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PDBsum entry 1bcc

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protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
1bcc
Jmol
Contents
Protein chains
442 a.a. *
406 a.a. *
379 a.a. *
241 a.a. *
196 a.a. *
100 a.a. *
78 a.a. *
66 a.a. *
33 a.a. *
59 a.a. *
Ligands
BOG
HEM ×3
FES
U10
PEE ×2
* Residue conservation analysis
PDB id:
1bcc
Name: Oxidoreductase
Title: Cytochrome bc1 complex from chicken
Structure: Ubiquinol cytochromE C oxidoreductase. Chain: a. Synonym: cytochrome bc1 complex, complex iii. Other_details: model includes ubiquinone and phospholipids. Ubiquinol cytochromE C oxidoreductase. Chain: b. Synonym: cytochrome bc1 complex, complex iii. Other_details: model includes ubiquinone and phospholipids. Ubiquinol cytochromE C oxidoreductase.
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Tissue: muscle. Organelle: mitochondria. Cellular_location: mitochondrial inner membrane. Other_details: isolated from natural heart muscle tissue. Other_details: isolated from natural heart muscle tissue
Biol. unit: Dimer (from PDB file)
Resolution:
3.16Å     R-factor:   0.270     R-free:   0.310
Authors: Z.Zhang,L.Huang,V.M.Shulmeister,Y.-I.Chi,K.K.Kim,L.-W.Hung, A.R.Crofts,E.A.Berry,S.-H.Kim
Key ref:
Z.Zhang et al. (1998). Electron transfer by domain movement in cytochrome bc1. Nature, 392, 677-684. PubMed id: 9565029 DOI: 10.1038/33612
Date:
23-Mar-98     Release date:   19-Aug-98    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P31800  (QCR1_BOVIN) -  Cytochrome b-c1 complex subunit 1, mitochondrial
Seq:
Struc:
480 a.a.
442 a.a.*
Protein chain
Pfam   ArchSchema ?
P23004  (QCR2_BOVIN) -  Cytochrome b-c1 complex subunit 2, mitochondrial
Seq:
Struc:
453 a.a.
406 a.a.*
Protein chain
Pfam   ArchSchema ?
P18946  (CYB_CHICK) -  Cytochrome b
Seq:
Struc:
380 a.a.
379 a.a.
Protein chain
Pfam   ArchSchema ?
P00125  (CY1_BOVIN) -  Cytochrome c1, heme protein, mitochondrial
Seq:
Struc:
325 a.a.
241 a.a.*
Protein chain
Pfam   ArchSchema ?
P13272  (UCRI_BOVIN) -  Cytochrome b-c1 complex subunit Rieske, mitochondrial
Seq:
Struc:
274 a.a.
196 a.a.*
Protein chain
Pfam   ArchSchema ?
P00129  (QCR7_BOVIN) -  Cytochrome b-c1 complex subunit 7
Seq:
Struc:
111 a.a.
100 a.a.*
Protein chain
Pfam   ArchSchema ?
P13271  (QCR8_BOVIN) -  Cytochrome b-c1 complex subunit 8
Seq:
Struc:
82 a.a.
78 a.a.*
Protein chain
Pfam   ArchSchema ?
P00126  (QCR6_BOVIN) -  Cytochrome b-c1 complex subunit 6, mitochondrial
Seq:
Struc:
91 a.a.
66 a.a.*
Protein chain
No UniProt id for this chain
Struc: 33 a.a.
Protein chain
Pfam   ArchSchema ?
P00130  (QCR9_BOVIN) -  Cytochrome b-c1 complex subunit 9
Seq:
Struc:
64 a.a.
59 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 116 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chain E: E.C.1.10.2.2  - Quinol--cytochrome-c reductase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+
Quinol
Bound ligand (Het Group name = U10)
matches with 62.50% similarity
+
2 × ferricytochrome c
Bound ligand (Het Group name = HEM)
matches with 63.64% similarity
= quinone
+ 2 × ferrocytochrome c
+ 2 × H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   8 terms 
  Biological process     oxidation-reduction process   13 terms 
  Biochemical function     catalytic activity     10 terms  

 

 
    reference    
 
 
DOI no: 10.1038/33612 Nature 392:677-684 (1998)
PubMed id: 9565029  
 
 
Electron transfer by domain movement in cytochrome bc1.
Z.Zhang, L.Huang, V.M.Shulmeister, Y.I.Chi, K.K.Kim, L.W.Hung, A.R.Crofts, E.A.Berry, S.H.Kim.
 
  ABSTRACT  
 
The cytochrome bc1 is one of the three major respiratory enzyme complexes residing in the inner mitochondrial membrane. Cytochrome bc1 transfers electrons from ubiquinol to cytochrome c and uses the energy thus released to form an electrochemical gradient across the inner membrane. Our X-ray crystal structures of the complex from chicken, cow and rabbit in both the presence and absence of inhibitors of quinone oxidation, reveal two different locations for the extrinsic domain of one component of the enzyme, an iron-sulphur protein. One location is close enough to the supposed quinol oxidation site to allow reduction of the Fe-S protein by ubiquinol. The other site is close enough to cytochrome c1 to allow oxidation of the Fe-S protein by the cytochrome. As neither location will allow both reactions to proceed at a suitable rate, the reaction mechanism must involve movement of the extrinsic domain of the Fe-S component in order to shuttle electrons from ubiquinol to cytochrome c1. Such a mechanism has not previously been observed in redox protein complexes.
