PDBsum entry 1cqe

Go to PDB code: 
protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
Protein chains
552 a.a. *
BOG ×5
HEM ×2
FLP ×2
Waters ×130
* Residue conservation analysis
PDB id:
Name: Oxidoreductase
Title: Prostaglandin h2 synthase-1 complex with flurbiprofen
Structure: Protein (prostaglandin h2 synthase-1). Chain: a, b. Synonym: cyclooxygenase 1, cox-1, prostaglandin-endoperoxid 1. Other_details: protein is glycosylated at residues asn68, a asn410
Source: Ovis aries. Sheep. Organism_taxid: 9940. Tissue: seminal vesicle
Biol. unit: Dimer (from PDB file)
3.10Å     R-factor:   0.186     R-free:   0.226
Authors: D.Picot,P.J.Loll,A.M.Mulichak,R.M.Garavito
Key ref: D.Picot et al. (1994). The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1. Nature, 367, 243-249. PubMed id: 8121489
15-Jun-99     Release date:   30-Jun-99    
Go to PROCHECK summary

Protein chains
Pfam   ArchSchema ?
P05979  (PGH1_SHEEP) -  Prostaglandin G/H synthase 1
600 a.a.
552 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.  - Prostaglandin-endoperoxide synthase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
Bound ligand (Het Group name = HEM)
matches with 51.16% similarity
+ AH(2)
+ 2 × O(2)
= prostaglandin H(2)
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     oxidation-reduction process   6 terms 
  Biochemical function     peroxidase activity     3 terms  


Nature 367:243-249 (1994)
PubMed id: 8121489  
The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1.
D.Picot, P.J.Loll, R.M.Garavito.
The three-dimensional structure of prostaglandin H2 synthase-1, an integral membrane protein, has been determined at 3.5 A resolution by X-ray crystallography. This bifunctional enzyme comprises three independent folding units: an epidermal growth factor domain, a membrane-binding motif and an enzymatic domain. Two adjacent but spatially distinct active sites were found for its haem-dependent peroxidase and cyclooxygenase activities. The cyclooxygenase active site is created by a long, hydrophobic channel that is the site of non-steroidal anti-inflammatory drug binding. The conformation of the membrane-binding motif strongly suggests that the enzyme integrates into only one leaflet of the lipid bilayer and is thus a monotopic membrane protein.

Literature references that cite this PDB file's key reference

  PubMed id Reference
21421123 A.L.Tsai, G.Wu, C.E.Rogge, J.M.Lü, S.Peng, W.A.van der Donk, G.Palmer, G.J.Gerfen, and R.J.Kulmacz (2011).
Structural comparisons of arachidonic acid-induced radicals formed by prostaglandin H synthase-1 and -2.
  J Inorg Biochem, 105, 366-374.  
21315729 G.E.Schulz (2011).
A new classification of membrane protein crystals.
  J Mol Biol, 407, 640-646.  
21403766 J.M.Lü, C.E.Rogge, G.Wu, R.J.Kulmacz, W.A.van der Donk, and A.L.Tsai (2011).
Cyclooxygenase reaction mechanism of PGHS--evidence for a reversible transition between a pentadienyl radical and a new tyrosyl radical by nitric oxide trapping.
  J Inorg Biochem, 105, 356-365.  
19728984 A.L.Tsai, and R.J.Kulmacz (2010).
Prostaglandin H synthase: resolved and unresolved mechanistic issues.
  Arch Biochem Biophys, 493, 103-124.  
19878096 F.Brodhun, S.Schneider, C.Göbel, E.Hornung, and I.Feussner (2010).
PpoC from Aspergillus nidulans is a fusion protein with only one active haem.
  Biochem J, 425, 553-565.  
18823646 H.E.Vonkeman, and M.A.van de Laar (2010).
Nonsteroidal anti-inflammatory drugs: adverse effects and their prevention.
  Semin Arthritis Rheum, 39, 294-312.  
20667175 K.R.Vinothkumar, and R.Henderson (2010).
Structures of membrane proteins.
  Q Rev Biophys, 43, 65.  
20430759 M.J.Uddin, B.C.Crews, A.L.Blobaum, P.J.Kingsley, D.L.Gorden, J.O.McIntyre, L.M.Matrisian, K.Subbaramaiah, A.J.Dannenberg, D.W.Piston, and L.J.Marnett (2010).
Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents.
  Cancer Res, 70, 3618-3627.  
20304090 P.D.Kiser, and K.Palczewski (2010).
Membrane-binding and enzymatic properties of RPE65.
  Prog Retin Eye Res, 29, 428-442.  
20196542 R.S.Deeb, C.Cheung, T.Nuriel, B.D.Lamon, R.K.Upmacis, S.S.Gross, and D.P.Hajjar (2010).
Physical evidence for substrate binding in preventing cyclooxygenase inactivation under nitrative stress.
  J Am Chem Soc, 132, 3914-3922.  
20237816 S.Bouaziz-Terrachet, A.Toumi-Maouche, B.Maouche, and S.Taïri-Kellou (2010).
Modeling the binding modes of stilbene analogs to cyclooxygenase-2: a molecular docking study.
  J Mol Model, 16, 1919-1929.  
20059330 T.Grosser, Y.Yu, and G.A.Fitzgerald (2010).
Emotion recollected in tranquility: lessons learned from the COX-2 saga.
  Annu Rev Med, 61, 17-33.  
20215464 V.Limongelli, M.Bonomi, L.Marinelli, F.L.Gervasio, A.Cavalli, E.Novellino, and M.Parrinello (2010).
Molecular basis of cyclooxygenase enzymes (COXs) selective inhibition.
  Proc Natl Acad Sci U S A, 107, 5411-5416.  
19266221 A.Sarkar, and G.Mostafa (2009).
Towards the design of cyclooxygenase (COX) inhibitors based on 4',5 di-substituted biphenyl acetic acid molecules: a QSAR study with a new DFT based descriptor - nucleus independent chemical shift.
  J Mol Model, 15, 1221-1228.  
19433337 C.E.Rogge, W.Liu, R.J.Kulmacz, and A.L.Tsai (2009).
Peroxide-induced radical formation at TYR385 and TYR504 in human PGHS-1.
  J Inorg Biochem, 103, 912-922.  
19060633 C.Pereira, R.M.Medeiros, and M.J.Dinis-Ribeiro (2009).
Cyclooxygenase polymorphisms in gastric and colorectal carcinogenesis: are conclusive results available?
  Eur J Gastroenterol Hepatol, 21, 76-91.  
19218248 C.Yuan, R.S.Sidhu, D.V.Kuklev, Y.Kado, M.Wada, I.Song, and W.L.Smith (2009).
Cyclooxygenase Allosterism, Fatty Acid-mediated Cross-talk between Monomers of Cyclooxygenase Homodimers.
  J Biol Chem, 284, 10046-10055.  
19056296 E.N.Churchill, N.Qvit, and D.Mochly-Rosen (2009).
Rationally designed peptide regulators of protein kinase C.
  Trends Endocrinol Metab, 20, 25-33.  
19286665 F.Brodhun, C.Göbel, E.Hornung, and I.Feussner (2009).
Identification of PpoA from Aspergillus nidulans as a Fusion Protein of a Fatty Acid Heme Dioxygenase/Peroxidase and a Cytochrome P450.
  J Biol Chem, 284, 11792-11805.  
19894761 G.Wu, A.L.Tsai, and R.J.Kulmacz (2009).
Cyclooxygenase competitive inhibitors alter tyrosyl radical dynamics in prostaglandin H synthase-2.
  Biochemistry, 48, 11902-11911.  
19767390 H.M.Eriksson, P.Wessman, C.Ge, K.Edwards, and A.Wieslander (2009).
Massive formation of intracellular membrane vesicles in Escherichia coli by a monotopic membrane-bound lipid glycosyltransferase.
  J Biol Chem, 284, 33904-33914.  
19902062 M.A.Murina, D.I.Roshchupkin, N.A.Chudina, A.O.Petrova, and V.I.Sergienko (2009).
Antiaggregant effect of taurine chloramines in the presence of serum albumin.
  Bull Exp Biol Med, 147, 704-707.  
19282279 M.Kämpf, B.Absmanner, M.Schwarz, and L.Lehle (2009).
Biochemical Characterization and Membrane Topology of Alg2 from Saccharomyces cerevisiae as a Bifunctional {alpha}1,3- and 1,6-Mannosyltransferase Involved in Lipid-linked Oligosaccharide Biosynthesis.
  J Biol Chem, 284, 11900-11912.  
19487671 M.Marcia, U.Ermler, G.Peng, and H.Michel (2009).
The structure of Aquifex aeolicus sulfide:quinone oxidoreductase, a basis to understand sulfide detoxification and respiration.
  Proc Natl Acad Sci U S A, 106, 9625-9630.
PDB codes: 3h27 3h28 3h29 3hyv 3hyw 3hyx
18926919 N.Wegner, R.Wait, and P.J.Venables (2009).
Evolutionarily conserved antigens in autoimmune disease: implications for an infective aetiology.
  Int J Biochem Cell Biol, 41, 390-397.  
19515770 R.Pejchal, J.S.Gach, F.M.Brunel, R.M.Cardoso, R.L.Stanfield, P.E.Dawson, D.R.Burton, M.B.Zwick, and I.A.Wilson (2009).
A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies.
  J Virol, 83, 8451-8462.
PDB code: 3fn0
20477063 S.Agarwal, G.V.Reddy, and P.Reddanna (2009).
Eicosanoids in inflammation and cancer: the role of COX-2.
  Expert Rev Clin Immunol, 5, 145-165.  
18250160 C.A.Rouzer, and L.J.Marnett (2008).
Non-redundant functions of cyclooxygenases: oxygenation of endocannabinoids.
  J Biol Chem, 283, 8065-8069.  
18621661 F.Forneris, and A.Mattevi (2008).
Enzymes without borders: mobilizing substrates, delivering products.
  Science, 321, 213-216.  
17624587 G.Singh-Ranger, M.Salhab, and K.Mokbel (2008).
The role of cyclooxygenase-2 in breast cancer: review.
  Breast Cancer Res Treat, 109, 189-198.  
18590695 K.H.Ruan, C.Wijaya, V.Cervantes, and J.Wu (2008).
Characterization of the prostaglandin H2 mimic: binding to the purified human thromboxane A2 receptor in solution.
  Arch Biochem Biophys, 477, 396-403.  
  19343100 M.F.Linton, and S.Fazio (2008).
Cyclooxygenase products and atherosclerosis.
  Drug Discov Today Ther Strateg, 5, 25-36.  
