PDBsum entry 1bzg

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protein links
Hormone PDB id
Protein chain
34 a.a. *
* Residue conservation analysis
PDB id:
Name: Hormone
Title: The solution structure of human parathyroid hormone-related protein (1-34) in near-physiological solution, nmr, 30 structures
Structure: Parathyroid hormone-related protein. Chain: a. Fragment: residues 1-34. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606
NMR struc: 30 models
Authors: M.Weidler,U.C.Marx,G.Seidel,P.Roesch
Key ref:
M.Weidler et al. (1999). The structure of human parathyroid hormone-related protein(1-34) in near-physiological solution. FEBS Lett, 444, 239-244. PubMed id: 10050767 DOI: 10.1016/S0014-5793(98)01658-5
28-Oct-98     Release date:   18-May-99    
Go to PROCHECK summary

Protein chain
Pfam   ArchSchema ?
P12272  (PTHR_HUMAN) -  Parathyroid hormone-related protein
177 a.a.
34 a.a.
Key:    PfamA domain  Secondary structure

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   1 term 
  Biological process     regulation of chondrocyte differentiation   1 term 
  Biochemical function     hormone activity     1 term  


DOI no: 10.1016/S0014-5793(98)01658-5 FEBS Lett 444:239-244 (1999)
PubMed id: 10050767  
The structure of human parathyroid hormone-related protein(1-34) in near-physiological solution.
M.Weidler, U.C.Marx, G.Seidel, W.Schäfer, E.Hoffmann, A.Esswein, P.Rösch.
Parathyroid hormone-related protein plays a major role in the pathogenesis of humoral hypercalcemia of malignancy. Under normal physiological conditions, parathyroid hormone-related protein is produced in a wide variety of tissues and acts in an autocrine or paracrine fashion. Parathyroid hormone-related protein and parathyroid hormone bind to and activate the same G-protein-coupled receptor. Here we present the structure of the biologically active NH2-terminal domain of human parathyroid hormone-related protein(1-34) in near-physiological solution in the absence of crowding reagents as determined by two-dimensional proton magnetic resonance spectroscopy. An improved strategy for structure calculation revealed the presence of two helices, His-5-Leu-8 and Gln-16-Leu-27, connected by a flexible linker. The parathyroid hormone-related protein(1-34) structure and the structure of human parathyroid hormone(1-37) as well as human parathyroid hormone(1-34) are highly similar, except for the well defined turn, His-14-Ser-17, present in parathyroid hormone. Thus, the similarity of the binding affinities of parathyroid hormone and parathyroid hormone-related protein to their common receptor may be based on their structural similarity.
  Selected figure(s)  
Figure 1.
Fig. 1. CD spectrum of hPTHrP(1â34) at 298 K, 1 mg/ml ( vert, similar 250 μM) peptide in 50 mM potassium phosphate, pH 5.1, 250 mM sodium chloride.
Figure 4.
Fig. 4. MOLMOL 2.5.1 [47] cartoon of the lowest internal energy structure. The amino- and carboxy-termini are indicated.
  The above figures are reprinted by permission from the Federation of European Biochemical Societies: FEBS Lett (1999, 444, 239-244) copyright 1999.  
  Figures were selected by an automated process.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
20979597 M.Abraham-Nordling, B.Persson, and E.Nordling (2010).
Model of the complex of Parathyroid hormone-2 receptor and Tuberoinfundibular peptide of 39 residues.
  BMC Res Notes, 3, 270.  
19674967 A.A.Pioszak, N.R.Parker, T.J.Gardella, and H.E.Xu (2009).
Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides.
  J Biol Chem, 284, 28382-28391.
PDB code: 3h3g
17525467 T.J.Kamerzell, S.B.Joshi, D.McClean, L.Peplinskie, K.Toney, D.Papac, M.Li, and C.R.Middaugh (2007).
Parathyroid hormone is a heparin/polyanion binding protein: binding energetics and structure modification.
  Protein Sci, 16, 1193-1203.  
15686531 A.Barazza, A.Wittelsberger, N.Fiori, E.Schievano, S.Mammi, C.Toniolo, J.M.Alexander, M.Rosenblatt, E.Peggion, and M.Chorev (2005).
Bioactive N-terminal undecapeptides derived from parathyroid hormone: the role of alpha-helicity.
  J Pept Res, 65, 23-35.  
14648764 E.Schievano, S.Mammi, E.Carretta, N.Fiori, M.Corich, A.Bisello, M.Rosenblatt, M.Chorev, and E.Peggion (2003).
Conformational and biological characterization of human parathyroid hormone hPTH(1-34) analogues containing beta-amino acid residues in positions 17-19.
  Biopolymers, 70, 534-547.  
12080067 M.Shimada, X.Chen, T.Cvrk, H.Hilfiker, M.Parfenova, and G.V.Segre (2002).
Purification and characterization of a receptor for human parathyroid hormone and parathyroid hormone-related peptide.
  J Biol Chem, 277, 31774-31780.  
11087406 J.R.Barbier, S.MacLean, P.Morley, J.F.Whitfield, and G.E.Willick (2000).
Structure and activities of constrained analogues of human parathyroid hormone and parathyroid hormone-related peptide: implications for receptor-activating conformations of the hormones.
  Biochemistry, 39, 14522-14530.  
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