PDBsum entry: 1esk

Viral protein

PDB-id

1esk


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Description

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Protein chain

Metal ions

_ZN ×2

* Residue conservation analysis

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PDB id:

1esk

Name:

Viral protein

Title:

Solution structure of ncp7 from HIV-1

Structure:

Gag polyprotein. Chain: a. Fragment: residues 12-53. Synonym: nucleocapsid protein ncp7. Engineered: yes

Source:

Synthetic: yes. Other_details: the protein was chemically synthesized. The sequence is naturally found in human immunodeficiency virus type 1 (HIV-1).

UniProt:

P04585 (POL_HV1H2)

Seq:

Struc:

Seq:

Struc:

Seq:

Struc:

Seq:

Struc:

Seq:

Struc:

Seq:

1435 a.a.

Struc:

42 a.a.*

Key:		PfamA domain
		Secondary structure			CATH domain

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme class 1:

E.C.2.7.7.49 [IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (see diagram below)

Enzyme class 2:

E.C.2.7.7.7 [IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (see diagram below)

Enzyme class 3:

E.C.3.1.26.4 [IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

Endonucleolytic cleavage to 5'-phosphomonoester.

Enzyme class 4:

E.C.3.4.23.16 [IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Resolution:

not givenÅ

NMR structure:

9 models

Authors:

N.Morellet,H.Demene,V.Teilleux,T.Huynh-Dinh,H.De Rocquigny, M.-C.Fournie-Zaluski,B.P.Roques

Key ref:

n.morellet et al. Solution Structure of (12-53)NCp7 of HIV-1. To be Published, .

Date:

10-Apr-00

Release date:

26-Apr-00