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PDBsum entry 1bkf

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protein ligands links
Isomerase PDB id
1bkf
Jmol
Contents
Protein chain
107 a.a. *
Ligands
FK5
Waters ×64
* Residue conservation analysis
PDB id:
1bkf
Name: Isomerase
Title: Fk506 binding protein fkbp mutant r42k/h87v complex with immunosuppressant fk506
Structure: Fk506 binding protein. Chain: a. Synonym: fkbp. Engineered: yes. Mutation: yes. Other_details: complexed with immunosuppressant fk506
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Biol. unit: Dimer (from PQS)
Resolution:
1.60Å     R-factor:   0.187    
Authors: S.Itoh,M.T.Decenzo,D.J.Livingston,D.A.Pearlman,M.A.Navia
Key ref: S.Itoh et al. (1995). Conformation of fk506 in X-Ray structures of its complexes with human recombinant fkbp12 mutants. Bioorg.Med.Chem.Lett., 5, 1983.
Date:
18-Oct-95     Release date:   01-Aug-96    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P62942  (FKB1A_HUMAN) -  Peptidyl-prolyl cis-trans isomerase FKBP1A
Seq:
Struc:
108 a.a.
107 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.5.2.1.8  - Peptidylprolyl isomerase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Peptidylproline (omega=180) = peptidylproline (omega=0)
Peptidylproline (omega=180)
= peptidylproline (omega=0)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   7 terms 
  Biological process     regulation of immune response   24 terms 
  Biochemical function     ion channel binding     14 terms