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Metalloprotease
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PDB id
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1bqo
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Contents |
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* Residue conservation analysis
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PDB id:
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Metalloprotease
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Title:
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Discovery of potent, achiral matrix metalloproteinase inhibi
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Structure:
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Stromelysin-1. Chain: a, b. Synonym: mmp-3. Engineered: yes. Other_details: complexed to pg-117025
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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2.30Å
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R-factor:
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0.229
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R-free:
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0.294
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Authors:
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S.Pikul,K.L.M.Dunham,N.G.Almstead,B.De,M.G.Natchus,M.V.Anast S.J.Mcphail,C.E.Snider,Y.O.Taiwo,T.J.Rydel,C.M.Dunaway,F.Gu G.E.Mieling
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Key ref:
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S.Pikul
et al.
(1998).
Discovery of potent, achiral matrix metalloproteinase inhibitors.
J Med Chem,
41,
3568-3571.
PubMed id:
DOI:
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Date:
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17-Aug-98
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Release date:
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17-Aug-99
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PROCHECK
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Headers
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References
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P08254
(MMP3_HUMAN) -
Stromelysin-1
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Seq:
Struc:
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477 a.a.
169 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.3.4.24.17
- Stromelysin 1.
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Reaction:
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Preferential cleavage where P1', P2' and P3' are hydrophobic residues.
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Cofactor:
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Calcium; Zinc
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Gene Ontology (GO) functional annotation
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Cellular component
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extracellular matrix
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1 term
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Biological process
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proteolysis
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1 term
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Biochemical function
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metallopeptidase activity
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3 terms
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DOI no:
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J Med Chem
41:3568-3571
(1998)
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PubMed id:
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Discovery of potent, achiral matrix metalloproteinase inhibitors.
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S.Pikul,
K.L.McDow Dunham,
N.G.Almstead,
B.De,
M.G.Natchus,
M.V.Anastasio,
S.J.McPhail,
C.E.Snider,
Y.O.Taiwo,
T.Rydel,
C.M.Dunaway,
F.Gu,
G.E.Mieling.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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D.Koda,
T.Maruyama,
N.Minakuchi,
K.Nakashima,
and
M.Goto
(2010).
Proteinase-mediated drastic morphological change of peptide-amphiphile to induce supramolecular hydrogelation.
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Chem Commun (Camb), 46,
979-981.
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M.M.Thwin,
E.Douni,
P.Arjunan,
G.Kollias,
P.V.Kumar,
and
P.Gopalakrishnakone
(2009).
Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice.
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Arthritis Res Ther, 11,
R138.
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F.M.Tholozan,
C.Gribbon,
Z.Li,
M.W.Goldberg,
A.R.Prescott,
N.McKie,
and
R.A.Quinlan
(2007).
FGF-2 release from the lens capsule by MMP-2 maintains lens epithelial cell viability.
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Mol Biol Cell, 18,
4222-4231.
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L.A.Alcaraz,
L.Banci,
I.Bertini,
F.Cantini,
A.Donaire,
and
L.Gonnelli
(2007).
Matrix metalloproteinase-inhibitor interaction: the solution structure of the catalytic domain of human matrix metalloproteinase-3 with different inhibitors.
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J Biol Inorg Chem, 12,
1197-1206.
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PDB codes:
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N.Simard,
G.Boire,
A.J.de Brum-Fernandes,
and
Y.St-Pierre
(2006).
A novel approach to measure the contribution of matrix metalloproteinase in the overall net proteolytic activity present in synovial fluids of patients with arthritis.
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Arthritis Res Ther, 8,
R125.
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K.C.Sorensen,
R.G.Newman,
B.E.Kitchell,
D.J.Schaeffer,
and
A.M.Siegel
(2005).
Isolation, characterization, and expression of stromelysin-1 in primary tumors of dogs.
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Am J Vet Res, 66,
1526-1535.
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S.Kansra,
S.W.Stoll,
J.L.Johnson,
and
J.T.Elder
(2004).
Autocrine extracellular signal-regulated kinase (ERK) activation in normal human keratinocytes: metalloproteinase-mediated release of amphiregulin triggers signaling from ErbB1 to ERK.
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Mol Biol Cell, 15,
4299-4309.
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V.Lukacova,
Y.Zhang,
M.Mackov,
P.Baricic,
S.Raha,
J.A.Calvo,
and
S.Balaz
(2004).
Similarity of binding sites of human matrix metalloproteinases.
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J Biol Chem, 279,
14194-14200.
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J.Yang,
R.W.Shultz,
W.M.Mars,
R.E.Wegner,
Y.Li,
C.Dai,
K.Nejak,
and
Y.Liu
(2002).
Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy.
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J Clin Invest, 110,
1525-1538.
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M.Kaup,
K.Dassler,
C.Weise,
and
H.Fuchs
(2002).
Shedding of the transferrin receptor is mediated constitutively by an integral membrane metalloprotease sensitive to tumor necrosis factor alpha protease inhibitor-2.
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J Biol Chem, 277,
38494-38502.
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B.De,
M.G.Natchus,
M.Cheng,
S.Pikul,
N.G.Almstead,
Y.O.Taiwo,
C.E.Snider,
L.Chen,
B.Barnett,
F.Gu,
and
M.Dowty
(1999).
The next generation of MMP inhibitors. Design and synthesis.
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Ann N Y Acad Sci, 878,
40-60.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
