PDBsum entry 1bgy

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protein ligands Protein-protein interface(s) links
Electron transport PDB id
Protein chains
446 a.a. *
419 a.a. *
379 a.a. *
241 a.a. *
75 a.a. *
106 a.a. *
81 a.a. *
64 a.a. *
33 a.a. *
62 a.a. *
22 a.a. *
196 a.a. *
HEM ×4
HEC ×2
* Residue conservation analysis
PDB id:
Name: Electron transport
Title: Cytochrome bc1 complex from bovine
Structure: Cytochrome bc1 complex. Chain: a, m. Synonym: ubiquinol cytochromE C oxidoreductase, complex iii. Cytochrome bc1 complex. Chain: b, n. Synonym: ubiquinol cytochromE C oxidoreductase, complex iii. Cytochrome bc1 complex.
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: heart. Tissue: heart muscle. Organelle: mitochondrion. Cellular_location: mitochondrial inner membrane. Cellular_location: mitochondrial inner membrane
Biol. unit: Decamer (from PQS)
3.00Å     R-factor:   0.320     R-free:   0.360
Authors: S.Iwata,J.W.Lee,K.Okada,J.K.Lee,M.Iwata,S.Ramaswamy,B.K.Jap
Key ref:
S.Iwata et al. (1998). Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex. Science, 281, 64-71. PubMed id: 9651245 DOI: 10.1126/science.281.5373.64
02-Jun-98     Release date:   06-Jan-99    
Go to PROCHECK summary

Protein chains
Pfam   ArchSchema ?
P31800  (QCR1_BOVIN) -  Cytochrome b-c1 complex subunit 1, mitochondrial
480 a.a.
446 a.a.
Protein chains
Pfam   ArchSchema ?
P23004  (QCR2_BOVIN) -  Cytochrome b-c1 complex subunit 2, mitochondrial
453 a.a.
419 a.a.
Protein chains
Pfam   ArchSchema ?
P00157  (CYB_BOVIN) -  Cytochrome b
379 a.a.
379 a.a.
Protein chains
Pfam   ArchSchema ?
P00125  (CY1_BOVIN) -  Cytochrome c1, heme protein, mitochondrial
325 a.a.
241 a.a.
Protein chain
Pfam   ArchSchema ?
P13272  (UCRI_BOVIN) -  Cytochrome b-c1 complex subunit Rieske, mitochondrial
274 a.a.
75 a.a.
Protein chains
Pfam   ArchSchema ?
P00129  (QCR7_BOVIN) -  Cytochrome b-c1 complex subunit 7
111 a.a.
106 a.a.*
Protein chains
Pfam   ArchSchema ?
P13271  (QCR8_BOVIN) -  Cytochrome b-c1 complex subunit 8
82 a.a.
81 a.a.
Protein chains
Pfam   ArchSchema ?
P00126  (QCR6_BOVIN) -  Cytochrome b-c1 complex subunit 6, mitochondrial
91 a.a.
64 a.a.
Protein chains
Pfam   ArchSchema ?
P13272  (UCRI_BOVIN) -  Cytochrome b-c1 complex subunit Rieske, mitochondrial
274 a.a.
33 a.a.
Protein chains
Pfam   ArchSchema ?
P00130  (QCR9_BOVIN) -  Cytochrome b-c1 complex subunit 9
64 a.a.
62 a.a.
Protein chains
Pfam   ArchSchema ?
P07552  (QCR10_BOVIN) -  Cytochrome b-c1 complex subunit 10
56 a.a.
22 a.a.*
Protein chain
Pfam   ArchSchema ?
P13272  (UCRI_BOVIN) -  Cytochrome b-c1 complex subunit Rieske, mitochondrial
274 a.a.
196 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 3 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chains E, I, Q, U: E.C.  - Quinol--cytochrome-c reductase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+
2 × ferricytochrome c
Bound ligand (Het Group name = HEM)
matches with 63.00% similarity
= quinone
+ 2 × ferrocytochrome c
+ 2 × H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   7 terms 
  Biological process     oxidation-reduction process   13 terms 
  Biochemical function     catalytic activity     10 terms  


    Added reference    
DOI no: 10.1126/science.281.5373.64 Science 281:64-71 (1998)
PubMed id: 9651245  
Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex.
S.Iwata, J.W.Lee, K.Okada, J.K.Lee, M.Iwata, B.Rasmussen, T.A.Link, S.Ramaswamy, B.K.Jap.
Mitochondrial cytochrome bc1 complex performs two functions: It is a respiratory multienzyme complex and it recognizes a mitochondrial targeting presequence. Refined crystal structures of the 11-subunit bc1 complex from bovine heart reveal full views of this bifunctional enzyme. The "Rieske" iron-sulfur protein subunit shows significant conformational changes in different crystal forms, suggesting a new electron transport mechanism of the enzyme. The mitochondrial targeting presequence of the "Rieske" protein (subunit 9) is lodged between the two "core" subunits at the matrix side of the complex. These "core" subunits are related to the matrix processing peptidase, and the structure unveils how mitochondrial targeting presequences are recognized.
  Selected figure(s)  
Figure 3.
