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protein Protein-protein interface(s) links
Serum protein PDB id
1c28
Jmol
Contents
Protein chains
125 a.a. *
111 a.a. *
102 a.a. *
Waters ×389
* Residue conservation analysis
PDB id:
1c28
Name: Serum protein
Title: The crystal structure of a complment-1q family protein suggests an evolutionary link to tumor necrosis factor
Structure: Protein (30 kd adipocyte complement-related protein precursor (acrp30)). Chain: a, b, c. Engineered: yes
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562
Biol. unit: Trimer (from PDB file)
Resolution:
2.10Å     R-factor:   0.212     R-free:   0.276
Authors: L.Shapiro,P.Scherer
Key ref:
L.Shapiro and P.E.Scherer (1998). The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr Biol, 8, 335-338. PubMed id: 9512423 DOI: 10.1016/S0960-9822(98)70133-2
Date:
22-Jul-99     Release date:   04-Aug-99    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q60994  (ADIPO_MOUSE) -  Adiponectin
Seq:
Struc: 		247 a.a.
125 a.a.
Protein chain
Pfam   ArchSchema ?
Q60994  (ADIPO_MOUSE) -  Adiponectin
Seq:
Struc: 		247 a.a.
111 a.a.
Protein chain
Pfam   ArchSchema ?
Q60994  (ADIPO_MOUSE) -  Adiponectin
Seq:
Struc: 		247 a.a.
102 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 

 
DOI no: 10.1016/S0960-9822(98)70133-2 Curr Biol 8:335-338 (1998)
PubMed id: 9512423  
 
 
The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor.
L.Shapiro, P.E.Scherer.
 
  ABSTRACT  
 
ACRP30--adipocyte complement-related protein of 30 kDa or AdipoQ--is an abundant serum protein, secreted exclusively from fat cells, which is implicated in energy homeostasis and obesity [1,2]. ACRP30 is a close homologue of the complement protein C1q, which is involved in the recognition of microbial in the classical pathway of complement. We have determined the crystal structure of a homotrimeric fragment from ACRP30 at 2.1 A resolution. The structure reveals an unexpected homology to the tumor necrosis factor (TNF) family. Identical folding topologies, key residue conservations, and similarity of trimer interfaces and intron positions firmly establish an evolutionary link between the TNF and C1q families. We suggest that TNFs--which control many aspects of inflammation, adaptive immunity, apoptosis and energy homeostasis--arose by divergence from a primordial recognition molecule of the innate immune system. The evolutionary connection between C1q-like proteins and TNFs illuminates the shared functions of these two important groups of proteins.
 
  Selected figure(s)  
 
Figure 2.
Figure 2. Representative electron density. (a) Experimental MIR/solvent-flattened map computed with structure factors from 8.0 to 2.4 å Bragg spacings. (b) Electron density map calculated with 2|F[o]|−|F[c]|coefficients and model phases from 8.0 to 2.1 å resolution. Each map is contoured at 1.0σ.
 