19090923 M.Khoshneviszadeh, N.Edraki, R.Miri, and B.Hemmateenejad (2008).
Exploring QSAR for substituted 2-sulfonyl-phenyl-indol derivatives as potent and selective COX-2 inhibitors using different chemometrics tools.
  Chem Biol Drug Des, 72, 564-574.  
18596034 M.Koszelak-Rosenblum, A.C.Krol, D.M.Simmons, C.C.Goulah, L.Wroblewski, and M.G.Malkowski (2008).
His-311 and Arg-559 Are Key Residues Involved in Fatty Acid Oxygenation in Pathogen-inducible Oxygenase.
  J Biol Chem, 283, 24962-24971.  
18226920 P.Sobrado, M.A.Goren, D.James, C.K.Amundson, and B.G.Fox (2008).
A Protein Structure Initiative approach to expression, purification, and in situ delivery of human cytochrome b5 to membrane vesicles.
  Protein Expr Purif, 58, 229-241.  
18473120 S.Chandrappa, S.B.Benaka Prasad, K.Vinaya, C.S.Ananda Kumar, N.R.Thimmegowda, and K.S.Rangappa (2008).
Synthesis and in vitro antiproliferative activity against human cancer cell lines of novel 5-(4-methyl-benzylidene)-thiazolidine-2,4-diones.
  Invest New Drugs, 26, 437-444.  
18216169 T.L.Tootle, and A.C.Spradling (2008).
Drosophila Pxt: a cyclooxygenase-like facilitator of follicle maturation.
  Development, 135, 839-847.  
18976171 T.Yoshida, J.S.Park, K.Yokosuka, K.Jimbo, K.Yamada, K.Sato, and K.Nagata (2008).
Effect of a nonprotein bioactive agent on the reduction of cyclooxygenase-2 and tumor necrosis factor-alpha in human intervertebral disc cells in vitro.
  J Neurosurg Spine, 9, 411-418.  
17434872 A.L.Blobaum, and L.J.Marnett (2007).
Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib.
  J Biol Chem, 282, 16379-16390.  
18038897 A.M.Ali, G.E.Saber, N.M.Mahfouz, M.A.El-Gendy, A.A.Radwan, and M.A.Hamid (2007).
Synthesis and three-dimensional qualitative structure selectivity relationship of 3,5-disubstituted-2,4-thiazolidinedione derivatives as COX2 inhibitors.
  Arch Pharm Res, 30, 1186-1204.  
17177291 A.Mancini, D.V.Jovanovic, Q.W.He, and J.A.Di Battista (2007).
Site-specific proteolysis of cyclooxygenase-2: a putative step in inflammatory prostaglandin E(2) biosynthesis.
  J Cell Biochem, 101, 425-441.  
18159230 A.Peretz, N.Degani-Katzav, M.Talmon, E.Danieli, A.Gopin, E.Malka, R.Nachman, A.Raz, D.Shabat, and B.Attali (2007).
A tale of switched functions: from cyclooxygenase inhibition to m-channel modulation in new diphenylamine derivatives.
  PLoS ONE, 2, e1332.  
17848558 B.A.Tews, and G.Meyers (2007).
The pestivirus glycoprotein Erns is anchored in plane in the membrane via an amphipathic helix.
  J Biol Chem, 282, 32730-32741.  
17656360 C.A.Harman, M.V.Turman, K.R.Kozak, L.J.Marnett, W.L.Smith, and R.M.Garavito (2007).
Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides.
  J Biol Chem, 282, 28096-28105.
PDB codes: 2oye 2oyu
17301694 C.R.Lee, F.G.Bottone, J.M.Krahn, L.Li, H.W.Mohrenweiser, M.E.Cook, R.M.Petrovich, D.A.Bell, T.E.Eling, and D.C.Zeldin (2007).
Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1).
  Pharmacogenet Genomics, 17, 145-160.  
17524979 C.Schneider, D.A.Pratt, N.A.Porter, and A.R.Brash (2007).
Control of oxygenation in lipoxygenase and cyclooxygenase catalysis.
  Chem Biol, 14, 473-488.  
17882334 F.Mancia, and W.A.Hendrickson (2007).
Expression of recombinant G-protein coupled receptors for structural biology.
  Mol Biosyst, 3, 723-734.  
17851687 G.Perrone, M.Zagami, V.Altomare, C.Battista, S.Morini, and C.Rabitti (2007).
COX-2 localization within plasma membrane caveolae-like structures in human lobular intraepithelial neoplasia of the breast.
  Virchows Arch, 451, 1039-1045.  
17462992 J.Liu, S.A.Seibold, C.J.Rieke, I.Song, R.I.Cukier, and W.L.Smith (2007).
Prostaglandin endoperoxide H synthases: peroxidase hydroperoxide specificity and cyclooxygenase activation.
  J Biol Chem, 282, 18233-18244.  
17652088 K.Valmsen, W.E.Boeglin, R.Järving, I.Järving, K.Varvas, A.R.Brash, and N.Samel (2007).
A critical role of non-active site residues on cyclooxygenase helices 5 and 6 in the control of prostaglandin stereochemistry at carbon 15.
  J Biol Chem, 282, 28157-28163.  
17630907 L.A.Tsaplina, and P.V.Vrzheshch (2007).
Cyclooxygenase and peroxidase inactivation of prostaglandin-H-synthase during catalysis.
  Biochemistry (Mosc), 72, 631-639.  
17893810 R.M.Jarvis, E.W.Blanch, A.P.Golovanov, J.Screen, and R.Goodacre (2007).
Quantification of casein phosphorylation with conformational interpretation using Raman spectroscopy.
  Analyst, 132, 1053-1060.  
17403665 S.Ichimura, T.Uchida, S.Taniguchi, S.Hira, T.Tosha, I.Morishima, T.Kitagawa, and K.Ishimori (2007).
Unique peroxidase reaction mechanism in prostaglandin endoperoxide H synthase-2: compound I in prostaglandin endoperoxide H synthase-2 can be formed without assistance by distal glutamine residue.
  J Biol Chem, 282, 16681-16690.  
17409707 S.Muraoka, and T.Miura (2007).
[Metabolism of non-steroidal anti-inflammatory drugs by peroxidase: implication for gastrointestinal mucosal lesions]
  Yakugaku Zasshi, 127, 749-756.  
17712823 S.Vandevoorde, and D.M.Lambert (2007).
The multiple pathways of endocannabinoid metabolism: a zoom out.
  Chem Biodivers, 4, 1858-1881.  
17482885 U.C.Tran, and C.F.Clarke (2007).
Endogenous synthesis of coenzyme Q in eukaryotes.
  Mitochondrion, 7, S62-S71.  
17316818 Y.J.Kang, U.R.Mbonye, C.J.DeLong, M.Wada, and W.L.Smith (2007).
Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradation.
  Prog Lipid Res, 46, 108-125.  
16731967 A.L.Lomize, I.D.Pogozheva, M.A.Lomize, and H.I.Mosberg (2006).
Positioning of proteins in membranes: a computational approach.
  Protein Sci, 15, 1318-1333.  
16401081 C.E.Rogge, B.Ho, W.Liu, R.J.Kulmacz, and A.L.Tsai (2006).
Role of Tyr348 in Tyr385 radical dynamics and cyclooxygenase inhibitor interactions in prostaglandin H synthase-2.
  Biochemistry, 45, 523-532.  
16606823 C.Yuan, C.J.Rieke, G.Rimon, B.A.Wingerd, and W.L.Smith (2006).
Partnering between monomers of cyclooxygenase-2 homodimers.
  Proc Natl Acad Sci U S A, 103, 6142-6147.  
17046834 H.R.Corradi, A.V.Corrigall, E.Boix, C.G.Mohan, E.D.Sturrock, P.N.Meissner, and K.R.Acharya (2006).
Crystal structure of protoporphyrinogen oxidase from Myxococcus xanthus and its complex with the inhibitor acifluorfen.
  J Biol Chem, 281, 38625-38633.
PDB codes: 2ivd 2ive
16531064 J.B.Méric, S.Rottey, K.Olaussen, J.C.Soria, D.Khayat, O.Rixe, and J.P.Spano (2006).
Cyclooxygenase-2 as a target for anticancer drug development.
  Crit Rev Oncol Hematol, 59, 51-64.  
17050691 J.Zhang, F.E.Frerman, and J.J.Kim (2006).
Structure of electron transfer flavoprotein-ubiquinone oxidoreductase and electron transfer to the mitochondrial ubiquinone pool.
  Proc Natl Acad Sci U S A, 103, 16212-16217.
PDB codes: 2gmh 2gmj
16421446 K.Gupta, B.S.Selinsky, and P.J.Loll (2006).
2.0 angstroms structure of prostaglandin H2 synthase-1 reconstituted with a manganese porphyrin cofactor.
  Acta Crystallogr D Biol Crystallogr, 62, 151-156.
PDB code: 2ayl
16869801 M.Buckland, C.B.Jago, H.Fazekasova, K.Scott, P.H.Tan, A.J.George, R.Lechler, and G.Lombardi (2006).
Aspirin-treated human DCs up-regulate ILT-3 and induce hyporesponsiveness and regulatory activity in responder T cells.
  Am J Transplant, 6, 2046-2059.  
16632499 P.W.Fowler, and P.V.Coveney (2006).
A computational protocol for the integration of the monotopic protein prostaglandin H2 synthase into a phospholipid bilayer.
  Biophys J, 91, 401-410.  
17071117 S.Bingham, P.J.Beswick, D.E.Blum, N.M.Gray, and I.P.Chessell (2006).
The role of the cylooxygenase pathway in nociception and pain.
  Semin Cell Dev Biol, 17, 544-554.  
17030994 S.D.Gilk, Y.Raviv, K.Hu, J.M.Murray, C.J.Beckers, and G.E.Ward (2006).
Identification of PhIL1, a novel cytoskeletal protein of the Toxoplasma gondii pellicle, through photosensitized labeling with 5-[125I]iodonaphthalene-1-azide.
  Eukaryot Cell, 5, 1622-1634.  
16395396 T.Grosser, S.Fries, and G.A.FitzGerald (2006).
Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities.
  J Clin Invest, 116, 4.  
17001073 U.R.Mbonye, M.Wada, C.J.Rieke, H.Y.Tang, D.L.Dewitt, and W.L.Smith (2006).
The 19-amino acid cassette of cyclooxygenase-2 mediates entry of the protein into the endoplasmic reticulum-associated degradation system.
  J Biol Chem, 281, 35770-35778.  