Fig. 3. Interaction of the mitochondrial targeting presequence of the ISP (subunit 9 in bright red) with the two core subunits (core^ 1 in aqua blue and core 2 in green). (A) Position of subunit 9 between the core 1 and core 2 subunits viewed from the mitochondrial matrix side of the complex. The cleaved NH[2]-terminal arm of the^ ISP is shown in magenta. The -sheet of the NH[2]-terminal domain of core 2 is highlighted (yellowish green), and the two possible^ Zn2+-binding sites are marked by black arrowheads. (B) Stereoview of various interactions between the COOH-terminal -strand of^ subunit 9 and its binding site in the core 2 subunit.
Figure 4.
Fig. 4. Structural comparison of the ISP in P6[5]22 and P6[5] crystal forms of bovine cytochrome bc[1]. Stereoview of the superimposed ISP functional domains at "c[1]" (red) and "Int" (blue) positional states using the base folds. The cluster-binding folds are shown in saturated^ colors, whereas the base folds are shown in pale colors. These^ structures are related by a hinge motion and the isomerization of Pro175 near the [2Fe-2S] center.
  The above figures are reprinted by permission from the AAAs: Science (1998, 281, 64-71) copyright 1998.  
  Figures were selected by an automated process.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
21278747 D.Ghezzi, P.Arzuffi, M.Zordan, C.Da Re, C.Lamperti, C.Benna, P.D'Adamo, D.Diodato, R.Costa, C.Mariotti, G.Uziel, C.Smiderle, and M.Zeviani (2011).
Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies.
  Nat Genet, 43, 259-263.  
21359406 I.Bertini, G.Cavallaro, and A.Rosato (2011).
Principles and patterns in the interaction between mono-heme cytochrome c and its partners in electron transfer processes.
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20305653 B.D.Freudenthal, L.Gakhar, S.Ramaswamy, and M.T.Washington (2010).
Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange.
  Nat Struct Mol Biol, 17, 479-484.
PDB codes: 3l0w 3l0x 3l10
20025846 E.A.Berry, L.S.Huang, D.W.Lee, F.Daldal, K.Nagai, and N.Minagawa (2010).
Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex.
  Biochim Biophys Acta, 1797, 360-370.
PDB code: 3h1l
19739941 G.Lenaz, and M.L.Genova (2010).
Structure and organization of mitochondrial respiratory complexes: a new understanding of an old subject.
  Antioxid Redox Signal, 12, 961.  
20345689 J.W.Ballard, and R.G.Melvin (2010).
Linking the mitochondrial genotype to the organismal phenotype.
  Mol Ecol, 19, 1523-1539.  
20496909 K.L.Hsueh, W.M.Westler, and J.L.Markley (2010).
NMR investigations of the Rieske protein from Thermus thermophilus support a coupled proton and electron transfer mechanism.
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19826804 K.McLuskey, A.W.Roszak, Y.Zhu, and N.W.Isaacs (2010).
Crystal structures of all-alpha type membrane proteins.
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20667175 K.R.Vinothkumar, and R.Henderson (2010).
Structures of membrane proteins.
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Impact of the mitochondrial genetic background in complex III deficiency.
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20518024 M.Morán, L.Marín-Buera, M.C.Gil-Borlado, H.Rivera, A.Blázquez, S.Seneca, M.Vázquez-López, J.Arenas, M.A.Martín, and C.Ugalde (2010).
Cellular pathophysiological consequences of BCS1L mutations in mitochondrial complex III enzyme deficiency.
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20533897 P.R.Rich, and A.Maréchal (2010).
The mitochondrial respiratory chain.
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20136511 T.Endo, K.Yamano, and S.Kawano (2010).
Structural basis for the disulfide relay system in the mitochondrial intermembrane space.
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19150419 B.Liu, A.K.Tewari, L.Zhang, K.B.Green-Church, J.L.Zweier, Y.R.Chen, and G.He (2009).
Proteomic analysis of protein tyrosine nitration after ischemia reperfusion injury: mitochondria as the major target.
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19692591 D.Arnoult, F.Soares, I.Tattoli, C.Castanier, D.J.Philpott, and S.E.Girardin (2009).
An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix.
  J Cell Sci, 122, 3161-3168.  
19099453 D.R.Kolling, R.I.Samoilova, A.A.Shubin, A.R.Crofts, and S.A.Dikanov (2009).
Proton environment of reduced Rieske iron-sulfur cluster probed by two-dimensional ESEEM spectroscopy.
  J Phys Chem A, 113, 653-667.  
19348884 F.Millett, and B.Durham (2009).
Chapter 5 Use of ruthenium photooxidation techniques to study electron transfer in the cytochrome bc1 complex.
  Methods Enzymol, 456, 95.  
19099403 G.Saab-Rincón, and B.Valderrama (2009).
Protein engineering of redox-active enzymes.
  Antioxid Redox Signal, 11, 167-192.  
20161522 H.B.Gray, and J.R.Winkler (2009).
Electron Flow through Proteins.
  Chem Phys Lett, 483, 1-9.  
19810688 J.L.Cape, D.Aidasani, D.M.Kramer, and M.K.Bowman (2009).
Substrate redox potential controls superoxide production kinetics in the cytochrome bc complex.
