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Contents |
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* Residue conservation analysis
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DOI no:
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Cell
101:47-56
(2000)
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PubMed id:
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Structural basis of collagen recognition by integrin alpha2beta1.
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J.Emsley,
C.G.Knight,
R.W.Farndale,
M.J.Barnes,
R.C.Liddington.
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ABSTRACT
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We have determined the crystal structure of a complex between the I domain of
integrin alpha2beta1 and a triple helical collagen peptide containing a critical
GFOGER motif. Three loops on the upper surface of the I domain that coordinate a
metal ion also engage the collagen, with a collagen glutamate completing the
coordination sphere of the metal. Comparison with the unliganded I domain
reveals a change in metal coordination linked to a reorganization of the upper
surface that together create a complementary surface for binding collagen.
Conformational changes propagate from the upper surface to the opposite pole of
the domain, suggesting both a basis for affinity regulation and a pathway for
signal transduction. The structural features observed here may represent a
general mechanism for integrin-ligand recognition.
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Selected figure(s)
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Figure 3.
Figure 3. Two Conformations of the Integrin α2-I Domain
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Figure 4.
Figure 4. Comparison of Conformational Changes in the α2-
and αM-I Domains
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The above figures are
reprinted
by permission from Cell Press:
Cell
(2000,
101,
47-56)
copyright 2000.
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Figures were
selected
by an automated process.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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J.A.Tamames,
and
M.J.Ramos
(2011).
Metals in proteins: cluster analysis studies.
|
| |
J Mol Model, 17,
429-442.
|
|
|
|
|
|
|
K.Vengadesan,
and
S.V.Narayana
(2011).
Structural biology of gram-positive bacterial adhesins.
|
| |
Protein Sci, 20,
759-772.
|
|
|
|
|
|
|
L.Vitagliano,
R.Berisio,
and
A.De Simone
(2011).
Role of hydration in collagen recognition by bacterial adhesins.
|
| |
Biophys J, 100,
2253-2261.
|
|
|
|
|
|
|
M.Landau,
and
N.Rosenberg
(2011).
Molecular insight into human platelet antigens: structural and evolutionary conservation analyses offer new perspective to immunogenic disorders.
|
| |
Transfusion, 51,
558-569.
|
|
|
|
|
|
|
Q.Lin,
J.Yan,
F.Qiu,
X.Song,
G.Fu,
and
J.Ji
(2011).
Heparin/collagen multilayer as a thromboresistant and endothelial favorable coating for intravascular stent.
|
| |
J Biomed Mater Res A, 96,
132-141.
|
|
|
|
|
|
|
Q.Xue,
C.Gu,
J.Rivera,
M.Höök,
X.Chen,
A.Pozzi,
and
Y.Xu
(2011).
Entry of Bacillus anthracis spores into epithelial cells is mediated by the spore surface protein BclA, integrin α2β1 and complement component C1q.
|
| |
Cell Microbiol, 13,
620-634.
|
|
|
|
|
|
|
C.M.Yamazaki,
Y.Kadoya,
K.Hozumi,
H.Okano-Kosugi,
S.Asada,
K.Kitagawa,
M.Nomizu,
and
T.Koide
(2010).
A collagen-mimetic triple helical supramolecule that evokes integrin-dependent cell responses.
|
| |
Biomaterials, 31,
1925-1934.
|
|
|
|
|
|
|
D.S.Tzeranis,
A.Roy,
P.T.So,
and
I.V.Yannas
(2010).
An optical method to quantify the density of ligands for cell adhesion receptors in three-dimensional matrices.
|
| |
J R Soc Interface, 7,
S649-S661.
|
|
|
|
|
|
|
G.B.Fields
(2010).
Synthesis and biological applications of collagen-model triple-helical peptides.
|
| |
Org Biomol Chem, 8,
1237-1258.
|
|
|
|
|
|
|
H.Yamashita,
M.Tripathi,
M.P.Harris,
S.Liu,
B.Weidow,
R.Zent,
and
V.Quaranta
(2010).
The role of a recombinant fragment of laminin-332 in integrin alpha3beta1-dependent cell binding, spreading and migration.
|
| |
Biomaterials, 31,
5110-5121.
|
|
|
|
|
|
|
J.A.Fallas,
L.E.O'Leary,
and
J.D.Hartgerink
(2010).
Synthetic collagen mimics: self-assembly of homotrimers, heterotrimers and higher order structures.
|
| |
Chem Soc Rev, 39,
3510-3527.
|
|
|
|
|
|
|
J.C.Leo,
H.Elovaara,
D.Bihan,
N.Pugh,
S.K.Kilpinen,
N.Raynal,
M.Skurnik,
R.W.Farndale,
and
A.Goldman
(2010).
First analysis of a bacterial collagen-binding protein with collagen Toolkits: promiscuous binding of YadA to collagens may explain how YadA interferes with host processes.
|
| |
Infect Immun, 78,
3226-3236.
|
|
|
|
|
|
|
J.Emsley
(2010).
Convergent recognition of a triple helical hydrophobic motif in collagen.
|
| |
Structure, 18,
1-2.
|
|
|
|
|
|
|
J.Jokinen,
D.J.White,
M.Salmela,
M.Huhtala,
J.Käpylä,
K.Sipilä,
J.S.Puranen,
L.Nissinen,
P.Kankaanpää,
V.Marjomäki,
T.Hyypiä,
M.S.Johnson,
and
J.Heino
(2010).
Molecular mechanism of alpha2beta1 integrin interaction with human echovirus 1.
|
| |
EMBO J, 29,
196-208.
|
|
|
|
|
|
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R.Liddington
(2010).
Catching pneumonia.
|
| |
Structure, 18,
6-8.
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|
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S.J.Shattil,
C.Kim,
and
M.H.Ginsberg
(2010).
The final steps of integrin activation: the end game.
|
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Nat Rev Mol Cell Biol, 11,
288-300.
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|
|
|
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T.Izoré,
C.Contreras-Martel,
L.El Mortaji,
C.Manzano,
R.Terrasse,
T.Vernet,
A.M.Di Guilmi,
and
A.Dessen
(2010).
Structural basis of host cell recognition by the pilus adhesin from Streptococcus pneumoniae.
|
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Structure, 18,
106-115.
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PDB code:
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T.Thijs,
B.P.Nuyttens,
H.Deckmyn,
and
K.Broos
(2010).
Platelet physiology and antiplatelet agents.
|
| |
Clin Chem Lab Med, 48,
S3-13.
|
|
|
|
|
|
|
U.Venkatraman Girija,
C.Furze,
J.Toth,
W.J.Schwaeble,
D.A.Mitchell,
A.H.Keeble,
and
R.Wallis
(2010).
Engineering novel complement activity into a pulmonary surfactant protein.
|
| |
J Biol Chem, 285,
10546-10552.
|
|
|
|
|
|
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A.B.Herr,
and
R.W.Farndale
(2009).
Structural insights into the interactions between platelet receptors and fibrillar collagen.
|
| |
J Biol Chem, 284,
19781-19785.
|
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|
|
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C.G.Gahmberg,
S.C.Fagerholm,
S.M.Nurmi,
T.Chavakis,
S.Marchesan,
and
M.Grönholm
(2009).
Regulation of integrin activity and signalling.
|
| |
Biochim Biophys Acta, 1790,
431-444.
|
|
|
|
|
|
|
C.T.Lefort,
Y.M.Hyun,
J.B.Schultz,
F.Y.Law,
R.E.Waugh,
P.A.Knauf,
and
M.Kim
(2009).
Outside-in signal transmission by conformational changes in integrin Mac-1.
|
| |
J Immunol, 183,
6460-6468.
|
|
|
|
|
|
|
D.W.Essex
(2009).
Redox control of platelet function.
|
| |
Antioxid Redox Signal, 11,
1191-1225.
|
|
|
|
|
|
|
F.Carafoli,
D.Bihan,
S.Stathopoulos,
A.D.Konitsiotis,
M.Kvansakul,
R.W.Farndale,
B.Leitinger,
and
E.Hohenester
(2009).
Crystallographic insight into collagen recognition by discoidin domain receptor 2.
|
| |
Structure, 17,
1573-1581.
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PDB code:
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F.Carafoli,
N.J.Clout,
and
E.Hohenester
(2009).
Crystal structure of the LG1-3 region of the laminin alpha2 chain.
|
| |
J Biol Chem, 284,
22786-22792.
