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PDBsum entry 1eqy

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protein ligands metals Protein-protein interface(s) links
Contractile protein PDB id
1eqy
Jmol
Contents
Protein chains
125 a.a. *
360 a.a. *
Ligands
ATP
Metals
_CA ×3
Waters ×635
* Residue conservation analysis
PDB id:
1eqy
Name: Contractile protein
Title: Complex between rabbit muscle alpha-actin: human gelsolin domain 1
Structure: Gelsolin. Chain: s. Fragment: domain 1. Engineered: yes. Mutation: yes. Alpha actin. Chain: a
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: plasma. Expressed in: escherichia coli. Expression_system_taxid: 562. Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986.
Biol. unit: Dimer (from PQS)
Resolution:
2.30Å     R-factor:   0.174     R-free:   0.280
Authors: P.J.Mclaughlin,J.T.Gooch,H.G.Mannherz,A.G.Weeds
Key ref: P.J.McLaughlin et al. (1993). Structure of gelsolin segment 1-actin complex and the mechanism of filament severing. Nature, 364, 685-692. PubMed id: 8395021
Date:
06-Apr-00     Release date:   03-May-00    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P06396  (GELS_HUMAN) -  Gelsolin
Seq:
Struc:
 
Seq:
Struc:
782 a.a.
125 a.a.*
Protein chain
Pfam   ArchSchema ?
P68135  (ACTS_RABIT) -  Actin, alpha skeletal muscle
Seq:
Struc:
377 a.a.
360 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   5 terms 
  Biological process     skeletal muscle fiber development   2 terms 
  Biochemical function     nucleotide binding     6 terms  

 

 
Nature 364:685-692 (1993)
PubMed id: 8395021  
 
 
Structure of gelsolin segment 1-actin complex and the mechanism of filament severing.
P.J.McLaughlin, J.T.Gooch, H.G.Mannherz, A.G.Weeds.
 
  ABSTRACT  
 
The structure of the segment 1 domain of gelsolin, a protein that fragments actin filaments in cells, is reported in complex with actin. Segment 1 binds monomer using an apolar patch rimmed by hydrogen bonds in a cleft between actin domains. On the actin filament model it binds tangentially, disrupting only those contacts between adjacent subunits in one helical strand. The segment 1 fold is general for all segments of the gelsolin family because the conserved residues form the core of the structure. It also provides a basis for understanding the origin of an amyloidosis caused by a gelsolin variant.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
19949432 C.Beyer, and D.S.Pisetsky (2010).
The role of microparticles in the pathogenesis of rheumatic diseases.
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20532239 M.Hertzog, F.Milanesi, L.Hazelwood, A.Disanza, H.Liu, E.Perlade, M.G.Malabarba, S.Pasqualato, A.Maiolica, S.Confalonieri, C.Le Clainche, N.Offenhauser, J.Block, K.Rottner, P.P.Di Fiore, M.F.Carlier, N.Volkmann, D.Hanein, and G.Scita (2010).
Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping.
  PLoS Biol, 8, e1000387.  
20446344 S.H.Lee, and R.Dominguez (2010).
Regulation of actin cytoskeleton dynamics in cells.
  Mol Cells, 29, 311-325.  
19900461 Z.A.Oztug Durer, K.Diraviyam, D.Sept, D.S.Kudryashov, and E.Reisler (2010).
F-actin structure destabilization and DNase I binding loop: fluctuations mutational cross-linking and electron microscopy analysis of loop states and effects on F-actin.
  J Mol Biol, 395, 544-557.  
  20463852 C.G.Pontrello, and I.M.Ethell (2009).
Accelerators, Brakes, and Gears of Actin Dynamics in Dendritic Spines.
  Open Neurosci J, 3, 67-86.  
19405116 H.G.Mannherz, and E.Hannappel (2009).
The beta-thymosins: intracellular and extracellular activities of a versatile actin binding protein family.
  Cell Motil Cytoskeleton, 66, 839-851.  
  19382535 T.S.Wong, B.Brough, and C.M.Ho (2009).
Creation of functional micro/nano systems through top-down and bottom-up approaches.
  Mol Cell Biomech, 6, 1.  
18615630 A.G.Ammer, and S.A.Weed (2008).
Cortactin branches out: roles in regulating protrusive actin dynamics.
  Cell Motil Cytoskeleton, 65, 687-707.  
19081064 C.M.Hampton, J.Liu, D.W.Taylor, D.J.DeRosier, and K.A.Taylor (2008).
The 3D structure of villin as an unusual F-Actin crosslinker.
  Structure, 16, 1882-1891.  
18258262 E.E.Grintsevich, S.A.Benchaar, D.Warshaviak, P.Boontheung, F.Halgand, J.P.Whitelegge, K.F.Faull, R.R.Loo, D.Sept, J.A.Loo, and E.Reisler (2008).
Mapping the cofilin binding site on yeast G-actin by chemical cross-linking.
  J Mol Biol, 377, 395-409.  
18945676 E.Stokasimov, M.McKane, and P.A.Rubenstein (2008).
Role of intermonomer ionic bridges in the stabilization of the actin filament.
  J Biol Chem, 283, 34844-34854.  
18490658 H.Tsuge, M.Nagahama, M.Oda, S.Iwamoto, H.Utsunomiya, V.E.Marquez, N.Katunuma, M.Nishizawa, and J.Sakurai (2008).
Structural basis of actin recognition and arginine ADP-ribosylation by Clostridium perfringens iota-toxin.
  Proc Natl Acad Sci U S A, 105, 7399-7404.
PDB code: 3buz
19325727 I.Aprodu, A.Redaelli, and M.Soncini (2008).
Actomyosin interaction: mechanical and energetic properties in different nucleotide binding States.
  Int J Mol Sci, 9, 1927-1943.  
18042684 J.K.Kamal, and M.R.Chance (2008).
Modeling of protein binary complexes using structural mass spectrometry data.
  Protein Sci, 17, 79-94.  
18689676 K.Baek, X.Liu, F.Ferron, S.Shu, E.D.Korn, and R.Dominguez (2008).
Modulation of actin structure and function by phosphorylation of Tyr-53 and profilin binding.
  Proc Natl Acad Sci U S A, 105, 11748-11753.