16732282 Y.Yu, J.Fan, X.S.Chen, D.Wang, A.J.Klein-Szanto, R.L.Campbell, G.A.FitzGerald, and C.D.Funk (2006).
Genetic model of selective COX2 inhibition reveals novel heterodimer signaling.
  Nat Med, 12, 699-704.  
16809339 Z.MirAfzali, J.R.Leipprandt, J.L.McCracken, and D.L.DeWitt (2006).
Topography of the prostaglandin endoperoxide H2 synthase-2 in membranes.
  J Biol Chem, 281, 28354-28364.  
15917246 C.A.Rouzer, and L.J.Marnett (2005).
Glycerylprostaglandin synthesis by resident peritoneal macrophages in response to a zymosan stimulus.
  J Biol Chem, 280, 26690-26700.  
16140766 C.Fetzer, B.A.Tews, and G.Meyers (2005).
The carboxy-terminal sequence of the pestivirus glycoprotein E(rns) represents an unusual type of membrane anchor.
  J Virol, 79, 11901-11913.  
16227351 C.J.Hawkey (2005).
COX-2 chronology.
  Gut, 54, 1509-1514.  
15605385 C.J.Jeffery (2005).
Mass spectrometry and the search for moonlighting proteins.
  Mass Spectrom Rev, 24, 772-782.  
16319876 D.M.Engelman (2005).
Membranes are more mosaic than fluid.
  Nature, 438, 578-580.  
15542590 D.Ogg, B.Elleby, C.Norström, K.Stefansson, L.Abrahmsén, U.Oppermann, and S.Svensson (2005).
The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions.
  J Biol Chem, 280, 3789-3794.
PDB code: 1xse
16059664 H.Park, and S.Lee (2005).
Free energy perturbation approach to the critical assessment of selective cyclooxygenase-2 inhibitors.
  J Comput Aided Mol Des, 19, 17-31.  
16203985 H.Zhou, V.N.Ivanov, J.Gillespie, C.R.Geard, S.A.Amundson, D.J.Brenner, Z.Yu, H.B.Lieberman, and T.K.Hei (2005).
Mechanism of radiation-induced bystander effect: role of the cyclooxygenase-2 signaling pathway.
  Proc Natl Acad Sci U S A, 102, 14641-14646.  
15700978 J.C.Wilson, G.Wu, A.L.Tsai, and G.J.Gerfen (2005).
Determination of the structural environment of the tyrosyl radical in prostaglandin H2 synthase-1: a high frequency ENDOR/EPR study.
  J Am Chem Soc, 127, 1618-1619.  
16211102 J.Lee, A.J.Chubb, E.Moman, B.M.McLoughlin, C.T.Sharkey, J.G.Kelly, K.B.Nolan, M.Devocelle, and D.J.Fitzgerald (2005).
Parallel synthesis and in vitro activity of novel anthranilic hydroxamate-based inhibitors of the prostaglandin H2 synthase peroxidase activity.
  Org Biomol Chem, 3, 3678-3685.  
15952893 M.K.McKinney, and B.F.Cravatt (2005).
Structure and function of fatty acid amide hydrolase.
  Annu Rev Biochem, 74, 411-432.  
16231707 M.S.Bergh, and S.C.Budsberg (2005).
The coxib NSAIDs: potential clinical and pharmacologic importance in veterinary medicine.
  J Vet Intern Med, 19, 633-643.  
15850674 P.Patrignani, S.Tacconelli, M.G.Sciulli, and M.L.Capone (2005).
New insights into COX-2 biology and inhibition.
  Brain Res Brain Res Rev, 48, 352-359.  
16849185 P.V.Coveney, and P.W.Fowler (2005).
Modelling biological complexity: a physical scientist's perspective.
  J R Soc Interface, 2, 267-280.  
17191953 R.G.Huff, E.Bayram, H.Tan, S.T.Knutson, M.H.Knaggs, A.B.Richon, P.Santago, and J.S.Fetrow (2005).
Chemical and structural diversity in cyclooxygenase protein active sites.
  Chem Biodivers, 2, 1533-1552.  
16335053 S.Prasanna, E.Manivannan, and S.C.Chaturvedi (2005).
Quantitative structure-activity relationship analysis of 2,3-diaryl indoles as selective cyclooxygenase-2 inhibitors.
  J Enzyme Inhib Med Chem, 20, 455-461.  
17191960 S.Songarsa, S.Rajviroongit, D.Sae-Tang, S.Hannongbua, K.Kirtikara, and P.Kittakoop (2005).
New racemosol derivatives as potent cyclooxygenase (COX) inhibitors.
  Chem Biodivers, 2, 1635-1647.  
15292194 C.A.Harman, C.J.Rieke, R.M.Garavito, and W.L.Smith (2004).
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  J Biol Chem, 279, 42929-42935.
PDB code: 1u67
15181007 C.A.Rouzer, P.J.Kingsley, H.Wang, H.Zhang, J.D.Morrow, S.K.Dey, and L.J.Marnett (2004).
Cyclooxygenase-1-dependent prostaglandin synthesis modulates tumor necrosis factor-alpha secretion in lipopolysaccharide-challenged murine resident peritoneal macrophages.
  J Biol Chem, 279, 34256-34268.  
15507640 C.A.Rue, M.A.Jarvis, A.J.Knoche, H.L.Meyers, V.R.DeFilippis, S.G.Hansen, M.Wagner, K.Früh, D.G.Anders, S.W.Wong, P.A.Barry, and J.A.Nelson (2004).
A cyclooxygenase-2 homologue encoded by rhesus cytomegalovirus is a determinant for endothelial cell tropism.
  J Virol, 78, 12529-12536.  
15039425 C.Colas, and P.R.De Montellano (2004).
Horseradish peroxidase mutants that autocatalytically modify their prosthetic heme group: insights into mammalian peroxidase heme-protein covalent bonds.
  J Biol Chem, 279, 24131-24140.  
14970279 E.T.Chang, T.Zheng, E.G.Weir, M.Borowitz, R.B.Mann, D.Spiegelman, and N.E.Mueller (2004).
Aspirin and the risk of Hodgkin's lymphoma in a population-based case-control study.
  J Natl Cancer Inst, 96, 305-315.  
15247283 F.Penin, V.Brass, N.Appel, S.Ramboarina, R.Montserret, D.Ficheux, H.E.Blum, R.Bartenschlager, and D.Moradpour (2004).
Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A.
  J Biol Chem, 279, 40835-40843.
PDB codes: 1r7c 1r7d 1r7e 1r7f 1r7g
15502639 G.Eibl, H.A.Reber, O.J.Hines, and V.L.Go (2004).
COX and PPAR: possible interactions in pancreatic cancer.
  Pancreas, 29, 247-253.  
15501074 J.B.Tuynman, M.P.Peppelenbosch, and D.J.Richel (2004).
COX-2 inhibition as a tool to treat and prevent colorectal cancer.
  Crit Rev Oncol Hematol, 52, 81.  
14966369 M.J.Wu, L.Wang, H.Y.Ding, C.Y.Weng, and J.H.Yen (2004).
Glossogyne tenuifolia acts to inhibit inflammatory mediator production in a macrophage cell line by downregulating LPS-induced NF-kappa B.
  J Biomed Sci, 11, 186-199.  
15345041 N.V.Chandrasekharan, and D.L.Simmons (2004).
The cyclooxygenases.
  Genome Biol, 5, 241.  
15078870 P.C.Rudberg, F.Tholander, M.Andberg, M.M.Thunnissen, and J.Z.Haeggström (2004).
Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates.
  J Biol Chem, 279, 27376-27382.
PDB code: 1sqm
14732711 R.Järving, I.Järving, R.Kurg, A.R.Brash, and N.Samel (2004).
On the evolutionary origin of cyclooxygenase (COX) isozymes: characterization of marine invertebrate COX genes points to independent duplication events in vertebrate and invertebrate lineages.
  J Biol Chem, 279, 13624-13633.  
15340929 T.Akiba, M.Nishio, I.Matsui, and K.Harata (2004).
X-ray structure of a membrane-bound beta-glycosidase from the hyperthermophilic archaeon Pyrococcus horikoshii.
  Proteins, 57, 422-431.
PDB code: 1vff
15100225 W.Liu, C.E.Rogge, B.Bambai, G.Palmer, A.L.Tsai, and R.J.Kulmacz (2004).
Characterization of the heme environment in Arabidopsis thaliana fatty acid alpha-dioxygenase-1.
  J Biol Chem, 279, 29805-29815.  
14645067 A.Sáez-Cirión, J.L.Arrondo, M.J.Gómara, M.Lorizate, I.Iloro, G.Melikyan, and J.L.Nieva (2003).
Structural and functional roles of HIV-1 gp41 pretransmembrane sequence segmentation.
  Biophys J, 85, 3769-3780.  
12401791 C.Reinbothe, A.Lepinat, M.Deckers, E.Beck, and S.Reinbothe (2003).
The extra loop distinguishing POR from the structurally related short-chain alcohol dehydrogenases is dispensable for pigment binding but needed for the assembly of light-harvesting POR-protochlorophyllide complex.
  J Biol Chem, 278, 816-822.  
14503001 D.A.Berthold, and P.Stenmark (2003).
Membrane-bound diiron carboxylate proteins.
  Annu Rev Plant Biol, 54, 497-517.  
12657638 F.G.Hernandez-Guzman, T.Higashiyama, W.Pangborn, Y.Osawa, and D.Ghosh (2003).
Structure of human estrone sulfatase suggests functional roles of membrane association.
  J Biol Chem, 278, 22989-22997.
PDB code: 1p49
14622024 G.Wu, R.J.Kulmacz, and A.L.Tsai (2003).
Cyclooxygenase inactivation kinetics during reaction of prostaglandin H synthase-1 with peroxide.
  Biochemistry, 42, 13772-13777.  
14585927 I.Dey, K.Keller, A.Belley, and K.Chadee (2003).
Identification and characterization of a cyclooxygenase-like enzyme from Entamoeba histolytica.
  Proc Natl Acad Sci U S A, 100, 13561-13566.  
12573692 J.H.Hurley (2003).
Membrane proteins: adapting to life at the interface.
  Chem Biol, 10, 2-3.  
  12562317 P.Patrignani, M.L.Capone, and S.Tacconelli (2003).
Clinical pharmacology of etoricoxib: a novel selective COX2 inhibitor.
  Expert Opin Pharmacother, 4, 265-284.  
14511323 R.Aleong, N.Aumont, D.Dea, and J.Poirier (2003).
Non-steroidal anti-inflammatory drugs mediate increased in vitro glial expression of apolipoprotein E protein.
  Eur J Neurosci, 18, 1428-1438.  