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PDB code:
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H.Uysal,
R.Bockermann,
K.S.Nandakumar,
B.Sehnert,
E.Bajtner,
A.Engström,
G.Serre,
H.Burkhardt,
M.M.Thunnissen,
and
R.Holmdahl
(2009).
Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis.
|
| |
J Exp Med, 206,
449-462.
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PDB codes:
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J.A.Fallas,
V.Gauba,
and
J.D.Hartgerink
(2009).
Solution structure of an ABC collagen heterotrimer reveals a single-register helix stabilized by electrostatic interactions.
|
| |
J Biol Chem, 284,
26851-26859.
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PDB code:
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J.D.San Antonio,
J.J.Zoeller,
K.Habursky,
K.Turner,
W.Pimtong,
M.Burrows,
S.Choi,
S.Basra,
J.S.Bennett,
W.F.DeGrado,
and
R.V.Iozzo
(2009).
A key role for the integrin alpha2beta1 in experimental and developmental angiogenesis.
|
| |
Am J Pathol, 175,
1338-1347.
|
|
|
|
|
|
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K.Okuyama,
C.Hongo,
G.Wu,
K.Mizuno,
K.Noguchi,
S.Ebisuzaki,
Y.Tanaka,
N.Nishino,
and
H.P.Bächinger
(2009).
High-resolution structures of collagen-like peptides [(Pro-Pro-Gly)(4)-Xaa-Yaa-Gly-(Pro-Pro-Gly)(4)]: Implications for triple-helix hydration and Hyp(X) puckering.
|
| |
Biopolymers, 91,
361-372.
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PDB codes:
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|
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K.Tan,
and
J.Lawler
(2009).
The interaction of Thrombospondins with extracellular matrix proteins.
|
| |
J Cell Commun Signal, 3,
177-187.
|
|
|
|
|
|
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K.Tan,
M.Duquette,
A.Joachimiak,
and
J.Lawler
(2009).
The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding.
|
| |
FASEB J, 23,
2490-2501.
|
|
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PDB code:
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M.C.Erat,
D.A.Slatter,
E.D.Lowe,
C.J.Millard,
R.W.Farndale,
I.D.Campbell,
and
I.Vakonakis
(2009).
Identification and structural analysis of type I collagen sites in complex with fibronectin fragments.
|
| |
Proc Natl Acad Sci U S A, 106,
4195-4200.
|
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PDB code:
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M.D.Shoulders,
and
R.T.Raines
(2009).
Collagen structure and stability.
|
| |
Annu Rev Biochem, 78,
929-958.
|
|
|
|
|
|
|
M.W.Miller,
S.Basra,
D.W.Kulp,
P.C.Billings,
S.Choi,
M.P.Beavers,
O.J.McCarty,
Z.Zou,
M.L.Kahn,
J.S.Bennett,
and
W.F.Degrado
(2009).
Small-molecule inhibitors of integrin {alpha}2{beta}1 that prevent pathological thrombus formation via an allosteric mechanism.
|
| |
Proc Natl Acad Sci U S A, 106,
719-724.
|
|
|
|
|
|
|
M.Y.Go,
E.M.Chow,
and
J.Mogridge
(2009).
The cytoplasmic domain of anthrax toxin receptor 1 affects binding of the protective antigen.
|
| |
Infect Immun, 77,
52-59.
|
|
|
|
|
|
|
P.A.McEwan,
R.K.Andrews,
and
J.Emsley
(2009).
Glycoprotein Ib{alpha} inhibitor complex structure reveals a combined steric and allosteric mechanism of von Willebrand factor antagonism.
|
| |
Blood, 114,
4883-4885.
|
|
|
PDB code:
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S.H.Lee,
S.Hatakeyama,
S.Y.Yu,
X.Bao,
C.Ohyama,
K.H.Khoo,
M.N.Fukuda,
and
M.Fukuda
(2009).
Core3 O-Glycan Synthase Suppresses Tumor Formation and Metastasis of Prostate Carcinoma PC3 and LNCaP Cells through Down-regulation of {alpha}2{beta}1 Integrin Complex.
|
| |
J Biol Chem, 284,
17157-17169.
|
|
|
|
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|
|
T.Szanto,
K.Vanhoorelbeke,
G.Toth,
A.Vandenbulcke,
J.Toth,
W.Noppe,
H.Deckmyn,
and
J.Harsfalvi
(2009).
Identification of a VWF peptide antagonist that blocks platelet adhesion under high shear conditions by selectively inhibiting the VWF-collagen interaction.
|
| |
J Thromb Haemost, 7,
1680-1687.
|
|
|
|
|
|
|
V.Krishnan,
K.Ponnuraj,
Y.Xu,
K.Macon,
J.E.Volanakis,
and
S.V.Narayana
(2009).
The crystal structure of cobra venom factor, a cofactor for C3- and C5-convertase CVFBb.
|
| |
Structure, 17,
611-619.
|
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PDB code:
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V.Krishnan,
Y.Xu,
K.Macon,
J.E.Volanakis,
and
S.V.Narayana
(2009).
The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation.
|
| |
Acta Crystallogr D Biol Crystallogr, 65,
266-274.
|
|
|
PDB code:
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Y.C.Yeh,
C.Z.Wang,
and
M.J.Tang
(2009).
Discoidin domain receptor 1 activation suppresses alpha2beta1 integrin-dependent cell spreading through inhibition of Cdc42 activity.
|
| |
J Cell Physiol, 218,
146-156.
|
|
|
|
|
|
|
Y.Sugita,
Y.Suzuki,
K.Someya,
A.Ogawa,
H.Furuhata,
S.Miyoshi,
T.Motomura,
H.Miyamoto,
S.Igo,
and
Y.Nosé
(2009).
Experimental evaluation of a new antithrombogenic stent using ion beam surface modification.
|
| |
Artif Organs, 33,
456-463.
|
|
|
|
|
|
|
Y.Taniguchi,
H.Ido,
N.Sanzen,
M.Hayashi,
R.Sato-Nishiuchi,
S.Futaki,
and
K.Sekiguchi
(2009).
The C-terminal Region of Laminin {beta} Chains Modulates the Integrin Binding Affinities of Laminins.
|
| |
J Biol Chem, 284,
7820-7831.
|
|
|
|
|
|
|
Z.Zou,
A.A.Schmaier,
L.Cheng,
P.Mericko,
S.K.Dickeson,
T.P.Stricker,
S.A.Santoro,
and
M.L.Kahn
(2009).
Negative regulation of activated {alpha}2 integrins during thrombopoiesis.
|
| |
Blood, 113,
6428-6439.
|
|
|
|
|
|
|
A.D.Konitsiotis,
N.Raynal,
D.Bihan,
E.Hohenester,
R.W.Farndale,
and
B.Leitinger
(2008).
Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen.
|
| |
J Biol Chem, 283,
6861-6868.
|
|
|
|
|
|
|
B.Brodsky,
G.Thiagarajan,
B.Madhan,
and
K.Kar
(2008).
Triple-helical peptides: an approach to collagen conformation, stability, and self-association.
|
| |
Biopolymers, 89,
345-353.
|
|
|
|
|
|
|
B.P.Woodall,
A.Nyström,
R.A.Iozzo,
J.A.Eble,
S.Niland,
T.Krieg,
B.Eckes,
A.Pozzi,
and
R.V.Iozzo
(2008).
Integrin {alpha}2 1 Is the Required Receptor for Endorepellin Angiostatic Activity.
|
| |
J Biol Chem, 283,
2335-2343.
|
|
|
|
|
|
|
C.C.Caswell,
M.Barczyk,
D.R.Keene,
E.Lukomska,
D.E.Gullberg,
and
S.Lukomski
(2008).
Identification of the first prokaryotic collagen sequence motif that mediates binding to human collagen receptors, integrins alpha2beta1 and alpha11beta1.
|
| |
J Biol Chem, 283,
36168-36175.
|
|
|
|
|
|
|
C.Giudici,
N.Raynal,
H.Wiedemann,
W.A.Cabral,
J.C.Marini,
R.Timpl,
H.P.Bächinger,
R.W.Farndale,
T.Sasaki,
and
R.Tenni
(2008).