PDB codes: 3chw 3ci5 3cip
17975833 M.Bathe (2008).
A finite element framework for computation of protein normal modes and mechanical response.
  Proteins, 70, 1595-1609.  
18326640 S.Fujiwara, M.Plazanet, F.Matsumoto, and T.Oda (2008).
Differences in internal dynamics of actin under different structural states detected by neutron scattering.
  Biophys J, 94, 4880-4889.  
19008859 S.Mouilleron, S.Guettler, C.A.Langer, R.Treisman, and N.Q.McDonald (2008).
Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL.
  EMBO J, 27, 3198-3208.
PDB codes: 2v51 2v52
18938176 U.B.Nair, P.B.Joel, Q.Wan, S.Lowey, M.A.Rould, and K.M.Trybus (2008).
Crystal structures of monomeric actin bound to cytochalasin D.
  J Mol Biol, 384, 848-864.
PDB codes: 3eks 3eku 3el2
18625842 V.O.Paavilainen, E.Oksanen, A.Goldman, and P.Lappalainen (2008).
Structure of the actin-depolymerizing factor homology domain in complex with actin.
  J Cell Biol, 182, 51-59.
PDB code: 3daw
17118501 A.Piccin, W.G.Murphy, and O.P.Smith (2007).
Circulating microparticles: pathophysiology and clinical implications.
  Blood Rev, 21, 157-171.  
17468836 D.Eulitz, and H.G.Mannherz (2007).
Inhibition of deoxyribonuclease I by actin is to protect cells from premature cell death.
  Apoptosis, 12, 1511-1521.  
17965017 E.Reisler, and E.H.Egelman (2007).
Actin structure and function: what we still do not understand.
  J Biol Chem, 282, 36133-36137.  
17470807 J.K.Kamal, S.A.Benchaar, K.Takamoto, E.Reisler, and M.R.Chance (2007).
Three-dimensional structure of cofilin bound to monomeric actin derived by structural mass spectrometry data.
  Proc Natl Acad Sci U S A, 104, 7910-7915.  
17360616 V.O.Paavilainen, M.Hellman, E.Helfer, M.Bovellan, A.Annila, M.F.Carlier, P.Permi, and P.Lappalainen (2007).
Structural basis and evolutionary origin of actin filament capping by twinfilin.
  Proc Natl Acad Sci U S A, 104, 3113-3118.
PDB code: 2hd7
16998842 Y.Azamar, S.Uribe, and A.Mújica (2007).
F-actin involvement in guinea pig sperm motility.
  Mol Reprod Dev, 74, 312-320.  
16531231 A.H.Aguda, B.Xue, E.Irobi, T.Préat, and R.C.Robinson (2006).
The structural basis of actin interaction with multiple WH2/beta-thymosin motif-containing proteins.
  Structure, 14, 469-476.
PDB codes: 2ff3 2ff6
17110933 A.Narita, S.Takeda, A.Yamashita, and Y.Maéda (2006).
Structural basis of actin filament capping at the barbed-end: a cryo-electron microscopy study.
  EMBO J, 25, 5626-5633.  
16757474 A.Pelikan Conchaudron, D.Didry, K.H.Le, E.Larquet, N.Boisset, D.Pantaloni, and M.F.Carlier (2006).
Analysis of tetramethylrhodamine-labeled actin polymerization and interaction with actin regulatory proteins.
  J Biol Chem, 281, 24036-24047.  
16565060 C.Guáqueta, L.K.Sanders, G.C.Wong, and E.Luijten (2006).
The effect of salt on self-assembled actin-lysozyme complexes.
  Biophys J, 90, 4630-4638.  
16473915 E.D.Grimm, R.V.Portugal, M.de Oliveira Neto, N.H.Martins, I.Polikarpov, A.Zaha, and H.B.Ferreira (2006).
Structural analysis of an Echinococcus granulosus actin-fragmenting protein by small-angle x-ray scattering studies and molecular modeling.
  Biophys J, 90, 3216-3223.  
16511569 E.Helfer, E.M.Nevalainen, P.Naumanen, S.Romero, D.Didry, D.Pantaloni, P.Lappalainen, and M.F.Carlier (2006).
Mammalian twinfilin sequesters ADP-G-actin and caps filament barbed ends: implications in motility.
  EMBO J, 25, 1184-1195.  
16689636 K.Takamoto, and M.R.Chance (2006).
Radiolytic protein footprinting with mass spectrometry to probe the structure of macromolecular complexes.
  Annu Rev Biophys Biomol Struct, 35, 251-276.  
16773128 N.D.Rendtorff, M.Zhu, T.Fagerheim, T.L.Antal, M.Jones, T.M.Teslovich, E.M.Gillanders, M.Barmada, E.Teig, J.M.Trent, K.H.Friderici, D.A.Stephan, and L.Tranebjaerg (2006).
A novel missense mutation in ACTG1 causes dominant deafness in a Norwegian DFNA20/26 family, but ACTG1 mutations are not frequent among families with hereditary hearing impairment.
  Eur J Hum Genet, 14, 1097-1105.  
17114056 V.Y.Gorbatyuk, N.J.Nosworthy, S.A.Robson, N.P.Bains, M.W.Maciejewski, C.G.Dos Remedios, and G.F.King (2006).
Mapping the phosphoinositide-binding site on chick cofilin explains how PIP2 regulates the cofilin-actin interaction.
  Mol Cell, 24, 511-522.  
16977317 Y.Zhang, S.M.Vorobiev, B.G.Gibson, B.Hao, G.S.Sidhu, V.S.Mishra, E.G.Yarmola, M.R.Bubb, S.C.Almo, and F.S.Southwick (2006).
A CapG gain-of-function mutant reveals critical structural and functional determinants for actin filament severing.
  EMBO J, 25, 4458-4467.  
15741975 A.H.Aguda, L.D.Burtnick, and R.C.Robinson (2005).
The state of the filament.
  EMBO Rep, 6, 220-226.  
16252969 A.I.Norman, R.Ivkov, J.G.Forbes, and S.C.Greer (2005).
The polymerization of actin: structural changes from small-angle neutron scattering.
  J Chem Phys, 123, 154904.  