12612644 R.J.Flower (2003).
The development of COX2 inhibitors.
  Nat Rev Drug Discov, 2, 179-191.  
12814642 R.J.Kulmacz, W.A.van der Donk, and A.L.Tsai (2003).
Comparison of the properties of prostaglandin H synthase-1 and -2.
  Prog Lipid Res, 42, 377-404.  
12574066 R.M.Garavito, and A.M.Mulichak (2003).
The structure of mammalian cyclooxygenases.
  Annu Rev Biophys Biomol Struct, 32, 183-206.  
12952981 S.A.Seibold, T.Ball, L.C.Hsi, D.A.Mills, R.D.Abeysinghe, R.Micielli, C.J.Rieke, R.I.Cukier, and W.L.Smith (2003).
Histidine 386 and its role in cyclooxygenase and peroxidase catalysis by prostaglandin-endoperoxide H synthases.
  J Biol Chem, 278, 46163-46170.  
14989043 S.J.Andersen (2003).
Cyclooxygenase-2 inhibitor treatment of older osteoarthritis patients.
  Compr Ther, 29, 215-223.  
12808042 S.Lin, X.Lu, C.C.Chang, and T.Y.Chang (2003).
Human acyl-coenzyme A:cholesterol acyltransferase expressed in chinese hamster ovary cells: membrane topology and active site location.
  Mol Biol Cell, 14, 2447-2460.  
12925531 S.W.Rowlinson, J.R.Kiefer, J.J.Prusakiewicz, J.L.Pawlitz, K.R.Kozak, A.S.Kalgutkar, W.C.Stallings, R.G.Kurumbail, and L.J.Marnett (2003).
A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385.
  J Biol Chem, 278, 45763-45769.
PDB code: 1pxx
12716479 V.B.O'Donnell (2003).
Free radicals and lipid signaling in endothelial cells.
  Antioxid Redox Signal, 5, 195-203.  
12167656 A.L.Tsai, G.Palmer, G.Wu, S.Peng, N.M.Okeley, W.A.van der Donk, and R.J.Kulmacz (2002).
Structural characterization of arachidonyl radicals formed by aspirin-treated prostaglandin H synthase-2.
  J Biol Chem, 277, 38311-38321.  
12453566 B.H.Havsteen (2002).
The biochemistry and medical significance of the flavonoids.
  Pharmacol Ther, 96, 67.  
11677234 C.Schneider, W.E.Boeglin, J.J.Prusakiewicz, S.W.Rowlinson, L.J.Marnett, N.Samel, and A.R.Brash (2002).
Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349.
  J Biol Chem, 277, 478-485.  
12447099 E.C.Hayes, and J.A.Rock (2002).
COX-2 inhibitors and their role in gynecology.
  Obstet Gynecol Surv, 57, 768-780.  
12445211 K.Müller-Decker, W.Hirschner, F.Marks, and G.Fürstenberger (2002).
The effects of cyclooxygenase isozyme inhibition on incisional wound healing in mouse skin.
  J Invest Dermatol, 119, 1189-1195.  
11807164 L.J.Marnett, and R.N.DuBois (2002).
COX-2: a target for colon cancer prevention.
  Annu Rev Pharmacol Toxicol, 42, 55-80.  
  12467519 L.J.Mengle-Gaw, and B.D.Schwartz (2002).
Cyclooxygenase-2 inhibitors: promise or peril?
  Mediators Inflamm, 11, 275-286.  
12459591 M.H.Bracey, M.A.Hanson, K.R.Masuda, R.C.Stevens, and B.F.Cravatt (2002).
Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling.
  Science, 298, 1793-1796.
PDB code: 1mt5
11985588 P.Milla, A.Lenhart, G.Grosa, F.Viola, W.A.Weihofen, G.E.Schulz, and G.Balliano (2002).
Thiol-modifying inhibitors for understanding squalene cyclase function.
  Eur J Biochem, 269, 2108-2116.  
12187272 S.Y.Nakada, T.J.Jerde, L.M.Jacobson, R.Saban, D.E.Bjorling, and D.A.Hullett (2002).
Cyclooxygenase-2 expression is up-regulated in obstructed human ureter.
  J Urol, 168, 1226-1229.  
11840453 T.Kalajdzic, W.H.Faour, Q.W.He, H.Fahmi, J.Martel-Pelletier, J.P.Pelletier, and J.A.Di Battista (2002).
Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism.
  Arthritis Rheum, 46, 494-506.  
11744739 V.Brass, E.Bieck, R.Montserret, B.Wölk, J.A.Hellings, H.E.Blum, F.Penin, and D.Moradpour (2002).
An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A.
  J Biol Chem, 277, 8130-8139.  
11159433 D.Bechor, and N.Ben-Tal (2001).
Implicit solvent model studies of the interactions of the influenza hemagglutinin fusion peptide with lipid bilayers.
  Biophys J, 80, 643-655.  
  11813903 D.Thurnher, M.Bakroeva, G.Schütz, M.Pelzmann, M.Formanek, B.Knerer, and J.Kornfehl (2001).
Non-steroidal anti-inflammatory drugs induce apoptosis in head and neck cancer cell lines.
  Acta Otolaryngol, 121, 957-962.  
11448449 E.H.Oliw, K.Stark, and J.Bylund (2001).
Oxidation of prostaglandin H(2) and prostaglandin H(2) analogues by human cytochromes P450: analysis of omega-side chain hydroxy metabolites and four steroisomers of 5-hydroxyprostaglandin I(1) by mass spectrometry.
  Biochem Pharmacol, 62, 407-415.  
11304658 K.M.Verburg, T.J.Maziasz, E.Weiner, L.Loose, G.S.Geis, and P.C.Isakson (2001).
Cox-2-specific inhibitors: definition of a new therapeutic concept.
  Am J Ther, 8, 49-64.  
11427702 K.Valmsen, I.Järving, W.E.Boeglin, K.Varvas, R.Koljak, T.Pehk, A.R.Brash, and N.Samel (2001).
The origin of 15R-prostaglandins in the Caribbean coral Plexaura homomalla: molecular cloning and expression of a novel cyclooxygenase.
  Proc Natl Acad Sci U S A, 98, 7700-7705.  
11412976 M.L.Price, and W.L.Jorgensen (2001).
Rationale for the observed COX-2/COX-1 selectivity of celecoxib from Monte Carlo simulations.
  Bioorg Med Chem Lett, 11, 1541-1544.  
11962253 P.Waffo-Téguo, M.E.Hawthorne, M.Cuendet, J.M.Mérillon, A.D.Kinghorn, J.M.Pezzuto, and R.G.Mehta (2001).
Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures.
  Nutr Cancer, 40, 173-179.  
11266632 S.Jayasinghe, K.Hristova, and S.H.White (2001).
MPtopo: A database of membrane protein topology.
  Protein Sci, 10, 455-458.  
11302965 W.A.Brown, S.A.Skinner, C.Malcontenti-Wilson, D.Vogiagis, and P.E.O'Brien (2001).
Non-steroidal anti-inflammatory drugs with activity against either cyclooxygenase 1 or cyclooxygenase 2 inhibit colorectal cancer in a DMH rodent model by inducing apoptosis and inhibiting cell proliferation.
  Gut, 48, 660-666.  
11500931 Y.C.Chen, S.C.Shen, W.R.Lee, W.C.Hou, L.L.Yang, and T.J.Lee (2001).
Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase-2 gene expressions by rutin, quercetin, and quercetin pentaacetate in RAW 264.7 macrophages.
  J Cell Biochem, 82, 537-548.  
11704632 Y.S.Bakhle (2001).
COX-2 and cancer: a new approach to an old problem.
  Br J Pharmacol, 134, 1137-1150.  
10692361 A.M.Grahn, J.Haase, D.H.Bamford, and E.Lanka (2000).
Components of the RP4 conjugative transfer apparatus form an envelope structure bridging inner and outer membranes of donor cells: implications for related macromolecule transport systems.
  J Bacteriol, 182, 1564-1574.  
10639181 A.S.Kalgutkar, B.C.Crews, S.W.Rowlinson, A.B.Marnett, K.R.Kozak, R.P.Remmel, and L.J.Marnett (2000).
Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.
  Proc Natl Acad Sci U S A, 97, 925-930.  
11015223 B.S.Lou, J.K.Snyder, P.Marshall, J.S.Wang, G.Wu, R.J.Kulmacz, A.L.Tsai, and J.Wang (2000).
Resonance Raman studies indicate a unique heme active site in prostaglandin H synthase.
  Biochemistry, 39, 12424-12434.  
11053137 B.Vogt, P.Ducarme, S.Schinzel, R.Brasseur, and B.Bechinger (2000).
The topology of lysine-containing amphipathic peptides in bilayers by circular dichroism, solid-state NMR, and molecular modeling.
  Biophys J, 79, 2644-2656.  
10821698 C.A.Lanzo, J.Sutin, S.Rowlinson, J.Talley, and L.J.Marnett (2000).
Fluorescence quenching analysis of the association and dissociation of a diarylheterocycle to cyclooxygenase-1 and cyclooxygenase-2: dynamic basis of cyclooxygenase-2 selectivity.
  Biochemistry, 39, 6228-6234.  
10976307 C.J.Jones, and S.C.Budsberg (2000).
Physiologic characteristics and clinical importance of the cyclooxygenase isoforms in dogs and cats.
  J Am Vet Med Assoc, 217, 721-729.  
11009606 C.Loeb-Hennard, and J.O.McIntyre (2000).
(R)-3-hydroxybutyrate dehydrogenase: selective phosphatidylcholine binding by the C-terminal domain.
  Biochemistry, 39, 11928-11938.  
10671506 C.Schneider, and A.R.Brash (2000).
Stereospecificity of hydrogen abstraction in the conversion of arachidonic acid to 15R-HETE by aspirin-treated cyclooxygenase-2. Implications for the alignment of substrate in the active site.
  J Biol Chem, 275, 4743-4746.  
11241212 C.Vigano, L.Manciu, F.Buyse, E.Goormaghtigh, and J.M.Ruysschaert (2000).
Attenuated total reflection IR spectroscopy as a tool to investigate the structure, orientation and tertiary structure changes in peptides and membrane proteins.
  Biopolymers, 55, 373-380.  
11106766 D.A.Berthold, M.E.Andersson, and P.Nordlund (2000).
New insight into the structure and function of the alternative oxidase.
  Biochim Biophys Acta, 1460, 241-254.  
10820014 D.C.Goodwin, S.W.Rowlinson, and L.J.Marnett (2000).
Substitution of tyrosine for the proximal histidine ligand to the heme of prostaglandin endoperoxide synthase 2: implications for the mechanism of cyclooxygenase activation and catalysis.