 
  Selected figure(s)  
 
Figure 3.
Figure 3 Structure of the intermembrane (external surface) domains of the chicken bc[1] complex. This is viewed from within the membrane, with the transmembrane helices truncated at roughly the membrane surface. Ball-and-stick models represent the haem group of cytochrome c[1], the Rieske iron-sulphur cluster, and the disulphide cysteines of subunit 8. SU, subunit; cyt, cytochrome.
Figure 6.
Figure 6 Relative positions of the redox centres in the two different conformations of the bc[1] complex dimer. a, b, Iron centres revealed by anomalous scattering near the iron edge. The net is a Bivoet difference map with X-ray wavelength 7,131 eV phased with experimental phases improved by averaging, and contoured at 4.5 . c, d, Schematic drawing representing the cofactors. a, c, Results from a native crystal, with the iron-sulphur cluster of the Rieske protein in the distal position (from the low-potential haem group of cytochrome b). b, d, Results from a crystal containing bound stigmatellin, with the cluster in the proximal position.
 
  The above figures are reprinted by permission from Macmillan Publishers Ltd: Nature (1998, 392, 677-684) copyright 1998.  
  Figures were selected by an automated process.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
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20398779 B.Malyarchuk, M.Derenko, D.Berman, M.Perkova, T.Grzybowski, A.Lejrikh, and N.Bulakhova (2010).
Phylogeography and molecular adaptation of Siberian salamander Salamandrella keyserlingii based on mitochondrial DNA variation.
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20655344 D.W.Urry, K.D.Urry, W.Szaflarski, and M.Nowicki (2010).
Elastic-contractile model proteins: Physical chemistry, protein function and drug design and delivery.
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20025846 E.A.Berry, L.S.Huang, D.W.Lee, F.Daldal, K.Nagai, and N.Minagawa (2010).
Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex.
  Biochim Biophys Acta, 1797, 360-370.
PDB code: 3h1l
20032466 E.L.Seifert, C.Estey, J.Y.Xuan, and M.E.Harper (2010).
Electron transport chain-dependent and -independent mechanisms of mitochondrial H2O2 emission during long-chain fatty acid oxidation.
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20091229 F.Baymann, and W.Nitschke (2010).
Heliobacterial Rieske/cytb complex.
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20496909 K.L.Hsueh, W.M.Westler, and J.L.Markley (2010).
NMR investigations of the Rieske protein from Thermus thermophilus support a coupled proton and electron transfer mechanism.
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19826804 K.McLuskey, A.W.Roszak, Y.Zhu, and N.W.Isaacs (2010).
Crystal structures of all-alpha type membrane proteins.
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19892700 M.Castellani, R.Covian, T.Kleinschroth, O.Anderka, B.Ludwig, and B.L.Trumpower (2010).
Direct demonstration of half-of-the-sites reactivity in the dimeric cytochrome bc1 complex: enzyme with one inactive monomer is fully active but unable to activate the second ubiquinol oxidation site in response to ligand binding at the ubiquinone reduction site.
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20217232 S.Lemeille, and J.D.Rochaix (2010).
State transitions at the crossroad of thylakoid signalling pathways.
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19431150 A.S.Walker, C.Auclair, M.Gredt, and P.Leroux (2009).
First occurrence of resistance to strobilurin fungicides in Microdochium nivale and Microdochium majus from French naturally infected wheat grains.
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19099453 D.R.Kolling, R.I.Samoilova, A.A.Shubin, A.R.Crofts, and S.A.Dikanov (2009).
Proton environment of reduced Rieske iron-sulfur cluster probed by two-dimensional ESEEM spectroscopy.
  J Phys Chem A, 113, 653-667.  
19348884 F.Millett, and B.Durham (2009).
Chapter 5 Use of ruthenium photooxidation techniques to study electron transfer in the cytochrome bc1 complex.
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20161522 H.B.Gray, and J.R.Winkler (2009).
Electron Flow through Proteins.
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19254042 J.W.Cooley, D.W.Lee, and F.Daldal (2009).
Across membrane communication between the Q(o) and Q(i) active sites of cytochrome bc(1).
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19960681 L.Zhao, J.W.Pridgeon, J.J.Becnel, G.G.Clark, and K.J.Linthicum (2009).
Mitochondrial gene cytochrome b developmental and environmental expression in Aedes aegypti (Diptera: Culicidae).
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19719482 M.S.Albury, C.Elliott, and A.L.Moore (2009).
Towards a structural elucidation of the alternative oxidase in plants.
  Physiol Plant, 137, 316-327.  
19415898 M.Sarewicz, M.Dutka, W.Froncisz, and A.Osyczka (2009).
Magnetic interactions sense changes in distance between heme b(L) and the iron-sulfur cluster in cytochrome bc(1).
  Biochemistry, 48, 5708-5720.  
19165831 P.Van Nieuwenhuyse, T.Van Leeuwen, J.Khajehali, B.Vanholme, and L.Tirry (2009).
Mutations in the mitochondrial cytochrome b of Tetranychus urticae Koch (Acari: Tetranychidae) confer cross-resistance between bifenazate and acequinocyl.