  Biochemistry, 48, 10716-10723.  
19786549 L.Aguilera-Aguirre, A.Bacsi, A.Saavedra-Molina, A.Kurosky, S.Sur, and I.Boldogh (2009).
Mitochondrial dysfunction increases allergic airway inflammation.
  J Immunol, 183, 5379-5387.  
19523237 L.Azevedo, J.Carneiro, B.van Asch, A.Moleirinho, F.Pereira, and A.Amorim (2009).
Epistatic interactions modulate the evolution of mammalian mitochondrial respiratory complex components.
  BMC Genomics, 10, 266.  
20040113 M.Freigassner, H.Pichler, and A.Glieder (2009).
wTuning microbial hosts for membrane protein production.
  Microb Cell Fact, 8, 69.  
19061483 M.P.Murphy (2009).
How mitochondria produce reactive oxygen species.
  Biochem J, 417, 1.  
19719482 M.S.Albury, C.Elliott, and A.L.Moore (2009).
Towards a structural elucidation of the alternative oxidase in plants.
  Physiol Plant, 137, 316-327.  
19415898 M.Sarewicz, M.Dutka, W.Froncisz, and A.Osyczka (2009).
Magnetic interactions sense changes in distance between heme b(L) and the iron-sulfur cluster in cytochrome bc(1).
  Biochemistry, 48, 5708-5720.  
19528227 O.Moiseeva, V.Bourdeau, A.Roux, X.Deschênes-Simard, and G.Ferbeyre (2009).
Mitochondrial dysfunction contributes to oncogene-induced senescence.
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19165831 P.Van Nieuwenhuyse, T.Van Leeuwen, J.Khajehali, B.Vanholme, and L.Tirry (2009).
Mutations in the mitochondrial cytochrome b of Tetranychus urticae Koch (Acari: Tetranychidae) confer cross-resistance between bifenazate and acequinocyl.
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19236481 V.Zara, L.Conte, and B.L.Trumpower (2009).
Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane.
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21578137 X.Q.Zhang, F.P.Huang, H.D.Bian, Q.Yu, and H.Liang (2009).
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  19727437 Z.Jiang, J.J.Michal, J.Chen, T.F.Daniels, T.Kunej, M.D.Garcia, C.T.Gaskins, J.R.Busboom, L.J.Alexander, R.W.Wright, and M.D.Macneil (2009).
Discovery of novel genetic networks associated with 19 economically important traits in beef cattle.
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18796602 A.P.Komarov, O.W.Rokhlin, C.A.Yu, and A.V.Gudkov (2008).
Functional genetic screening reveals the role of mitochondrial cytochrome b as a mediator of FAS-induced apoptosis.
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18501698 A.R.Crofts, J.T.Holland, D.Victoria, D.R.Kolling, S.A.Dikanov, R.Gilbreth, S.Lhee, R.Kuras, and M.G.Kuras (2008).
The Q-cycle reviewed: How well does a monomeric mechanism of the bc(1) complex account for the function of a dimeric complex?
  Biochim Biophys Acta, 1777, 1001-1019.  
18701458 B.Gurung, L.Yu, and C.A.Yu (2008).
Stigmatellin induces reduction of iron-sulfur protein in the oxidized cytochrome bc1 complex.
  J Biol Chem, 283, 28087-28094.  
18953640 D.Xia, L.Esser, M.Elberry, F.Zhou, L.Yu, and C.A.Yu (2008).
The road to the crystal structure of the cytochrome bc (1) complex from the anoxigenic, photosynthetic bacterium Rhodobacter sphaeroides.
  J Bioenerg Biomembr, 40, 485-492.  
18418633 E.A.Berry, and F.A.Walker (2008).
Bis-histidine-coordinated hemes in four-helix bundles: how the geometry of the bundle controls the axial imidazole plane orientations in transmembrane cytochromes of mitochondrial complexes II and III and related proteins.
  J Biol Inorg Chem, 13, 481-498.  
18515061 E.J.Lesnefsky, and C.L.Hoppel (2008).
Cardiolipin as an oxidative target in cardiac mitochondria in the aged rat.
  Biochim Biophys Acta, 1777, 1020-1027.  
18719951 E.N.Brown, R.Friemann, A.Karlsson, J.V.Parales, M.M.Couture, L.D.Eltis, and S.Ramaswamy (2008).
Determining Rieske cluster reduction potentials.
  J Biol Inorg Chem, 13, 1301-1313.
PDB code: 2qpz
18022381 F.A.Rotsaert, M.G.Ding, and B.L.Trumpower (2008).
Differential efficacy of inhibition of mitochondrial and bacterial cytochrome bc1 complexes by center N inhibitors antimycin, ilicicolin H and funiculosin.
  Biochim Biophys Acta, 1777, 211-219.  
18513324 H.Sumimoto (2008).
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  FEBS J, 275, 3249-3277.  
18258178 H.W.Ma, S.Yang, L.Yu, and C.A.Yu (2008).
Formation of engineered intersubunit disulfide bond in cytochrome bc1 complex disrupts electron transfer activity in the complex.
  Biochim Biophys Acta, 1777, 317-326.  
