PDBsum entry 1cwc

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protein Protein-protein interface(s) links
Isomerase/immunosuppressant PDB id
Protein chains
165 a.a. *
11 a.a. *
Waters ×169
* Residue conservation analysis
PDB id:
Name: Isomerase/immunosuppressant
Title: Improved binding affinity for cyclophilin a by a cyclosporin derivative singly modified at its effector domain
Structure: Peptidyl-prolyl cis-trans isomerase a. Chain: a. Synonym: ppiase, rotamase, cyclophilin a. Engineered: yes. Cyclosporin a. Chain: c. Synonym: cyclosporine, ciclosporin, ciclosporine. Engineered: yes. Mutation: yes.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cyclophilin. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Tolypocladium inflatum. Organism_taxid: 29910
1.86Å     R-factor:   0.177    
Authors: V.Mikol
Key ref: C.Papageorgiou et al. (1994). Improved binding affinity for cyclophilin A by a cyclosporin derivative singly modified at its effector domain. J Med Chem, 37, 3674-3676. PubMed id: 7966126 DOI: 10.1021/jm00048a002
06-Sep-95     Release date:   29-Jan-96    
Go to PROCHECK summary

Protein chain
Pfam   ArchSchema ?
P62937  (PPIA_HUMAN) -  Peptidyl-prolyl cis-trans isomerase A
165 a.a.
165 a.a.
Protein chain
No UniProt id for this chain
Struc: 11 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chain A: E.C.  - Peptidylprolyl isomerase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Peptidylproline (omega=180) = peptidylproline (omega=0)
Peptidylproline (omega=180)
= peptidylproline (omega=0)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   8 terms 
  Biological process     viral reproduction   18 terms 
  Biochemical function     protein binding     7 terms  


    Added reference    
DOI no: 10.1021/jm00048a002 J Med Chem 37:3674-3676 (1994)
PubMed id: 7966126  
Improved binding affinity for cyclophilin A by a cyclosporin derivative singly modified at its effector domain.
C.Papageorgiou, A.Florineth, V.Mikol.
No abstract given.


Literature references that cite this PDB file's key reference

  PubMed id Reference
17476570 K.Undheim (2008).
The Schöllkopf chiron and transition metal mediated reactions, a powerful combination for stereoselective construction of cyclic alpha-quaternary-alpha-amino acid derivatives.
  Amino Acids, 34, 357-402.  
12357034 L.Jin, and S.C.Harrison (2002).
Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin.
  Proc Natl Acad Sci U S A, 99, 13522-13526.
PDB code: 1mf8
11058892 M.T.Ivery (2000).
Immunophilins: switched on protein binding domains?
  Med Res Rev, 20, 452-484.  
7545076 S.Teague (1995).
Lessons from molecular matchmakers.
  Nat Struct Biol, 2, 360-361.  
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