  Pest Manag Sci, 65, 404-412.  
  19774111 Q.L.Chen, X.S.Tang, W.J.Yao, and S.Q.Lu (2009).
Bioinformatics analysis of the complete sequences of cytochrome b of Takydromus sylvaticus and modeling the tertiary structure of encoded protein.
  Int J Biol Sci, 5, 596-602.  
19176478 R.Covian, and B.L.Trumpower (2009).
Ilicicolin Inhibition and Binding at Center N of the Dimeric Cytochrome bc1 Complex Reveal Electron Transfer and Regulatory Interactions between Monomers.
  J Biol Chem, 284, 8614-8620.  
19175316 R.E.Berry, M.N.Shokhirev, A.Y.Ho, F.Yang, T.K.Shokhireva, H.Zhang, A.Weichsel, W.R.Montfort, and F.A.Walker (2009).
Effect of mutation of carboxyl side-chain amino acids near the heme on the midpoint potentials and ligand binding constants of nitrophorin 2 and its NO, histamine, and imidazole complexes.
  J Am Chem Soc, 131, 2313-2327.
PDB code: 3fll
19260761 S.Lemeille, A.Willig, N.Depège-Fargeix, C.Delessert, R.Bassi, and J.D.Rochaix (2009).
Analysis of the chloroplast protein kinase Stt7 during state transitions.
  PLoS Biol, 7, e45.  
19236481 V.Zara, L.Conte, and B.L.Trumpower (2009).
Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane.
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18796602 A.P.Komarov, O.W.Rokhlin, C.A.Yu, and A.V.Gudkov (2008).
Functional genetic screening reveals the role of mitochondrial cytochrome b as a mediator of FAS-induced apoptosis.
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18501698 A.R.Crofts, J.T.Holland, D.Victoria, D.R.Kolling, S.A.Dikanov, R.Gilbreth, S.Lhee, R.Kuras, and M.G.Kuras (2008).
The Q-cycle reviewed: How well does a monomeric mechanism of the bc(1) complex account for the function of a dimeric complex?
  Biochim Biophys Acta, 1777, 1001-1019.  
18701458 B.Gurung, L.Yu, and C.A.Yu (2008).
Stigmatellin Induces Reduction of Iron-Sulfur Protein in the Oxidized Cytochrome bc1 Complex.
  J Biol Chem, 283, 28087-28094.  
18247319 D.Fernández-Ortuño, J.A.Torés, A.de Vicente, and A.Pérez-García (2008).
Field resistance to QoI fungicides in Podosphaera fusca is not supported by typical mutations in the mitochondrial cytochrome b gene.
  Pest Manag Sci, 64, 694-702.  
18953640 D.Xia, L.Esser, M.Elberry, F.Zhou, L.Yu, and C.A.Yu (2008).
The road to the crystal structure of the cytochrome bc (1) complex from the anoxigenic, photosynthetic bacterium Rhodobacter sphaeroides.
  J Bioenerg Biomembr, 40, 485-492.  
18418633 E.A.Berry, and F.A.Walker (2008).
Bis-histidine-coordinated hemes in four-helix bundles: how the geometry of the bundle controls the axial imidazole plane orientations in transmembrane cytochromes of mitochondrial complexes II and III and related proteins.
  J Biol Inorg Chem, 13, 481-498.  
18022381 F.A.Rotsaert, M.G.Ding, and B.L.Trumpower (2008).
Differential efficacy of inhibition of mitochondrial and bacterial cytochrome bc1 complexes by center N inhibitors antimycin, ilicicolin H and funiculosin.
  Biochim Biophys Acta, 1777, 211-219.  
18535145 G.J.Workun, K.Moquin, R.A.Rothery, and J.H.Weiner (2008).
Evolutionary persistence of the molybdopyranopterin-containing sulfite oxidase protein fold.
  Microbiol Mol Biol Rev, 72, 228.  
18258178 H.W.Ma, S.Yang, L.Yu, and C.A.Yu (2008).
Formation of engineered intersubunit disulfide bond in cytochrome bc1 complex disrupts electron transfer activity in the complex.
  Biochim Biophys Acta, 1777, 317-326.  
18039651 L.Esser, M.Elberry, F.Zhou, C.A.Yu, L.Yu, and D.Xia (2008).
Inhibitor-complexed Structures of the Cytochrome bc1 from the Photosynthetic Bacterium Rhodobacter sphaeroides.
  J Biol Chem, 283, 2846-2857.
PDB codes: 2qjk 2qjp 2qjy
18533432 L.Zhao, J.W.Pridgeon, J.J.Becnel, G.G.Clark, and K.J.Linthicum (2008).
Cytochrome c gene and protein expression: developmental regulation, environmental response, and pesticide sensitivity in Aedes aegypti.
  J Med Entomol, 45, 401-408.  
18786405 M.V.Petoukhov, J.B.Vicente, P.B.Crowley, M.A.Carrondo, M.Teixeira, and D.I.Svergun (2008).
Quaternary structure of flavorubredoxin as revealed by synchrotron radiation small-angle X-ray scattering.
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18093133 N.Fisher, and B.Meunier (2008).
