PDBsum entry 1cnh

Lyase (oxo-acid)

PDB id: 1cnh

Contents

Protein chain

257 a.a. *

Metals

_ZN

Waters ×168

* Residue conservation analysis

PDB id:

1cnh

Name:

Lyase (oxo-acid)

Title:

X-ray crystallographic studies of engineered hydrogen bond networks in a protein-zinc binding site

Structure:

Carbonic anhydrase ii. Chain: a. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2.

Resolution:

2.05Å R-factor: 0.158

Authors:

C.A.Lesburg,D.W.Christianson

Key ref:

C.A.Lesburg and d.w.christianson (1995). X-Ray crystallographic studies of engineered hydrogen bond networks in a protein-Zinc binding site. J am chem soc, 117, 6838-6844.

Date:

03-Apr-95 Release date: 10-Jul-95

Protein chain

P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2 from Homo sapiens

Seq: 260 a.a.

Struc: 257 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class 2: E.C.4.2.1.1 - carbonic anhydrase.
• Reaction: hydrogencarbonate + H⁺ = CO2 + H2O
• Cofactor: Zn(2+)
• Enzyme class 3: E.C.4.2.1.69 - cyanamide hydratase.
• Reaction: urea = cyanamide + H2O

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site