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DNA binding protein PDB id
1cdz
Jmol
Contents
Protein chain
96 a.a. *
* Residue conservation analysis
PDB id:
1cdz
Name: DNA binding protein
Title: Brct domain from DNA-repair protein xrcc1
Structure: Protein (DNA-repair protein xrcc1). Chain: a. Fragment: c-terminal brct domain. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Biol. unit: Dimer (from PQS)
Resolution:
3.20Å     R-factor:   0.224     R-free:   0.266
Authors: X.Zhang,S.Morera,P.Bates,P.Whitehead,A.Coffer,K.Hainbucher, R.Nash,M.Sternberg,T.Lindahl,P.Freemont
Key ref: X.Zhang et al. (1998). Structure of an XRCC1 BRCT domain: a new protein-protein interaction module. Embo J, 17, 6404-6411. PubMed id: 9799248 DOI: 10.1093/emboj/17.21.6404
Date:
04-Mar-99     Release date:   28-Feb-00    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P18887  (XRCC1_HUMAN) -  DNA repair protein XRCC1
Seq:
Struc: 		 
Seq:
Struc: 		633 a.a.
96 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     intracellular   1 term 

 

 
DOI no: 10.1093/emboj/17.21.6404 Embo J 17:6404-6411 (1998)
PubMed id: 9799248  
 
 
Structure of an XRCC1 BRCT domain: a new protein-protein interaction module.
X.Zhang, S.Moréra, P.A.Bates, P.C.Whitehead, A.I.Coffer, K.Hainbucher, R.A.Nash, M.J.Sternberg, T.Lindahl, P.S.Freemont.
 
  ABSTRACT  
 
The BRCT domain (BRCA1 C-terminus), first identified in the breast cancer suppressor protein BRCA1, is an evolutionarily conserved protein-protein interaction region of approximately 95 amino acids found in a large number of proteins involved in DNA repair, recombination and cell cycle control. Here we describe the first three-dimensional structure and fold of a BRCT domain determined by X-ray crystallography at 3.2 A resolution. The structure has been obtained from the C-terminal region of the human DNA repair protein XRCC1, and comprises a four-stranded parallel beta-sheet surrounded by three alpha-helices, which form an autonomously folded domain. The compact XRCC1 structure explains the observed sequence homology between different BRCT motifs and provides a framework for modelling other BRCT domains. Furthermore, the established structure of an XRCC1 BRCT homodimer suggests potential protein-protein interaction sites for the complementary BRCT domain in DNA ligase III, since these two domains form a stable heterodimeric complex. Based on the XRCC1 BRCT structure, we have constructed a model for the C-terminal BRCT domain of BRCA1, which frequently is mutated in familial breast and ovarian cancer. The model allows insights into the effects of such mutations on the fold of the BRCT domain.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
20724438 M.Rappas, A.W.Oliver, and L.H.Pearl (2011).
Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1.
  Nucleic Acids Res, 39, 313-324.
PDB codes: 2xnh 2xnk
20081198 M.Kobayashi, E.Ab, A.M.Bonvin, and G.Siegal (2010).
Structure of the DNA-bound BRCA1 C-terminal region from human replication factor C p140 and model of the protein-DNA complex.
  J Biol Chem, 285, 10087-10097.
PDB code: 2k7f
19925808 M.W.Richards, J.W.Leung, S.M.Roe, K.Li, J.Chen, and R.Bayliss (2010).
A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation.
  J Mol Biol, 395, 908-915.
PDB code: 2wt8
  20798883 S.Sterpone, and R.Cozzi (2010).
Influence of XRCC1 Genetic Polymorphisms on Ionizing Radiation-Induced DNA Damage and Repair.
  J Nucleic Acids, 2010, 0.  
20140625 S.Sterpone, V.Mastellone, L.Padua, F.Novelli, C.Patrono, T.Cornetta, D.Giammarino, V.Donato, A.Testa, and R.Cozzi (2010).
Single-nucleotide polymorphisms in BER and HRR genes, XRCC1 haplotypes and breast cancer risk in Caucasian women.
  J Cancer Res Clin Oncol, 136, 631-636.  