18296637 J.I.Yeh, U.Chinte, and S.Du (2008).
Structure of glycerol-3-phosphate dehydrogenase, an essential monotopic membrane enzyme involved in respiration and metabolism.
  Proc Natl Acad Sci U S A, 105, 3280-3285.
PDB codes: 2qcu 2r45 2r46 2r4e 2r4j
19009337 J.J.Wen, and N.J.Garg (2008).
Mitochondrial generation of reactive oxygen species is enhanced at the Q(o) site of the complex III in the myocardium of Trypanosoma cruzi-infected mice: beneficial effects of an antioxidant.
  J Bioenerg Biomembr, 40, 587-598.  
19006325 J.Janzon, Q.Yuan, F.Malatesta, P.Hellwig, B.Ludwig, B.Durham, and F.Millett (2008).
Probing the Paracoccus denitrificans cytochrome c(1)-cytochrome c(552) interaction by mutagenesis and fast kinetics.
  Biochemistry, 47, 12974-12984.  
18843528 M.Hüttemann, I.Lee, A.Pecinova, P.Pecina, K.Przyklenk, and J.W.Doan (2008).
Regulation of oxidative phosphorylation, the mitochondrial membrane potential, and their role in human disease.
  J Bioenerg Biomembr, 40, 445-456.  
18839290 N.V.Dudkina, S.Sunderhaus, E.J.Boekema, and H.P.Braun (2008).
The higher level of organization of the oxidative phosphorylation system: mitochondrial supercomplexes.
  J Bioenerg Biomembr, 40, 419-424.  
18516048 O.A.Ulanovskaya, J.Janjic, M.Suzuki, S.S.Sabharwal, P.T.Schumacker, S.J.Kron, and S.A.Kozmin (2008).
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide.
  Nat Chem Biol, 4, 418-424.  
18439546 O.Barel, Z.Shorer, H.Flusser, R.Ofir, G.Narkis, G.Finer, H.Shalev, A.Nasasra, A.Saada, and O.S.Birk (2008).
Mitochondrial complex III deficiency associated with a homozygous mutation in UQCRQ.
  Am J Hum Genet, 82, 1211-1216.  
18996700 P.J.Crowley, E.A.Berry, T.Cromartie, F.Daldal, C.R.Godfrey, D.W.Lee, J.E.Phillips, A.Taylor, and R.Viner (2008).
The role of molecular modeling in the design of analogues of the fungicidal natural products crocacins A and D.
  Bioorg Med Chem, 16, 10345-10355.
PDB code: 3cwb
18454936 R.Covian, and B.L.Trumpower (2008).
The dimeric structure of the cytochrome bc(1) complex prevents center P inhibition by reverse reactions at center N.
  Biochim Biophys Acta, 1777, 1044-1052.  
18471987 R.Covian, and B.L.Trumpower (2008).
Regulatory interactions in the dimeric cytochrome bc(1) complex: the advantages of being a twin.
  Biochim Biophys Acta, 1777, 1079-1091.  
18713733 S.Yang, H.W.Ma, L.Yu, and C.A.Yu (2008).
On the mechanism of quinol oxidation at the QP site in the cytochrome bc1 complex: studied using mutants lacking cytochrome bL or bH.
  J Biol Chem, 283, 28767-28776.  
18852042 T.A.Theodossiou, A.Papakyriakou, and J.S.Hothersall (2008).
Molecular modeling and experimental evidence for hypericin as a substrate for mitochondrial complex III; mitochondrial photodamage as demonstrated using specific inhibitors.
  Free Radic Biol Med, 45, 1581-1590.  
18721136 T.Kleinschroth, O.Anderka, M.Ritter, A.Stocker, T.A.Link, B.Ludwig, and P.Hellwig (2008).
Characterization of mutations in crucial residues around the Q(o) binding site of the cytochrome bc complex from Paracoccus denitrificans.
  FEBS J, 275, 4773-4785.  
17028136 A.Aird, J.Wrachtrup, K.Schulten, and C.Tietz (2007).
Possible pathway for ubiquinone shuttling in Rhodospirillum rubrum revealed by molecular dynamics simulation.
  Biophys J, 92, 23-33.  
17200733 A.Y.Mulkidjanian (2007).
Proton translocation by the cytochrome bc1 complexes of phototrophic bacteria: introducing the activated Q-cycle.
  Photochem Photobiol Sci, 6, 19-34.  
17506638 D.C.Wallace (2007).
Why do we still have a maternally inherited mitochondrial DNA? Insights from evolutionary medicine.
  Annu Rev Biochem, 76, 781-821.  
17223530 D.J.Kolling, J.S.Brunzelle, S.Lhee, A.R.Crofts, and S.K.Nair (2007).
Atomic resolution structures of rieske iron-sulfur protein: role of hydrogen bonds in tuning the redox potential of iron-sulfur clusters.
  Structure, 15, 29-38.
PDB codes: 2nuk 2num 2nve 2nvf 2nvg 2nwf
17457691 D.Xia, L.Esser, L.Yu, and C.A.Yu (2007).
Structural basis for the mechanism of electron bifurcation at the quinol oxidation site of the cytochrome bc1 complex.