16141336 D.S.Kudryashov, M.R.Sawaya, H.Adisetiyo, T.Norcross, G.Hegyi, E.Reisler, and T.O.Yeates (2005).
The crystal structure of a cross-linked actin dimer suggests a detailed molecular interface in F-actin.
  Proc Natl Acad Sci U S A, 102, 13105-13110.
PDB code: 2a5x
15738427 J.L.Hodgkinson, C.Peters, S.A.Kuznetsov, and W.Steffen (2005).
Three-dimensional reconstruction of the dynactin complex by single-particle image analysis.
  Proc Natl Acad Sci U S A, 102, 3667-3672.  
15726624 M.Babor, H.M.Greenblatt, M.Edelman, and V.Sobolev (2005).
Flexibility of metal binding sites in proteins on a database scale.
  Proteins, 59, 221-230.  
15939738 M.Barzik, T.I.Kotova, H.N.Higgs, L.Hazelwood, D.Hanein, F.B.Gertler, and D.A.Schafer (2005).
Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins.
  J Biol Chem, 280, 28653-28662.  
16118223 M.McKane, K.K.Wen, I.R.Boldogh, S.Ramcharan, L.A.Pon, and P.A.Rubenstein (2005).
A mammalian actin substitution in yeast actin (H372R) causes a suppressible mitochondria/vacuole phenotype.
  J Biol Chem, 280, 36494-36501.  
15770676 S.K.Archer, C.Claudianos, and H.D.Campbell (2005).
Evolution of the gelsolin family of actin-binding proteins as novel transcriptional coactivators.
  Bioessays, 27, 388-396.  
15505213 B.J.Nolen, R.S.Littlefield, and T.D.Pollard (2004).
Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP.
  Proc Natl Acad Sci U S A, 101, 15627-15632.
PDB codes: 1tyq 1u2v
15329672 E.Irobi, A.H.Aguda, M.Larsson, C.Guerin, H.L.Yin, L.D.Burtnick, L.Blanchoin, and R.C.Robinson (2004).
Structural basis of actin sequestration by thymosin-beta4: implications for WH2 proteins.
  EMBO J, 23, 3599-3608.
PDB code: 1t44
14992720 E.J.McGhie, R.D.Hayward, and V.Koronakis (2004).
Control of actin turnover by a salmonella invasion protein.
  Mol Cell, 13, 497-510.  
15060630 J.Summerscales, and J.F.Dawson (2004).
Probing Dictyostelium severin structure and function by cross linking to actin.
  Biochem Cell Biol, 82, 343-350.  
15100690 L.Craig, M.E.Pique, and J.A.Tainer (2004).
Type IV pilus structure and bacterial pathogenicity.
  Nat Rev Microbiol, 2, 363-378.  
15215896 L.D.Burtnick, D.Urosev, E.Irobi, K.Narayan, and R.C.Robinson (2004).
Structure of the N-terminal half of gelsolin bound to actin: roles in severing, apoptosis and FAF.
  EMBO J, 23, 2713-2722.
PDB code: 1rgi
15362226 M.A.Wear, and J.A.Cooper (2004).
Capping protein: new insights into mechanism and regulation.
  Trends Biochem Sci, 29, 418-428.  
15039431 M.Domanski, M.Hertzog, J.Coutant, I.Gutsche-Perelroizen, F.Bontems, M.F.Carlier, E.Guittet, and C.van Heijenoort (2004).
Coupling of folding and binding of thymosin beta4 upon interaction with monomeric actin monitored by nuclear magnetic resonance.
  J Biol Chem, 279, 23637-23645.
PDB code: 1uy5
15163409 M.Hertzog, C.van Heijenoort, D.Didry, M.Gaudier, J.Coutant, B.Gigant, G.Didelot, T.Préat, M.Knossow, E.Guittet, and M.F.Carlier (2004).
The beta-thymosin/WH2 domain; structural basis for the switch from inhibition to promotion of actin assembly.
  Cell, 117, 611-623.
PDB code: 1sqk
15272027 N.Kumar, A.Tomar, A.L.Parrill, and S.Khurana (2004).
Functional dissection and molecular characterization of calcium-sensitive actin-capping and actin-depolymerizing sites in villin.
  J Biol Chem, 279, 45036-45046.  
15501675 R.Dominguez (2004).
Actin-binding proteins--a unifying hypothesis.
  Trends Biochem Sci, 29, 572-578.  
15039433 S.Huang, L.Blanchoin, F.Chaudhry, V.E.Franklin-Tong, and C.J.Staiger (2004).
A gelsolin-like protein from Papaver rhoeas pollen (PrABP80) stimulates calcium-regulated severing and depolymerization of actin filaments.
  J Biol Chem, 279, 23364-23375.  
14695255 Y.Wu, and J.Ma (2004).
Refinement of F-actin model against fiber diffraction data by long-range normal modes.
  Biophys J, 86, 116-124.  
12660160 A.Yamashita, K.Maeda, and Y.Maéda (2003).
Crystal structure of CapZ: structural basis for actin filament barbed end capping.
  EMBO J, 22, 1529-1538.
PDB code: 1izn
12554937 C.Verboven, I.Bogaerts, E.Waelkens, A.Rabijns, H.Van Baelen, R.Bouillon, and C.De Ranter (2003).
Actin-DBP: the perfect structural fit?
  Acta Crystallogr D Biol Crystallogr, 59, 263-273.
PDB code: 1ma9
12829461 D.Ming, Y.Kong, Y.Wu, and J.Ma (2003).
Simulation of F-actin filaments of several microns.
  Biophys J, 85, 27-35.  
14507709 D.S.Kudryashov, and E.Reisler (2003).
Solution properties of tetramethylrhodamine-modified G-actin.
  Biophys J, 85, 2466-2475.  
12923524 E.H.Egelman (2003).
A tale of two polymers: new insights into helical filaments.
  Nat Rev Mol Cell Biol, 4, 621-630.  
14519122 E.Lagarrigue, D.Ternent, S.K.Maciver, A.Fattoum, Y.Benyamin, and C.Roustan (2003).
The activation of gelsolin by low pH: the calcium latch is sensitive to calcium but not pH.
  Eur J Biochem, 270, 4105-4112.  
