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PDBsum entry 1eff
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Knowledge based model of an inhibitor bound to a thiol(cystein) protease, papain complexed with napqi
Papain. Chain: a. Ec: 22.214.171.124
Carica papaya. Papaya. Organ: fruit. Secretion: latex
A.Banerjee et al. Structural basis of inactivation of thiol protease by imine (napqi). A knowledge based molecular modelling study of the adduct of napqi with the thiol protease of papain family..
To be published
(PAPA1_CARPA) - Papain
PDB and UniProt seqs differ at 3 residue positions (black crosses)
Hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic sidechain at the P2 position. Does not accept Val at P1'.
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