Mapping of SPARC/BM-40/osteonectin-binding sites on fibrillar collagens.
|
| |
J Biol Chem, 283,
19551-19560.
|
|
|
|
|
|
|
E.Hohenester,
T.Sasaki,
C.Giudici,
R.W.Farndale,
and
H.P.Bächinger
(2008).
Structural basis of sequence-specific collagen recognition by SPARC.
|
| |
Proc Natl Acad Sci U S A, 105,
18273-18277.
|
|
|
PDB code:
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|
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|
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|
|
H.Ido,
S.Ito,
Y.Taniguchi,
M.Hayashi,
R.Sato-Nishiuchi,
N.Sanzen,
Y.Hayashi,
S.Futaki,
and
K.Sekiguchi
(2008).
Laminin Isoforms Containing the {gamma}3 Chain Are Unable to Bind to Integrins due to the Absence of the Glutamic Acid Residue Conserved in the C-terminal Regions of the {gamma}1 and {gamma}2 Chains.
|
| |
J Biol Chem, 283,
28149-28157.
|
|
|
|
|
|
|
H.Zhang,
J.M.Casasnovas,
M.Jin,
J.H.Liu,
C.G.Gahmberg,
T.A.Springer,
and
J.H.Wang
(2008).
An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5.
|
| |
Mol Cell, 31,
432-437.
|
|
|
PDB code:
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|
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|
|
|
|
|
I.C.Munnix,
K.Gilio,
P.R.Siljander,
N.Raynal,
M.A.Feijge,
T.M.Hackeng,
H.Deckmyn,
P.A.Smethurst,
R.W.Farndale,
and
J.W.Heemskerk
(2008).
Collagen-mimetic peptides mediate flow-dependent thrombus formation by high- or low-affinity binding of integrin alpha2beta1 and glycoprotein VI.
|
| |
J Thromb Haemost, 6,
2132-2142.
|
|
|
|
|
|
|
J.M.Cosemans,
B.F.Iserbyt,
H.Deckmyn,
and
J.W.Heemskerk
(2008).
Multiple ways to switch platelet integrins on and off.
|
| |
J Thromb Haemost, 6,
1253-1261.
|
|
|
|
|
|
|
L.J.Lambert,
A.A.Bobkov,
J.W.Smith,
and
F.M.Marassi
(2008).
Competitive interactions of collagen and a jararhagin-derived disintegrin peptide with the integrin alpha2-I domain.
|
| |
J Biol Chem, 283,
16665-16672.
|
|
|
|
|
|
|
L.R.Fiedler,
E.Schönherr,
R.Waddington,
S.Niland,
D.G.Seidler,
D.Aeschlimann,
and
J.A.Eble
(2008).
Decorin regulates endothelial cell motility on collagen I through activation of insulin-like growth factor I receptor and modulation of alpha2beta1 integrin activity.
|
| |
J Biol Chem, 283,
17406-17415.
|
|
|
|
|
|
|
N.S.Seo,
C.Q.Zeng,
J.M.Hyser,
B.Utama,
S.E.Crawford,
K.J.Kim,
M.Höök,
and
M.K.Estes
(2008).
Inaugural article: integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin.
|
| |
Proc Natl Acad Sci U S A, 105,
8811-8818.
|
|
|
|
|
|
|
O.Inoue,
K.Suzuki-Inoue,
and
Y.Ozaki
(2008).
Redundant mechanism of platelet adhesion to laminin and collagen under flow: involvement of von Willebrand factor and glycoprotein Ib-IX-V.
|
| |
J Biol Chem, 283,
16279-16282.
|
|
|
|
|
|
|
P.Gros,
F.J.Milder,
and
B.J.Janssen
(2008).
Complement driven by conformational changes.
|
| |
Nat Rev Immunol, 8,
48-58.
|
|
|
|
|
|
|
S.M.Sweeney,
J.P.Orgel,
A.Fertala,
J.D.McAuliffe,
K.R.Turner,
G.A.Di Lullo,
S.Chen,
O.Antipova,
S.Perumal,
L.Ala-Kokko,
A.Forlino,
W.A.Cabral,
A.M.Barnes,
J.C.Marini,
and
J.D.San Antonio
(2008).
Candidate cell and matrix interaction domains on the collagen fibril, the predominant protein of vertebrates.
|
| |
J Biol Chem, 283,
21187-21197.
|
|
|
|
|
|
|
T.D.Abair,
M.Sundaramoorthy,
D.Chen,
J.Heino,
J.Ivaska,
B.G.Hudson,
C.R.Sanders,
A.Pozzi,
and
R.Zent
(2008).
Cross-talk between integrins alpha1beta1 and alpha2beta1 in renal epithelial cells.
|
| |
Exp Cell Res, 314,
3593-3604.
|
|
|
|
|
|
|
T.Takao,
and
A.Tsujimura
(2008).
Prostate stem cells: the niche and cell markers.
|
| |
Int J Urol, 15,
289-294.
|
|
|
|
|
|
|
A.Kasirer-Friede,
M.L.Kahn,
and
S.J.Shattil
(2007).
Platelet integrins and immunoreceptors.
|
| |
Immunol Rev, 218,
247-264.
|
|
|
|
|
|
|
A.Taubenberger,
D.A.Cisneros,
J.Friedrichs,
P.H.Puech,
D.J.Muller,
and
C.M.Franz
(2007).
Revealing early steps of alpha2beta1 integrin-mediated adhesion to collagen type I by using single-cell force spectroscopy.
|
| |
Mol Biol Cell, 18,
1634-1644.
|
|
|
|
|
|
|
B.H.Luo,
C.V.Carman,
and
T.A.Springer
(2007).
Structural basis of integrin regulation and signaling.
|
| |
Annu Rev Immunol, 25,
619-647.
|
|
|
|
|
|
|
C.D.Reyes,
T.A.Petrie,
K.L.Burns,
Z.Schwartz,
and
A.J.García
(2007).
Biomolecular surface coating to enhance orthopaedic tissue healing and integration.
|
| |
Biomaterials, 28,
3228-3235.
|
|
|
|
|
|
|
C.Ghevaert,
K.Campbell,
J.Walton,
G.A.Smith,
D.Allen,
L.M.Williamson,
W.H.Ouwehand,
and
E.Ranasinghe
(2007).
Management and outcome of 200 cases of fetomaternal alloimmune thrombocytopenia.
|
| |
Transfusion, 47,
901-910.
|
|
|
|
|
|
|
F.J.Milder,
L.Gomes,
A.Schouten,
B.J.Janssen,
E.G.Huizinga,
R.A.Romijn,
W.Hemrika,
A.Roos,
M.R.Daha,
and
P.Gros
(2007).
Factor B structure provides insights into activation of the central protease of the complement system.
|
| |
Nat Struct Mol Biol, 14,
224-228.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.Heino
(2007).
The collagen family members as cell adhesion proteins.
|
| |
Bioessays, 29,
1001-1010.
|
|
|
|
|
|
|
J.M.Rhodes,
and
M.Simons
(2007).
The extracellular matrix and blood vessel formation: not just a scaffold.
|
| |
J Cell Mol Med, 11,
176-205.
|
|
|
|
|
|
|
J.Takagi
(2007).
Structural basis for ligand recognition by integrins.
|
| |
Curr Opin Cell Biol, 19,
557-564.
|
|
|
|
|
|
|
K.A.Bush,
B.R.Downing,
S.E.Walsh,
and
G.D.Pins
(2007).
Conjugation of extracellular matrix proteins to basal lamina analogs enhances keratinocyte attachment.
|
| |
J Biomed Mater Res A, 80,
444-452.
|
|
|
|
|
|
|
K.Okuyama,
H.Narita,
T.Kawaguchi,
K.Noguchi,
Y.Tanaka,
and
N.Nishino
(2007).
Unique side chain conformation of a Leu residue in a triple-helical structure.
|
| |
Biopolymers, 86,
212-221.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
M.Cheng,
S.Y.Foo,
M.L.Shi,
R.H.Tang,
L.S.Kong,
S.K.Law,
and
S.M.Tan
(2007).
Mutation of a conserved asparagine in the I-like domain promotes constitutively active integrins alphaLbeta2 and alphaIIbbeta3.
|
| |
J Biol Chem, 282,
18225-18232.
|
|
|
|
|
|
|
M.Fresquet,
T.A.Jowitt,
J.Ylöstalo,
P.Coffey,
R.S.Meadows,
L.Ala-Kokko,
D.J.Thornton,
and
M.D.Briggs
(2007).
