp, T.K.Sixma, and N.de Wind (2006).
Dual role of MutS glutamate 38 in DNA mismatch discrimination and in the authorization of repair.
  EMBO J, 25, 409-419.
PDB codes: 1wb9 1wbb 1wbd
16612326 J.Jiricny (2006).
The multifaceted mismatch-repair system.
  Nat Rev Mol Cell Biol, 7, 335-346.  
16418736 J.Plaschke, M.Linnebacher, M.Kloor, J.Gebert, F.W.Cremer, S.Tinschert, D.E.Aust, M.von Knebel Doeberitz, and H.K.Schackert (2006).
Compound heterozygosity for two MSH6 mutations in a patient with early onset of HNPCC-associated cancers, but without hematological malignancy and brain tumor.
  Eur J Hum Genet, 14, 561-566.  
16473850 J.R.Horton, X.Zhang, R.Maunus, Z.Yang, G.G.Wilson, R.J.Roberts, and X.Cheng (2006).
DNA nicking by HinP1I endonuclease: bending, base flipping and minor groove expansion.
  Nucleic Acids Res, 34, 939-948.
PDB codes: 2fkc 2fkh 2fl3 2flc
16600867 L.Fan, A.S.Arvai, P.K.Cooper, S.Iwai, F.Hanaoka, and J.A.Tainer (2006).
Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair.
  Mol Cell, 22, 27-37.
PDB codes: 2fwr 2fz4 2fzl
17012287 L.Manelyte, C.Urbanke, L.Giron-Monzon, and P.Friedhoff (2006).
Structural and functional analysis of the MutS C-terminal tetramerization domain.
  Nucleic Acids Res, 34, 5270-5279.  
16545956 M.Garcia-Diaz, and T.A.Kunkel (2006).
Mechanism of a genetic glissando: structural biology of indel mutations.
  Trends Biochem Sci, 31, 206-214.  
16407100 M.T.Hess, M.L.Mendillo, D.J.Mazur, and R.D.Kolodner (2006).
Biochemical basis for dominant mutations in the Saccharomyces cerevisiae MSH6 gene.
  Proc Natl Acad Sci U S A, 103, 558-563.  
16698780 M.Zacharias (2006).
Minor groove deformability of DNA: a molecular dynamics free energy simulation study.
  Biophys J, 91, 882-891.  
16472609 S.B.Gruber (2006).
New developments in Lynch syndrome (hereditary nonpolyposis colorectal cancer) and mismatch repair gene testing.
  Gastroenterology, 130, 577-587.  
16623698 S.H.Jun, T.G.Kim, and C.Ban (2006).
DNA mismatch repair system. Classical and fresh roles.
  FEBS J, 273, 1609-1619.  
17101317 S.Ollila, L.Sarantaus, R.Kariola, P.Chan, H.Hampel, E.Holinski-Feder, F.Macrae, M.Kohonen-Corish, A.M.Gerdes, P.Peltomäki, E.Mangold, A.de la Chapelle, M.Greenblatt, and M.Nyström (2006).
Pathogenicity of MSH2 missense mutations is typically associated with impaired repair capability of the mutated protein.
  Gastroenterology, 131, 1408-1417.  
16357857 T.Davidsen, and T.Tønjum (2006).
Meningococcal genome dynamics.
  Nat Rev Microbiol, 4, 11-22.  
15837203 A.Karcher, K.Büttner, B.Märtens, R.P.Jansen, and K.P.Hopfner (2005).
X-ray structure of RLI, an essential twin cassette ABC ATPase involved in ribosome biogenesis and HIV capsid assembly.
  Structure, 13, 649-659.
PDB code: 1yqt
15866932 A.L.Prunier, and R.Leclercq (2005).
Role of mutS and mutL genes in hypermutability and recombination in Staphylococcus aureus.
  J Bacteriol, 187, 3455-3464.  
16107880 A.Vaisman, H.Ling, R.Woodgate, and W.Yang (2005).
Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis.
  EMBO J, 24, 2957-2967.
PDB codes: 2ago 2agp 2agq
16085769 C.Yuan, E.Rhoades, D.M.Heuer, and L.A.Archer (2005).
Mismatch-induced DNA unbending upon duplex opening.