12752443 E.Lagarrigue, S.K.Maciver, A.Fattoum, Y.Benyamin, and C.Roustan (2003).
Co-operation of domain-binding and calcium-binding sites in the activation of gelsolin.
  Eur J Biochem, 270, 2236-2243.  
12660995 H.Benyamini, K.Gunasekaran, H.Wolfson, and R.Nussinov (2003).
Conservation and amyloid formation: a study of the gelsolin-like family.
  Proteins, 51, 266-282.  
12712500 I.Liepiņa, C.Czaplewski, P.Janmey, and A.Liwo (2003).
Molecular dynamics study of a gelsolin-derived peptide binding to a lipid bilayer containing phosphatidylinositol 4,5-bisphosphate.
  Biopolymers, 71, 49-70.  
12356759 J.F.Dawson, E.P.Sablin, J.A.Spudich, and R.J.Fletterick (2003).
Structure of an F-actin trimer disrupted by gelsolin and implications for the mechanism of severing.
  J Biol Chem, 278, 1229-1238.
PDB code: 1mdu
12655044 J.G.Kiselar, P.A.Janmey, S.C.Almo, and M.R.Chance (2003).
Visualizing the Ca2+-dependent activation of gelsolin by using synchrotron footprinting.
  Proc Natl Acad Sci U S A, 100, 3942-3947.  
14556630 J.Q.Guan, S.C.Almo, E.Reisler, and M.R.Chance (2003).
Structural reorganization of proteins revealed by radiolysis and mass spectrometry: G-actin solution structure is divalent cation dependent.
  Biochemistry, 42, 11992-12000.  
14612571 J.Tanaka, Y.Yan, J.Choi, J.Bai, V.A.Klenchin, I.Rayment, and G.Marriott (2003).
Biomolecular mimicry in the actin cytoskeleton: mechanisms underlying the cytotoxicity of kabiramide C and related macrolides.
  Proc Natl Acad Sci U S A, 100, 13851-13856.  
12956956 M.A.Wear, A.Yamashita, K.Kim, Y.Maéda, and J.A.Cooper (2003).
How capping protein binds the barbed end of the actin filament.
  Curr Biol, 13, 1531-1537.  
14675544 M.E.Huff, W.E.Balch, and J.W.Kelly (2003).
Pathological and functional amyloid formation orchestrated by the secretory pathway.
  Curr Opin Struct Biol, 13, 674-682.  
12730212 M.R.Bubb, E.G.Yarmola, B.G.Gibson, and F.S.Southwick (2003).
Depolymerization of actin filaments by profilin. Effects of profilin on capping protein function.
  J Biol Chem, 278, 24629-24635.  
12813032 P.Graceffa, and R.Dominguez (2003).
Crystal structure of monomeric actin in the ATP state. Structural basis of nucleotide-dependent actin dynamics.
  J Biol Chem, 278, 34172-34180.
PDB code: 1nwk
12517699 S.J.Winder (2003).
Structural insights into actin-binding, branching and bundling proteins.
  Curr Opin Cell Biol, 15, 14-22.  
14621980 S.Ono (2003).
Regulation of actin filament dynamics by actin depolymerizing factor/cofilin and actin-interacting protein 1: new blades for twisted filaments.
  Biochemistry, 42, 13363-13370.  
12732734 S.Vorobiev, B.Strokopytov, D.G.Drubin, C.Frieden, S.Ono, J.Condeelis, P.A.Rubenstein, and S.C.Almo (2003).
The structure of nonvertebrate actin: implications for the ATP hydrolytic mechanism.
  Proc Natl Acad Sci U S A, 100, 5760-5765.
PDB codes: 1d4x 1nlv 1nm1 1nmd 1yag
14578936 V.A.Klenchin, J.S.Allingham, R.King, J.Tanaka, G.Marriott, and I.Rayment (2003).
Trisoxazole macrolide toxins mimic the binding of actin-capping proteins to actin.
  Nat Struct Biol, 10, 1058-1063.
PDB codes: 1qz5 1qz6
14657234 V.E.Galkin, A.Orlova, M.S.VanLoock, A.Shvetsov, E.Reisler, and E.H.Egelman (2003).
ADF/cofilin use an intrinsic mode of F-actin instability to disrupt actin filaments.
  J Cell Biol, 163, 1057-1066.  
12023237 I.V.Dedova, V.N.Dedov, N.J.Nosworthy, B.D.Hambly, and C.G.dos Remedios (2002).
Cofilin and DNase I affect the conformation of the small domain of actin.
  Biophys J, 82, 3134-3143.  
12119014 J.F.Head, N.Swamy, and R.Ray (2002).
Crystal structure of the complex between actin and human vitamin D-binding protein at 2.5 A resolution.
  Biochemistry, 41, 9015-9020.
PDB code: 1lot
11980480 J.Q.Guan, S.Vorobiev, S.C.Almo, and M.R.Chance (2002).
Mapping the G-actin binding surface of cofilin using synchrotron protein footprinting.
  Biochemistry, 41, 5765-5775.  
12048248 L.R.Otterbein, C.Cosio, P.Graceffa, and R.Dominguez (2002).
Crystal structures of the vitamin D-binding protein and its complex with actin: structural basis of the actin-scavenger system.
  Proc Natl Acad Sci U S A, 99, 8003-8008.
PDB codes: 1kw2 1kxp
11932258 M.R.Bubb, L.Govindasamy, E.G.Yarmola, S.M.Vorobiev, S.C.Almo, T.Somasundaram, M.S.Chapman, M.Agbandje-McKenna, and R.McKenna (2002).
Polylysine induces an antiparallel actin dimer that nucleates filament assembly: crystal structure at 3.5-A resolution.
  J Biol Chem, 277, 20999-21006.
PDB codes: 1ijj 1lcu
  12380684 N.Mounier, and A.P.Arrigo (2002).
Actin cytoskeleton and small heat shock proteins: how do they interact?
  Cell Stress Chaperones, 7, 167-176.  
11959868 R.Musib, G.Wang, L.Geng, and P.A.Rubenstein (2002).
Effect of polymerization on the subdomain 3/4 loop of yeast actin.
  J Biol Chem, 277, 22699-22709.  
11751319 S.Y.Khaitlina, and H.Strzelecka-Gołaszewska (2002).
Role of the DNase-I-binding loop in dynamic properties of actin filament.