Structural and functional characterization of recombinant matrilin-3 A-domain and implications for human genetic bone diseases.
|
| |
J Biol Chem, 282,
34634-34643.
|
|
|
|
|
|
|
M.H.Zaman
(2007).
Understanding the molecular basis for differential binding of integrins to collagen and gelatin.
|
| |
Biophys J, 92,
L17-L19.
|
|
|
|
|
|
|
M.Sen,
and
G.B.Legge
(2007).
Pactolus I-domain: functional switching of the Rossmann fold.
|
| |
Proteins, 68,
626-635.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
O.Ichikawa,
M.Osawa,
N.Nishida,
N.Goshima,
N.Nomura,
and
I.Shimada
(2007).
Structural basis of the collagen-binding mode of discoidin domain receptor 2.
|
| |
EMBO J, 26,
4168-4176.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
R.W.Farndale,
D.A.Slatter,
P.R.Siljander,
and
G.E.Jarvis
(2007).
Platelet receptor recognition and cross-talk in collagen-induced activation of platelets.
|
| |
J Thromb Haemost, 5,
220-229.
|
|
|
|
|
|
|
S.A.Chong,
W.Lee,
P.D.Arora,
C.Laschinger,
E.W.Young,
C.A.Simmons,
M.Manolson,
J.Sodek,
and
C.A.McCulloch
(2007).
Methylglyoxal inhibits the binding step of collagen phagocytosis.
|
| |
J Biol Chem, 282,
8510-8520.
|
|
|
|
|
|
|
T.Koide
(2007).
Designed triple-helical peptides as tools for collagen biochemistry and matrix engineering.
|
| |
Philos Trans R Soc Lond B Biol Sci, 362,
1281-1291.
|
|
|
|
|
|
|
T.Vorup-Jensen,
T.T.Waldron,
N.Astrof,
M.Shimaoka,
and
T.A.Springer
(2007).
The connection between metal ion affinity and ligand affinity in integrin I domains.
|
| |
Biochim Biophys Acta, 1774,
1148-1155.
|
|
|
|
|
|
|
T.Yang,
and
M.H.Zaman
(2007).
Free energy landscape of receptor-mediated cell adhesion.
|
| |
J Chem Phys, 126,
045103.
|
|
|
|
|
|
|
U.V.Girija,
A.W.Dodds,
S.Roscher,
K.B.Reid,
and
R.Wallis
(2007).
Localization and characterization of the mannose-binding lectin (MBL)-associated-serine protease-2 binding site in rat ficolin-A: equivalent binding sites within the collagenous domains of MBLs and ficolins.
|
| |
J Immunol, 179,
455-462.
|
|
|
|
|
|
|
V.Gupta,
A.Gylling,
J.L.Alonso,
T.Sugimori,
P.Ianakiev,
J.P.Xiong,
and
M.A.Arnaout
(2007).
The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18.
|
| |
Blood, 109,
3513-3520.
|
|
|
|
|
|
|
V.M.Leppänen,
H.Tossavainen,
P.Permi,
L.Lehtiö,
G.Rönnholm,
A.Goldman,
I.Kilpelaïnen,
and
T.Pihlajamaa
(2007).
Crystal structure of the N-terminal NC4 domain of collagen IX, a zinc binding member of the laminin-neurexin-sex hormone binding globulin (LNS) domain family.
|
| |
J Biol Chem, 282,
23219-23230.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
W.L.Connors,
J.Jokinen,
D.J.White,
J.S.Puranen,
P.Kankaanpää,
P.Upla,
M.Tulla,
M.S.Johnson,
and
J.Heino
(2007).
Two synergistic activation mechanisms of alpha2beta1 integrin-mediated collagen binding.
|
| |
J Biol Chem, 282,
14675-14683.
|
|
|
|
|
|
|
B.T.Edelson,
T.P.Stricker,
Z.Li,
S.K.Dickeson,
V.L.Shepherd,
S.A.Santoro,
and
M.M.Zutter
(2006).
Novel collectin/C1q receptor mediates mast cell activation and innate immunity.
|
| |
Blood, 107,
143-150.
|
|
|
|
|
|
|
F.J.Milder,
H.C.Raaijmakers,
M.D.Vandeputte,
A.Schouten,
E.G.Huizinga,
R.A.Romijn,
W.Hemrika,
A.Roos,
M.R.Daha,
and
P.Gros
(2006).
Structure of complement component C2A: implications for convertase formation and substrate binding.
|
| |
Structure, 14,
1587-1597.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
H.M.Scobie,
D.J.Wigelsworth,
J.M.Marlett,
D.Thomas,
G.J.Rainey,
D.B.Lacy,
M.Manchester,
R.J.Collier,
and
J.A.Young
(2006).
Anthrax toxin receptor 2-dependent lethal toxin killing in vivo.
|
| |
PLoS Pathog, 2,
e111.
|
|
|
|
|
|
|
K.Nam,
V.Maiorov,
B.Feuston,
and
S.Kearsley
(2006).
Dynamic control of allosteric antagonism of leukocyte function antigen-1 and intercellular adhesion molecule-1 interaction.
|
| |
Proteins, 64,
376-384.
|
|
|
|
|
|
|
K.Okuyama,
G.Wu,
N.Jiravanichanun,
C.Hongo,
and
K.Noguchi
(2006).
Helical twists of collagen model peptides.
|
| |
Biopolymers, 84,
421-432.
|
|
|
|
|
|
|
K.Okuyama,
X.Xu,
M.Iguchi,
and
K.Noguchi
(2006).
Revision of collagen molecular structure.
|
| |
Biopolymers, 84,
181-191.
|
|
|
|
|
|
|
L.Galois,
S.Hutasse,
D.Cortial,
C.F.Rousseau,
L.Grossin,
M.C.Ronziere,
D.Herbage,
and
A.M.Freyria
(2006).
Bovine chondrocyte behaviour in three-dimensional type I collagen gel in terms of gel contraction, proliferation and gene expression.
|
| |
Biomaterials, 27,
79-90.
|
|
|
|
|
|
|
L.Huang,
M.Shimaoka,
I.J.Rondon,
I.Roy,
Q.Chang,
M.Po,
D.T.Dransfield,
R.C.Ladner,
A.S.Edge,
A.Salas,
C.R.Wood,
T.A.Springer,
and
E.H.Cohen
(2006).
Identification and characterization of a human monoclonal antagonistic antibody AL-57 that preferentially binds the high-affinity form of lymphocyte function-associated antigen-1.
|
| |
J Leukoc Biol, 80,
905-914.
|
|
|
|
|
|
|
M.Gao,
and
K.Schulten
(2006).
Onset of anthrax toxin pore formation.
|
| |
Biophys J, 90,
3267-3279.
|
|
|
|
|
|
|
M.Gao,
M.Sotomayor,
E.Villa,
E.H.Lee,
and
K.Schulten
(2006).
Molecular mechanisms of cellular mechanics.
|
| |
Phys Chem Chem Phys, 8,
3692-3706.
|
|
|
|
|
|
|
M.Jin,
G.Song,
C.V.Carman,
Y.S.Kim,
N.S.Astrof,
M.Shimaoka,
D.K.Wittrup,
and
T.A.Springer
(2006).
Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity.
|
| |
Proc Natl Acad Sci U S A, 103,
5758-5763.
|
|
|
|
|
|
|
M.Shimaoka,
M.Kim,
E.H.Cohen,
W.Yang,
N.Astrof,
D.Peer,
A.Salas,
A.Ferrand,
and
T.A.Springer
(2006).
AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes.
|
| |
Proc Natl Acad Sci U S A, 103,
13991-13996.
|
|
|
|
|
|
|
N.Jiravanichanun,
N.Nishino,
and
K.Okuyama
(2006).
Conformation of alloHyp in the Y position in the host-guest peptide with the pro-pro-gly sequence: implication of the destabilization of (Pro-alloHyp-Gly)10.
|
| |
Biopolymers, 81,
225-233.
|
|
|
|
|
|
|
N.Raynal,
S.W.Hamaia,
P.R.Siljander,
B.Maddox,
A.R.Peachey,
R.Fernandez,
L.J.Foley,
D.A.Slatter,
G.E.Jarvis,
and
R.W.Farndale
(2006).