  20862368 T.Ochi, B.L.Sibanda, Q.Wu, D.Y.Chirgadze, V.M.Bolanos-Garcia, and T.L.Blundell (2010).
Structural biology of DNA repair: spatial organisation of the multicomponent complexes of nonhomologous end joining.
  J Nucleic Acids, 2010, 0.  
19230024 K.M.Applebaum, M.D.McClean, H.H.Nelson, C.J.Marsit, B.C.Christensen, and K.T.Kelsey (2009).
Smoking modifies the relationship between XRCC1 haplotypes and HPV16-negative head and neck squamous cell carcinoma.
  Int J Cancer, 124, 2690-2696.  
19089598 P.Kotoglou, A.Kalaitzakis, P.Vezyraki, T.Tzavaras, L.K.Michalis, F.Dantzer, J.U.Jung, and C.Angelidis (2009).
Hsp70 translocates to the nuclei and nucleoli, binds to XRCC1 and PARP-1, and protects HeLa cells from single-strand DNA breaks.
  Cell Stress Chaperones, 14, 391-406.  
19345190 X.Yang, L.M.Figueiredo, A.Espinal, E.Okubo, and B.Li (2009).
RAP1 is essential for silencing telomeric variant surface glycoprotein genes in Trypanosoma brucei.
  Cell, 137, 99.  
19026779 A.Ghosh, S.Shuman, and C.D.Lima (2008).
The structure of Fcp1, an essential RNA polymerase II CTD phosphatase.
  Mol Cell, 32, 478-490.
PDB code: 3ef0
18579587 A.Kumar, W.S.Joo, G.Meinke, S.Moine, E.N.Naumova, and P.A.Bullock (2008).
Evidence for a structural relationship between BRCT domains and the helicase domains of the replication initiators encoded by the Polyomaviridae and Papillomaviridae families of DNA tumor viruses.
  J Virol, 82, 8849-8862.  
18166980 E.Weterings, and D.J.Chen (2008).
The endless tale of non-homologous end-joining.
  Cell Res, 18, 114-124.  
18518823 T.Ellenberger, and A.E.Tomkinson (2008).
Eukaryotic DNA ligases: structural and functional insights.
  Annu Rev Biochem, 77, 313-338.  
17631059 A.F.Moon, M.Garcia-Diaz, V.K.Batra, W.A.Beard, K.Bebenek, T.A.Kunkel, S.H.Wilson, and L.C.Pedersen (2007).
The X family portrait: structural insights into biological functions of X family polymerases.
  DNA Repair (Amst), 6, 1709-1725.  
17915942 E.F.DeRose, M.W.Clarkson, S.A.Gilmore, C.J.Galban, A.Tripathy, J.M.Havener, G.A.Mueller, D.A.Ramsden, R.E.London, and A.L.Lee (2007).
Solution structure of polymerase mu's BRCT Domain reveals an element essential for its role in nonhomologous end joining.
  Biochemistry, 46, 12100-12110.
PDB code: 2htf
17899335 R.Monaco, R.Rosal, M.A.Dolan, M.R.Pincus, and P.W.Brandt-Rauf (2007).
Conformational effects of a common codon 399 polymorphism on the BRCT1 domain of the XRCC1 protein.
  Protein J, 26, 541-546.  
17355263 S.Y.Kang, K.G.Lee, W.Lee, J.Y.Shim, S.I.Ji, K.W.Chung, Y.K.Chung, and N.K.Kim (2007).
Polymorphisms in the DNA repair gene XRCC1 associated with basal cell carcinoma and squamous cell carcinoma of the skin in a Korean population.
  Cancer Sci, 98, 716-720.  
16547092 C.Gabrielse, C.T.Miller, K.H.McConnell, A.DeWard, C.A.Fox, and M.Weinreich (2006).
A Dbf4p BRCA1 C-terminal-like domain required for the response to replication fork arrest in budding yeast.
  Genetics, 173, 541-555.  
17094803 D.C.Zappulla, A.S.Maharaj, J.J.Connelly, R.A.Jockusch, and R.Sternglanz (2006).
Rtt107/Esc4 binds silent chromatin and DNA repair proteins using different BRCT motifs.
  BMC Mol Biol, 7, 40.  