  Biophys J, 82, 321-334.  
11956227 V.E.Galkin, A.Orlova, M.S.VanLoock, I.N.Rybakova, J.M.Ervasti, and E.H.Egelman (2002).
The utrophin actin-binding domain binds F-actin in two different modes: implications for the spectrin superfamily of proteins.
  J Cell Biol, 157, 243-251.  
12207032 V.O.Paavilainen, M.C.Merckel, S.Falck, P.J.Ojala, E.Pohl, M.Wilmanns, and P.Lappalainen (2002).
Structural conservation between the actin monomer-binding sites of twinfilin and actin-depolymerizing factor (ADF)/cofilin.
  J Biol Chem, 277, 43089-43095.
PDB code: 1m4j
11940592 X.Yao, V.Nguyen, W.Wriggers, and P.A.Rubenstein (2002).
Regulation of yeast actin behavior by interaction of charged residues across the interdomain cleft.
  J Biol Chem, 277, 22875-22882.  
11733011 C.Renoult, L.Blondin, A.Fattoum, D.Ternent, S.K.Maciver, F.Raynaud, Y.Benyamin, and C.Roustan (2001).
Binding of gelsolin domain 2 to actin. An actin interface distinct from that of gelsolin domain 1 and from ADF/cofilin.
  Eur J Biochem, 268, 6165-6175.  
11524667 E.H.Egelman (2001).
Actin allostery again?
  Nat Struct Biol, 8, 735-736.  
11747839 E.H.Egelman (2001).
Molecular evolution: actin's long lost relative found.
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11320323 I.Bogaerts, C.Verboven, A.Rabijns, E.Waelkens, H.Van Baelen, and C.De Ranter (2001).
Purification, crystallization and preliminary X-ray investigation of the complex of human vitamin D binding protein and rabbit muscle actin.
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11737197 L.Blondin, V.Sapountzi, S.K.Maciver, C.Renoult, Y.Benyamin, and C.Roustan (2001).
The second ADF/cofilin actin-binding site exists in F-actin, the cofilin-G-actin complex, but not in G-actin.
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11170411 L.Feng, M.Mejillano, H.L.Yin, J.Chen, and G.D.Prestwich (2001).
Full-contact domain labeling: identification of a novel phosphoinositide binding site on gelsolin that requires the complete protein.
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11474115 L.R.Otterbein, P.Graceffa, and R.Dominguez (2001).
The crystal structure of uncomplexed actin in the ADP state.
  Science, 293, 708-711.
PDB code: 1j6z
11577104 M.A.Chellaiah, R.S.Biswas, D.Yuen, U.M.Alvarez, and K.A.Hruska (2001).
Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolin.
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11721045 R.C.Robinson, K.Turbedsky, D.A.Kaiser, J.B.Marchand, H.N.Higgs, S.Choe, and T.D.Pollard (2001).
Crystal structure of Arp2/3 complex.
  Science, 294, 1679-1684.
PDB code: 1k8k
11226199 R.C.Robinson, S.Choe, and L.D.Burtnick (2001).
The disintegration of a molecule: the role of gelsolin in FAF, familial amyloidosis (Finnish type).
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11997945 S.D.Maleknia, and K.Downard (2001).
Radical approaches to probe protein structure, folding, and interactions by mass spectrometry.
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11311852 T.Huff, C.S.Müller, A.M.Otto, R.Netzker, and E.Hannappel (2001).
beta-Thymosins, small acidic peptides with multiple functions.
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  11045622 A.Milzani, R.Rossi, P.Di Simplicio, D.Giustarini, R.Colombo, and I.DalleDonne (2000).
The oxidation produced by hydrogen peroxide on Ca-ATP-G-actin.
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10767822 C.P.Maury, M.Liljeström, G.Boysen, T.Törnroth, A.de la Chapelle, and E.L.Nurmiaho-Lassila (2000).
Danish type gelsolin related amyloidosis: 654G-T mutation is associated with a disease pathogenetically and clinically similar to that caused by the 654G-A mutation (familial amyloidosis of the Finnish type).
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10880956 D.Gremm, and A.Wegner (2000).
Gelsolin as a calcium-regulated actin filament-capping protein.
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10777749 E.M.De La Cruz, E.M.Ostap, R.A.Brundage, K.S.Reddy, H.L.Sweeney, and D.Safer (2000).
Thymosin-beta(4) changes the conformation and dynamics of actin monomers.
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10623895 H.P.Ehrlich, G.M.Allison, M.J.Page, W.A.Kolton, and M.Graham (2000).
Increased gelsolin expression and retarded collagen lattice contraction with smooth muscle cells from Crohn's diseased intestine.
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10866806 H.Schüler, M.Nyåkern, C.E.Schutt, U.Lindberg, and R.Karlsson (2000).
Mutational analysis of arginine 177 in the nucleotide binding site of beta-actin.
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10632717 H.Schüler, U.Lindberg, C.E.Schutt, and R.Karlsson (2000).
Thermal unfolding of G-actin monitored with the DNase I-inhibition assay stabilities of actin isoforms.
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10820002 Y.A.Puius, E.V.Fedorov, L.Eichinger, M.Schleicher, and S.C.Almo (2000).
Mapping the functional surface of domain 2 in the gelsolin superfamily.
  Biochemistry, 39, 5322-5331.
PDB code: 1svy
10653807 Z.Shao, D.Shi, and A.V.Somlyo (2000).
Cryoatomic force microscopy of filamentous actin.
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10506760 C.A.Schoenenberger, M.O.Steinmetz, D.Stoffler, A.Mandinova, and U.Aebi (1999).
Structure, assembly, and dynamics of actin filaments in situ and in vitro.
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10545173 C.M.Yengo, L.Chrin, A.S.Rovner, and C.L.Berger (1999).
Intrinsic tryptophan fluorescence identifies specific conformational changes at the actomyosin interface upon actin binding and ADP release.
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10506133 C.Renoult, D.Ternent, S.K.Maciver, A.Fattoum, C.Astier, Y.Benyamin, and C.Roustan (1999).
The identification of a second cofilin binding site on actin suggests a novel, intercalated arrangement of F-actin binding.
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Co-operative binding of Ca2+ ions to the regulatory binding sites of gelsolin.