  Photosynth Res, 92, 17-34.  
17498743 E.Yamashita, H.Zhang, and W.A.Cramer (2007).
Structure of the cytochrome b6f complex: quinone analogue inhibitors as ligands of heme cn.
  J Mol Biol, 370, 39-52.
PDB codes: 2e74 2e75 2e76
17470780 J.L.Cape, M.K.Bowman, and D.M.Kramer (2007).
A semiquinone intermediate generated at the Qo site of the cytochrome bc1 complex: importance for the Q-cycle and superoxide production.
  Proc Natl Acad Sci U S A, 104, 7887-7892.  
17312024 J.M.Herrmann, and R.Köhl (2007).
Catch me if you can! Oxidative protein trapping in the intermembrane space of mitochondria.
  J Cell Biol, 176, 559-563.  
17360398 J.Zhu, T.Egawa, S.R.Yeh, L.Yu, and C.A.Yu (2007).
Simultaneous reduction of iron-sulfur protein and cytochrome b(L) during ubiquinol oxidation in cytochrome bc(1) complex.
  Proc Natl Acad Sci U S A, 104, 4864-4869.  
16900298 K.Yoshimatsu, O.Araya, and T.Fujiwara (2007).
Haloarcula marismortui cytochrome b-561 is encoded by the narC gene in the dissimilatory nitrate reductase operon.
  Extremophiles, 11, 41-47.  
17573435 L.Giachini, F.Francia, G.Veronesi, D.W.Lee, F.Daldal, L.S.Huang, E.A.Berry, T.Cocco, S.Papa, F.Boscherini, and G.Venturoli (2007).
X-Ray absorption studies of Zn2+ binding sites in bacterial, avian, and bovine cytochrome bc1 complexes.
  Biophys J, 93, 2934-2951.  
18240421 M.Hüttemann, I.Lee, L.Samavati, H.Yu, and J.W.Doan (2007).
Regulation of mitochondrial oxidative phosphorylation through cell signaling.
  Biochim Biophys Acta, 1773, 1701-1720.  
17825565 M.J.Baker, A.E.Frazier, J.M.Gulbis, and M.T.Ryan (2007).
Mitochondrial protein-import machinery: correlating structure with function.
  Trends Cell Biol, 17, 456-464.  
  17401203 M.Senda, S.Kishigami, S.Kimura, and T.Senda (2007).
Crystallization and preliminary X-ray analysis of the reduced Rieske-type [2Fe-2S] ferredoxin derived from Pseudomonas sp. strain KKS102.
  Acta Crystallogr Sect F Struct Biol Cryst Commun, 63, 311-314.  
17557793 N.Buzhynskyy, P.Sens, V.Prima, J.N.Sturgis, and S.Scheuring (2007).
Rows of ATP synthase dimers in native mitochondrial inner membranes.
  Biophys J, 93, 2870-2876.  
17562131 P.Kakkar, and B.K.Singh (2007).
Mitochondria: a hub of redox activities and cellular distress control.
  Mol Cell Biochem, 305, 235-253.  
17616531 S.A.Dikanov, J.T.Holland, B.Endeward, D.R.Kolling, R.I.Samoilova, T.F.Prisner, and A.R.Crofts (2007).
Hydrogen bonds between nitrogen donors and the semiquinone in the Qi-site of the bc1 complex.
  J Biol Chem, 282, 25831-25841.  
17516628 S.Devanathan, Z.Salamon, G.Tollin, J.C.Fitch, T.E.Meyer, E.A.Berry, and M.A.Cusanovich (2007).
Plasmon waveguide resonance spectroscopic evidence for differential binding of oxidized and reduced Rhodobacter capsulatus cytochrome c2 to the cytochrome bc1 complex mediated by the conformation of the Rieske iron-sulfur protein.
  Biochemistry, 46, 7138-7145.  
17253777 S.Rajagukguk, S.Yang, C.A.Yu, L.Yu, B.Durham, and F.Millett (2007).
Effect of mutations in the cytochrome b ef loop on the electron-transfer reactions of the Rieske iron-sulfur protein in the cytochrome bc1 complex.
  Biochemistry, 46, 1791-1798.  
18198295 T.Kunej, Z.Wang, J.J.Michal, T.F.Daniels, N.S.Magnuson, and Z.Jiang (2007).
Functional UQCRC1 Polymorphisms Affect Promoter Activity and Body Lipid Accumulation.
  Obesity (Silver Spring), 15, 2896-2901.  
17399709 V.P.Shinkarev, and C.A.Wraight (2007).
Intermonomer electron transfer in the bc1 complex dimer is controlled by the energized state and by impaired electron transfer between low and high potential hemes.
  FEBS Lett, 581, 1535-1541.  
17680808 V.Zara, L.Conte, and B.L.Trumpower (2007).
Identification and characterization of cytochrome bc(1) subcomplexes in mitochondria from yeast with single and double deletions of genes encoding cytochrome bc(1) subunits.
  FEBS J, 274, 4526-4539.  
17960747 W.Gu, and V.Helms (2007).
Different protonation equilibria of 4-methylimidazole and acetic acid.
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16624922 C.S.Willett (2006).