16522671 E.Becker, V.Meyer, H.Madaoui, and R.Guerois (2006).
Detection of a tandem BRCT in Nbs1 and Xrs2 with functional implications in the DNA damage response.
  Bioinformatics, 22, 1289-1292.  
16598689 H.Cartagena-Lirola, A.Durán, and M.H.Valdivieso (2006).
The Schizosaccharomyces pombe cfr1+ gene participates in mating through a new pathway that is independent of fus1+.
  Yeast, 23, 375-388.  
16569515 J.K.Chin, V.I.Bashkirov, W.D.Heyer, and F.E.Romesberg (2006).
Esc4/Rtt107 and the control of recombination during replication.
  DNA Repair (Amst), 5, 618-628.  
16361700 M.Kobayashi, F.Figaroa, N.Meeuwenoord, L.E.Jansen, and G.Siegal (2006).
Characterization of the DNA binding and structural properties of the BRCT region of human replication factor C p140 subunit.
  J Biol Chem, 281, 4308-4317.  
16648486 N.Puebla-Osorio, D.B.Lacey, F.W.Alt, and C.Zhu (2006).
Early embryonic lethality due to targeted inactivation of DNA ligase III.
  Mol Cell Biol, 26, 3935-3941.  
16483311 T.Takeuchi, T.Ishidoh, H.Iijima, I.Kuriyama, N.Shimazaki, O.Koiwai, K.Kuramochi, S.Kobayashi, F.Sugawara, K.Sakaguchi, H.Yoshida, and Y.Mizushina (2006).
Structural relationship of curcumin derivatives binding to the BRCT domain of human DNA polymerase lambda.
  Genes Cells, 11, 223-235.  
16550161 W.C.Ladiges (2006).
Mouse models of XRCC1 DNA repair polymorphisms and cancer.
  Oncogene, 25, 1612-1619.  
15545273 J.E.Kim, D.D.Billadeau, and J.Chen (2005).
The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis.
  J Biol Chem, 280, 5733-5739.  
16285867 J.M.Daley, P.L.Palmbos, D.Wu, and T.E.Wilson (2005).
Nonhomologous end joining in yeast.
  Annu Rev Genet, 39, 431-451.  
15666192 P.Chacko, B.Rajan, T.Joseph, B.S.Mathew, and M.R.Pillai (2005).
Polymorphisms in DNA repair gene XRCC1 and increased genetic susceptibility to breast cancer.
  Breast Cancer Res Treat, 89, 15-21.  
15987676 P.T.Beernink, M.Hwang, M.Ramirez, M.B.Murphy, S.A.Doyle, and M.P.Thelen (2005).
Specificity of protein interactions mediated by BRCT domains of the XRCC1 DNA repair protein.
  J Biol Chem, 280, 30206-30213.  
14978302 C.M.Ekblad, A.Friedler, D.Veprintsev, R.L.Weinberg, and L.S.Itzhaki (2004).
Comparison of BRCT domains of BRCA1 and 53BP1: a biophysical analysis.
  Protein Sci, 13, 617-625.  
  15381933 J.Han, S.E.Hankinson, G.A.Colditz, and D.J.Hunter (2004).
Genetic variation in XRCC1, sun exposure, and risk of skin cancer.
  Br J Cancer, 91, 1604-1609.  
15501676 J.N.Glover, R.S.Williams, and M.S.Lee (2004).
Interactions between BRCT repeats and phosphoproteins: tangled up in two.
  Trends Biochem Sci, 29, 579-585.  
15133503 R.S.Williams, M.S.Lee, D.D.Hau, and J.N.Glover (2004).
Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1.
  Nat Struct Mol Biol, 11, 519-525.
PDB codes: 1t2u 1t2v
15194694 Y.G.Wang, C.Nnakwe, W.S.Lane, M.Modesti, and K.M.Frank (2004).
Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase.
  J Biol Chem, 279, 37282-37290.  
  12854754 B.T.Ang, E.Yap, J.Lim, W.L.Tan, P.Y.Ng, I.Ng, and T.T.Yeo (2003).
Poly(adenosine diphosphate-ribose) polymerase expression in human traumatic brain injury.
  J Neurosurg, 99, 125-130.  
