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Hydrolase PDB-id
1ewm
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Contents
Description
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Header records
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PROCHECK
Protein chain
215 a.a. *
Ligands
RL2
Waters ×57

* Residue conservation analysis
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PDB id: 1ewm
Name: Hydrolase
Title: The cysteine protease cruzain bound to wrr-112

Structure:
Cruzain. Chain: a. Fragment: catalytic domain. Synonym: cruzipain, cruzaine. Engineered: yes

Source:
Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli. Expression_system_taxid: 562.

UniProt:
P25779 (CYSP_TRYCR) Pfam   ArchSchema ?
Seq:
Struc:
Seq: 467 a.a.
Struc: 215 a.a.
Key:    PfamA domain  PfamB domain
 Secondary structure  CATH domain

Enzyme class:
E.C.3.4.22.51   [IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

Resolution:
2.00Å

R-factor:
0.173

R-free:
0.206

Authors:
L.S.Brinen,S.A.Gillmor,R.J.Fletterick

Key ref:
l.s.brinen et al. Crystal Structure of Cruzain bound to WRR-112. To be Published, .

Date:
26-Apr-00

Release date:
10-Jun-03

Related entries:
1aim
same protein, zya inhibitor
2aim
same protein, zra inhibitor
1ewl
same protein, wrr-99 inhibitor
1ewo
same protein, wrr-204 inhibitor
1ewp
same protein, mor-leu-hpq inhibitor
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Clefts
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