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Functions of gelsolin: motility, signaling, apoptosis, cancer.
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10559185 H.Q.Sun, M.Yamamoto, M.Mejillano, and H.L.Yin (1999).
Gelsolin, a multifunctional actin regulatory protein.
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10491176 H.Schüler, E.Korenbaum, C.E.Schutt, U.Lindberg, and R.Karlsson (1999).
Mutational analysis of Ser14 and Asp157 in the nucleotide-binding site of beta-actin.
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10388764 J.Moraczewska, B.Wawro, K.Seguro, and H.Strzelecka-Golaszewska (1999).
Divalent cation-, nucleotide-, and polymerization-dependent changes in the conformation of subdomain 2 of actin.
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Proteins of the ADF/cofilin family: essential regulators of actin dynamics.
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Putting a new twist on actin: ADF/cofilins modulate actin dynamics.
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10581248 K.Moriyama, and I.Yahara (1999).
Two activities of cofilin, severing and accelerating directional depolymerization of actin filaments, are affected differentially by mutations around the actin-binding helix.
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10523791 L.Eichinger, S.S.Lee, and M.Schleicher (1999).
Dictyostelium as model system for studies of the actin cytoskeleton by molecular genetics.
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10564357 L.W.Roth, P.Bormann, C.Wiederkehr, and E.Reinhard (1999).
Beta-thymosin, a modulator of the actin cytoskeleton is increased in regenerating retinal ganglion cells.
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10872464 M.A.Geeves, and K.C.Holmes (1999).
Structural mechanism of muscle contraction.
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10635330 M.Marino, L.Braun, P.Cossart, and P.Ghosh (1999).
Structure of the lnlB leucine-rich repeats, a domain that triggers host cell invasion by the bacterial pathogen L. monocytogenes.
  Mol Cell, 4, 1063-1072.
PDB code: 1d0b
9990286 M.Van Troys, J.Vandekerckhove, and C.Ampe (1999).
Structural modules in actin-binding proteins: towards a new classification.
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10583954 R.C.Robinson, M.Mejillano, V.P.Le, L.D.Burtnick, H.L.Yin, and S.Choe (1999).
Domain movement in gelsolin: a calcium-activated switch.
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PDB code: 1db0
10357805 S.Steinbacher, P.Hof, L.Eichinger, M.Schleicher, J.Gettemans, J.Vandekerckhove, R.Huber, and J.Benz (1999).
The crystal structure of the Physarum polycephalum actin-fragmin kinase: an atypical protein kinase with a specialized substrate-binding domain.
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PDB code: 1cja
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Phototactic migration of Dictyostelium cells is linked to a new type of gelsolin-related protein.
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10223297 W.Wriggers, and K.Schulten (1999).
Investigating a back door mechanism of actin phosphate release by steered molecular dynamics.
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His(73), often methylated, is an important structural determinant for actin. A mutagenic analysis of HIS(73) of yeast actin.
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Determination of the gelsolin binding site on F-actin: implications for severing and capping.
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F-actin-binding proteins.
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Influence of tightly bound Mg2+ and Ca2+, nucleotides, and phalloidin on the microsecond torsional flexibility of F-actin.
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9789020 C.M.Yengo, P.M.Fagnant, L.Chrin, A.S.Rovner, and C.L.Berger (1998).
Smooth muscle myosin mutants containing a single tryptophan reveal molecular interactions at the actin-binding interface.
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9687375 E.T.Baldwin, R.W.Sarver, G.L.Bryant, K.A.Curry, M.B.Fairbanks, B.C.Finzel, R.L.Garlick, R.L.Heinrikson, N.C.Horton, L.L.Kelley, A.M.Mildner, J.B.Moon, J.E.Mott, V.T.Mutchler, C.S.Tomich, K.D.Watenpaugh, and V.H.Wiley (1998).
Cation binding to the integrin CD11b I domain and activation model assessment.
  Structure, 6, 923-935.
PDB codes: 1bho 1bhq 1idn
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Intrastrand cross-linked actin between Gln-41 and Cys-374. I. Mapping of sites cross-linked in F-actin by N-(4-azido-2-nitrophenyl) putrescine.
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9826630 H.J.Kinosian, J.Newman, B.Lincoln, L.A.Selden, L.C.Gershman, and J.E.Estes (1998).
Ca2+ regulation of gelsolin activity: binding and severing of F-actin.
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9521082 J.Delon, N.Bercovici, R.Liblau, and A.Trautmann (1998).
Imaging antigen recognition by naive CD4+ T cells: compulsory cytoskeletal alterations for the triggering of an intracellular calcium response.
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9620616 J.Feinberg, O.Kwiatek, C.Astier, S.Diennet, J.Mery, F.Heitz, Y.Benyamin, and C.Roustan (1998).
Capping and dynamic relation between domains 1 and 2 of gelsolin.
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Severing of F-actin by the amino-terminal half of gelsolin suggests internal cooperativity in gelsolin.
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9452496 M.G.Marcu, L.Zhang, A.Elzagallaai, and J.M.Trifaró (1998).
Localization by segmental deletion analysis and functional characterization of a third actin-binding site in domain 5 of scinderin.
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Deconstructing gelsolin: identifying sites that mimic or alter binding to actin and phosphoinositides.
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The ADF homology (ADF-H) domain: a highly exploited actin-binding module.
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9484606 S.K.Maciver (1998).
How ADF/cofilin depolymerizes actin filaments.
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Gelsolin-related familial amyloidosis, Finnish type (FAF), and its variants found worldwide.
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9826591 T.Oda, K.Makino, I.Yamashita, K.Namba, and Y.Maéda (1998).
Effect of the length and effective diameter of F-actin on the filament orientation in liquid crystalline sols measured by x-ray fiber diffraction.
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9692980 V.K.Vinson, E.M.De La Cruz, H.N.Higgs, and T.D.Pollard (1998).
Interactions of Acanthamoeba profilin with actin and nucleotides bound to actin.
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9668123 X.Li, Y.Matsuoka, and V.Bennett (1998).
Adducin preferentially recruits spectrin to the fast growing ends of actin filaments in a complex requiring the MARCKS-related domain and a newly defined oligomerization domain.