Molecular basis of resistance to cytochrome bc1 inhibitors.
  FEMS Yeast Res, 8, 183-192.  
18516048 O.A.Ulanovskaya, J.Janjic, M.Suzuki, S.S.Sabharwal, P.T.Schumacker, S.J.Kron, and S.A.Kozmin (2008).
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide.
  Nat Chem Biol, 4, 418-424.  
18996700 P.J.Crowley, E.A.Berry, T.Cromartie, F.Daldal, C.R.Godfrey, D.W.Lee, J.E.Phillips, A.Taylor, and R.Viner (2008).
The role of molecular modeling in the design of analogues of the fungicidal natural products crocacins A and D.
  Bioorg Med Chem, 16, 10345-10355.
PDB code: 3cwb
18454936 R.Covian, and B.L.Trumpower (2008).
The dimeric structure of the cytochrome bc(1) complex prevents center P inhibition by reverse reactions at center N.
  Biochim Biophys Acta, 1777, 1044-1052.  
18471987 R.Covian, and B.L.Trumpower (2008).
Regulatory interactions in the dimeric cytochrome bc(1) complex: the advantages of being a twin.
  Biochim Biophys Acta, 1777, 1079-1091.  
18390544 S.R.Solmaz, and C.Hunte (2008).
Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer.
  J Biol Chem, 283, 17542-17549.
PDB codes: 3cx5 3cxh
18713733 S.Yang, H.W.Ma, L.Yu, and C.A.Yu (2008).
On the Mechanism of Quinol Oxidation at the QP Site in the Cytochrome bc1 Complex: STUDIED USING MUTANTS LACKING CYTOCHROME bL OR bH.
  J Biol Chem, 283, 28767-28776.  
18721136 T.Kleinschroth, O.Anderka, M.Ritter, A.Stocker, T.A.Link, B.Ludwig, and P.Hellwig (2008).
Characterization of mutations in crucial residues around the Q(o) binding site of the cytochrome bc complex from Paracoccus denitrificans.
  FEBS J, 275, 4773-4785.  
17908308 A.Bresell, and B.Persson (2007).
Characterization of oligopeptide patterns in large protein sets.
  BMC Genomics, 8, 346.  
  18978960 A.R.Crofts (2007).
Life, Information, Entropy, and Time: Vehicles for Semantic Inheritance.
  Complexity, 13, 14-50.  
17200733 A.Y.Mulkidjanian (2007).
Proton translocation by the cytochrome bc1 complexes of phototrophic bacteria: introducing the activated Q-cycle.
  Photochem Photobiol Sci, 6, 19-34.  
17223530 D.J.Kolling, J.S.Brunzelle, S.Lhee, A.R.Crofts, and S.K.Nair (2007).
Atomic resolution structures of rieske iron-sulfur protein: role of hydrogen bonds in tuning the redox potential of iron-sulfur clusters.
  Structure, 15, 29-38.
PDB codes: 2nuk 2num 2nve 2nvf 2nvg 2nwf
17457691 D.Xia, L.Esser, L.Yu, and C.A.Yu (2007).
Structural basis for the mechanism of electron bifurcation at the quinol oxidation site of the cytochrome bc1 complex.
  Photosynth Res, 92, 17-34.  
17498743 E.Yamashita, H.Zhang, and W.A.Cramer (2007).
Structure of the cytochrome b6f complex: quinone analogue inhibitors as ligands of heme cn.
  J Mol Biol, 370, 39-52.
PDB codes: 2e74 2e75 2e76
17322303 J.Heinemeyer, H.P.Braun, E.J.Boekema, and R.Kouril (2007).
A structural model of the cytochrome C reductase/oxidase supercomplex from yeast mitochondria.
  J Biol Chem, 282, 12240-12248.  
17174478 J.J.Perry, L.Fan, and J.A.Tainer (2007).
Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair.
  Neuroscience, 145, 1280-1299.  
17360398 J.Zhu, T.Egawa, S.R.Yeh, L.Yu, and C.A.Yu (2007).
Simultaneous reduction of iron-sulfur protein and cytochrome b(L) during ubiquinol oxidation in cytochrome bc(1) complex.
  Proc Natl Acad Sci U S A, 104, 4864-4869.  
17573435 L.Giachini, F.Francia, G.Veronesi, D.W.Lee, F.Daldal, L.S.Huang, E.A.Berry, T.Cocco, S.Papa, F.Boscherini, and G.Venturoli (2007).
X-Ray absorption studies of Zn2+ binding sites in bacterial, avian, and bovine cytochrome bc1 complexes.
  Biophys J, 93, 2934-2951.  
17237510 M.S.Chae, C.C.Lin, K.E.Kessler, C.E.Nargang, L.L.Tanton, L.B.Hahn, and F.E.Nargang (2007).
Identification of an alternative oxidase induction motif in the promoter region of the aod-1 gene in Neurospora crassa.
  Genetics, 175, 1597-1606.  
17584742 R.Covian, K.Zwicker, F.A.Rotsaert, and B.L.Trumpower (2007).
Asymmetric and redox-specific binding of quinone and quinol at center N of the dimeric yeast cytochrome bc1 complex. Consequences for semiquinone stabilization.
  J Biol Chem, 282, 24198-24208.  