12786946 K.Fujita, N.Shimazaki, Y.Ohta, T.Kubota, S.Ibe, S.Toji, K.Tamai, S.Fujisaki, T.Hayano, and O.Koiwai (2003).
Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone.
  Genes Cells, 8, 559-571.  
14576410 K.W.Caldecott (2003).
Cell signaling. The BRCT domain: signaling with friends?
  Science, 302, 579-580.  
14578343 M.Rodriguez, X.Yu, J.Chen, and Z.Songyang (2003).
Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.
  J Biol Chem, 278, 52914-52918.  
12944481 M.Ueno, T.Nakazaki, Y.Akamatsu, K.Watanabe, K.Tomita, H.D.Lindsay, H.Shinagawa, and H.Iwasaki (2003).
Molecular characterization of the Schizosaccharomyces pombe nbs1+ gene involved in DNA repair and telomere maintenance.
  Mol Cell Biol, 23, 6553-6563.  
14534301 R.S.Williams, D.I.Chasman, D.D.Hau, B.Hui, A.Y.Lau, and J.N.Glover (2003).
Detection of protein folding defects caused by BRCA1-BRCT truncation and missense mutations.
  J Biol Chem, 278, 53007-53016.  
12427738 R.S.Williams, and J.N.Glover (2003).
Structural consequences of a cancer-causing BRCA1-BRCT missense mutation.
  J Biol Chem, 278, 2630-2635.
PDB code: 1n5o
12748298 S.Okano, L.Lan, K.W.Caldecott, T.Mori, and A.Yasui (2003).
Spatial and temporal cellular responses to single-strand breaks in human cells.
  Mol Cell Biol, 23, 3974-3981.  
14648765 T.Haliloglu, A.Kolinski, and J.Skolnick (2003).
Use of residual dipolar couplings as restraints in ab initio protein structure prediction.
  Biopolymers, 70, 548-562.  
12475977 Y.L.Shang, A.J.Bodero, and P.L.Chen (2003).
NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response.
  J Biol Chem, 278, 6323-6329.  
12730134 Y.Takayama, Y.Kamimura, M.Okawa, S.Muramatsu, A.Sugino, and H.Araki (2003).
GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast.
  Genes Dev, 17, 1153-1165.  
14581536 Z.Deng, C.Atanasiu, J.S.Burg, D.Broccoli, and P.M.Lieberman (2003).
Telomere repeat binding factors TRF1, TRF2, and hRAP1 modulate replication of Epstein-Barr virus OriP.
  J Virol, 77, 11992-12001.  
12501160 A.V.Veselovsky, Y.D.Ivanov, A.S.Ivanov, A.I.Archakov, P.Lewi, and P.Janssen (2002).
Protein-protein interactions: mechanisms and modification by drugs.
  J Mol Recognit, 15, 405-422.  
12364621 B.Wang, S.Matsuoka, P.B.Carpenter, and S.J.Elledge (2002).
53BP1, a mediator of the DNA damage checkpoint.
  Science, 298, 1435-1438.  
11911362 C.C.Adams, J.Jakovljevic, J.Roman, P.Harnpicharnchai, and J.L.Woolford (2002).
Saccharomyces cerevisiae nucleolar protein Nop7p is necessary for biogenesis of 60S ribosomal subunits.
  RNA, 8, 150-165.  
12110597 D.J.Derbyshire, B.P.Basu, L.C.Serpell, W.S.Joo, T.Date, K.Iwabuchi, and A.J.Doherty (2002).
Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor.
  EMBO J, 21, 3863-3872.
PDB code: 1gzh
12351827 D.J.Derbyshire, B.P.Basu, T.Date, K.Iwabuchi, and A.J.Doherty (2002).
Purification, crystallization and preliminary X-ray analysis of the BRCT domains of human 53BP1 bound to the p53 tumour suppressor.
  Acta Crystallogr D Biol Crystallogr, 58, 1826-1829.  
  11973288 H.Wang, and S.J.Elledge (2002).
Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway.
  Genetics, 160, 1295-1304.  
  11983065 I.V.Martin, and S.A.MacNeill (2002).
ATP-dependent DNA ligases.
  Genome Biol, 3, REVIEWS3005.  