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9484592 Y.A.Puius, N.M.Mahoney, and S.C.Almo (1998).
The modular structure of actin-regulatory proteins.
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9525888 Y.T.Liu, and H.L.Yin (1998).
Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies.
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9145106 A.A.Fedorov, P.Lappalainen, E.V.Fedorov, D.G.Drubin, and S.C.Almo (1997).
Structure determination of yeast cofilin.
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PDB codes: 1cfy 1cof 1qpv
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Structural trees for protein superfamilies.
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8995427 B.Kuang, and P.A.Rubenstein (1997).
Beryllium fluoride and phalloidin restore polymerizability of a mutant yeast actin (V266G,L267G) with severely decreased hydrophobicity in a subdomain 3/4 loop.
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9164452 C.E.Schutt, C.Kreatsoulas, R.Page, and U.Lindberg (1997).
Plugging into actin's architectonic socket.
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9153421 D.Safer, T.R.Sosnick, and M.Elzinga (1997).
Thymosin beta 4 binds actin in an extended conformation and contacts both the barbed and pointed ends.
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9151693 F.Rauch, B.Polzar, H.Stephan, S.Zanotti, R.Paddenberg, and H.G.Mannherz (1997).
Androgen ablation leads to an upregulation and intranuclear accumulation of deoxyribonuclease I in rat prostate epithelial cells paralleling their apoptotic elimination.
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9108732 J.Feinberg, J.Mery, F.Heitz, Y.Benyamin, and C.Roustan (1997).
Conformational and functional studies of three gelsolin subdomain-1 synthetic peptides and their implication in actin polymerization.
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9202421 J.J.Hsuan, and S.H.Tan (1997).
Growth factor-dependent phosphoinositide signalling.
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9289015 K.Davoodian, B.W.Ritchings, R.Ramphal, and M.R.Bubb (1997).
Gelsolin activates DNase I in vitro and cystic fibrosis sputum.
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9164454 K.Djinovic Carugo, S.Bañuelos, and M.Saraste (1997).
Crystal structure of a calponin homology domain.
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PDB code: 1aa2
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Gelsolin binding to phosphatidylinositol 4,5-bisphosphate is modulated by calcium and pH.
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9201989 L.Feng, E.Kim, W.L.Lee, C.J.Miller, B.Kuang, E.Reisler, and P.A.Rubenstein (1997).
Fluorescence probing of yeast actin subdomain 3/4 hydrophobic loop 262-274. Actin-actin and actin-myosin interactions in actin filaments.
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Refined structure of villin 14T and a detailed comparison with other actin-severing domains.
  Protein Sci, 6, 1197-1209.
PDB codes: 2vik 2vil
9407048 M.Van Troys, D.Dewitte, J.L.Verschelde, M.Goethals, J.Vandekerckhove, and C.Ampe (1997).
Analogous F-actin binding by cofilin and gelsolin segment 2 substantiates their structural relationship.
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9200683 P.D.Moens, and C.G.dos Remedios (1997).
A conformational change in F-actin when myosin binds: fluorescence resonance energy transfer detects an increase in the radial coordinate of Cys-374.
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Essential functions and actin-binding surfaces of yeast cofilin revealed by systematic mutagenesis.
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9238011 R.Mendelson, and E.P.Morris (1997).
The structure of the acto-myosin subfragment 1 complex: results of searches using data from electron microscopy and x-ray crystallography.
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PDB code: 1alm
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Crystal structure of the actin-binding protein actophorin from Acanthamoeba.
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PDB code: 1ahq
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Interhead distances in myosin attached to F-actin estimated by fluorescence energy transfer spectroscopy.
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9251809 S.Khaitlina, and H.Hinssen (1997).
Conformational changes in actin induced by its interaction with gelsolin.
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9251782 W.Wriggers, and K.Schulten (1997).
Stability and dynamics of G-actin: back-door water diffusion and behavior of a subdomain 3/4 loop.
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The plasma and cytoplasmic forms of human gelsolin differ in disulfide structure.
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Multiple pathways for denaturation of horse plasma gelsolin.
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Kinetics of gelsolin interaction with phalloidin-stabilized F-actin. Rate constants for binding and severing.
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Yeast actin: polymerization kinetic studies of wild type and a poorly polymerizing mutant.
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8970724 K.R.Ayscough, and D.G.Drubin (1996).
ACTIN: general principles from studies in yeast.
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Local mobility within villin 14T probed via heteronuclear relaxation measurements and a reduced spectral density mapping.
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Binding of phosphate, aluminum fluoride, or beryllium fluoride to F-actin inhibits severing by gelsolin.
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Phospholipase D regulation by a physical interaction with the actin-binding protein gelsolin.
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8552606 R.A.Milligan (1996).
Protein-protein interactions in the rigor actomyosin complex.
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Fifty ways to love your lever: myosin motors.
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Sequences of actin implicated in the polymerization process: a simplified mathematical approach to probe the role of these segments.
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Purification and characterization of bovine profilin II. Actin, poly(L-proline) and inositolphospholipid binding.
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N-ethylmaleimide-modified actin filaments do not bundle in the presence of alpha-actinin.
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Structural studies on the ribbon-to-helix transition in profilin: actin crystals.
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Actin and the actomyosin interface: a review.
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Deletion of amino acids from the carboxy-terminal end of actin.
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Dynamic and elastic properties of F-actin: a normal-modes analysis.
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Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families.
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New insights into actin filament dynamics.
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8749383 E.H.Egelman (1995).
Motile systems: Tubulin-based motility races ahead.
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Conformational changes in subdomain 2 of G-actin: fluorescence probing by dansyl ethylenediamine attached to Gln-41.
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Microtubules and microtubule-associated proteins.
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Gain-of-function mutations conferring actin-severing activity to human macrophage cap G.
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Functions of [His321]gelsolin isolated from a flat revertant of ras-transformed cells.
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Molecular and mutational analysis of a gelsolin-family member encoded by the flightless I gene of Drosophila melanogaster.
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Binding of divalent cation and nucleotide to G-actin in the presence of profilin.
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Molecular cloning, expression, and mapping of the high affinity actin-capping domain of chicken cardiac tensin.
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Identification of two sites in gelsolin with different sensitivities to adenine nucleotides.