17561507 R.Covian, T.Kleinschroth, B.Ludwig, and B.L.Trumpower (2007).
Asymmetric binding of stigmatellin to the dimeric Paracoccus denitrificans bc1 complex: evidence for anti-cooperative ubiquinol oxidation and communication between center P ubiquinol oxidation sites.
  J Biol Chem, 282, 22289-22297.  
17535914 R.Kuras, D.Saint-Marcoux, F.A.Wollman, and C.de Vitry (2007).
A specific c-type cytochrome maturation system is required for oxygenic photosynthesis.
  Proc Natl Acad Sci U S A, 104, 9906-9910.  
17616531 S.A.Dikanov, J.T.Holland, B.Endeward, D.R.Kolling, R.I.Samoilova, T.F.Prisner, and A.R.Crofts (2007).
Hydrogen bonds between nitrogen donors and the semiquinone in the Qi-site of the bc1 complex.
  J Biol Chem, 282, 25831-25841.  
17516628 S.Devanathan, Z.Salamon, G.Tollin, J.C.Fitch, T.E.Meyer, E.A.Berry, and M.A.Cusanovich (2007).
Plasmon waveguide resonance spectroscopic evidence for differential binding of oxidized and reduced Rhodobacter capsulatus cytochrome c2 to the cytochrome bc1 complex mediated by the conformation of the Rieske iron-sulfur protein.
  Biochemistry, 46, 7138-7145.  
17253777 S.Rajagukguk, S.Yang, C.A.Yu, L.Yu, B.Durham, and F.Millett (2007).
Effect of mutations in the cytochrome b ef loop on the electron-transfer reactions of the Rieske iron-sulfur protein in the cytochrome bc1 complex.
  Biochemistry, 46, 1791-1798.  
17399709 V.P.Shinkarev, and C.A.Wraight (2007).
Intermonomer electron transfer in the bc1 complex dimer is controlled by the energized state and by impaired electron transfer between low and high potential hemes.
  FEBS Lett, 581, 1535-1541.  
17680808 V.Zara, L.Conte, and B.L.Trumpower (2007).
Identification and characterization of cytochrome bc(1) subcomplexes in mitochondria from yeast with single and double deletions of genes encoding cytochrome bc(1) subunits.
  FEBS J, 274, 4526-4539.  
17848555 Y.R.Chen, C.L.Chen, D.R.Pfeiffer, and J.L.Zweier (2007).
Mitochondrial complex II in the post-ischemic heart: oxidative injury and the role of protein S-glutathionylation.
  J Biol Chem, 282, 32640-32654.  
16624922 C.S.Willett (2006).
Deleterious epistatic interactions between electron transport system protein-coding loci in the copepod Tigriopus californicus.
  Genetics, 173, 1465-1477.  
16844750 E.J.Haddadian, and E.L.Gross (2006).
A Brownian dynamics study of the interactions of the luminal domains of the cytochrome b6f complex with plastocyanin and cytochrome c6: the effects of the Rieske FeS protein on the interactions.
  Biophys J, 91, 2589-2600.  
16551638 E.Schäfer, H.Seelert, N.H.Reifschneider, F.Krause, N.A.Dencher, and J.Vonck (2006).
Architecture of active mammalian respiratory chain supercomplexes.
  J Biol Chem, 281, 15370-15375.  
16586113 F.A.Walker (2006).
The heme environment of mouse neuroglobin: histidine imidazole plane orientations obtained from solution NMR and EPR spectroscopy as compared with X-ray crystallography.
  J Biol Inorg Chem, 11, 391-397.  
17008316 I.Forquer, R.Covian, M.K.Bowman, B.L.Trumpower, and D.M.Kramer (2006).
Similar transition states mediate the Q-cycle and superoxide production by the cytochrome bc1 complex.
  J Biol Chem, 281, 38459-38465.  
16987314 J.Bachmann, B.Bauer, K.Zwicker, B.Ludwig, and O.Anderka (2006).
The Rieske protein from Paracoccus denitrificans is inserted into the cytoplasmic membrane by the twin-arginine translocase.
  FEBS J, 273, 4817-4830.  
16352458 J.L.Cape, M.K.Bowman, and D.M.Kramer (2006).
Understanding the cytochrome bc complexes by what they don't do. The Q-cycle at 30.
  Trends Plant Sci, 11, 46-55.  
16371475 J.Yan, G.Kurisu, and W.A.Cramer (2006).
Intraprotein transfer of the quinone analogue inhibitor 2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone in the cytochrome b6f complex.
  Proc Natl Acad Sci U S A, 103, 69-74.
PDB code: 2d2c
17050691 J.Zhang, F.E.Frerman, and J.J.Kim (2006).
Structure of electron transfer flavoprotein-ubiquinone oxidoreductase and electron transfer to the mitochondrial ubiquinone pool.
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PDB codes: 2gmh 2gmj
16924113 L.Esser, X.Gong, S.Yang, L.Yu, C.A.Yu, and D.Xia (2006).
Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex.
  Proc Natl Acad Sci U S A, 103, 13045-13050.
PDB codes: 2fyn 2fyu
16908520 R.Covian, and B.L.Trumpower (2006).
Regulatory interactions between ubiquinol oxidation and ubiquinone reduction sites in the dimeric cytochrome bc1 complex.