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PDB codes: 2gmh 2gmj
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PDB codes: 1zoy 1zp0
15817397 J.M.Herrmann, and K.Hell (2005).
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15906147 J.W.Doan, T.R.Schmidt, D.E.Wildman, M.Goodman, M.L.Weiss, and L.I.Grossman (2005).
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PDB codes: 1pp9 1ppj 2a06
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PDB code: 1q90
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Biosynthesis and biophysical analysis of domains of a yeast G protein-coupled receptor.
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PDB code: 1mgy
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PDB code: 1jni
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PDB code: 1kyo
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Heterologous expression and purification systems for structural proteomics of Mammalian membrane proteins.
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Interhelical hydrogen bonds and spatial motifs in membrane proteins: polar clamps and serine zippers.
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PDB code: 1gv4
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Golden mean to longevity: rareness of mitochondrial cytochrome b variants in centenarians but not in patients with Parkinson's disease.
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The alpha-helix and the organization and gating of channels.
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Absorption and CD spectroscopy and modeling of various LH2 complexes from purple bacteria.
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PDB code: 1kb9
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Large scale domain movement in cytochrome bc(1): a new device for electron transfer in proteins.
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A structural genomics approach to the study of quorum sensing: crystal structures of three LuxS orthologs.
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PDB codes: 1inn 1j6v 1j6w 1j6x 1vje
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Quantitative analysis of the frequency spectrum of the radiation emitted by cytochrome oxidase enzymes.
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11329288 J.E.McLean, E.A.Neidhardt, T.H.Grossman, and L.Hedstrom (2001).
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Proton pumps: mechanism of action and applications.
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Crystal structure of the 100 kDa arsenite oxidase from Alcaligenes faecalis in two crystal forms at 1.64 A and 2.03 A.
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PDB codes: 1g8j 1g8k
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Human proteome enhancement: high-recovery method and improved two-dimensional map of colostral fat globule membrane proteins.
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Mutagenesis and computer modelling approach to study determinants for recognition of signal peptides by the mitochondrial processing peptidase.
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Cytochrome b(6)f mutation specifically affects thermal dissipation of absorbed light energy in Arabidopsis.
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Assembly of the Rieske iron-sulphur protein into the cytochrome bf complex in thylakoid membranes of isolated pea chloroplasts.
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A missense mutation in the mitochondrial cytochrome b gene in a revisited case with histiocytoid cardiomyopathy.
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Structures of redox enzymes.
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10727220 B.K.Rao, A.M.Tyryshkin, A.G.Roberts, M.K.Bowman, and D.M.Kramer (2000).
Inhibitory copper binding site on the spinach cytochrome b6f complex: implications for Qo site catalysis.
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The cytochrome b(6)f complex: structural studies and comparison with the bc(1) complex.
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Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment.
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PDB code: 1ezv
11188691 C.L.Colbert, M.M.Couture, L.D.Eltis, and J.T.Bolin (2000).
A cluster exposed: structure of the Rieske ferredoxin from biphenyl dioxygenase and the redox properties of Rieske Fe-S proteins.
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PDB code: 1fqt
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Photo-induced cyclic electron transfer involving cytochrome bc1 complex and reaction center in the obligate aerobic phototroph Roseobacter denitrificans.
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PDB code: 3h1k
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Uncovering the [2Fe2S] domain movement in cytochrome bc1 and its implications for energy conversion.
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Changes to the length of the flexible linker region of the Rieske protein impair the interaction of ubiquinol with the cytochrome bc1 complex.
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10966478 J.L.Popot, and D.M.Engelman (2000).
Helical membrane protein folding, stability, and evolution.
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11101297 J.M.Shifman, B.R.Gibney, R.E.Sharp, and P.L.Dutton (2000).
Heme redox potential control in de novo designed four-alpha-helix bundle proteins.
  Biochemistry, 39, 14813-14821.  
10627300 K.C.Hansen, B.E.Schultz, G.Wang, and S.I.Chan (2000).
Reaction of Escherichia coli cytochrome bo(3) and mitochondrial cytochrome bc(1) with a photoreleasable decylubiquinol.
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11112550 K.Kobayashi, S.Tagawa, and T.Mogi (2000).
Transient formation of ubisemiquinone radical and subsequent electron transfer process in the Escherichia coli cytochrome bo.
  Biochemistry, 39, 15620-15625.  
10852722 L.A.Sazanov, S.Y.Peak-Chew, I.M.Fearnley, and J.E.Walker (2000).
Resolution of the membrane domain of bovine complex I into subcomplexes: implications for the structural organization of the enzyme.
  Biochemistry, 39, 7229-7235.  
10681446 M.Brugna, S.Rodgers, A.Schricker, G.Montoya, M.Kazmeier, W.Nitschke, and I.Sinning (2000).
A spectroscopic method for observing the domain movement of the Rieske iron-sulfur protein.
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10823938 M.Eilers, S.C.Shekar, T.Shieh, S.O.Smith, and P.J.Fleming (2000).
Internal packing of helical membrane proteins.
  Proc Natl Acad Sci U S A, 97, 5796-5801.  