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Sequence and domain organization of scruin, an actin-cross-linking protein in the acrosomal process of Limulus sperm.
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9383404 P.A.Janmey (1995).
Protein regulation by phosphatidylinositol lipids.
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Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells.
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7579653 S.R.Price, and K.Nagai (1995).
Protein engineering as a tool for crystallography.
  Curr Opin Biotechnol, 6, 425-430.  
8599675 W.Xian, R.Vegners, P.A.Janmey, and W.H.Braunlin (1995).
Spectroscopic studies of a phosphoinositide-binding peptide from gelsolin: behavior in solutions of mixed solvent and anionic micelles.
  Biophys J, 69, 2695-2702.
PDB code: 1sol
8078936 A.A.Fedorov, K.A.Magnus, M.H.Graupe, E.E.Lattman, T.D.Pollard, and S.C.Almo (1994).
X-ray structures of isoforms of the actin-binding protein profilin that differ in their affinity for phosphatidylinositol phosphates.
  Proc Natl Acad Sci U S A, 91, 8636-8640.
PDB codes: 1acf 2acg
8076643 A.Ditsch, and A.Wegner (1994).
Nucleation of actin polymerization by gelsolin.
  Eur J Biochem, 224, 223-227.  
8034744 A.McGough, M.Way, and D.DeRosier (1994).
Determination of the alpha-actinin-binding site on actin filaments by cryoelectron microscopy and image analysis.
  J Cell Biol, 126, 433-443.  
7656044 C.R.Bagshaw, and M.J.Sutcliffe (1994).
Another turn for E-F hands.
  Nat Struct Biol, 1, 209-212.  
8034743 D.A.Holtzman, K.F.Wertman, and D.G.Drubin (1994).
Mapping actin surfaces required for functional interactions in vivo.
  J Cell Biol, 126, 423-432.  
7945275 D.Safer, and V.T.Nachmias (1994).
Beta thymosins as actin binding peptides.
  Bioessays, 16, 473-479.  
7953532 E.Donnadieu, G.Bismuth, and A.Trautmann (1994).
Antigen recognition by helper T cells elicits a sequence of distinct changes of their shape and intracellular calcium.
  Curr Biol, 4, 584-595.  
7922321 E.H.Egelman (1994).
Actin filament structure. The ghost of ribbons past.
  Curr Biol, 4, 79-81.  
8001585 K.Giehl, R.Valenta, M.Rothkegel, M.Ronsiek, H.G.Mannherz, and B.M.Jockusch (1994).
Interaction of plant profilin with mammalian actin.
  Eur J Biochem, 226, 681-689.  
  8137812 K.Weber, and W.Kabsch (1994).
Intron positions in actin genes seem unrelated to the secondary structure of the protein.
  EMBO J, 13, 1280-1286.  
8075541 M.A.Markus, T.Nakayama, P.Matsudaira, and G.Wagner (1994).
1H, 15N, 13C and 13CO resonance assignments and secondary structure of villin 14T, a domain conserved among actin-severing proteins.
  J Biomol NMR, 4, 553-574.  
8175883 M.C.Stella, H.Schauerte, K.L.Straub, and M.Leptin (1994).
Identification of secreted and cytosolic gelsolin in Drosophila.
  J Cell Biol, 125, 607-616.  
8167031 M.D.Rozycki, J.C.Myslik, C.E.Schutt, and U.Lindberg (1994).
Structural aspects of actin-binding proteins.
  Curr Opin Cell Biol, 6, 87-95.  
8170944 M.Feese, D.W.Pettigrew, N.D.Meadow, S.Roseman, and S.J.Remington (1994).
Cation-promoted association of a regulatory and target protein is controlled by protein phosphorylation.
  Proc Natl Acad Sci U S A, 91, 3544-3548.
PDB codes: 1glc 1gld 1gle
7891673 M.G.Marcu, A.Rodríguez del Castillo, M.L.Vitale, and J.M.Trifaró (1994).
Molecular cloning and functional expression of chromaffin cell scinderin indicates that it belongs to the family of Ca(2+)-dependent F-actin severing proteins.
  Mol Cell Biochem, 141, 153-165.  
8058791 M.Harata, A.Karwan, and U.Wintersberger (1994).
An essential gene of Saccharomyces cerevisiae coding for an actin-related protein.
  Proc Natl Acad Sci U S A, 91, 8258-8262.  
7858132 R.H.Crosbie, C.Miller, P.Cheung, T.Goodnight, A.Muhlrad, and E.Reisler (1994).
Structural connectivity in actin: effect of C-terminal modifications on the properties of actin.
  Biophys J, 67, 1957-1964.  
8044841 S.Mahajan-Miklos, and L.Cooley (1994).
The villin-like protein encoded by the Drosophila quail gene is required for actin bundle assembly during oogenesis.
  Cell, 78, 291-301.  
7957213 T.Giebing, H.Hinssen, and J.D'Haese (1994).
The complete sequence of a 40-kDa actin-modulating protein from the earthworm Lumbricus terrestris.
  Eur J Biochem, 225, 773-779.  
  8247001 B.K.Haarer, A.S.Petzold, and S.S.Brown (1993).
Mutational analysis of yeast profilin.
  Mol Cell Biol, 13, 7864-7873.  
14731651 D.Bray (1993).
Towards the molecular physiology of cell movements.
  Trends Cell Biol, 3, 363-365.  
  8167410 D.G.Drubin, H.D.Jones, and K.F.Wertman (1993).
Actin structure and function: roles in mitochondrial organization and morphogenesis in budding yeast and identification of the phalloidin-binding site.
  Mol Biol Cell, 4, 1277-1294.  
15335826 M.Way, and P.Matsudaira (1993).
The secrets of severing?
  Curr Biol, 3, 887-890.  
8269940 T.Hesterkamp, A.G.Weeds, and H.G.Mannherz (1993).
The actin monomers in the ternary gelsolin: 2 actin complex are in an antiparallel orientation.
  Eur J Biochem, 218, 507-513.  
16100951 V.Guillet, A.Lapthorn, R.W.Hartley, and Y.Mauguen (1993).
Recognition between a bacterial ribonuclease, barnase, and its natural inhibitor, barstar.
  Structure, 1, 165-176.
PDB code: 1bgs
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