11886860 K.Ramadan, I.V.Shevelev, G.Maga, and U.Hübscher (2002).
DNA polymerase lambda from calf thymus preferentially replicates damaged DNA.
  J Biol Chem, 277, 18454-18458.  
11823435 M.Delarue, J.B.Boulé, J.Lescar, N.Expert-Bezançon, N.Jourdan, N.Sukumar, F.Rougeon, and C.Papanicolaou (2002).
Crystal structures of a template-independent DNA polymerase: murine terminal deoxynucleotidyltransferase.
  EMBO J, 21, 427-439.
PDB codes: 1jms 1kdh 1kej
11909950 R.M.Taylor, A.Thistlethwaite, and K.W.Caldecott (2002).
Central role for the XRCC1 BRCT I domain in mammalian DNA single-strand break repair.
  Mol Cell Biol, 22, 2556-2563.  
12370301 S.S.Mandal, H.Cho, S.Kim, K.Cabane, and D.Reinberg (2002).
FCP1, a phosphatase specific for the heptapeptide repeat of the largest subunit of RNA polymerase II, stimulates transcription elongation.
  Mol Cell Biol, 22, 7543-7552.  
12100744 V.R.Yassaee, S.Zeinali, I.Harirchi, S.Jarvandi, M.A.Mohagheghi, D.P.Hornby, and A.Dalton (2002).
Novel mutations in the BRCA1 and BRCA2 genes in Iranian women with early-onset breast cancer.
  Breast Cancer Res, 4, R6.  
11877378 W.S.Joo, P.D.Jeffrey, S.B.Cantor, M.S.Finnin, D.M.Livingston, and N.P.Pavletich (2002).
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.
  Genes Dev, 16, 583-593.
PDB codes: 1kzy 1l0b
11909969 Y.Kobayashi, M.Watanabe, Y.Okada, H.Sawa, H.Takai, M.Nakanishi, Y.Kawase, H.Suzuki, K.Nagashima, K.Ikeda, and N.Motoyama (2002).
Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome.
  Mol Cell Biol, 22, 2769-2776.  
11879553 Y.Liu, and S.C.West (2002).
Distinct functions of BRCA1 and BRCA2 in double-strand break repair.
  Breast Cancer Res, 4, 9.  
11205337 J.F.Ruiz, O.Domínguez, T.Laín de Lera, M.Garcia-Díaz, A.Bernad, and L.Blanco (2001).
DNA polymerase mu, a candidate hypermutase?
  Philos Trans R Soc Lond B Biol Sci, 356, 99.  
11400117 J.M.Lee, Y.C.Lee, S.Y.Yang, P.W.Yang, S.P.Luh, C.J.Lee, C.J.Chen, and M.T.Wu (2001).
Genetic polymorphisms of XRCC1 and risk of the esophageal cancer.
  Int J Cancer, 95, 240-246.  
11573079 R.Baer (2001).
With the ends in sight: images from the BRCA1 tumor suppressor.
  Nat Struct Biol, 8, 822-824.  
11573086 R.S.Williams, R.Green, and J.N.Glover (2001).
Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1.
  Nat Struct Biol, 8, 838-842.
PDB code: 1jnx
11554927 S.Ibe, K.Fujita, T.Toyomoto, N.Shimazaki, R.Kaneko, A.Tanabe, I.Takebe, S.Kuroda, T.Kobayashi, S.Toji, K.Tamai, H.Yamamoto, and O.Koiwai (2001).
Terminal deoxynucleotidyltransferase is negatively regulated by direct interaction with proliferating cell nuclear antigen.
  Genes Cells, 6, 815-824.  
11296242 Y.Kamimura, Y.S.Tak, A.Sugino, and H.Araki (2001).
Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae.
  EMBO J, 20, 2097-2107.  
11058099 A.J.Doherty, and S.W.Suh (2000).
Structural and mechanistic conservation in DNA ligases.
  Nucleic Acids Res, 28, 4051-4058.  
10773072 A.Marintchev, A.Robertson, E.K.Dimitriadis, R.Prasad, S.H.Wilson, and G.P.Mullen (2000).
Domain specific interaction in the XRCC1-DNA polymerase beta complex.
  Nucleic Acids Res, 28, 2049-2059.  