Use of synthetic peptides to locate novel integrin alpha2beta1-binding motifs in human collagen III.
|
| |
J Biol Chem, 281,
3821-3831.
|
|
|
|
|
|
|
O.Inoue,
K.Suzuki-Inoue,
O.J.McCarty,
M.Moroi,
Z.M.Ruggeri,
T.J.Kunicki,
Y.Ozaki,
and
S.P.Watson
(2006).
Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI.
|
| |
Blood, 107,
1405-1412.
|
|
|
|
|
|
|
P.Vanderslice,
and
D.G.Woodside
(2006).
Integrin antagonists as therapeutics for inflammatory diseases.
|
| |
Expert Opin Investig Drugs, 15,
1235-1255.
|
|
|
|
|
|
|
T.A.Petrie,
J.R.Capadona,
C.D.Reyes,
and
A.J.García
(2006).
Integrin specificity and enhanced cellular activities associated with surfaces presenting a recombinant fibronectin fragment compared to RGD supports.
|
| |
Biomaterials, 27,
5459-5470.
|
|
|
|
|
|
|
T.A.Springer
(2006).
Complement and the multifaceted functions of VWA and integrin I domains.
|
| |
Structure, 14,
1611-1616.
|
|
|
|
|
|
|
T.J.Lu,
W.Y.Lai,
C.Y.Huang,
W.J.Hsieh,
J.S.Yu,
Y.J.Hsieh,
W.T.Chang,
T.H.Leu,
W.C.Chang,
W.J.Chuang,
M.J.Tang,
T.Y.Chen,
T.L.Lu,
and
M.D.Lai
(2006).
Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST.
|
| |
J Biol Chem, 281,
38405-38417.
|
|
|
|
|
|
|
D.García-Bernal,
N.Wright,
E.Sotillo-Mallo,
C.Nombela-Arrieta,
J.V.Stein,
X.R.Bustelo,
and
J.Teixidó
(2005).
Vav1 and Rac control chemokine-promoted T lymphocyte adhesion mediated by the integrin alpha4beta1.
|
| |
Mol Biol Cell, 16,
3223-3235.
|
|
|
|
|
|
|
H.M.Scobie,
and
J.A.Young
(2005).
Interactions between anthrax toxin receptors and protective antigen.
|
| |
Curr Opin Microbiol, 8,
106-112.
|
|
|
|
|
|
|
J.Bella,
and
M.J.Humphries
(2005).
Calpha-H...O = C hydrogen bonds contribute to the specificity of RGD cell-adhesion interactions.
|
| |
BMC Struct Biol, 5,
4.
|
|
|
|
|
|
|
J.D.Humphries,
N.R.Schofield,
Z.Mostafavi-Pour,
L.J.Green,
A.N.Garratt,
A.P.Mould,
and
M.J.Humphries
(2005).
Dual functionality of the anti-beta1 integrin antibody, 12G10, exemplifies agonistic signalling from the ligand binding pocket of integrin adhesion receptors.
|
| |
J Biol Chem, 280,
10234-10243.
|
|
|
|
|
|
|
J.K.Kim,
Y.Xu,
X.Xu,
D.R.Keene,
S.Gurusiddappa,
X.Liang,
K.K.Wary,
and
M.Höök
(2005).
A novel binding site in collagen type III for integrins alpha1beta1 and alpha2beta1.
|
| |
J Biol Chem, 280,
32512-32520.
|
|
|
|
|
|
|
J.O.Humtsoe,
J.K.Kim,
Y.Xu,
D.R.Keene,
M.Höök,
S.Lukomski,
and
K.K.Wary
(2005).
A streptococcal collagen-like protein interacts with the alpha2beta1 integrin and induces intracellular signaling.
|
| |
J Biol Chem, 280,
13848-13857.
|
|
|
|
|
|
|
M.A.Arnaout,
B.Mahalingam,
and
J.P.Xiong
(2005).
Integrin structure, allostery, and bidirectional signaling.
|
| |
Annu Rev Cell Dev Biol, 21,
381-410.
|
|
|
|
|
|
|
M.Huhtala,
J.Heino,
D.Casciari,
A.de Luise,
and
M.S.Johnson
(2005).
Integrin evolution: insights from ascidian and teleost fish genomes.
|
| |
Matrix Biol, 24,
83-95.
|
|
|
|
|
|
|
M.Shi,
K.Sundramurthy,
B.Liu,
S.M.Tan,
S.K.Law,
and
J.Lescar
(2005).
The crystal structure of the plexin-semaphorin-integrin domain/hybrid domain/I-EGF1 segment from the human integrin beta2 subunit at 1.8-A resolution.
|
| |
J Biol Chem, 280,
30586-30593.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
R.V.Iozzo
(2005).
Basement membrane proteoglycans: from cellar to ceiling.
|
| |
Nat Rev Mol Cell Biol, 6,
646-656.
|
|
|
|
|
|
|
S.J.Webb,
L.Trembleau,
R.J.Mart,
and
X.Wang
(2005).
Membrane composition determines the fate of aggregated vesicles.
|
| |
Org Biomol Chem, 3,
3615-3617.
|
|
|
|
|
|
|
T.Kinashi
(2005).
Intracellular signalling controlling integrin activation in lymphocytes.
|
| |
Nat Rev Immunol, 5,
546-559.
|
|
|
|
|
|
|
T.Koide
(2005).
Triple helical collagen-like peptides: engineering and applications in matrix biology.
|
| |
Connect Tissue Res, 46,
131-141.
|
|
|
|
|
|
|
T.Vorup-Jensen,
C.V.Carman,
M.Shimaoka,
P.Schuck,
J.Svitel,
and
T.A.Springer
(2005).
Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin alphaXbeta2.
|
| |
Proc Natl Acad Sci U S A, 102,
1614-1619.
|
|
|
|
|
|
|
Y.Zong,
Y.Xu,
X.Liang,
D.R.Keene,
A.Höök,
S.Gurusiddappa,
M.Höök,
and
S.V.Narayana
(2005).
A 'Collagen Hug' model for Staphylococcus aureus CNA binding to collagen.
|
| |
EMBO J, 24,
4224-4236.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
A.A.Bhattacharya,
M.L.Lupher,
D.E.Staunton,
and
R.C.Liddington
(2004).
Crystal structure of the A domain from complement factor B reveals an integrin-like open conformation.
|
| |
Structure, 12,
371-378.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
A.L.Jannuzi,
T.A.Bunch,
R.F.West,
and
D.L.Brower
(2004).
Identification of integrin beta subunit mutations that alter heterodimer function in situ.
|
| |
Mol Biol Cell, 15,
3829-3840.
|
|
|
|
|
|
|
B.H.Luo,
J.Takagi,
and
T.A.Springer
(2004).
Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides.
|
| |
J Biol Chem, 279,
10215-10221.
|
|
|
|
|
|
|
C.Renner,
B.Saccà,
and
L.Moroder
(2004).
Synthetic heterotrimeric collagen peptides as mimics of cell adhesion sites of the basement membrane.
|
| |
Biopolymers, 76,
34-47.
|
|
|
|
|
|
|
D.B.Lacy,
D.J.Wigelsworth,
H.M.Scobie,
J.A.Young,
and
R.J.Collier
(2004).
Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor.
|
| |
Proc Natl Acad Sci U S A, 101,
6367-6372.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
D.B.Lacy,
D.J.Wigelsworth,
R.A.Melnyk,
S.C.Harrison,
and
R.J.Collier
(2004).
Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation.
|
| |
Proc Natl Acad Sci U S A, 101,
13147-13151.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
D.Baronas-Lowell,
J.L.Lauer-Fields,
and
G.B.Fields
(2004).
Induction of endothelial cell activation by a triple helical alpha2beta integrin ligand, derived from type I collagen alpha1(I)496-507.
|
| |
J Biol Chem, 279,
952-962.
|
|
|
|
|
|
|
D.Baronas-Lowell,
J.L.Lauer-Fields,
J.A.Borgia,
G.F.Sferrazza,
M.Al-Ghoul,
D.Minond,
and
G.B.Fields
(2004).
Differential modulation of human melanoma cell metalloproteinase expression by alpha2beta1 integrin and CD44 triple-helical ligands derived from type IV collagen.
|
| |
J Biol Chem, 279,
43503-43513.
|
|
|
|
|
|
|
D.J.White,
S.Puranen,
M.S.Johnson,
and
J.Heino
(2004).
