PDBsum entry: 1e80

Hydrolase/hydrolase inhibitor

PDB id: 1e80

Contents

Protein chain

330 a.a. *

Ligands

0GQ

Waters ×166

* Residue conservation analysis

PDB id:

1e80

Name:

Hydrolase/hydrolase inhibitor

Title:

Endothiapepsin complex with renin inhibitor merck-kgaa-emd56

Structure:

Endothiapepsin. Chain: e. Fragment: residues 90-419. Ec: 3.4.23.23

Source:

Endothia parasitica. Organism_taxid: 5116

Biol. unit:

Dimer (from PQS)

Resolution:

2.05Å R-factor: 0.186 R-free: 0.221

Authors:

J.A.Read,J.B.Cooper,L.Toldo,F.Rippmann,P.Raddatz

Key ref:

J.A.Read Refinement of four endothiapepsin inhibitor complexes. Crystallographic studies of cytochrome ch from methylobacterium extorquens and inhibitor complexes of aspartic proteinases.. Ph d thesis, PubMed id: -1

Date:

15-Sep-00 Release date: 26-Sep-00

Protein chain

P11838  (CARP_CRYPA) -  Endothiapepsin

Seq: 419 a.a.

Struc: 330 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.23.22 - Endothiapepsin.
• Reaction: Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but does not cleave 14-Ala-|-Leu-15 in the B chain of insulin or Z-Glu-Tyr. Clots milk.

 Gene Ontology (GO) functional annotation 

• Biological process: proteolysis (1 term)
• Biochemical function: aspartic-type endopeptidase activity (1 term)