PDBsum entry: 1ewm

Hydrolase/hydrolase inhibitor

PDB id

1ewm

Contents

			Protein chain

					215 a.a. *

			Ligands

					RL2

			Waters ×57

* Residue conservation analysis

PDB id:

1ewm

Links
- PDBe
- RCSB
- SRS
- MMDB
- JenaLib
- OCA
- PDBWiki
- Proteopedia
- CATH
- SCOP
- FSSP
- HSSP
- PDBSWS
- PQS
- CSA
- ProSAT
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- Whatcheck

Name:

Hydrolase/hydrolase inhibitor

Title:

The cysteine protease cruzain bound to wrr-112

Structure:

Cruzain. Chain: a. Fragment: catalytic domain. Synonym: cruzipain, cruzaine. Engineered: yes

Source:

Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.00Å

R-factor:

0.173

R-free:

0.206

Authors:

L.S.Brinen,S.A.Gillmor,R.J.Fletterick

Key ref:

L.S.Brinen et al. Crystal structure of cruzain bound to wrr-112. To be published,

Date:

26-Apr-00

Release date:

10-Jun-03

PROCHECK

	Headers

	References

Protein chain

P25779 (CYSP_TRYCR) - Cruzipain

Seq: Struc:					467 a.a. 215 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.3.4.22.51 - Cruzipain.

[IntEnz] [ExPASy] [KEGG] [BRENDA]



		Gene Ontology (GO) functional annotation

Biological process	proteolysis	1 term
Biochemical function	cysteine-type peptidase activity	2 terms