PDBsum entry 1e3b

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Isomerase PDB id
Protein chain
172 a.a. *
Waters ×217
* Residue conservation analysis
PDB id:
Name: Isomerase
Title: Cyclophilin 3 from c.Elegans complexed with aup(et)3
Structure: Cyclophilin 3. Chain: a. Engineered: yes
Source: Caenorhabditis elegans. Organism_taxid: 6239. Expressed in: escherichia coli. Expression_system_taxid: 511693.
1.85Å     R-factor:   0.184     R-free:   0.246
Authors: J.Zou,P.Taylor,J.Dornan,S.P.Robinson,M.D.Walkinshaw, P.J.Sadler
Key ref: J.Zou et al. (2000). First Crystal Structure of a Medicinally Relevant Gold Protein Complex: Unexpected Binding of Angew Chem Int Ed Engl, 39, 2931-2934. PubMed id: 11028014
08-Jun-00     Release date:   22-Oct-00    
Go to PROCHECK summary

Protein chain
Pfam   ArchSchema ?
P52011  (CYP3_CAEEL) -  Peptidyl-prolyl cis-trans isomerase 3
173 a.a.
172 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.  - Peptidylprolyl isomerase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Peptidylproline (omega=180) = peptidylproline (omega=0)
Peptidylproline (omega=180)
= peptidylproline (omega=0)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cell   1 term 
  Biological process     protein folding   2 terms 
  Biochemical function     protein binding     3 terms  


    Added reference    
Angew Chem Int Ed Engl 39:2931-2934 (2000)
PubMed id: 11028014  
First Crystal Structure of a Medicinally Relevant Gold Protein Complex: Unexpected Binding of
J.Zou, P.Taylor, J.Dornan, S.P.Robinson, M.D.Walkinshaw, P.J.Sadler.
No abstract given.


Literature references that cite this PDB file's key reference

  PubMed id Reference
21321730 K.P.Bhabak, B.J.Bhuyan, and G.Mugesh (2011).
Bioinorganic and medicinal chemistry: aspects of gold(i)-protein complexes.
  Dalton Trans, 40, 2099-2111.  
21181484 L.Messori, A.Balerna, I.Ascone, C.Castellano, C.Gabbiani, A.Casini, C.Marchioni, G.Jaouen, and A.Congiu Castellano (2011).
X-ray absorption spectroscopy studies of the adducts formed between cytotoxic gold compounds and two major serum proteins.
  J Biol Inorg Chem, 16, 491-499.  
19278006 D.S.Hage, A.Jackson, M.R.Sobansky, J.E.Schiel, M.J.Yoo, and K.S.Joseph (2009).
Characterization of drug-protein interactions in blood using high-performance affinity chromatography.
  J Sep Sci, 32, 835-853.  
19225621 E.Meggers (2009).
Targeting proteins with metal complexes.
  Chem Commun (Camb), (), 1001-1010.  
19296478 M.L.Conrad, A.C.Moser, and D.S.Hage (2009).
Evaluation of indole-based probes for high-throughput screening of drug binding to human serum albumin: Analysis by high-performance affinity chromatography.
  J Sep Sci, 32, 1145-1155.  
17534481 X.Liang, D.J.Campopiano, and P.J.Sadler (2007).
Metals in membranes.
  Chem Soc Rev, 36, 968-992.  
16892376 A.Casini, C.Gabbiani, G.Mastrobuoni, L.Messori, G.Moneti, and G.Pieraccini (2006).
Exploring metallodrug-protein interactions by ESI mass spectrometry: the reaction of anticancer platinum drugs with horse heart cytochrome c.
  ChemMedChem, 1, 413-417.  
16791640 J.Talib, J.L.Beck, and S.F.Ralph (2006).
A mass spectrometric investigation of the binding of gold antiarthritic agents and the metabolite [Au(CN)2]- to human serum albumin.
  J Biol Inorg Chem, 11, 559-570.  
17056271 S.Urig, and K.Becker (2006).
On the potential of thioredoxin reductase inhibitors for cancer therapy.
  Semin Cancer Biol, 16, 452-465.  
16493712 S.Urig, K.Fritz-Wolf, R.Réau, C.Herold-Mende, K.Tóth, E.Davioud-Charvet, and K.Becker (2006).
Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases.
  Angew Chem Int Ed Engl, 45, 1881-1886.
PDB code: 2aaq
15792952 M.Deponte, S.Urig, L.D.Arscott, K.Fritz-Wolf, R.Réau, C.Herold-Mende, S.Koncarevic, M.Meyer, E.Davioud-Charvet, D.P.Ballou, C.H.Williams, and K.Becker (2005).
Mechanistic studies on a novel, highly potent gold-phosphole inhibitor of human glutathione reductase.
  J Biol Chem, 280, 20628-20637.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.