The collagen receptor subfamily of the integrins.
|
| |
Int J Biochem Cell Biol, 36,
1405-1410.
|
|
|
|
|
|
|
D.W.Essex
(2004).
The role of thiols and disulfides in platelet function.
|
| |
Antioxid Redox Signal, 6,
736-746.
|
|
|
|
|
|
|
E.Santelli,
L.A.Bankston,
S.H.Leppla,
and
R.C.Liddington
(2004).
Crystal structure of a complex between anthrax toxin and its host cell receptor.
|
| |
Nature, 430,
905-908.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
E.Tng,
S.M.Tan,
S.Ranganathan,
M.Cheng,
and
S.K.Law
(2004).
The integrin alpha L beta 2 hybrid domain serves as a link for the propagation of activation signal from its stalk regions to the I-like domain.
|
| |
J Biol Chem, 279,
54334-54339.
|
|
|
|
|
|
|
G.Bix,
J.Fu,
E.M.Gonzalez,
L.Macro,
A.Barker,
S.Campbell,
M.M.Zutter,
S.A.Santoro,
J.K.Kim,
M.Höök,
C.C.Reed,
and
R.V.Iozzo
(2004).
Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin.
|
| |
J Cell Biol, 166,
97.
|
|
|
|
|
|
|
H.Deckmyn,
H.Ulrichts,
G.Van De Walle,
and
K.Vanhoorelbeke
(2004).
Platelet antigens and their function.
|
| |
Vox Sang, 87,
105-111.
|
|
|
|
|
|
|
H.Nummelin,
M.C.Merckel,
J.C.Leo,
H.Lankinen,
M.Skurnik,
and
A.Goldman
(2004).
The Yersinia adhesin YadA collagen-binding domain structure is a novel left-handed parallel beta-roll.
|
| |
EMBO J, 23,
701-711.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
I.D.Campbell,
and
M.H.Ginsberg
(2004).
The talin-tail interaction places integrin activation on FERM ground.
|
| |
Trends Biochem Sci, 29,
429-435.
|
|
|
|
|
|
|
J.G.Bann,
and
S.J.Hultgren
(2004).
Structural biology: anthrax hijacks host receptor.
|
| |
Nature, 430,
843-844.
|
|
|
|
|
|
|
J.Käpylä,
J.Jäälinoja,
M.Tulla,
J.Ylöstalo,
L.Nissinen,
T.Viitasalo,
P.Vehviläinen,
V.Marjomäki,
P.Nykvist,
A.M.Säämänen,
R.W.Farndale,
D.E.Birk,
L.Ala-Kokko,
and
J.Heino
(2004).
The fibril-associated collagen IX provides a novel mechanism for cell adhesion to cartilaginous matrix.
|
| |
J Biol Chem, 279,
51677-51687.
|
|
|
|
|
|
|
K.Ajroud,
T.Sugimori,
W.H.Goldmann,
D.M.Fathallah,
J.P.Xiong,
and
M.A.Arnaout
(2004).
Binding Affinity of Metal Ions to the CD11b A-domain Is Regulated by Integrin Activation and Ligands.
|
| |
J Biol Chem, 279,
25483-25488.
|
|
|
|
|
|
|
K.L.Graham,
W.Zeng,
Y.Takada,
D.C.Jackson,
and
B.S.Coulson
(2004).
Effects on rotavirus cell binding and infection of monomeric and polymeric peptides containing alpha2beta1 and alphaxbeta2 integrin ligand sequences.
|
| |
J Virol, 78,
11786-11797.
|
|
|
|
|
|
|
K.Ponnuraj,
Y.Xu,
K.Macon,
D.Moore,
J.E.Volanakis,
and
S.V.Narayana
(2004).
Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase.
|
| |
Mol Cell, 14,
17-28.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
L.Xing,
M.Huhtala,
V.Pietiäinen,
J.Käpylä,
K.Vuorinen,
V.Marjomäki,
J.Heino,
M.S.Johnson,
T.Hyypiä,
and
R.H.Cheng
(2004).
Structural and functional analysis of integrin alpha2I domain interaction with echovirus 1.
|
| |
J Biol Chem, 279,
11632-11638.
|
|
|
|
|
|
|
M.Gao,
and
K.Schulten
(2004).
Integrin activation in vivo and in silico.
|
| |
Structure, 12,
2096-2098.
|
|
|
|
|
|
|
M.Jin,
I.Andricioaei,
and
T.A.Springer
(2004).
Conversion between three conformational states of integrin I domains with a C-terminal pull spring studied with molecular dynamics.
|
| |
Structure, 12,
2137-2147.
|
|
|
|
|
|
|
P.R.Siljander,
S.Hamaia,
A.R.Peachey,
D.A.Slatter,
P.A.Smethurst,
W.H.Ouwehand,
C.G.Knight,
and
R.W.Farndale
(2004).
Integrin activation state determines selectivity for novel recognition sites in fibrillar collagens.
|
| |
J Biol Chem, 279,
47763-47772.
|
|
|
|
|
|
|
R.Abdulhussein,
C.McFadden,
P.Fuentes-Prior,
and
W.F.Vogel
(2004).
Exploring the collagen-binding site of the DDR1 tyrosine kinase receptor.
|
| |
J Biol Chem, 279,
31462-31470.
|
|
|
|
|
|
|
R.W.Farndale,
J.J.Sixma,
M.J.Barnes,
and
P.G.de Groot
(2004).
The role of collagen in thrombosis and hemostasis.
|
| |
J Thromb Haemost, 2,
561-573.
|
|
|
|
|
|
|
V.Lake,
U.Olsson,
R.D.Willows,
and
M.Hansson
(2004).
ATPase activity of magnesium chelatase subunit I is required to maintain subunit D in vivo.
|
| |
Eur J Biochem, 271,
2182-2188.
|
|
|
|
|
|
|
W.Yang,
M.Shimaoka,
A.Salas,
J.Takagi,
and
T.A.Springer
(2004).
Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring.
|
| |
Proc Natl Acad Sci U S A, 101,
2906-2911.
|
|
|
|
|
|
|
W.Yang,
M.Shimaoka,
J.Chen,
and
T.A.Springer
(2004).
Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletions.
|
| |
Proc Natl Acad Sci U S A, 101,
2333-2338.
|
|
|
|
|
|
|
Y.Nymalm,
J.S.Puranen,
T.K.Nyholm,
J.Käpylä,
H.Kidron,
O.T.Pentikäinen,
T.T.Airenne,
J.Heino,
J.P.Slotte,
M.S.Johnson,
and
T.A.Salminen
(2004).
Jararhagin-derived RKKH peptides induce structural changes in alpha1I domain of human integrin alpha1beta1.
|
| |
J Biol Chem, 279,
7962-7970.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
Z.Zhang,
G.Izaguirre,
S.Y.Lin,
H.Y.Lee,
E.Schaefer,
and
B.Haimovich
(2004).
The phosphorylation of vinculin on tyrosine residues 100 and 1065, mediated by SRC kinases, affects cell spreading.
|
| |
Mol Biol Cell, 15,
4234-4247.
|
|
|
|
|
|
|
A.J.Ridley,
M.A.Schwartz,
K.Burridge,
R.A.Firtel,
M.H.Ginsberg,
G.Borisy,
J.T.Parsons,
and
A.R.Horwitz
(2003).
Cell migration: integrating signals from front to back.
|
| |
Science, 302,
1704-1709.
|
|
|
|
|
|
|
A.Srivastava,
R.Ralhan,
and
J.Kaur
(2003).
Angiogenesis in cutaneous melanoma: pathogenesis and clinical implications.
|
| |
Microsc Res Tech, 60,
208-224.
|
|
|
|
|
|
|
B.Leitinger
(2003).
Molecular analysis of collagen binding by the human discoidin domain receptors, DDR1 and DDR2. Identification of collagen binding sites in DDR2.
|
| |
J Biol Chem, 278,
16761-16769.
|
|
|
|
|
|
|
C.V.Carman,
and
T.A.Springer
(2003).
Integrin avidity regulation: are changes in affinity and conformation underemphasized?
|
| |
Curr Opin Cell Biol, 15,
547-556.
|
|
|
|
|
|
|
G.Sengle,
B.Kobbe,
M.Morgelin,
M.Paulsson,
and
R.Wagener
(2003).