  Biochemistry, 39, 5422-5432.  
10931557 D.L.Harris, E.King, P.A.Ramsland, and A.B.Edmundson (2000).
Binding of nascent collagen by amyloidogenic light chains and amyloid fibrillogenesis in monolayers of human fibrocytes.
  J Mol Recognit, 13, 198-212.  
11113025 D.L.Simmons, D.Wagner, and K.Westover (2000).
Nonsteroidal anti-inflammatory drugs, acetaminophen, cyclooxygenase 2, and fever.
  Clin Infect Dis, 31, S211-S218.  
10722687 E.D.Thuresson, K.M.Lakkides, and W.L.Smith (2000).
Different catalytically competent arrangements of arachidonic acid within the cyclooxygenase active site of prostaglandin endoperoxide H synthase-1 lead to the formation of different oxygenated products.
  J Biol Chem, 275, 8501-8507.  
10903961 H.C.Köfeler, G.Fauler, W.Windischhofer, and H.J.Leis (2000).
Effect of cytochrome P-450 inhibitors econazole, bifonazole and clotrimazole on prostanoid formation.
  Br J Pharmacol, 130, 1241-1246.  
10966478 J.L.Popot, and D.M.Engelman (2000).
Helical membrane protein folding, stability, and evolution.
  Annu Rev Biochem, 69, 881-922.  
10809766 J.Y.Liou, S.K.Shyue, M.J.Tsai, C.L.Chung, K.Y.Chu, and K.K.Wu (2000).
Colocalization of prostacyclin synthase with prostaglandin H synthase-1 (PGHS-1) but not phorbol ester-induced PGHS-2 in cultured endothelial cells.
  J Biol Chem, 275, 15314-15320.  
11027983 K.U.Wendt, G.E.Schulz, E.J.Corey, and D.R.Liu (2000).
Enzyme Mechanisms for Polycyclic Triterpene Formation.
  Angew Chem Int Ed Engl, 39, 2812-2833.  
11006543 L.J.Marnett (2000).
Cyclooxygenase mechanisms.
  Curr Opin Chem Biol, 4, 545-552.  
10988074 M.G.Malkowski, S.L.Ginell, W.L.Smith, and R.M.Garavito (2000).
The productive conformation of arachidonic acid bound to prostaglandin synthase.
  Science, 289, 1933-1937.
PDB code: 1diy
  10977130 N.J.van Haeringen, A.A.van Sorge, J.L.Van Delft, and V.M.Carballosa Coré-Bodelier (2000).
Flurbiprofen and enantiomers in ophthalmic solution tested as inhibitors of prostanoid synthesis in human blood.
  J Ocul Pharmacol Ther, 16, 345-352.  
10944213 O.Dym, E.A.Pratt, C.Ho, and D.Eisenberg (2000).
The crystal structure of D-lactate dehydrogenase, a peripheral membrane respiratory enzyme.
  Proc Natl Acad Sci U S A, 97, 9413-9418.
PDB code: 1f0x
10828979 S.A.Seibold, J.F.Cerda, A.M.Mulichak, I.Song, R.M.Garavito, T.Arakawa, W.L.Smith, and G.T.Babcock (2000).
Peroxidase activity in prostaglandin endoperoxide H synthase-1 occurs with a neutral histidine proximal heme ligand.
  Biochemistry, 39, 6616-6624.  
10992545 S.J.Vane (2000).
Aspirin and other anti-inflammatory drugs.
  Thorax, 55, S3-S9.  
10673429 S.Liu, E.A.Neidhardt, T.H.Grossman, T.Ocain, and J.Clardy (2000).
Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.
  Structure, 8, 25-33.
PDB codes: 1d3g 1d3h
10792129 S.Somasundaram, G.Sigthorsson, R.J.Simpson, J.Watts, M.Jacob, I.A.Tavares, S.Rafi, A.Roseth, R.Foster, A.B.Price, J.M.Wrigglesworth, and I.Bjarnason (2000).
Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat.
  Aliment Pharmacol Ther, 14, 639-650.  
10692466 S.W.Rowlinson, B.C.Crews, D.C.Goodwin, C.Schneider, J.K.Gierse, and L.J.Marnett (2000).
Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-hete.
  J Biol Chem, 275, 6586-6591.  
10647695 S.Y.Nakada, T.J.Jerde, D.E.Bjorling, and R.Saban (2000).
Selective cyclooxygenase-2 inhibitors reduce ureteral contraction in vitro: a better alternative for renal colic?
  J Urol, 163, 607-612.  
10766826 T.J.Fiedler, C.A.Davey, and R.E.Fenna (2000).
X-ray crystal structure and characterization of halide-binding sites of human myeloperoxidase at 1.8 A resolution.
  J Biol Chem, 275, 11964-11971.
PDB codes: 1cxp 1d2v
10966456 W.L.Smith, D.L.DeWitt, and R.M.Garavito (2000).
Cyclooxygenases: structural, cellular, and molecular biology.
  Annu Rev Biochem, 69, 145-182.  
10747802 W.Shi, C.W.Hoganson, M.Espe, C.J.Bender, G.T.Babcock, G.Palmer, R.J.Kulmacz, and A.Tsai (2000).
Electron paramagnetic resonance and electron nuclear double resonance spectroscopic identification and characterization of the tyrosyl radicals in prostaglandin H synthase 1.
  Biochemistry, 39, 4112-4121.  
10551860 A.G.Spencer, E.Thuresson, J.C.Otto, I.Song, T.Smith, D.L.DeWitt, R.M.Garavito, and W.L.Smith (1999).
The membrane binding domains of prostaglandin endoperoxide H synthases 1 and 2. Peptide mapping and mutational analysis.
  J Biol Chem, 274, 32936-32942.  
  10338019 A.M.Dean, and F.M.Dean (1999).
Carbocations in the synthesis of prostaglandins by the cyclooxygenase of PGH synthase? A radical departure!
  Protein Sci, 8, 1087-1098.  
10419480 A.Tsai, G.Wu, G.Palmer, B.Bambai, J.A.Koehn, P.J.Marshall, and R.J.Kulmacz (1999).
Rapid kinetics of tyrosyl radical formation and heme redox state changes in prostaglandin H synthase-1 and -2.
  J Biol Chem, 274, 21695-21700.  
9929039 C.J.Hawkey (1999).
COX-2 inhibitors.
  Lancet, 353, 307-314.  
10358065 C.J.Rieke, A.M.Mulichak, R.M.Garavito, and W.L.Smith (1999).
The role of arginine 120 of human prostaglandin endoperoxide H synthase-2 in the interaction with fatty acid substrates and inhibitors.
  J Biol Chem, 274, 17109-17114.  
10358043 C.Oxvig, A.R.Thomsen, M.T.Overgaard, E.S.Sorensen, P.Højrup, M.J.Bjerrum, G.J.Gleich, and L.Sottrup-Jensen (1999).
Biochemical evidence for heme linkage through esters with Asp-93 and Glu-241 in human eosinophil peroxidase. The ester with Asp-93 is only partially formed in vivo.
  J Biol Chem, 274, 16953-16958.  
10354443 D.P.Tieleman, H.J.Berendsen, and M.S.Sansom (1999).
Surface binding of alamethicin stabilizes its helical structure: molecular dynamics simulations.
  Biophys J, 76, 3186-3191.  
10393271 E.Goormaghtigh, V.Raussens, and J.M.Ruysschaert (1999).
Attenuated total reflection infrared spectroscopy of proteins and lipids in biological membranes.
  Biochim Biophys Acta, 1422, 105-185.  
10347169 G.Lu, A.L.Tsai, H.E.Van Wart, and R.J.Kulmacz (1999).
Comparison of the peroxidase reaction kinetics of prostaglandin H synthase-1 and -2.
  J Biol Chem, 274, 16162-16167.  
10092596 G.Wu, C.Wei, R.J.Kulmacz, Y.Osawa, and A.L.Tsai (1999).
A mechanistic study of self-inactivation of the peroxidase activity in prostaglandin H synthase-1.
  J Biol Chem, 274, 9231-9237.  
10578123 J.A.Mitchell, and T.D.Warner (1999).
Cyclo-oxygenase-2: pharmacology, physiology, biochemistry and relevance to NSAID therapy.
  Br J Pharmacol, 128, 1121-1132.  
10334274 J.M.Besson (1999).
The neurobiology of pain.
  Lancet, 353, 1610-1615.  
10497176 L.Hörnsten, C.Su, A.E.Osbourn, P.Garosi, U.Hellman, C.Wernstedt, and E.H.Oliw (1999).
Cloning of linoleate diol synthase reveals homology with prostaglandin H synthases.
  J Biol Chem, 274, 28219-28224.  
10542447 L.J.Marnett, and A.S.Kalgutkar (1999).
Cyclooxygenase 2 inhibitors: discovery, selectivity and the future.
  Trends Pharmacol Sci, 20, 465-469.  
10438452 L.J.Marnett, S.W.Rowlinson, D.C.Goodwin, A.S.Kalgutkar, and C.A.Lanzo (1999).
Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition.
  J Biol Chem, 274, 22903-22906.  
15992098 L.M.Jackson, and C.J.Hawkey (1999).
Gastrointestinal effects of COX-2 inhibitors.
  Expert Opin Investig Drugs, 8, 963-971.  
10360948 L.Voglino, S.A.Simon, and T.J.McIntosh (1999).
Orientation of LamB signal peptides in bilayers: influence of lipid probes on peptide binding and interpretation of fluorescence quenching data.
  Biochemistry, 38, 7509-7516.  
10531341 M.Ouzzine, J.Magdalou, B.Burchell, and S.Fournel-Gigleux (1999).
An internal signal sequence mediates the targeting and retention of the human UDP-glucuronosyltransferase 1A6 to the endoplasmic reticulum.
  J Biol Chem, 274, 31401-31409.  
10477832 M.Rosenstock, A.Danon, and G.Rimon (1999).
PGHS-2 inhibitors, NS-398 and DuP-697, attenuate the inhibition of PGHS-1 by aspirin and indomethacin without altering its activity.
  Biochim Biophys Acta, 1440, 127-137.  
10570255 R.M.Garavito, and D.L.DeWitt (1999).
The cyclooxygenase isoforms: structural insights into the conversion of arachidonic acid to prostaglandins.
  Biochim Biophys Acta, 1441, 278-287.  
10611297 S.Arnould, M.Takahashi, and J.M.Camadro (1999).
Acylation stabilizes a protease-resistant conformation of protoporphyrinogen oxidase, the molecular target of diphenyl ether-type herbicides.
