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* Residue conservation analysis
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Gene Ontology (GO) functional annotation
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Cellular component
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extracellular region
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8 terms
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Biological process
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viral reproduction
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13 terms
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Biochemical function
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protein binding
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1 term
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J Immunol
165:3260-3267
(2000)
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PubMed id:
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Nonstandard peptide binding revealed by crystal structures of HLA-B*5101 complexed with HIV immunodominant epitopes.
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K.Maenaka,
T.Maenaka,
H.Tomiyama,
M.Takiguchi,
D.I.Stuart,
E.Y.Jones.
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ABSTRACT
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The crystal structures of the human MHC class I allele HLA-B*5101 in complex
with 8-mer, TAFTIPSI, and 9-mer, LPPVVAKEI, immunodominant peptide epitopes from
HIV-1 have been determined by x-ray crystallography. In both complexes, the
hydrogen-bonding network in the N-terminal anchor (P1) pocket is rearranged as a
result of the replacement of the standard tyrosine with histidine at position
171. This results in a nonstandard positioning of the peptide N terminus, which
is recognized by B*5101-restricted T cell clones. Unexpectedly, the P5 peptide
residues appear to act as anchors, drawing the peptides unusually deeply into
the peptide-binding groove of B51. The unique characteristics of P1 and P5 are
likely to be responsible for the zig-zag conformation of the 9-mer peptide and
the slow assembly of B*5101. A comparison of the surface characteristics in the
alpha1-helix C-terminal region for B51 and other MHC class I alleles highlights
mainly electrostatic differences that may be important in determining the
specificity of human killer cell Ig-like receptor binding.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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Y.Kawashima,
N.Kuse,
H.Gatanaga,
T.Naruto,
M.Fujiwara,
S.Dohki,
T.Akahoshi,
K.Maenaka,
P.Goulder,
S.Oka,
and
M.Takiguchi
(2010).
Long-term control of HIV-1 in hemophiliacs carrying slow-progressing allele HLA-B*5101.
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J Virol, 84,
7151-7160.
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P.Kumar,
A.Vahedi-Faridi,
W.Saenger,
E.Merino,
J.A.López de Castro,
B.Uchanska-Ziegler,
and
A.Ziegler
(2009).
Structural basis for T cell alloreactivity among three HLA-B14 and HLA-B27 antigens.
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J Biol Chem, 284,
29784-29797.
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PDB codes:
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B.Sanjanwala,
M.Draghi,
P.J.Norman,
L.A.Guethlein,
and
P.Parham
(2008).
Polymorphic sites away from the Bw4 epitope that affect interaction of Bw4+ HLA-B with KIR3DL1.
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J Immunol, 181,
6293-6300.
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G.M.Gillespie,
A.Bashirova,
T.Dong,
D.W.McVicar,
S.L.Rowland-Jones,
and
M.Carrington
(2007).
Lack of KIR3DS1 binding to MHC class I Bw4 tetramers in complex with CD8+ T cell epitopes.
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AIDS Res Hum Retroviruses, 23,
451-455.
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I.Görzer,
E.Puchhammer-Stöckl,
J.W.van Esser,
H.G.Niesters,
and
J.J.Cornelissen
(2007).
Associations among Epstein-Barr virus subtypes, human leukocyte antigen class I alleles, and the development of posttransplantation lymphoproliferative disorder in bone marrow transplant recipients.
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Clin Infect Dis, 44,
693-695.
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K.E.Garrison,
R.B.Jones,
D.A.Meiklejohn,
N.Anwar,
L.C.Ndhlovu,
J.M.Chapman,
A.L.Erickson,
A.Agrawal,
G.Spotts,
F.M.Hecht,
S.Rakoff-Nahoum,
J.Lenz,
M.A.Ostrowski,
and
D.F.Nixon
(2007).
T cell responses to human endogenous retroviruses in HIV-1 infection.
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PLoS Pathog, 3,
e165.
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A.J.Bordner,
and
R.Abagyan
(2006).
Ab initio prediction of peptide-MHC binding geometry for diverse class I MHC allotypes.
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Proteins, 63,
512-526.
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D.Gebreselassie,
H.Spiegel,
and
S.Vukmanovic
(2006).
Sampling of major histocompatibility complex class I-associated peptidome suggests relatively looser global association of HLA-B*5101 with peptides.
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Hum Immunol, 67,
894-906.
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J.Y.Baek,
Y.Y.Cha,
Y.S.Heo,
K.Kwack,
and
O.J.Kwon
(2006).
Identification of a novel HLA-B*51 allele, HLA-B*5137, in the Korean population.
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Tissue Antigens, 67,
254-255.
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B.Loll,
A.Zawacka,
J.Biesiadka,
C.Rückert,
A.Volz,
W.Saenger,
B.Uchanska-Ziegler,
and
A.Ziegler
(2005).
Purification, crystallization and preliminary X-ray diffraction analysis of the human major histocompatibility antigen HLA-B*2703 complexed with a viral peptide and with a self-peptide.
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Acta Crystallogr Sect F Struct Biol Cryst Commun, 61,
372-374.
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L.Li,
W.Chen,
and
M.Bouvier
(2005).
A biochemical and structural analysis of genetic diversity within the HLA-A*11 subtype.
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Immunogenetics, 57,
315-325.
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H.A.Stephens,
R.Klaythong,
M.Sirikong,
D.W.Vaughn,
S.Green,
S.Kalayanarooj,
T.P.Endy,
D.H.Libraty,
A.Nisalak,
B.L.Innis,
A.L.Rothman,
F.A.Ennis,
and
D.Chandanayingyong
(2002).
HLA-A and -B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais.
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Tissue Antigens, 60,
309-318.
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O.Schueler-Furman,
Y.Altuvia,
and
H.Margalit
(2001).
Examination of possible structural constraints of MHC-binding peptides by assessment of their native structure within their source proteins.
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Proteins, 45,
47-54.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