Identification and characterization of AMACO, a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney.
|
| |
J Biol Chem, 278,
50240-50249.
|
|
|
|
|
|
|
H.Feinberg,
J.C.Uitdehaag,
J.M.Davies,
R.Wallis,
K.Drickamer,
and
W.I.Weis
(2003).
Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2.
|
| |
EMBO J, 22,
2348-2359.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.Chen,
A.Salas,
and
T.A.Springer
(2003).
Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster.
|
| |
Nat Struct Biol, 10,
995.
|
|
|
|
|
|
|
J.H.Wang,
and
M.J.Eck
(2003).
Assembling atomic resolution views of the immunological synapse.
|
| |
Curr Opin Immunol, 15,
286-293.
|
|
|
|
|
|
|
J.J.Wilson,
O.Matsushita,
A.Okabe,
and
J.Sakon
(2003).
A bacterial collagen-binding domain with novel calcium-binding motif controls domain orientation.
|
| |
EMBO J, 22,
1743-1752.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.L.Lauer-Fields,
N.B.Malkar,
G.Richet,
K.Drauz,
and
G.B.Fields
(2003).
Melanoma cell CD44 interaction with the alpha 1(IV)1263-1277 region from basement membrane collagen is modulated by ligand glycosylation.
|
| |
J Biol Chem, 278,
14321-14330.
|
|
|
|
|
|
|
J.L.Lauer-Fields,
T.Sritharan,
M.S.Stack,
H.Nagase,
and
G.B.Fields
(2003).
Selective hydrolysis of triple-helical substrates by matrix metalloproteinase-2 and -9.
|
| |
J Biol Chem, 278,
18140-18145.
|
|
|
|
|
|
|
J.L.Tomsig,
S.L.Snyder,
and
C.E.Creutz
(2003).
Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.
|
| |
J Biol Chem, 278,
10048-10054.
|
|
|
|
|
|
|
J.P.Xiong,
T.Stehle,
S.L.Goodman,
and
M.A.Arnaout
(2003).
Integrins, cations and ligands: making the connection.
|
| |
J Thromb Haemost, 1,
1642-1654.
|
|
|
|
|
|
|
K.A.Bradley,
J.Mogridge,
G.Jonah,
A.Rainey,
S.Batty,
and
J.A.Young
(2003).
Binding of anthrax toxin to its receptor is similar to alpha integrin-ligand interactions.
|
| |
J Biol Chem, 278,
49342-49347.
|
|
|
|
|
|
|
K.Horii,
D.Okuda,
T.Morita,
and
H.Mizuno
(2003).
Structural characterization of EMS16, an antagonist of collagen receptor (GPIa/IIa) from the venom of Echis multisquamatus.
|
| |
Biochemistry, 42,
12497-12502.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
L.Sanz,
L.García-Bermejo,
F.J.Blanco,
P.Kristensen,
M.Feijóo,
E.Suárez,
B.Blanco,
and
L.Alvarez-Vallina
(2003).
A novel cell binding site in the coiled-coil domain of laminin involved in capillary morphogenesis.
|
| |
EMBO J, 22,
1508-1517.
|
|
|
|
|
|
|
M.J.Humphries,
P.A.McEwan,
S.J.Barton,
P.A.Buckley,
J.Bella,
and
A.P.Mould
(2003).
Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble.
|
| |
Trends Biochem Sci, 28,
313-320.
|
|
|
|
|
|
|
M.J.Rosovitz,
P.Schuck,
M.Varughese,
A.P.Chopra,
V.Mehra,
Y.Singh,
L.M.McGinnis,
and
S.H.Leppla
(2003).
Alanine-scanning mutations in domain 4 of anthrax toxin protective antigen reveal residues important for binding to the cellular receptor and to a neutralizing monoclonal antibody.
|
| |
J Biol Chem, 278,
30936-30944.
|
|
|
|
|
|
|
M.P.Moreno-Murciano,
D.Monleón,
J.J.Calvete,
B.Celda,
and
C.Marcinkiewicz
(2003).
Amino acid sequence and homology modeling of obtustatin, a novel non-RGD-containing short disintegrin isolated from the venom of Vipera lebetina obtusa.
|
| |
Protein Sci, 12,
366-371.
|
|
|
|
|
|
|
M.Shimaoka,
T.Xiao,
J.H.Liu,
Y.Yang,
Y.Dong,
C.D.Jun,
A.McCormack,
R.Zhang,
A.Joachimiak,
J.Takagi,
J.H.Wang,
and
T.A.Springer
(2003).
Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.
|
| |
Cell, 112,
99.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
N.Nishida,
H.Sumikawa,
M.Sakakura,
N.Shimba,
H.Takahashi,
H.Terasawa,
E.Suzuki,
and
I.Shimada
(2003).
Collagen-binding mode of vWF-A3 domain determined by a transferred cross-saturation experiment.
|
| |
Nat Struct Biol, 10,
53-58.
|
|
|
|
|
|
|
N.Suzuki,
H.Nakatsuka,
M.Mochizuki,
N.Nishi,
Y.Kadoya,
A.Utani,
S.Oishi,
N.Fujii,
H.K.Kleinman,
and
M.Nomizu
(2003).
Biological activities of homologous loop regions in the laminin alpha chain G domains.
|
| |
J Biol Chem, 278,
45697-45705.
|
|
|
|
|
|
|
R.R.Hantgan,
D.S.Lyles,
T.C.Mallett,
M.Rocco,
C.Nagaswami,
and
J.W.Weisel
(2003).
Ligand binding promotes the entropy-driven oligomerization of integrin alpha IIb beta 3.
|
| |
J Biol Chem, 278,
3417-3426.
|
|
|
|
|
|
|
S.Ball,
J.Bella,
C.Kielty,
and
A.Shuttleworth
(2003).
Structural basis of type VI collagen dimer formation.
|
| |
J Biol Chem, 278,
15326-15332.
|
|
|
|
|
|
|
S.L.Londrigan,
K.L.Graham,
Y.Takada,
P.Halasz,
and
B.S.Coulson
(2003).
Monkey rotavirus binding to alpha2beta1 integrin requires the alpha2 I domain and is facilitated by the homologous beta1 subunit.
|
| |
J Virol, 77,
9486-9501.
|
|
|
|
|
|
|
S.Perret,
J.A.Eble,
P.R.Siljander,
C.Merle,
R.W.Farndale,
M.Theisen,
and
F.Ruggiero
(2003).
Prolyl hydroxylation of collagen type I is required for efficient binding to integrin alpha 1 beta 1 and platelet glycoprotein VI but not to alpha 2 beta 1.
|
| |
J Biol Chem, 278,
29873-29879.
|
|
|
|
|
|
|
T.Vorup-Jensen,
C.Ostermeier,
M.Shimaoka,
U.Hommel,
and
T.A.Springer
(2003).
Structure and allosteric regulation of the alpha X beta 2 integrin I domain.
|
| |
Proc Natl Acad Sci U S A, 100,
1873-1878.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
W.M.Zhang,
J.Kapyla,
J.S.Puranen,
C.G.Knight,
C.F.Tiger,
O.T.Pentikainen,
M.S.Johnson,
R.W.Farndale,
J.Heino,
and
D.Gullberg
(2003).
alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagens.
|
| |
J Biol Chem, 278,
7270-7277.
|
|
|
|
|
|
|
Y.Li,
and
L.Zhang
(2003).
The fourth blade within the beta-propeller is involved specifically in C3bi recognition by integrin alpha M beta 2.
|
| |
J Biol Chem, 278,
34395-34402.
|
|
|
|
|
|
|
A.Cierniewska-Cieslak,
C.S.Cierniewski,
K.Blecka,
M.Papierak,
L.Michalec,
L.Zhang,
T.A.Haas,
and
E.F.Plow
(2002).
Identification and characterization of two cation binding sites in the integrin beta 3 subunit.
|
| |
J Biol Chem, 277,
11126-11134.
|
|
|
|
|
|
|
A.Hansson,
R.D.Willows,
T.H.Roberts,
and
M.Hansson
(2002).
Three semidominant barley mutants with single amino acid substitutions in the smallest magnesium chelatase subunit form defective AAA+ hexamers.
|
| |
Proc Natl Acad Sci U S A, 99,
13944-13949.
|
|
|
|
|
|
|
A.Krasko,
H.C.Schröder,
R.Batel,
V.A.Grebenjuk,
R.Steffen,
I.M.Müller,
and
W.E.Müller
(2002).