  Proc Natl Acad Sci U S A, 96, 14825-14830.  
10410805 S.H.White, and W.C.Wimley (1999).
Membrane protein folding and stability: physical principles.
  Annu Rev Biophys Biomol Struct, 28, 319-365.  
10438506 S.W.Rowlinson, B.C.Crews, C.A.Lanzo, and L.J.Marnett (1999).
The binding of arachidonic acid in the cyclooxygenase active site of mouse prostaglandin endoperoxide synthase-2 (COX-2). A putative L-shaped binding conformation utilizing the top channel region.
  J Biol Chem, 274, 23305-23310.  
10357827 T.Ahola, A.Lampio, P.Auvinen, and L.Kääriäinen (1999).
Semliki Forest virus mRNA capping enzyme requires association with anionic membrane phospholipids for activity.
  EMBO J, 18, 3164-3172.  
10399316 T.Hla, D.Bishop-Bailey, C.H.Liu, H.J.Schaefers, and O.C.Trifan (1999).
Cyclooxygenase-1 and -2 isoenzymes.
  Int J Biochem Cell Biol, 31, 551-557.  
10336459 T.J.Smith, T.A.Jennings, D.Sciaky, and H.J.Cao (1999).
Prostaglandin-endoperoxide H synthase-2 expression in human thyroid epithelium. Evidence for constitutive expression in vivo and in cultured KAT-50 cells.
  J Biol Chem, 274, 15622-15632.  
10329674 U.Quitterer, E.Zaki, and S.AbdAlla (1999).
Investigation of the extracellular accessibility of the connecting loop between membrane domains I and II of the bradykinin B2 receptor.
  J Biol Chem, 274, 14773-14778.  
  10514410 U.Schönbeck, G.K.Sukhova, P.Graber, S.Coulter, and P.Libby (1999).
Augmented expression of cyclooxygenase-2 in human atherosclerotic lesions.
  Am J Pathol, 155, 1281-1291.  
10082961 V.Koshkin, and H.B.Dunford (1999).
Coupling of the peroxidase and cyclooxygenase reactions of prostaglandin H synthase.
  Biochim Biophys Acta, 1430, 341-348.  
10400651 W.Chen, T.R.Pawelek, and R.J.Kulmacz (1999).
Hydroperoxide dependence and cooperative cyclooxygenase kinetics in prostaglandin H synthase-1 and -2.
  J Biol Chem, 274, 20301-20306.  
  9630831 A.B.Edmundson, and C.V.Manion (1998).
Treatment of osteoarthritis with aspartame.
  Clin Pharmacol Ther, 63, 580-593.
PDB code: 1a8j
9545330 A.G.Spencer, J.W.Woods, T.Arakawa, I.I.Singer, and W.L.Smith (1998).
Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopy.
  J Biol Chem, 273, 9886-9893.  
9596581 A.S.Kalgutkar, B.C.Crews, S.W.Rowlinson, C.Garner, K.Seibert, and L.J.Marnett (1998).
Aspirin-like molecules that covalently inactivate cyclooxygenase-2.
  Science, 280, 1268-1270.  
9461572 A.Tsai, G.Palmer, G.Xiao, D.C.Swinney, and R.J.Kulmacz (1998).
Structural characterization of arachidonyl radicals formed by prostaglandin H synthase-2 and prostaglandin H synthase-1 reconstituted with mangano protoporphyrin IX.
  J Biol Chem, 273, 3888-3894.  
9626023 B.Cryer, and M.Feldman (1998).
Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs.
  Am J Med, 104, 413-421.  
9620167 C.Miller, M.Zhang, Y.He, J.Zhao, J.P.Pelletier, J.Martel-Pelletier, and J.A.Di Battista (1998).
Transcriptional induction of cyclooxygenase-2 gene by okadaic acid inhibition of phosphatase activity in human chondrocytes: co-stimulation of AP-1 and CRE nuclear binding proteins.
  J Cell Biochem, 69, 392-413.  
9694817 C.Su, M.Sahlin, and E.H.Oliw (1998).
A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities.
  J Biol Chem, 273, 20744-20751.  
9653133 D.A.Proshlyakov, M.A.Pressler, and G.T.Babcock (1998).
Dioxygen activation and bond cleavage by mixed-valence cytochrome c oxidase.
  Proc Natl Acad Sci U S A, 95, 8020-8025.  
9535872 D.C.Goodwin, M.R.Gunther, L.C.Hsi, B.C.Crews, T.E.Eling, R.P.Mason, and L.J.Marnett (1998).
Nitric oxide trapping of tyrosyl radicals generated during prostaglandin endoperoxide synthase turnover. Detection of the radical derivative of tyrosine 385.
  J Biol Chem, 273, 8903-8909.  
9715829 D.J.Bjorkman (1998).
The effect of aspirin and nonsteroidal anti-inflammatory drugs on prostaglandins.
  Am J Med, 105, 8S.  
  9711054 D.O.Stichtenoth, H.Zeidler, and J.C.Frölich (1998).
[New non-steroidal anti-rheumatic drugs: selective inhibitors of inducible cyclooxygenase]
  Med Klin (Munich), 93, 407-415.  
9506982 G.Xiao, W.Chen, and R.J.Kulmacz (1998).
Comparison of structural stabilities of prostaglandin H synthase-1 and -2.
  J Biol Chem, 273, 6801-6811.  
9649334 J.E.Johnson, N.M.Rao, S.W.Hui, and R.B.Cornell (1998).
Conformation and lipid binding properties of four peptides derived from the membrane-binding domain of CTP:phosphocholine cytidylyltransferase.
  Biochemistry, 37, 9509-9519.  
9597150 J.R.Vane, Y.S.Bakhle, and R.M.Botting (1998).
Cyclooxygenases 1 and 2.
  Annu Rev Pharmacol Toxicol, 38, 97.  
9871612 K.D.Stewart, S.Loren, L.Frey, E.Otis, V.Klinghofer, and K.I.Hulkower (1998).
Discovery of a new cyclooxygenase-2 lead compound through 3-D database searching and combinatorial chemistry.
  Bioorg Med Chem Lett, 8, 529-534.  
9515564 K.K.Wu (1998).
Biochemical pharmacology of nonsteroidal anti-inflammatory drugs.
  Biochem Pharmacol, 55, 543-547.  
9736921 L.J.Marnett, and A.S.Kalgutkar (1998).
Design of selective inhibitors of cyclooxygenase-2 as nonulcerogenic anti-inflammatory agents.
  Curr Opin Chem Biol, 2, 482-490.  
9726967 L.P.Liu, and C.M.Deber (1998).
Uncoupling hydrophobicity and helicity in transmembrane segments. Alpha-helical propensities of the amino acids in non-polar environments.
  J Biol Chem, 273, 23645-23648.  
9761893 L.Song, and E.Gouaux (1998).
Crystallization of the alpha-hemolysin heptamer solubilized in decyldimethyl- and decyldiethylphosphine oxide.
  Acta Crystallogr D Biol Crystallogr, 54, 276-278.  
9790682 M.P.Patricelli, H.A.Lashuel, D.K.Giang, J.W.Kelly, and B.F.Cravatt (1998).
Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization.
  Biochemistry, 37, 15177-15187.  
  9663182 M.R.Panara, R.Padovano, M.G.Sciulli, G.Santini, G.Renda, M.T.Rotondo, A.Pace, C.Patrono, and P.Patrignani (1998).
Effects of nimesulide on constitutive and inducible prostanoid biosynthesis in human beings.
  Clin Pharmacol Ther, 63, 672-681.  
9488715 O.Y.So, L.E.Scarafia, A.Y.Mak, O.H.Callan, and D.C.Swinney (1998).
The dynamics of prostaglandin H synthases. Studies with prostaglandin h synthase 2 Y355F unmask mechanisms of time-dependent inhibition and allosteric activation.
  J Biol Chem, 273, 5801-5807.  
9437421 P.C.Preusch, J.C.Norvell, J.C.Cassatt, and M.Cassman (1998).
Progress away from 'no crystals, no grant'.
  Nat Struct Biol, 5, 12-14.  
9751640 R.M.Garavito (1998).
Membrane protein structures: the known world expands.
  Curr Opin Biotechnol, 9, 344-349.  
9724741 S.Arnould, and J.M.Camadro (1998).
The domain structure of protoporphyrinogen oxidase, the molecular target of diphenyl ether-type herbicides.
  Proc Natl Acad Sci U S A, 95, 10553-10558.  
9799507 S.L.Schwager, A.J.Chubb, R.R.Scholle, W.F.Brandt, C.Eckerskorn, E.D.Sturrock, and M.R.Ehlers (1998).
Phorbol ester-induced juxtamembrane cleavage of angiotensin-converting enzyme is not inhibited by a stalk containing intrachain disulfides.
  Biochemistry, 37, 15449-15456.  
9726937 S.Persson, J.A.Killian, and G.Lindblom (1998).
Molecular ordering of interfacially localized tryptophan analogs in ester- and ether-lipid bilayers studied by 2H-NMR.
  Biophys J, 75, 1365-1371.  
  9774958 T.L.Yaksh, D.M.Dirig, and A.B.Malmberg (1998).
Mechanism of action of nonsteroidal anti-inflammatory drugs.
  Cancer Invest, 16, 509-527.  
9497320 V.Koshkin, and H.B.Dunford (1998).
Reaction of prostaglandin endoperoxide synthase with cis,cis-eicosa-11,14-dienoic acid.
  J Biol Chem, 273, 6046-6049.  
9792699 Y.Li, T.Smith, S.Grabski, and D.L.DeWitt (1998).
The membrane association sequences of the prostaglandin endoperoxide synthases-1 and -2 isozymes.
  J Biol Chem, 273, 29830-29837.  
9335571 A.L.Tsai, G.Wu, and R.J.Kulmacz (1997).
Stoichiometry of the interaction of prostaglandin H synthase with substrates.
  Biochemistry, 36, 13085-13094.  
9108338 B.Linder, and U.A.Heinlein (1997).
Decreased in vitro fertilization efficiencies in the presence of specific cyritestin peptides.
  Dev Growth Differ, 39, 243-247.  
9164466 B.Sha, and M.Luo (1997).
Structure of a bifunctional membrane-RNA binding protein, influenza virus matrix protein M1.
  Nat Struct Biol, 4, 239-244.
PDB code: 1aa7
9406540 C.D.Funk, and P.J.Loll (1997).
A molecular dipstick?
  Nat Struct Biol, 4, 966-968.  
9029480 D.Bayle, D.Weeks, S.Hallen, K.Melchers, K.Bamberg, and G.Sachs (1997).
In vitro translation analysis of integral membrane proteins.