10858292 M.Guergova-Kuras, R.Kuras, N.Ugulava, I.Hadad, and A.R.Crofts (2000).
Specific mutagenesis of the rieske iron-sulfur protein in Rhodobacter sphaeroides shows that both the thermodynamic gradient and the pK of the oxidized form determine the rate of quinol oxidation by the bc(1) complex.
  Biochemistry, 39, 7436-7444.  
10898682 M.Korsinczky, N.Chen, B.Kotecka, A.Saul, K.Rieckmann, and Q.Cheng (2000).
Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site.
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11079541 M.Rana, Coo, F.Diaz, H.Smeets, and C.T.Moraes (2000).
An out-of-frame cytochrome b gene deletion from a patient with parkinsonism is associated with impaired complex III assembly and an increase in free radical production.
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11112534 M.Valkova-Valchanova, E.Darrouzet, C.R.Moomaw, C.A.Slaughter, and F.Daldal (2000).
Proteolytic cleavage of the Fe-S subunit hinge region of Rhodobacter capsulatus bc(1) complex: effects of inhibitors and mutations.
  Biochemistry, 39, 15484-15492.  
10801478 M.W.Vetting, and D.H.Ohlendorf (2000).
The 1.8 A crystal structure of catechol 1,2-dioxygenase reveals a novel hydrophobic helical zipper as a subunit linker.
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PDB codes: 1dlm 1dlq 1dlt 1dmh
10704472 M.van Geest, and J.S.Lolkema (2000).
Membrane topology and insertion of membrane proteins: search for topogenic signals.
  Microbiol Mol Biol Rev, 64, 13-33.  
11123802 P.Dessi, C.Rudhe, and E.Glaser (2000).
Studies on the topology of the protein import channel in relation to the plant mitochondrial processing peptidase integrated into the cytochrome bc1 complex.
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10757970 R.C.Sadoski, G.Engstrom, H.Tian, L.Zhang, C.A.Yu, L.Yu, B.Durham, and F.Millett (2000).
Use of a photoactivated ruthenium dimer complex to measure electron transfer between the Rieske iron-sulfur protein and cytochrome c(1) in the cytochrome bc(1) complex.
  Biochemistry, 39, 4231-4236.  
10704220 S.Heimann, M.V.Ponamarev, and W.A.Cramer (2000).
Movement of the Rieske iron-sulfur protein in the p-side bulk aqueous phase: effect of lumenal viscosity on redox reactions of the cytochrome b6f complex.
  Biochemistry, 39, 2692-2699.  
10848994 S.Rodgers, C.Moser, M.Martinez-Julvez, and I.Sinning (2000).
Deletion of the 6-kDa subunit affects the activity and yield of the bc1 complex from Rhodovulum sulfidophilum.
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10946110 S.S.Nakamoto, P.Hamel, and S.Merchant (2000).
Assembly of chloroplast cytochromes b and c.
  Biochimie, 82, 603-614.  
11112521 T.C.Mueser, P.H.Rogers, and A.Arnone (2000).
Interface sliding as illustrated by the multiple quaternary structures of liganded hemoglobin.
  Biochemistry, 39, 15353-15364.
PDB codes: 1g08 1g09 1g0a 1g0b
10981634 T.M.Iverson, C.Luna-Chavez, I.Schröder, G.Cecchini, and D.C.Rees (2000).
Analyzing your complexes: structure of the quinol-fumarate reductase respiratory complex.
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10673443 T.Ohnishi, C.C.Moser, C.C.Page, P.L.Dutton, and T.Yano (2000).
Simple redox-linked proton-transfer design: new insights from structures of quinol-fumarate reductase.
  Structure, 8, R23-R32.  
10692548 V.H.Obungu, Y.Wang, S.M.Amyot, C.B.Gocke, and D.S.Beattie (2000).
Mutations in the tether region of the iron-sulfur protein affect the activity and assembly of the cytochrome bc(1) complex of yeast mitochondria.
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11123950 V.P.Shinkarev, N.B.Ugulava, A.R.Crofts, and C.A.Wraight (2000).
DCCD inhibits the reactions of the iron-sulfur protein in Rhodobacter sphaeroides chromatophores.
  Biochemistry, 39, 16206-16212.  
11087372 V.P.Shinkarev, N.B.Ugulava, E.Takahashi, A.R.Crofts, and C.A.Wraight (2000).
Aspartate-187 of cytochrome b is not needed for DCCD inhibition of ubiquinol: cytochrome c oxidoreductase in Rhodobacter sphaeroides chromatophores.
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10786880 V.Santoni, M.Molloy, and T.Rabilloud (2000).
Membrane proteins and proteomics: un amour impossible?
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Mechanism of ubiquinol oxidation by the bc(1) complex: different domains of the quinol binding pocket and their role in the mechanism and binding of inhibitors.
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Mechanism of ubiquinol oxidation by the bc(1) complex: role of the iron sulfur protein and its mobility.
  Biochemistry, 38, 15791-15806.  
10468555 A.R.Crofts, S.Hong, N.Ugulava, B.Barquera, R.Gennis, M.Guergova-Kuras, and E.A.Berry (1999).
Pathways for proton release during ubihydroquinone oxidation by the bc(1) complex.