  Biophys J, 89, 2564-2573.  
15659661 E.S.Hong, A.Yeung, P.Funchain, M.M.Slupska, and J.H.Miller (2005).
Mutants with temperature-sensitive defects in the Escherichia coli mismatch repair system: sensitivity to mispairs generated in vivo.
  J Bacteriol, 187, 840-846.  
15947132 J.E.Clodfelter, M.B Gentry, and K.Drotschmann (2005).
MSH2 missense mutations alter cisplatin cytotoxicity and promote cisplatin-induced genome instability.
  Nucleic Acids Res, 33, 3323-3330.  
15866941 J.Kang, S.Huang, and M.J.Blaser (2005).
Structural and functional divergence of MutS2 from bacterial MutS1 and eukaryotic MSH4-MSH5 homologs.
  J Bacteriol, 187, 3528-3537.  
15731339 M.A.Calmann, A.Nowosielska, and M.G.Marinus (2005).
Separation of mutation avoidance and antirecombination functions in an Escherichia coli mutS mutant.
  Nucleic Acids Res, 33, 1193-1200.  
16159793 M.A.Calmann, A.Nowosielska, and M.G.Marinus (2005).
The MutS C terminus is essential for mismatch repair activity in vivo.
  J Bacteriol, 187, 6577-6579.  
16157599 M.Hammel, H.P.Fierobe, M.Czjzek, V.Kurkal, J.C.Smith, E.A.Bayer, S.Finet, and V.Receveur-Bréchot (2005).
Structural basis of cellulosome efficiency explored by small angle X-ray scattering.
  J Biol Chem, 280, 38562-38568.  
16336261 N.Nag, G.Krishnamoorthy, and B.J.Rao (2005).
A single mismatch in the DNA induces enhanced aggregation of MutS. Hydrodynamic analyses of the protein-DNA complexes.
  FEBS J, 272, 6228-6243.  
16174844 P.Macpherson, F.Barone, G.Maga, F.Mazzei, P.Karran, and M.Bignami (2005).
8-oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSalpha.
  Nucleic Acids Res, 33, 5094-5105.  
15601698 P.Meier, and W.Wackernagel (2005).
Impact of mutS inactivation on foreign DNA acquisition by natural transformation in Pseudomonas stutzeri.
  J Bacteriol, 187, 143-154.  
15611870 S.A.Mookerjee, H.D.Lyon, and E.A.Sia (2005).
Analysis of the functional domains of the mismatch repair homologue Msh1p and its role in mitochondrial genome maintenance.
  Curr Genet, 47, 84-99.  
15746000 S.Banerjee, and H.Flores-Rozas (2005).
Cadmium inhibits mismatch repair by blocking the ATPase activity of the MSH2-MSH6 complex.
  Nucleic Acids Res, 33, 1410-1419.  
15607931 S.G.Chaney, S.L.Campbell, E.Bassett, and Y.Wu (2005).
Recognition and processing of cisplatin- and oxaliplatin-DNA adducts.
  Crit Rev Oncol Hematol, 53, 3.  
15952900 T.A.Kunkel, and D.A.Erie (2005).
DNA mismatch repair.
  Annu Rev Biochem, 74, 681-710.  
15489516 T.Goldfarb, and E.Alani (2005).
Distinct roles for the Saccharomyces cerevisiae mismatch repair proteins in heteroduplex rejection, mismatch repair and nonhomologous tail removal.
  Genetics, 169, 563-574.  
16061937 Y.Yang, L.E.Sass, C.Du, P.Hsieh, and D.A.Erie (2005).
Determination of protein-DNA binding constants and specificities from statistical analyses of single molecules: MutS-DNA interactions.
  Nucleic Acids Res, 33, 4322-4334.  
15513922 A.B.Clark, and T.A.Kunkel (2004).
Cadmium inhibits the functions of eukaryotic MutS complexes.
  J Biol Chem, 279, 53903-53906.  
15470502 A.Guarné, S.Ramon-Maiques, E.M.Wolff, R.Ghirlando, X.Hu, J.H.Miller, and W.Yang (2004).
Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair.