  J Recept Signal Transduct Res, 17, 29-56.  
8995366 Vet, A.W.Zomer, G.J.Lahaut, and H.van den Bosch (1997).
Polymerase chain reaction-based cloning of alkyl-dihydroxyacetonephosphate synthase complementary DNA from guinea pig liver.
  J Biol Chem, 272, 798-803.  
9167450 G.Dannhardt, A.Bauer, and U.Nowe (1997).
Non-steroidal anti-inflammatory agents, Part 24. Pyrrolidino enaminones as models to mimic arachidonic acid.
  Arch Pharm (Weinheim), 330, 74-82.  
9048568 G.Xiao, A.L.Tsai, G.Palmer, W.C.Boyar, P.J.Marshall, and R.J.Kulmacz (1997).
Analysis of hydroperoxide-induced tyrosyl radicals and lipoxygenase activity in aspirin-treated human prostaglandin H synthase-2.
  Biochemistry, 36, 1836-1845.  
9168030 H.S.Young, J.L.Rigaud, J.J.Lacapère, L.G.Reddy, and D.L.Stokes (1997).
How to make tubular crystals by reconstitution of detergent-solubilized Ca2(+)-ATPase.
  Biophys J, 72, 2545-2558.  
  17694360 J.Berg, H.Fellier, A.Bodenteich, T.Christoph, and R.Towart (1997).
Selective prostaglandin G/H synthase (PGHS)-2 inhibitors show greater inhibitory activities on human PGHS-2 than on murine PGHS-2 in intact cells.
  Inflammopharmacology, 5, 119-126.  
9219313 J.R.Vane, and R.M.Botting (1997).
Mechanism of action of aspirin-like drugs.
  Semin Arthritis Rheum, 26, 2.  
15989624 J.van Ryn, and M.Pairet (1997).
Selective cyclooxygenase-2 inhibitors: pharmacology, clinical effects and therapeutic potential.
  Expert Opin Investig Drugs, 6, 609-614.  
9295270 K.U.Wendt, K.Poralla, and G.E.Schulz (1997).
Structure and function of a squalene cyclase.
  Science, 277, 1811-1815.
PDB code: 1sqc
9261177 L.M.Landino, B.C.Crews, J.K.Gierse, S.D.Hauser, and L.J.Marnett (1997).
Mutational analysis of the role of the distal histidine and glutamine residues of prostaglandin-endoperoxide synthase-2 in peroxidase catalysis, hydroperoxide reduction, and cyclooxygenase activation.
  J Biol Chem, 272, 21565-21574.  
9233814 M.C.Schaad, P.E.Jensen, and J.C.Carrington (1997).
Formation of plant RNA virus replication complexes on membranes: role of an endoplasmic reticulum-targeted viral protein.
  EMBO J, 16, 4049-4059.  
9092813 M.Lohmeyer, P.M.Harrison, S.Kannan, M.DeSantis, N.J.O'Reilly, M.J.Sternberg, D.S.Salomon, and W.J.Gullick (1997).
Chemical synthesis, structural modeling, and biological activity of the epidermal growth factor-like domain of human cripto.
  Biochemistry, 36, 3837-3845.  
15989631 M.Schattenkirchner (1997).
Meloxicam: a selective COX-2 inhibitor non-steroidal anti-inflammatory drug.
  Expert Opin Investig Drugs, 6, 321-334.  
9261124 M.Yu, D.Ives, and C.S.Ramesha (1997).
Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2.
  J Biol Chem, 272, 21181-21186.  
9378368 N.Hanna, K.G.Peri, D.Abran, P.Hardy, A.Doke, P.Lachapelle, M.S.Roy, J.Orquin, D.R.Varma, and S.Chemtob (1997).
Light induces peroxidation in retina by activating prostaglandin G/H synthase.
  Free Radic Biol Med, 23, 885-897.  
  9182072 P.Devillier, and G.Bessard (1997).
Thromboxane A2 and related prostaglandins in airways.
  Fundam Clin Pharmacol, 11, 2.  
9305956 R.A.Musah, and D.B.Goodin (1997).
Introduction of novel substrate oxidation into cytochrome c peroxidase by cavity complementation: oxidation of 2-aminothiazole and covalent modification of the enzyme.
  Biochemistry, 36, 11665-11674.
PDB code: 1aev
9266175 R.M.Garavito, and S.H.White (1997).
Membrane proteins. Structure, assembly, and function: a panoply of progress.
  Curr Opin Struct Biol, 7, 533-536.  
9406550 S.A.Gillmor, A.Villaseñor, R.Fletterick, E.Sigal, and M.F.Browner (1997).
The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity.
  Nat Struct Biol, 4, 1003-1009.
PDB code: 1lox
  9203938 S.Somasundaram, S.Rafi, M.Jacob, G.Sigthorsson, T.Mahmud, R.Sherwood, A.B.Price, A.Macpherson, D.Scott, J.M.Wrigglesworth, and I.Bjarnason (1997).
Intestinal tolerability of nitroxybutyl-flurbiprofen in rats.
  Gut, 40, 608-613.  
9367957 U.Ermler, W.Grabarse, S.Shima, M.Goubeaud, and R.K.Thauer (1997).
Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation.
  Science, 278, 1457-1462.
PDB code: 1mro
8703911 A.S.Kalgutkar, B.C.Crews, and L.J.Marnett (1996).
Kinetics of the interaction of nonsteroidal antiinflammatory drugs with prostaglandin endoperoxide synthase-1 studied by limited proteolysis.
  Biochemistry, 35, 9076-9082.  
8643612 B.A.Ballif, N.V.Mincek, J.T.Barratt, M.L.Wilson, and D.L.Simmons (1996).
Interaction of cyclooxygenases with an apoptosis- and autoimmunity-associated protein.
  Proc Natl Acad Sci U S A, 93, 5544-5549.  
8952502 B.Holton, X.Wu, A.I.Tsapin, D.M.Kramer, R.Malkin, and T.Kallas (1996).
Reconstitution of the 2Fe-2S center and g = 1.89 electron paramagnetic resonance signal into overproduced Nostoc sp. PCC 7906 Rieske protein.
  Biochemistry, 35, 15485-15493.  
  8745415 B.Persson, and P.Argos (1996).
Topology prediction of membrane proteins.
  Protein Sci, 5, 363-371.  
8901870 C.Luong, A.Miller, J.Barnett, J.Chow, C.Ramesha, and M.F.Browner (1996).
Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2.
  Nat Struct Biol, 3, 927-933.  
8662736 C.Su, and E.H.Oliw (1996).
Purification and characterization of linoleate 8-dioxygenase from the fungus Gaeumannomyces graminis as a novel hemoprotein.
  J Biol Chem, 271, 14112-14118.  
8567676 D.K.Bhattacharyya, M.Lecomte, C.J.Rieke, M.Garavito, and W.L.Smith (1996).
Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1.
  J Biol Chem, 271, 2179-2184.  
8805541 F.Mancia, N.H.Keep, A.Nakagawa, P.F.Leadlay, S.McSweeney, B.Rasmussen, P.Bösecke, O.Diat, and P.R.Evans (1996).
How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 A resolution.
  Structure, 4, 339-350.
PDB code: 1req
8611540 I.E.Holzbaur, A.M.English, and A.A.Ismail (1996).
FTIR study of the thermal denaturation of horseradish and cytochrome c peroxidases in D2O.
  Biochemistry, 35, 5488-5494.  
  8771195 I.Shin, I.Silman, and L.M.Weiner (1996).
Interaction of partially unfolded forms of Torpedo acetylcholinesterase with liposomes.
  Protein Sci, 5, 42-51.  
8626626 J.C.Otto, and W.L.Smith (1996).
Photolabeling of prostaglandin endoperoxide H synthase-1 with 3-trifluoro-3-(m-[125I]iodophenyl)diazirine as a probe of membrane association and the cyclooxygenase active site.
  J Biol Chem, 271, 9906-9910.  
8663121 J.K.Gierse, J.J.McDonald, S.D.Hauser, S.H.Rangwala, C.M.Koboldt, and K.Seibert (1996).
A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors.
  J Biol Chem, 271, 15810-15814.  
  8786235 J.M.Sowadski (1996).
Introduction: crystallization of membrane proteins--in need of a new focus?
  J Bioenerg Biomembr, 28, 3-5.  
8550601 K.Melchers, T.Weitzenegger, A.Buhmann, W.Steinhilber, G.Sachs, and K.P.Schäfer (1996).
Cloning and membrane topology of a P type ATPase from Helicobacter pylori.
  J Biol Chem, 271, 446-457.  
8567658 M.Bakovic, and H.B.Dunford (1996).
Reactions of prostaglandin endoperoxide synthase and its compound I with hydroperoxides.
  J Biol Chem, 271, 2048-2056.  
  9035685 M.Bakovic, and H.B.Dunford (1996).
pH and temperature dependence of the rate of compound I formation from the reaction of prostaglandin endoperoxide synthase with hydrogen peroxide.
  Biochem Cell Biol, 74, 117-124.  
8673607 M.M.Fitzgerald, R.A.Musah, D.E.McRee, and D.B.Goodin (1996).
A ligand-gated, hinged loop rearrangement opens a channel to a buried artificial protein cavity.
  Nat Struct Biol, 3, 626-631.
PDB codes: 1aa4 1ac4 1ac8 1aes 1aet 1aeu 1cci 1ryc
  8900495 M.Pairet, and G.Engelhardt (1996).
Distinct isoforms (COX-1 and COX-2) of cyclooxygenase: possible physiological and therapeutic implications.
  Fundam Clin Pharmacol, 10, 1.  
8794734 M.Sunnerhagen, G.A.Olah, J.Stenflo, S.Forsén, T.Drakenberg, and J.Trewhella (1996).
The relative orientation of Gla and EGF domains in coagulation factor X is altered by Ca2+ binding to the first EGF domain. A combined NMR-small angle X-ray scattering study.
  Biochemistry, 35, 11547-11559.
PDB codes: 1whe 1whf
8631960 O.H.Callan, O.Y.So, and D.C.Swinney (1996).
The kinetic factors that determine the affinity and selectivity for slow binding inhibition of human prostaglandin H synthase 1 and 2 by indomethacin and flurbiprofen.
  J Biol Chem, 271, 3548-3554.  
8652509 P.J.Loll, D.Picot, O.Ekabo, and R.M.Garavito (1996).
Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site.
  Biochemistry, 35, 7330-7340.
PDB codes: 1pge 1pgf 1pgg
8702589 Q.Guo, L.H.Wang, K.H.Ruan, and R.J.Kulmacz (1996).
Role of Val509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents.