11050427 A.N.Monteiro (2000).
BRCA1: exploring the links to transcription.
  Trends Biochem Sci, 25, 469-474.  
10850490 B.Li, S.Oestreich, and T.de Lange (2000).
Identification of human Rap1: implications for telomere evolution.
  Cell, 101, 471-483.  
11095742 D.J.Moore, R.M.Taylor, P.Clements, and K.W.Caldecott (2000).
Mutation of a BRCT domain selectively disrupts DNA single-strand break repair in noncycling Chinese hamster ovary cells.
  Proc Natl Acad Sci U S A, 97, 13649-13654.  
11058877 H.Shen, Y.Xu, Y.Qian, R.Yu, Y.Qin, L.Zhou, X.Wang, M.R.Spitz, and Q.Wei (2000).
Polymorphisms of the DNA repair gene XRCC1 and risk of gastric cancer in a Chinese population.
  Int J Cancer, 88, 601-606.  
10698952 J.Y.Lee, C.Chang, H.K.Song, J.Moon, J.K.Yang, H.K.Kim, S.T.Kwon, and S.W.Suh (2000).
Crystal structure of NAD(+)-dependent DNA ligase: modular architecture and functional implications.
  EMBO J, 19, 1119-1129.
PDB codes: 1dgs 1dgt 1v9p
10677679 L.H.Thompson, and M.G.West (2000).
XRCC1 keeps DNA from getting stranded.
  Mutat Res, 459, 1.  
11003641 M.S.Kobor, L.D.Simon, J.Omichinski, G.Zhong, J.Archambault, and J.Greenblatt (2000).
A motif shared by TFIIF and TFIIB mediates their interaction with the RNA polymerase II carboxy-terminal domain phosphatase Fcp1p in Saccharomyces cerevisiae.
  Mol Cell Biol, 20, 7438-7449.  
11092939 N.Sukumar, J.B.Boulé, N.Expert-Bezançon, N.Jourdan, J.Lescar, F.Rougeon, C.Papanicolaou, and M.Delarue (2000).
Crystallization of the catalytic domain of murine terminal deoxynucleotidyl transferase.
  Acta Crystallogr D Biol Crystallogr, 56, 1662-1664.  
  10652533 P.L.Welcsh, K.N.Owens, and M.C.King (2000).
Insights into the functions of BRCA1 and BRCA2.
  Trends Genet, 16, 69-74.  
10679327 S.H.Teo, and S.P.Jackson (2000).
Lif1p targets the DNA ligase Lig4p to sites of DNA double-strand breaks.
  Curr Biol, 10, 165-168.  
12760027 T.Lindahl, and D.E.Barnes (2000).
Repair of endogenous DNA damage.
  Cold Spring Harb Symp Quant Biol, 65, 127-133.  
12760071 X.Wu, G.Rathbun, W.S.Lane, D.T.Weaver, and D.M.Livingston (2000).
Interactions of the Nijmegen breakage syndrome protein with ATM and BRCA1.
  Cold Spring Harb Symp Quant Biol, 65, 535-545.  
10195418 I.Irminger-Finger, B.D.Siegel, and W.C.Leung (1999).
The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins.
  Biol Chem, 380, 117-128.  
10339432 J.Soulier, and N.F.Lowndes (1999).
The BRCT domain of the S. cerevisiae checkpoint protein Rad9 mediates a Rad9-Rad9 interaction after DNA damage.
  Curr Biol, 9, 551-554.  
10570175 K.N.Mahajan, L.Gangi-Peterson, D.H.Sorscher, J.Wang, K.N.Gathy, N.P.Mahajan, W.H.Reeves, and B.S.Mitchell (1999).
Association of terminal deoxynucleotidyl transferase with Ku.
  Proc Natl Acad Sci U S A, 96, 13926-13931.  
10047578 S.S.Parikh, C.D.Mol, D.J.Hosfield, and J.A.Tainer (1999).
Envisioning the molecular choreography of DNA base excision repair.
  Curr Opin Struct Biol, 9, 37-47.  
10528224 Y.Chen, W.H.Lee, and H.K.Chew (1999).
Emerging roles of BRCA1 in transcriptional regulation and DNA repair.
  J Cell Physiol, 181, 385-392.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.