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10625447 A.R.Crofts, S.Hong, Z.Zhang, and E.A.Berry (1999).
Physicochemical aspects of the movement of the rieske iron sulfur protein during quinol oxidation by the bc(1) complex from mitochondria and photosynthetic bacteria.
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An engineered cytochrome b6c1 complex with a split cytochrome b is able to support photosynthetic growth of Rhodobacter capsulatus.
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10413476 B.Gomez, and N.C.Robinson (1999).
Phospholipase digestion of bound cardiolipin reversibly inactivates bovine cytochrome bc1.
  Biochemistry, 38, 9031-9038.  
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Structure and reaction mechanisms of multifunctional mitochondrial cytochrome bc1 complex.
  Biofactors, 9, 103-109.  
10508156 C.M.Cruciat, K.Hell, H.Fölsch, W.Neupert, and R.A.Stuart (1999).
Bcs1p, an AAA-family member, is a chaperone for the assembly of the cytochrome bc(1) complex.
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10387032 E.Darrouzet, S.Mandaci, J.Li, H.Qin, D.B.Knaff, and F.Daldal (1999).
Substitution of the sixth axial ligand of Rhodobacter capsulatus cytochrome c1 heme yields novel cytochrome c1 variants with unusual properties.
  Biochemistry, 38, 7908-7917.  
10357809 F.Zito, G.Finazzi, R.Delosme, W.Nitschke, D.Picot, and F.A.Wollman (1999).
The Qo site of cytochrome b6f complexes controls the activation of the LHCII kinase.
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10092855 G.Montoya, K.te Kaat, S.Rodgers, W.Nitschke, and I.Sinning (1999).
The cytochrome bc1 complex from Rhodovulum sulfidophilum is a dimer with six quinones per monomer and an additional 6-kDa component.
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  10572140 G.Zheng, L.Z.Yan, J.C.Vederas, and P.Zuber (1999).
Genes of the sbo-alb locus of Bacillus subtilis are required for production of the antilisterial bacteriocin subtilosin.
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Topographical characterization of the ubiquinone reduction site of glucose dehydrogenase in Escherichia coli using depth-dependent fluorescent inhibitors.
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10447880 I.K.Srivastava, J.M.Morrisey, E.Darrouzet, F.Daldal, and A.B.Vaidya (1999).
Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites.
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10611277 K.E.McAuley, P.K.Fyfe, J.P.Ridge, N.W.Isaacs, R.J.Cogdell, and M.R.Jones (1999).
Structural details of an interaction between cardiolipin and an integral membrane protein.
  Proc Natl Acad Sci U S A, 96, 14706-14711.
PDB code: 1qov
  10595562 K.S.Makarova, and N.V.Grishin (1999).
Thermolysin and mitochondrial processing peptidase: how far structure-functional convergence goes.
  Protein Sci, 8, 2537-2540.  
10531513 P.F.Lindley (1999).
Macromolecular crystallography with a third-generation synchrotron source.
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Ubiquinone binding capacity of the Rhodobacter capsulatus cytochrome bc1 complex: effect of diphenylamine, a weak binding QO site inhibitor.
  Biochemistry, 38, 3440-3446.  
10555979 R.E.Sharp, B.R.Gibney, A.Palmitessa, J.L.White, J.A.Dixon, C.C.Moser, F.Daldal, and P.L.Dutton (1999).
Effect of inhibitors on the ubiquinone binding capacity of the primary energy conversion site in the Rhodobacter capsulatus cytochrome bc(1) complex.
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10410805 S.H.White, and W.C.Wimley (1999).
Membrane protein folding and stability: physical principles.
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10512801 S.Izrailev, A.R.Crofts, E.A.Berry, and K.Schulten (1999).
Steered molecular dynamics simulation of the Rieske subunit motion in the cytochrome bc(1) complex.
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Proton translocation in the respiratory chain involving ubiquinone--a hypothetical semiquinone switch mechanism for complex I.
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10413471 V.Schünemann, A.X.Trautwein, J.Illerhaus, and W.Haehnel (1999).
Mössbauer and electron paramagnetic resonance studies of the cytochrome bf complex.
  Biochemistry, 38, 8981-8991.  
  10416018 W.A.Cramer, and G.M.Soriano (1999).
Energy transduction function of the quinone reactions in cytochrome bc complexes.
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9729743 A.R.Crofts, and E.A.Berry (1998).
Structure and function of the cytochrome bc1 complex of mitochondria and photosynthetic bacteria.
  Curr Opin Struct Biol, 8, 501-509.  
9729740 M.Saraste, and J.E.Walker (1998).
Membrane proteins. Channels, pumps and charge separators.
  Curr Opin Struct Biol, 8, 477-479.  
9860833 M.V.Ponamarev, and W.A.Cramer (1998).
Perturbation of the internal water chain in cytochrome f of oxygenic photosynthesis: loss of the concerted reduction of cytochromes f and b6.
  Biochemistry, 37, 17199-17208.  
9914255 U.Ermler, W.Grabarse, S.Shima, M.Goubeaud, and R.K.Thauer (1998).
Active sites of transition-metal enzymes with a focus on nickel.
  Curr Opin Struct Biol, 8, 749-758.  
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