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16391778 S.Balakumar, P.Thanasekaran, E.Rajkumar, K.J.Adaikalasamy, S.Rajagopal, R.Ramaraj, T.Rajendran, B.Manimaran, and K.L.Lu (2006).
Micellar catalysis on the electron transfer reactions of iron(III)-polypyridyl complexes with organic sulfides-importance of hydrophobic interactions.
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16504567 T.M.Iverson (2006).
Evolution and unique bioenergetic mechanisms in oxygenic photosynthesis.
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16433558 T.Teschner, L.Yatsunyk, V.Schünemann, H.Paulsen, H.Winkler, C.Hu, W.R.Scheidt, F.A.Walker, and A.X.Trautwein (2006).
Models of the membrane-bound cytochromes: mössbauer spectra of crystalline low-spin ferriheme complexes having axial ligand plane dihedral angles ranging from 0 degree to 90 degrees.
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16756511 W.A.Cramer, H.Zhang, J.Yan, G.Kurisu, and J.L.Smith (2006).
Transmembrane traffic in the cytochrome b6f complex.
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16172928 A.J.Watson, A.V.Hughes, P.K.Fyfe, M.C.Wakeham, K.Holden-Dye, P.Heathcote, and M.R.Jones (2005).
On the role of basic residues in adapting the reaction centre-LH1 complex for growth at elevated temperatures in purple bacteria.
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15817393 A.Osyczka, C.C.Moser, and P.L.Dutton (2005).
Fixing the Q cycle.
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15807660 A.Y.Andreyev, Y.E.Kushnareva, and A.A.Starkov (2005).
Mitochondrial metabolism of reactive oxygen species.
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15878858 B.Gurung, L.Yu, D.Xia, and C.A.Yu (2005).
The iron-sulfur cluster of the Rieske iron-sulfur protein functions as a proton-exiting gate in the cytochrome bc(1) complex.
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15691836 F.Musiani, A.Dikiy, A.Y.Semenov, and S.Ciurli (2005).
Structure of the intermolecular complex between plastocyanin and cytochrome f from spinach.
  J Biol Chem, 280, 18833-18841.
PDB code: 1ylb
15989954 F.Sun, X.Huo, Y.Zhai, A.Wang, J.Xu, D.Su, M.Bartlam, and Z.Rao (2005).
Crystal structure of mitochondrial respiratory membrane protein complex II.
  Cell, 121, 1043-1057.
PDB codes: 1zoy 1zp0
15746278 H.Leonov, and I.T.Arkin (2005).
A periodicity analysis of transmembrane helices.
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15894632 J.N.Forkey, M.E.Quinlan, and Y.E.Goldman (2005).
Measurement of single macromolecule orientation by total internal reflection fluorescence polarization microscopy.
  Biophys J, 89, 1261-1271.  
16060661 J.W.Cooley, T.Ohnishi, and F.Daldal (2005).
Binding dynamics at the quinone reduction (Qi) site influence the equilibrium interactions of the iron sulfur protein and hydroquinone oxidation (Qo) site of the cytochrome bc1 complex.
  Biochemistry, 44, 10520-10532.  
16024040 L.S.Huang, D.Cobessi, E.Y.Tung, and E.A.Berry (2005).
Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern.
  J Mol Biol, 351, 573-597.
PDB codes: 1pp9 1ppj 2a06
15632120 M.E.Nelson, G.Finazzi, Q.J.Wang, K.A.Middleton-Zarka, J.Whitmarsh, and T.Kallas (2005).
Cytochrome b6 arginine 214 of Synechococcus sp. PCC 7002, a key residue for quinone-reductase site function and turnover of the cytochrome bf complex.
  J Biol Chem, 280, 10395-10402.  
15917236 M.W.Mather, E.Darrouzet, M.Valkova-Valchanova, J.W.Cooley, M.T.McIntosh, F.Daldal, and A.B.Vaidya (2005).
Uncovering the molecular mode of action of the antimalarial drug atovaquone using a bacterial system.
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15778449 N.Dashdorj, H.Zhang, H.Kim, J.Yan, W.A.Cramer, and S.Savikhin (2005).
The single chlorophyll a molecule in the cytochrome b6f complex: unusual optical properties protect the complex against singlet oxygen.
  Biophys J, 88, 4178-4187.  
15937161 O.Zafra, F.Cava, F.Blasco, A.Magalon, and J.Berenguer (2005).
Membrane-associated maturation of the heterotetrameric nitrate reductase of Thermus thermophilus.
  J Bacteriol, 187, 3990-3996.  
15833742 R.Covian, and B.L.Trumpower (2005).
Rapid electron transfer between monomers when the cytochrome bc1 complex dimer is reduced through center N.
  J Biol Chem, 280, 22732-22740.  
15948965 S.Ouchane, W.Nitschke, P.Bianco, A.Vermeglio, and C.Astier (2005).
Multiple Rieske genes in prokaryotes: exchangeable Rieske subunits in the cytochrome bc-complex of Rubrivivax gelatinosus.
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15615714 X.Gong, L.Yu, D.Xia, and C.A.Yu (2005).
Evidence for electron equilibrium between the two hemes bL in the dimeric cytochrome bc1 complex.