  The above figure is reprinted by permission from Cell Press: Curr Biol (1998, 8, 335-338) copyright 1998.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
21424675 A.M.Van Berendoncks, and V.M.Conraads (2011).
Functional adiponectin resistance and exercise intolerance in heart failure.
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21069809 D.Fan, L.Li, C.Wang, X.B.Cui, Y.Zhou, and L.L.Wu (2011).
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Adiponectin increases MMP-3 expression in human chondrocytes through adipor1 signaling pathway.
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20434953 A.Schäffler, and J.Schölmerich (2010).
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PDB code: 2ka3
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18395775 W.Tan, F.Wang, M.Zhang, D.Guo, Q.Zhang, and S.He (2009).
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18931039 Y.Ikegami, K.Inukai, K.Imai, Y.Sakamoto, H.Katagiri, S.Kurihara, T.Awata, and S.Katayama (2009).
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[Adipocytokines as driving forces in rheumatoid arthritis]
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17532004 G.Ding, Q.Qin, N.He, S.C.Francis-David, J.Hou, J.Liu, E.Ricks, and Q.Yang (2007).
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17953526 K.Duus, R.T.Pagh, U.Holmskov, P.Højrup, S.Skov, and G.Houen (2007).
Interaction of calreticulin with CD40 ligand, TRAIL and Fas ligand.
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17700265 K.Karmiris, I.E.Koutroubakis, C.Xidakis, M.Polychronaki, and E.A.Kouroumalis (2007).
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  Eur J Gastroenterol Hepatol, 19, 789-794.  
17498506 M.K.Badman, and J.S.Flier (2007).
The adipocyte as an active participant in energy balance and metabolism.
  Gastroenterology, 132, 2103-2115.  
17572841 M.Nishida, T.Funahashi, and I.Shimomura (2007).
Pathophysiological significance of adiponectin.
  Med Mol Morphol, 40, 55-67.  
17391150 N.L.Brooks, K.S.Moore, R.D.Clark, M.T.Perfetti, C.M.Trent, and T.P.Combs (2007).
Do low levels of circulating adiponectin represent a biomarker or just another risk factor for the metabolic syndrome?
  Diabetes Obes Metab, 9, 246-258.  
16912318 A.C.Chang, L.Zsak, Y.Feng, R.Mosseri, Q.Lu, P.Kowalski, A.Zsak, T.G.Burrage, J.G.Neilan, G.F.Kutish, Z.Lu, W.Laegreid, D.L.Rock, and S.N.Cohen (2006).
Phenotype-based identification of host genes required for replication of African swine fever virus.
  J Virol, 80, 8705-8717.  
16394799 C.Aygun, O.Senturk, S.Hulagu, S.Uraz, A.Celebi, T.Konduk, B.Mutlu, and Z.Canturk (2006).
Serum levels of hepatoprotective peptide adiponectin in non-alcoholic fatty liver disease.
  Eur J Gastroenterol Hepatol, 18, 175-180.  
16926524 C.H.Jung, E.J.Rhee, S.Y.Kim, H.S.Shin, B.J.Kim, K.C.Sung, B.S.Kim, W.Y.Lee, J.H.Kang, K.W.Oh, M.H.Lee, S.W.Kim, and J.R.Park (2006).
Associations between two single nucleotide polymorphisms of adiponectin gene and coronary artery diseases.
  Endocr J, 53, 671-677.  
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Cbln1 is essential for interaction-dependent secretion of Cbln3.
  Mol Cell Biol, 26, 9327-9337.  
16905106 D.M.Compaan, and S.G.Hymowitz (2006).
The crystal structure of the costimulatory OX40-OX40L complex.
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PDB codes: 2hev 2hew 2hey
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Identification of amino-terminal region of adiponectin as a physiologically functional domain.
  J Cell Biochem, 98, 194-207.  
16634986 J.P.Whitehead, A.A.Richards, I.J.Hickman, G.A.Macdonald, and J.B.Prins (2006).
Adiponectin--a key adipokine in the metabolic syndrome.
  Diabetes Obes Metab, 8, 264-280.  
16616484 J.W.Choi, W.Lee, B.K.Oh, H.J.Lee, and D.B.Lee (2006).
Application of complement 1q for the site-selective recognition of immune complex in protein chip.
  Biosens Bioelectron, 22, 764-767.  
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Circulating levels of leptin, adiponectin, resistin, and ghrelin in inflammatory bowel disease.
  Inflamm Bowel Dis, 12, 100-105.  
17024245 L.D.McVay, S.A.Keilbaugh, T.M.Wong, S.Kierstein, M.E.Shin, M.Lehrke, M.I.Lefterova, D.E.Shifflett, S.L.Barnes, F.Cominelli, S.M.Cohn, G.Hecht, M.A.Lazar, A.Haczku, and G.D.Wu (2006).
Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis.
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Modification of accessory molecule signaling.
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Serum adiponectin concentration: its correlation with diabetes-related traits and quantitative trait loci analysis in mouse SMXA recombinant inbred strains.
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17021375 R.S.Ahima (2006).
Adipose tissue as an endocrine organ.
  Obesity (Silver Spring), 14, 242S-249S.  
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Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.
  J Clin Invest, 116, 1784-1792.  
15888774 A.Schäffler, and H.Herfarth (2005).
Creeping fat in Crohn's disease: travelling in a creeper lane of research?
  Gut, 54, 742-744.  
15843989 B.S.Sutton, S.Weinert, C.D.Langefeld, A.H.Williams, J.K.Campbell, M.F.Saad, S.M.Haffner, J.M.Norris, and D.W.Bowden (2005).
Genetic analysis of adiponectin and obesity in Hispanic families: the IRAS Family Study.
  Hum Genet, 117, 107-118.  
16135095 D.Bao, Z.Pang, and J.I.Morgan (2005).
The structure and proteolytic processing of Cbln1 complexes.
  J Neurochem, 95, 618-629.  
16250043 E.Bugianesi, A.J.McCullough, and G.Marchesini (2005).
Insulin resistance: a metabolic pathway to chronic liver disease.
  Hepatology, 42, 987.  
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The emerging role of adipocytokines as inflammatory mediators in inflammatory bowel disease.
  Inflamm Bowel Dis, 11, 847-855.  
15656875 M.E.Trujillo, and P.E.Scherer (2005).
Adiponectin--journey from an adipocyte secretory protein to biomarker of the metabolic syndrome.
  J Intern Med, 257, 167-175.  
15744804 M.J.Kim, K.H.Yoo, H.S.Park, S.M.Chung, C.J.Jin, Y.Lee, Y.G.Shin, and C.H.Chung (2005).
Plasma adiponectin and insulin resistance in Korean type 2 diabetes mellitus.
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15664187 M.L.Narasimhan, M.A.Coca, J.Jin, T.Yamauchi, Y.Ito, T.Kadowaki, K.K.Kim, J.M.Pardo, B.Damsz, P.M.Hasegawa, D.J.Yun, and R.A.Bressan (2005).
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The crystal structure of the Bacillus anthracis spore surface protein BclA shows remarkable similarity to mammalian proteins.
  J Biol Chem, 280, 43073-43078.
PDB code: 1wck
16059715 Y.H.Lee, S.Nair, E.Rousseau, D.B.Allison, G.P.Page, P.A.Tataranni, C.Bogardus, and P.A.Permana (2005).
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  Proc Natl Acad Sci U S A, 101, 10302-10307.  
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15199964 M.Nonaka, and F.Yoshizaki (2004).
Primitive complement system of invertebrates.
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Disulfide-dependent multimeric assembly of resistin family hormones.
  Science, 304, 1154-1158.
PDB codes: 1rfx 1rgx 1rh7
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C1q and tumor necrosis factor superfamily: modularity and versatility.
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The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice.
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12728641 F.Vasseur, F.Leprêtre, C.Lacquemant, and P.Froguel (2003).
The genetics of adiponectin.
  Curr Diab Rep, 3, 151-158.  
  12948526 H.Ruan, and H.F.Lodish (2003).
Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-alpha.
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Ectodysplasin signaling in development.
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Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex.
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Obesity, adiponectin and vascular inflammatory disease.
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Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways.
  J Biol Chem, 278, 50810-50817.  
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ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism.
  Trends Endocrinol Metab, 13, 84-89.  
  11750858 C.M.Steppan, and M.A.Lazar (2002).
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PDB code: 1gr3
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PDB code: 1jtz
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PDB code: 1c8z
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