  J Biol Chem, 271, 19134-19139.  
  8745396 R.Hrabal, E.A.Komives, and F.Ni (1996).
Structural resiliency of an EGF-like subdomain bound to its target protein, thrombin.
  Protein Sci, 5, 195-203.
PDB codes: 1fgd 1fge
8901861 R.M.Garavito (1996).
The cyclooxygenase-2 structure: new drugs for an old target?
  Nat Struct Biol, 3, 897-901.  
  8786233 R.M.Garavito, D.Picot, and P.J.Loll (1996).
Strategies for crystallizing membrane proteins.
  J Bioenerg Biomembr, 28, 13-27.  
8681968 S.Gaspard, G.Chottard, J.P.Mahy, and D.Mansuy (1996).
Study of the coordination chemistry of prostaglandin G/H synthase by resonance Raman spectroscopy.
  Eur J Biochem, 238, 529-537.  
8573195 T.Klein, R.M.Nüsing, I.Wiesenberg-Boettcher, and V.Ullrich (1996).
Mechanistic studies on the selective inhibition of cyclooxygenase-2 by indanone derivatives.
  Biochem Pharmacol, 51, 285-290.  
8718891 V.Houtzager, M.Ouellet, J.P.Falgueyret, L.A.Passmore, C.Bayly, and M.D.Percival (1996).
Inhibitor-induced changes in the intrinsic fluorescence of human cyclooxygenase-2.
  Biochemistry, 35, 10974-10984.  
15012298 W.A.Cramer, G.M.Soriano, M.Ponomarev, D.Huang, H.Zhang, S.E.Martinez, and J.L.Smith (1996).
  Annu Rev Plant Physiol Plant Mol Biol, 47, 477-508.  
  8786236 W.A.Hendrickson (1996).
Production of crystallizable fragments of membrane proteins.
  J Bioenerg Biomembr, 28, 35-40.  
  18475724 Y.S.Bakhle, and R.M.Botting (1996).
Cyclooxygenase-2 and its regulation in inflammation.
  Mediators Inflamm, 5, 305-323.  
7737984 A.Tsai, R.J.Kulmacz, and G.Palmer (1995).
Spectroscopic evidence for reaction of prostaglandin H synthase-1 tyrosyl radical with arachidonic acid.
  J Biol Chem, 270, 10503-10508.  
  8520624 A.Watts, A.S.Ulrich, and D.A.Middleton (1995).
Membrane protein structure: the contribution and potential of novel solid state NMR approaches.
  Mol Membr Biol, 12, 233-246.  
7746145 B.Heym, P.M.Alzari, N.Honoré, and S.T.Cole (1995).
Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis.
  Mol Microbiol, 15, 235-245.  
7552705 C.Ostermeier, S.Iwata, B.Ludwig, and H.Michel (1995).
Fv fragment-mediated crystallization of the membrane protein bacterial cytochrome c oxidase.
  Nat Struct Biol, 2, 842-846.  
7592746 D.Bayle, D.Weeks, and G.Sachs (1995).
The membrane topology of the rat sarcoplasmic and endoplasmic reticulum calcium ATPases by in vitro translation scanning.
  J Biol Chem, 270, 25678-25684.  
9383435 D.G.Munroe, and C.Y.Lau (1995).
Turning down the heat: new routes to inhibition of inflammatory signaling by prostaglandin H2 synthases.
  Chem Biol, 2, 343-350.  
7818572 D.R.Lichtenstein, S.Syngal, and M.M.Wolfe (1995).
Nonsteroidal antiinflammatory drugs and the gastrointestinal tract. The double-edged sword.
  Arthritis Rheum, 38, 5.  
7753846 F.A.Samatey, C.Xu, and J.L.Popot (1995).
On the distribution of amino acid residues in transmembrane alpha-helix bundles.
  Proc Natl Acad Sci U S A, 92, 4577-4581.  
  7587278 F.Eisenhaber, B.Persson, and P.Argos (1995).
Protein structure prediction: recognition of primary, secondary, and tertiary structural features from amino acid sequence.
  Crit Rev Biochem Mol Biol, 30, 1.  
7610486 F.Milpetz, P.Argos, and B.Persson (1995).
TMAP: a new email and WWW service for membrane-protein structural predictions.
  Trends Biochem Sci, 20, 204-205.  
7781068 G.Zhang, M.G.Kazanietz, P.M.Blumberg, and J.H.Hurley (1995).
Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester.
  Cell, 81, 917-924.
PDB codes: 1ptq 1ptr
7738031 I.Morita, M.Schindler, M.K.Regier, J.C.Otto, T.Hori, D.L.DeWitt, and W.L.Smith (1995).
Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2.
  J Biol Chem, 270, 10902-10908.  
7493972 J.A.Mancini, D.Riendeau, J.P.Falgueyret, P.J.Vickers, and G.P.O'Neill (1995).
Arginine 120 of prostaglandin G/H synthase-1 is required for the inhibition by nonsteroidal anti-inflammatory drugs containing a carboxylic acid moiety.
  J Biol Chem, 270, 29372-29377.  
7599212 J.E.Walker (1995).
Determination of the structures of respiratory enzyme complexes from mammalian mitochondria.
  Biochim Biophys Acta, 1271, 221-227.  
8580335 J.H.Davis, M.Auger, and R.S.Hodges (1995).
High resolution 1H nuclear magnetic resonance of a transmembrane peptide.
  Biophys J, 69, 1917-1932.  
7579649 J.L.Popot, and M.Saraste (1995).
Engineering membrane proteins.
  Curr Opin Biotechnol, 6, 394-402.  
7585209 K.N.Allen (1995).
Aspirin--now we can see it.
  Nat Med, 1, 882-883.  
  7730259 L.Seligman, J.Bailey, and C.Manoil (1995).
Sequences determining the cytoplasmic localization of a chemoreceptor domain.
  J Bacteriol, 177, 2315-2320.  
7559494 M.Adler, M.H.Seto, D.E.Nitecki, J.H.Lin, D.R.Light, and J.Morser (1995).
The structure of a 19-residue fragment from the C-loop of the fourth epidermal growth factor-like domain of thrombomodulin.
  J Biol Chem, 270, 23366-23372.
PDB code: 1tmr
17020863 M.Bakovic, and H.Brian Dunford (1995).
Pre-steady-state kinetics and modelling of the oxygenase and cyclooxygenase reactions of prostaglandin endoperoxide synthase.
  Biophys Chem, 54, 237-251.  
8591022 M.Fontecave, and H.Eklund (1995).
Copper amine oxidase: a novel use for a tyrosine.
  Structure, 3, 1127-1129.  
  7698598 M.J.Langman (1995).
Can incoagulable blood protect against inflammatory bowel disease?
  Gastroenterology, 108, 1305-1307.  
7642610 O.Laneuville, D.K.Breuer, N.Xu, Z.H.Huang, D.A.Gage, J.T.Watson, M.Lagarde, D.L.DeWitt, and W.L.Smith (1995).
Fatty acid substrate specificities of human prostaglandin-endoperoxide H synthase-1 and -2. Formation of 12-hydroxy-(9Z, 13E/Z, 15Z)- octadecatrienoic acids from alpha-linolenic acid.
  J Biol Chem, 270, 19330-19336.  
7552725 P.J.Loll, D.Picot, and R.M.Garavito (1995).
The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase.
  Nat Struct Biol, 2, 637-643.
PDB code: 1pth
8528765 R.A.Reithmeier (1995).
Characterization and modeling of membrane proteins using sequence analysis.
  Curr Opin Struct Biol, 5, 491-500.  
7480624 R.Grisshammer, and C.G.Tate (1995).
Overexpression of integral membrane proteins for structural studies.
  Q Rev Biophys, 28, 315-422.  
  7579702 S.Monier, R.G.Parton, F.Vogel, J.Behlke, A.Henske, and T.V.Kurzchalia (1995).
VIP21-caveolin, a membrane protein constituent of the caveolar coat, oligomerizes in vivo and in vitro.
  Mol Biol Cell, 6, 911-927.  
7775455 S.S.Tam, D.H.Lee, E.Y.Wang, D.G.Munroe, and C.Y.Lau (1995).
Tepoxalin, a novel dual inhibitor of the prostaglandin-H synthase cyclooxygenase and peroxidase activities.
  J Biol Chem, 270, 13948-13955.  
7857960 T.Haltia, and E.Freire (1995).
Forces and factors that contribute to the structural stability of membrane proteins.
  Biochim Biophys Acta, 1228, 1.  
  7580359 V.A.Ferraris, and S.P.Ferraris (1995).
Limiting excessive postoperative blood transfusion after cardiac procedures. A review.
  Tex Heart Inst J, 22, 216-230.  
7642553 Y.Wang, and C.Kent (1995).
Identification of an inhibitory domain of CTP:phosphocholine cytidylyltransferase.
  J Biol Chem, 270, 18948-18952.  
  7592368 Y.Yamada, M.Yamada, and A.Nakazawa (1995).
A ColE1-encoded gene directs entry exclusion of the plasmid.
  J Bacteriol, 177, 6064-6068.  
7922363 C.Blake (1994).
Prostaglandin synthase. At the heart of the matter.
  Curr Biol, 4, 452-454.  
7922037 C.L.Verlinde, and W.G.Hol (1994).
Structure-based drug design: progress, results and challenges.
  Structure, 2, 577-587.  
8001562 J.P.Mahy, S.Gaspard, M.Delaforge, and D.Mansuy (1994).
Reactions of prostaglandin H synthase with monosubstituted hydrazines and diazenes. Formation of iron(II)-diazene and iron(III)-sigma-alkyl or iron(III)-sigma-aryl complexes.
  Eur J Biochem, 226, 445-457.  
7712592 L.J.Marnett (1994).
Generation of mutagens during arachidonic acid metabolism.
  Cancer Metastasis Rev, 13, 303-308.  
7712291 M.J.Nelson, and S.P.Seitz (1994).
The structure and function of lipoxygenase.
  Curr Opin Struct Biol, 4, 878-884.  
7712290 P.M.Colman (1994).
Structure-based drug design.
  Curr Opin Struct Biol, 4, 868-874.  
  8071224 R.L.Smith, J.F.O'Toole, M.E.Maguire, and C.R.Sanders (1994).
Membrane topology of Escherichia coli diacylglycerol kinase.
  J Bacteriol, 176, 5459-5465.  
7925419 V.Niggli, S.Kaufmann, W.H.Goldmann, T.Weber, and G.Isenberg (1994).
Identification of functional domains in the cytoskeletal protein talin.
  Eur J Biochem, 224, 951-957.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.