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14726526 A.Kounosu, Z.Li, N.J.Cosper, J.E.Shokes, R.A.Scott, T.Imai, A.Urushiyama, and T.Iwasaki (2004).
Engineering a three-cysteine, one-histidine ligand environment into a new hyperthermophilic archaeal Rieske-type [2Fe-2S] ferredoxin from Sulfolobus solfataricus.
  J Biol Chem, 279, 12519-12528.  
14961113 A.Osyczka, C.C.Moser, F.Daldal, and P.L.Dutton (2004).
Reversible redox energy coupling in electron transfer chains.
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14977419 A.R.Crofts (2004).
The cytochrome bc1 complex: function in the context of structure.
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14610094 A.Stroh, O.Anderka, K.Pfeiffer, T.Yagi, M.Finel, B.Ludwig, and H.Schägger (2004).
Assembly of respiratory complexes I, III, and IV into NADH oxidase supercomplex stabilizes complex I in Paracoccus denitrificans.
  J Biol Chem, 279, 5000-5007.  
15316016 C.de Vitry, Y.Ouyang, G.Finazzi, F.A.Wollman, and T.Kallas (2004).
The chloroplast Rieske iron-sulfur protein. At the crossroad of electron transport and signal transduction.
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15060070 D.Ghibaudo, L.Cohen, F.Penin, and A.Martin (2004).
Characterization of GB virus B polyprotein processing reveals the existence of a novel 13-kDa protein with partial homology to hepatitis C virus p7 protein.
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15542678 D.Moradpour, V.Brass, E.Bieck, P.Friebe, R.Gosert, H.E.Blum, R.Bartenschlager, F.Penin, and V.Lohmann (2004).
Membrane association of the RNA-dependent RNA polymerase is essential for hepatitis C virus RNA replication.
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15262969 D.Schneider, S.Berry, T.Volkmer, A.Seidler, and M.Rögner (2004).
PetC1 is the major Rieske iron-sulfur protein in the cytochrome b6f complex of Synechocystis sp. PCC 6803.
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14670947 E.B.Gutierrez-Cirlos, T.Merbitz-Zahradnik, and B.L.Trumpower (2004).
Inhibition of the yeast cytochrome bc1 complex by ilicicolin H, a novel inhibitor that acts at the Qn site of the bc1 complex.
  J Biol Chem, 279, 8708-8714.  
15208315 E.D.Garcin, C.M.Bruns, S.J.Lloyd, D.J.Hosfield, M.Tiso, R.Gachhui, D.J.Stuehr, J.A.Tainer, and E.D.Getzoff (2004).
Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase.
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PDB code: 1tll
15591339 F.Baymann, E.Lebrun, and W.Nitschke (2004).
Mitochondrial cytochrome c1 is a collapsed di-heme cytochrome.
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15317809 F.L.Muller, Y.Liu, and H.Van Remmen (2004).
Complex III releases superoxide to both sides of the inner mitochondrial membrane.
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15039445 G.Brasseur, D.Lemesle-Meunier, F.Reinaud, and B.Meunier (2004).
QO site deficiency can be compensated by extragenic mutations in the hinge region of the iron-sulfur protein in the bc1 complex of Saccharomyces cerevisiae.
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15159392 H.S.Toogood, A.van Thiel, J.Basran, M.J.Sutcliffe, N.S.Scrutton, and D.Leys (2004).
Extensive domain motion and electron transfer in the human electron transferring flavoprotein.medium chain Acyl-CoA dehydrogenase complex.
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PDB code: 1t9g
15313237 J.L.Smith, H.Zhang, J.Yan, G.Kurisu, and W.A.Cramer (2004).
Cytochrome bc complexes: a common core of structure and function surrounded by diversity in the outlying provinces.
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15364912 J.S.Armstrong, H.Yang, W.Duan, and M.Whiteman (2004).
Cytochrome bc(1) regulates the mitochondrial permeability transition by two distinct pathways.
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15304252 M.D.Brand, C.Affourtit, T.C.Esteves, K.Green, A.J.Lambert, S.Miwa, J.L.Pakay, and N.Parker (2004).
Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins.
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15569093 M.E.Harper, L.Bevilacqua, K.Hagopian, R.Weindruch, and J.J.Ramsey (2004).
Ageing, oxidative stress, and mitochondrial uncoupling.
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15116357 M.Lei, M.I.Zavodszky, L.A.Kuhn, and M.F.Thorpe (2004).
Sampling protein conformations and pathways.
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15153117 N.Fisher, A.C.Brown, G.Sexton, A.Cook, J.Windass, and B.Meunier (2004).
Modeling the Qo site of crop pathogens in Saccharomyces cerevisiae cytochrome b.
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15573135 N.Nelson, and A.Ben-Shem (2004).
The complex architecture of oxygenic photosynthesis.
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15122630 P.Jeschke (2004).
The unique role of fluorine in the design of active ingredients for modern crop protection.
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14761953 R.Covian, E.B.Gutierrez-Cirlos, and B.L.Trumpower (2004).
Anti-cooperative oxidation of ubiquinol by the yeast cytochrome bc1 complex.
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15272185 T.Uchiyama, A.Kounosu, T.Sato, N.Tanaka, T.Iwasaki, and T.Kumasaka (2004).
