PDBsum entry: 1esk

Viral protein

PDB id: 1esk

Contents

Protein chain

42 a.a. *

Metals

_ZN ×2

* Residue conservation analysis

PDB id:

1esk

Name:

Viral protein

Title:

Solution structure of ncp7 from HIV-1

Structure:

Gag polyprotein. Chain: a. Fragment: residues 12-53. Synonym: nucleocapsid protein ncp7. Engineered: yes

Source:

Synthetic: yes. Other_details: the protein was chemically synthesized. The sequence is naturally found in human immunodeficiency virus type 1 (HIV-1).

NMR struc:

9 models

Authors:

N.Morellet,H.Demene,V.Teilleux,T.Huynh-Dinh,H.De Rocquigny, M.-C.Fournie-Zaluski,B.P.Roques

Key ref:

N.Morellet et al. Solution structure of (12-53)ncp7 of HIV-1. To be published,

Date:

10-Apr-00 Release date: 26-Apr-00

Protein chain

P04585  (POL_HV1H2) -  Gag-Pol polyprotein

Seq: 1435 a.a.

Struc: 42 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class 1: E.C.2.7.7.49 - RNA-directed Dna polymerase.
• Reaction: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
• Enzyme class 2: E.C.2.7.7.7 - DNA-directed Dna polymerase.
• Reaction: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
• Enzyme class 3: E.C.3.1.13.2 - Exoribonuclease H.
• Reaction: Exonucleolytic cleavage to 5'-phosphomonoester oligonucleotides in both 5'- to 3'- and 3'- to 5'-directions.
• Enzyme class 4: E.C.3.1.26.13 - Retroviral ribonuclease H.
• Enzyme class 5: E.C.3.4.23.16 - HIV-1 retropepsin.
• Reaction: Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Biochemical function: nucleic acid binding (2 terms)