  EMBO J, 23, 4134-4145.
PDB code: 1x9z
15273279 C.Ban, S.Chung, D.S.Park, and Y.B.Shim (2004).
Detection of protein-DNA interaction with a DNA probe: distinction between single-strand and double-strand DNA-protein interaction.
  Nucleic Acids Res, 32, e110.  
15452563 C.F.Higgins, and K.J.Linton (2004).
The ATP switch model for ABC transporters.
  Nat Struct Mol Biol, 11, 918-926.  
15105434 D.Martik, C.Baitinger, and P.Modrich (2004).
Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites.
  J Biol Chem, 279, 28402-28410.  
15476405 E.Antony, and M.M.Hingorani (2004).
Asymmetric ATP binding and hydrolysis activity of the Thermus aquaticus MutS dimer is key to modulation of its interactions with mismatched DNA.
  Biochemistry, 43, 13115-13128.  
14742430 E.Matsui, J.Abe, H.Yokoyama, and I.Matsui (2004).
Aromatic residues located close to the active center are essential for the catalytic reaction of flap endonuclease-1 from hyperthermophilic archaeon Pyrococcus horikoshii.
  J Biol Chem, 279, 16687-16696.  
15014079 F.Yuan, L.Gu, S.Guo, C.Wang, and G.M.Li (2004).
Evidence for involvement of HMGB1 protein in human DNA mismatch repair.
  J Biol Chem, 279, 20935-20940.  
15225322 H.Yang, E.Wolff, M.Kim, A.Diep, and J.H.Miller (2004).
Identification of mutator genes and mutational pathways in Escherichia coli using a multicopy cloning approach.
  Mol Microbiol, 53, 283-295.  
15489296 J.D.Higgins, S.J.Armstrong, F.C.Franklin, and G.H.Jones (2004).
The Arabidopsis MutS homolog AtMSH4 functions at an early step in recombination: evidence for two classes of recombination in Arabidopsis.
  Genes Dev, 18, 2557-2570.  
14651619 J.S.Bell, T.I.Harvey, A.M.Sims, and R.McCulloch (2004).
Characterization of components of the mismatch repair machinery in Trypanosoma brucei.
  Mol Microbiol, 51, 159-173.  
15264277 L.Edelmann, and W.Edelmann (2004).
Loss of DNA mismatch repair function and cancer predisposition in the mouse: animal models for human hereditary nonpolyposis colorectal cancer.
  Am J Med Genet C Semin Med Genet, 129, 91-99.  
15297450 M.H.Lamers, D.Georgijevic, J.H.Lebbink, H.H.Winterwerp, B.Agianian, N.de Wind, and T.K.Sixma (2004).
ATP increases the affinity between MutS ATPase domains. Implications for ATP hydrolysis and conformational changes.
  J Biol Chem, 279, 43879-43885.
PDB code: 1w7a
15345113 T.Rajkumar, N.Soumittra, D.Pandey, K.N.Nancy, V.Mahajan, and U.Majhi (2004).
Mutation analysis of hMSH2 and hMLH1 in colorectal cancer patients in India.
  Genet Test, 8, 157-162.  
14506224 C.Baitinger, V.Burdett, and P.Modrich (2003).
Hydrolytically deficient MutS E694A is defective in the MutL-dependent activation of MutH and in the mismatch-dependent assembly of the MutS.MutL.heteroduplex complex.
  J Biol Chem, 278, 49505-49511.  
12582174 E.Alani, J.Y.Lee, M.J.Schofield, A.W.Kijas, P.Hsieh, and W.Yang (2003).
Crystal structure and biochemical analysis of the MutS.ADP.beryllium fluoride complex suggests a conserved mechanism for ATP interactions in mismatch repair.
  J Biol Chem, 278, 16088-16094.
PDB code: 1nne
12820877 E.Antony, and M.M.Hingorani (2003).
Mismatch recognition-coupled stabilization of Msh2-Msh6 in an ATP-bound state at the initiation of DNA repair.
  Biochemistry, 42, 7682-7693.  
