PDBsum entry: 1cs8

Hydrolase

PDB id: 1cs8

Contents

Protein chain

316 a.a. *

Waters ×747

* Residue conservation analysis

PDB id:

1cs8

Name:

Hydrolase

Title:

Crystal structure of procathepsin l

Structure:

Human procathepsin l. Chain: a. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922.

Biol. unit:

Dimer (from PQS)

Resolution:

1.80Å R-factor: 0.207 R-free: 0.229

Authors:

M.Cygler,R.Coulombe

Date:

17-Aug-99 Release date: 23-Aug-99

Protein chain

P07711  (CATL1_HUMAN) -  Cathepsin L1

Seq: 333 a.a.

Struc: 316 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.4.22.15 - Cathepsin L.
• Reaction: Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.

 Gene Ontology (GO) functional annotation 

• Cellular component: extracellular region (2 terms)
• Biological process: proteolysis (1 term)
• Biochemical function: protein binding (5 terms)