Iron induces proliferation and morphogenesis in primmorphs from the marine sponge Suberites domuncula.
|
| |
DNA Cell Biol, 21,
67-80.
|
|
|
|
|
|
|
A.Salas,
M.Shimaoka,
S.Chen,
C.V.Carman,
and
T.Springer
(2002).
Transition from rolling to firm adhesion is regulated by the conformation of the I domain of the integrin lymphocyte function-associated antigen-1.
|
| |
J Biol Chem, 277,
50255-50262.
|
|
|
|
|
|
|
B.D.Adair,
and
M.Yeager
(2002).
Three-dimensional model of the human platelet integrin alpha IIbbeta 3 based on electron cryomicroscopy and x-ray crystallography.
|
| |
Proc Natl Acad Sci U S A, 99,
14059-14064.
|
|
|
|
|
|
|
C.A.Whittaker,
and
R.O.Hynes
(2002).
Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere.
|
| |
Mol Biol Cell, 13,
3369-3387.
|
|
|
|
|
|
|
D.E.Gullberg,
and
E.Lundgren-Akerlund
(2002).
Collagen-binding I domain integrins--what do they do?
|
| |
Prog Histochem Cytochem, 37,
3.
|
|
|
|
|
|
|
E.G.Huizinga,
S.Tsuji,
R.A.Romijn,
M.E.Schiphorst,
P.G.de Groot,
J.J.Sixma,
and
P.Gros
(2002).
Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain.
|
| |
Science, 297,
1176-1179.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
G.A.Di Lullo,
S.M.Sweeney,
J.Korkko,
L.Ala-Kokko,
and
J.D.San Antonio
(2002).
Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen.
|
| |
J Biol Chem, 277,
4223-4231.
|
|
|
|
|
|
|
G.B.Legge,
G.M.Morris,
M.F.Sanner,
Y.Takada,
A.J.Olson,
and
F.Grynszpan
(2002).
Model of the alphaLbeta2 integrin I-domain/ICAM-1 DI interface suggests that subtle changes in loop orientation determine ligand specificity.
|
| |
Proteins, 48,
151-160.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
G.E.Jarvis,
B.T.Atkinson,
D.C.Snell,
and
S.P.Watson
(2002).
Distinct roles of GPVI and integrin alpha(2)beta(1) in platelet shape change and aggregation induced by different collagens.
|
| |
Br J Pharmacol, 137,
107-117.
|
|
|
|
|
|
|
J.E.Garbarino,
and
I.R.Gibbons
(2002).
Expression and genomic analysis of midasin, a novel and highly conserved AAA protein distantly related to dynein.
|
| |
BMC Genomics, 3,
18.
|
|
|
|
|
|
|
J.H.Min,
H.Yang,
M.Ivan,
F.Gertler,
W.G.Kaelin,
and
N.P.Pavletich
(2002).
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.
|
| |
Science, 296,
1886-1889.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.L.Alonso,
M.Essafi,
J.P.Xiong,
T.Stehle,
and
M.A.Arnaout
(2002).
Does the integrin alphaA domain act as a ligand for its betaA domain?
|
| |
Curr Biol, 12,
R340-R342.
|
|
|
|
|
|
|
J.Takagi,
and
T.A.Springer
(2002).
Integrin activation and structural rearrangement.
|
| |
Immunol Rev, 186,
141-163.
|
|
|
|
|
|
|
J.W.Smith,
H.Le Calvez,
L.Parra-Gessert,
N.E.Preece,
X.Jia,
and
N.Assa-Munt
(2002).
Selection and structure of ion-selective ligands for platelet integrin alpha IIb(beta) 3.
|
| |
J Biol Chem, 277,
10298-10305.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
K.E.Gottschalk,
P.D.Adams,
A.T.Brunger,
and
H.Kessler
(2002).
Transmembrane signal transduction of the alpha(IIb)beta(3) integrin.
|
| |
Protein Sci, 11,
1800-1812.
|
|
|
|
|
|
|
K.Fukuda,
T.A.Doggett,
L.A.Bankston,
M.A.Cruz,
T.G.Diacovo,
and
R.C.Liddington
(2002).
Structural basis of von Willebrand factor activation by the snake toxin botrocetin.
|
| |
Structure, 10,
943-950.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
K.Matuschewski,
A.C.Nunes,
V.Nussenzweig,
and
R.Ménard
(2002).
Plasmodium sporozoite invasion into insect and mammalian cells is directed by the same dual binding system.
|
| |
EMBO J, 21,
1597-1606.
|
|
|
|
|
|
|
K.Welzenbach,
U.Hommel,
and
G.Weitz-Schmidt
(2002).
Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition.
|
| |
J Biol Chem, 277,
10590-10598.
|
|
|
|
|
|
|
L.S.Mizoue,
and
W.J.Chazin
(2002).
Engineering and design of ligand-induced conformational change in proteins.
|
| |
Curr Opin Struct Biol, 12,
459-463.
|
|
|
|
|
|
|
M.A.Arnaout
(2002).
Integrin structure: new twists and turns in dynamic cell adhesion.
|
| |
Immunol Rev, 186,
125-140.
|
|
|
|
|
|
|
M.A.Arnaout,
S.L.Goodman,
and
J.P.Xiong
(2002).
Coming to grips with integrin binding to ligands.
|
| |
Curr Opin Cell Biol, 14,
641-651.
|
|
|
|
|
|
|
M.Shimaoka,
C.Lu,
A.Salas,
T.Xiao,
J.Takagi,
and
T.A.Springer
(2002).
Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds.
|
| |
Proc Natl Acad Sci U S A, 99,
16737-16741.
|
|
|
|
|
|
|
M.Shimaoka,
J.Takagi,
and
T.A.Springer
(2002).
Conformational regulation of integrin structure and function.
|
| |
Annu Rev Biophys Biomol Struct, 31,
485-516.
|
|
|
|
|
|
|
N.Beglova,
S.C.Blacklow,
J.Takagi,
and
T.A.Springer
(2002).
Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation.
|
| |
Nat Struct Biol, 9,
282-287.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
N.Hogg,
R.Henderson,
B.Leitinger,
A.McDowall,
J.Porter,
and
P.Stanley
(2002).
Mechanisms contributing to the activity of integrins on leukocytes.
|
| |
Immunol Rev, 186,
164-171.
|
|
|
|
|
|
|
O.Holtkötter,
B.Nieswandt,
N.Smyth,
W.Müller,
M.Hafner,
V.Schulte,
T.Krieg,
and
B.Eckes
(2002).
Integrin alpha 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen.
|
| |
J Biol Chem, 277,
10789-10794.
|
|
|
|
|
|
|
P.Gresele,
and
G.Agnelli
(2002).
Novel approaches to the treatment of thrombosis.
|
| |
Trends Pharmacol Sci, 23,
25-32.
|
|
|
|
|
|
|
Q.Ma,
M.Shimaoka,
C.Lu,
H.Jing,
C.V.Carman,
and
T.A.Springer
(2002).
Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1.
|
| |
J Biol Chem, 277,
10638-10641.
|
|
|
|
|
|
|
R.C.Liddington,
and
M.H.Ginsberg
(2002).
Integrin activation takes shape.
|
| |
J Cell Biol, 158,
833-839.
|
|
|
|
|
|
|
Y.M.Xiong,
T.A.Haas,
and
L.Zhang
(2002).
Identification of functional segments within the beta2I-domain of integrin alphaMbeta2.
|
| |
J Biol Chem, 277,
46639-46644.
|
|
|
|
|
|
|
C.A.Curat,
M.Eck,
X.Dervillez,
and
W.F.Vogel
(2001).
Mapping of epitopes in discoidin domain receptor 1 critical for collagen binding.
|
| |
J Biol Chem, 276,
45952-45958.
|
|
|
|
|
|
|
C.Lu,
M.Shimaoka,
M.Ferzly,
C.Oxvig,
J.Takagi,
and
T.A.Springer
(2001).
An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.
|
| |
Proc Natl Acad Sci U S A, 98,
2387-2392.
|
|
|
|
|
|
|
C.Lu,
M.Shimaoka,
Q.Zang,
J.Takagi,
and
T.A.Springer
(2001).
Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains.
|
| |
Proc Natl Acad Sci U S A, 98,
2393-2398.
|
|
|
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