12560476 G.H.Toedt, R.Krishnan, and P.Friedhoff (2003).
Site-specific protein modification to identify the MutL interface of MutH.
  Nucleic Acids Res, 31, 819-825.  
12907723 G.Natrajan, M.H.Lamers, J.H.Enzlin, H.H.Winterwerp, A.Perrakis, and T.K.Sixma (2003).
Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substrates.
  Nucleic Acids Res, 31, 4814-4821.
PDB codes: 1oh5 1oh6 1oh7 1oh8
12783877 H.C.Ahn, T.Ohkubo, S.Iwai, K.Morikawa, and B.J.Lee (2003).
Interaction of T4 endonuclease V with DNA: importance of the flexible loop regions in protein-DNA interaction.
  J Biol Chem, 278, 30985-30992.  
14634210 H.Wang, Y.Yang, M.J.Schofield, C.Du, Y.Fridman, S.D.Lee, E.D.Larson, J.T.Drummond, E.Alani, P.Hsieh, and D.A.Erie (2003).
DNA bending and unbending by MutS govern mismatch recognition and specificity.
  Proc Natl Acad Sci U S A, 100, 14822-14827.  
12626704 K.A.Bunting, S.M.Roe, A.Headley, T.Brown, R.Savva, and L.H.Pearl (2003).
Crystal structure of the Escherichia coli dcm very-short-patch DNA repair endonuclease bound to its reaction product-site in a DNA superhelix.
  Nucleic Acids Res, 31, 1633-1639.
PDB code: 1odg
12829697 K.P.Bjornson, L.J.Blackwell, H.Sage, C.Baitinger, D.Allen, and P.Modrich (2003).
Assembly and molecular activities of the MutS tetramer.
  J Biol Chem, 278, 34667-34673.  
12624105 K.P.Bjornson, and P.Modrich (2003).
Differential and simultaneous adenosine di- and triphosphate binding by MutS.
  J Biol Chem, 278, 18557-18562.  
12526851 K.S.McKeegan, M.I.Borges-Walmsley, and A.R.Walmsley (2003).
The structure and function of drug pumps: an update.
  Trends Microbiol, 11, 21-29.  
  12750325 L.Augusto-Pinto, S.M.Teixeira, S.D.Pena, and C.R.Machado (2003).
Single-nucleotide polymorphisms of the Trypanosoma cruzi MSH2 gene support the existence of three phylogenetic lineages presenting differences in mismatch-repair efficiency.
  Genetics, 164, 117-126.  
12554674 M.H.Lamers, H.H.Winterwerp, and T.K.Sixma (2003).
The alternating ATPase domains of MutS control DNA mismatch repair.
  EMBO J, 22, 746-756.
PDB code: 1ng9
14527292 M.J.Schofield, and P.Hsieh (2003).
DNA mismatch repair: molecular mechanisms and biological function.
  Annu Rev Microbiol, 57, 579-608.  
12435741 P.J.Lau, and R.D.Kolodner (2003).
Transfer of the MSH2.MSH6 complex from proliferating cell nuclear antigen to mispaired bases in DNA.
  J Biol Chem, 278, 14-17.  
14520694 P.Peterlongo, K.Nafa, G.S.Lerman, E.Glogowski, J.Shia, T.Z.Ye, A.J.Markowitz, J.G.Guillem, P.Kolachana, J.A.Boyd, K.Offit, and N.A.Ellis (2003).
MSH6 germline mutations are rare in colorectal cancer families.
  Int J Cancer, 107, 571-579.  
14506009 R.J.Willems, J.Top, D.J.Smith, D.I.Roper, S.E.North, and N.Woodford (2003).
Mutations in the DNA mismatch repair proteins MutS and MutL of oxazolidinone-resistant or -susceptible Enterococcus faecium.
  Antimicrob Agents Chemother, 47, 3061-3066.  
12730382 R.V.Abdelnoor, R.Yule, A.Elo, A.C.Christensen, G.Meyer-Gauen, and S.A.Mackenzie (2003).
Substoichiometric shifting in the plant mitochondrial genome is influenced by a gene homologous to MutS.
  Proc Natl Acad Sci U S A, 100, 5968-5973.  
12887908 S.Acharya, P.L.Foster, P.Brooks, and R.Fishel (2003).
The coordinated functions of the E. coli MutS and MutL proteins in mismatch repair.
  Mol Cell, 12, 233-246.  
14530450 S.Y.Wu, K.Culligan, M.Lamers, and J.Hays (2003).
Dissimilar mispair-recognition spectra of Arabidopsis DNA-mismatch-repair proteins MSH2*MSH6 (MutSalpha) and MSH2*MSH7 (MutSgamma).
  Nucleic Acids Res, 31, 6027-6034.  
11756455 A.Mazurek, M.Berardini, and R.Fishel (2002).
Activation of human MutS homologs by 8-oxo-guanine DNA damage.
  J Biol Chem, 277, 8260-8266.  
12067333 A.S.Bhagwat, and M.Lieb (2002).
Cooperation and competition in mismatch repair: very short-patch repair and methyl-directed mismatch repair in Escherichia coli.
  Mol Microbiol, 44, 1421-1428.  
12124176 C.D.Heinen, T.Wilson, A.Mazurek, M.Berardini, C.Butz, and R.Fishel (2002).
HNPCC mutations in hMSH2 result in reduced hMSH2-hMSH6 molecular switch functions.
  Cancer Cell, 1, 469-478.  
  12454061 C.Welz-Voegele, J.E.Stone, P.T.Tran, H.M.Kearney, R.M.Liskay, T.D.Petes, and S.Jinks-Robertson (2002).
Alleles of the yeast Pms1 mismatch-repair gene that differentially affect recombination- and replication-related processes.
  Genetics, 162, 1131-1145.  
11809883 G.Plotz, J.Raedle, A.Brieger, J.Trojan, and S.Zeuzem (2002).
hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA.
  Nucleic Acids Res, 30, 711-718.  
11788718 J.C.Shiels, J.B.Tuite, S.J.Nolan, and A.M.Baranger (2002).
Investigation of a conserved stacking interaction in target site recognition by the U1A protein.
  Nucleic Acids Res, 30, 550-558.  
12222686 K.Drotschmann, M.C.Hall, P.V.Shcherbakova, H.Wang, D.A.Erie, F.R.Brownewell, E.T.Kool, and T.A.Kunkel (2002).
DNA binding properties of the yeast Msh2-Msh6 and Mlh1-Pms1 heterodimers.
  Biol Chem, 383, 969-975.  
11839498 K.P.Hopfner, C.D.Putnam, and J.A.Tainer (2002).
DNA double-strand break repair from head to tail.
  Curr Opin Struct Biol, 12, 115-122.  
11986324 M.T.Hess, R.D.Gupta, and R.D.Kolodner (2002).
Dominant Saccharomyces cerevisiae msh6 mutations cause increased mispair binding and decreased dissociation from mispairs by Msh2-Msh6 in the presence of ATP.
  J Biol Chem, 277, 25545-25553.  
11950940 N.S.Frolova, N.Schek, N.Tikhmyanova, and T.R.Coleman (2002).
Xenopus Cdc6 performs separate functions in initiating DNA replication.
  Mol Biol Cell, 13, 1298-1312.  
11920679 T.M.Marti, C.Kunz, and O.Fleck (2002).
DNA mismatch repair and mutation avoidance pathways.
  J Cell Physiol, 191, 28-41.  
12454801 W.D.Foulkes, I.Thiffault, S.B.Gruber, M.Horwitz, N.Hamel, C.Lee, J.Shia, A.Markowitz, A.Figer, E.Friedman, D.Farber, C.M.Greenwood, J.D.Bonner, K.Nafa, T.Walsh, V.Marcus, L.Tomsho, J.Gebert, F.A.Macrae, C.L.Gaff, B.B.Paillerets, P.K.Gregersen, J.N.Weitzel, P.H.Gordon, E.MacNamara, M.C.King, H.Hampel, A.De La Chapelle, J.Boyd, K.Offit, G.Rennert, G.Chong, and N.A.Ellis (2002).
The founder mutation MSH2*1906G-->C is an important cause of hereditary nonpolyposis colorectal cancer in the Ashkenazi Jewish population.
  Am J Hum Genet, 71, 1395-1412.  
11574484 A.Guarné, M.S.Junop, and W.Yang (2001).
Structure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPase.
  EMBO J, 20, 5521-5531.
PDB codes: 1ea6 1h7s 1h7u
11807290 A.Joshi, and B.J.Rao (2001).
MutS recognition: multiple mismatches and sequence context effects.
  J Biosci, 26, 595-606.  
11551790 C.Geourjon, C.Orelle, E.Steinfels, C.Blanchet, G.Deléage, A.Di Pietro, and J.M.Jault (2001).
A common mechanism for ATP hydrolysis in ABC transporter and helicase superfamilies.
  Trends Biochem Sci, 26, 539-544.  
11588250 D.Baker, and A.Sali (2001).
Protein structure prediction and structural genomics.
  Science, 294, 93-96.  
11698371 D.M.Young, and L.N.Ornston (2001).
Functions of the mismatch repair gene mutS from Acinetobacter sp. strain ADP1.
  J Bacteriol, 183, 6822-6831.  
11689704 E.A.Sia, M.Dominska, L.Stefanovic, and T.D.Petes (2001).
Isolation and characterization of point mutations in mismatch repair genes that destabilize microsatellites in yeast.
  Mol Cell Biol, 21, 8157-8167.  
11459978 F.J.López de Saro, and M.O'Donnell (2001).
Interaction of the beta sliding clamp with MutS, ligase, and DNA polymerase I.
  Proc Natl Acad Sci U S A, 98, 8376-8380.  
11595188 H.Ling, F.Boudsocq, R.Woodgate, and W.Yang (2001).
Crystal structure of a Y-family DNA polymerase in action: a mechanism for error-prone and lesion-bypass replication.
  Cell, 107, 91.
PDB codes: 1jx4 1jxl
12113123 J.A.Irving, and A.G.Hall (2001).
Mismatch repair defects as a cause of resistance to cytotoxic drugs.
  Expert Rev Anticancer Ther, 1, 149-158.  
11641390 K.Drotschmann, W.Yang, F.E.Brownewell, E.T.Kool, and T.A.Kunkel (2001).
Asymmetric recognition of DNA local distortion. Structure-based functional studies of eukaryotic Msh2-Msh6.
  J Biol Chem, 276, 46225-46229.  
11371344 K.P.Hopfner, A.Karcher, L.Craig, T.T.Woo, J.P.Carney, and J.A.Tainer (2001).
Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase.
  Cell, 105, 473-485.
PDB codes: 1ii7 1ii8
11602569 M.J.Schofield, F.E.Brownewell, S.Nayak, C.Du, E.T.Kool, and P.Hsieh (2001).
The Phe-X-Glu DNA binding motif of MutS. The role of hydrogen bonding in mismatch recognition.
  J Biol Chem, 276, 45505-45508.  
11835482 M.J.Sippl, P.Lackner, F.S.Domingues, A.Prlić, R.Malik, A.Andreeva, and M.Wiederstein (2001).
Assessment of the CASP4 fold recognition category.
  Proteins, (), 55-67.  
11591694 M.Lieb, S.Rehmat, and A.S.Bhagwat (2001).
Interaction of MutS and Vsr: some dominant-negative mutS mutations that disable methyladenine-directed mismatch repair are active in very-short-patch repair.
  J Bacteriol, 183, 6487-6490.  
11172706 M.S.Junop, G.Obmolova, K.Rausch, P.Hsieh, and W.Yang (2001).
Composite active site of an ABC ATPase: MutS uses ATP to verify mismatch recognition and authorize DNA repair.
  Mol Cell, 7, 1.
PDB code: 1fw6
11532960 R.Gaudet, and D.C.Wiley (2001).
Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing.
  EMBO J, 20, 4964-4972.
PDB code: 1jj7
11084351 J.Jiricny (2000).
Mismatch repair: the praying hands of fidelity.
  Curr Biol, 10, R788-R790.  
11188699 K.P.Hopfner, and J.A.Tainer (2000).
DNA mismatch repair: the hands of a genome guardian.
  Structure, 8, R237-R241.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.