Crystallization and preliminary X-ray diffraction studies of the hyperthermophilic archaeal sulredoxin having the unique Rieske [2Fe-2S] cluster environment.
  Acta Crystallogr D Biol Crystallogr, 60, 1487-1489.  
15009199 V.Zara, I.Palmisano, L.Conte, and B.L.Trumpower (2004).
Further insights into the assembly of the yeast cytochrome bc1 complex based on analysis of single and double deletion mutants lacking supernumerary subunits and cytochrome b.
  Eur J Biochem, 271, 1209-1218.  
12829696 A.R.Crofts, V.P.Shinkarev, D.R.Kolling, and S.Hong (2003).
The modified Q-cycle explains the apparent mismatch between the kinetics of reduction of cytochromes c1 and bH in the bc1 complex.
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12915488 C.Gissi, and G.Pesole (2003).
Transcript mapping and genome annotation of ascidian mtDNA using EST data.
  Genome Res, 13, 2203-2212.  
12567183 D.Leys, J.Basran, F.Talfournier, M.J.Sutcliffe, and N.S.Scrutton (2003).
Extensive conformational sampling in a ternary electron transfer complex.
  Nat Struct Biol, 10, 219-225.
PDB codes: 1o94 1o95 1o96 1o97
12874282 D.R.Kolling, R.I.Samoilova, J.T.Holland, E.A.Berry, S.A.Dikanov, and A.R.Crofts (2003).
Exploration of ligands to the Qi site semiquinone in the bc1 complex using high-resolution EPR.
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14647374 D.Stroebel, Y.Choquet, J.L.Popot, and D.Picot (2003).
An atypical haem in the cytochrome b(6)f complex.
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PDB code: 1q90
12560322 E.C.Slater, D.Keilin, and E.C.Slater (2003).
Keilin, cytochrome, and the respiratory chain.
  J Biol Chem, 278, 16455-16461.  
12626117 E.M.Aro, and I.Ohad (2003).
Redox regulation of thylakoid protein phosphorylation.
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14507738 F.Francia, G.Palazzo, A.Mallardi, L.Cordone, and G.Venturoli (2003).
Residual water modulates QA- -to-QB electron transfer in bacterial reaction centers embedded in trehalose amorphous matrices.
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14526088 G.Kurisu, H.Zhang, J.L.Smith, and W.A.Cramer (2003).
Structure of the cytochrome b6f complex of oxygenic photosynthesis: tuning the cavity.
  Science, 302, 1009-1014.
PDB codes: 1um3 1vf5
12782631 H.Palsdottir, C.G.Lojero, B.L.Trumpower, and C.Hunte (2003).
Structure of the yeast cytochrome bc1 complex with a hydroxyquinone anion Qo site inhibitor bound.
  J Biol Chem, 278, 31303-31311.
PDB code: 1p84
12702760 H.Zhang, G.Kurisu, J.L.Smith, and W.A.Cramer (2003).
A defined protein-detergent-lipid complex for crystallization of integral membrane proteins: The cytochrome b6f complex of oxygenic photosynthesis.
  Proc Natl Acad Sci U S A, 100, 5160-5163.  
12829278 I.Schröder, E.Johnson, and S.de Vries (2003).
Microbial ferric iron reductases.
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12949071 J.S.Armstrong, M.Whiteman, P.Rose, and D.P.Jones (2003).
The Coenzyme Q10 analog decylubiquinone inhibits the redox-activated mitochondrial permeability transition: role of mitcohondrial [correction mitochondrial] complex III.
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12672829 J.Yan, and W.A.Cramer (2003).
Functional insensitivity of the cytochrome b6f complex to structure changes in the hinge region of the Rieske iron-sulfur protein.
  J Biol Chem, 278, 20925-20933.  
12525495 K.Xiao, G.Engstrom, S.Rajagukguk, C.A.Yu, L.Yu, B.Durham, and F.Millett (2003).
Effect of famoxadone on photoinduced electron transfer between the iron-sulfur center and cytochrome c1 in the cytochrome bc1 complex.
  J Biol Chem, 278, 11419-11426.  
14567700 M.Ritter, O.Anderka, B.Ludwig, W.Mäntele, and P.Hellwig (2003).
Electrochemical and FTIR spectroscopic characterization of the cytochrome bc1 complex from Paracoccus denitrificans: evidence for protonation reactions coupled to quinone binding.
  Biochemistry, 42, 12391-12399.  
12829500 M.T.Facciotti, V.S.Cheung, D.Nguyen, S.Rouhani, and R.M.Glaeser (2003).
Crystal structure of the bromide-bound D85S mutant of bacteriorhodopsin: principles of ion pumping.
  Biophys J, 85, 451-458.
PDB code: 1mgy
14556858 S.Miwa, J.St-Pierre, L.Partridge, and M.D.Brand (2003).
Superoxide and hydrogen peroxide production by Drosophila mitochondria.
  Free Radic Biol Med, 35, 938-948.  
14567701 Y.Zu, M.M.Couture, D.R.Kolling, A.R.Crofts, L.D.Eltis, J.A.Fee, and J.Hirst (2003).
Reduction potentials of Rieske clusters: importance of the coupling between oxidation state and histidine protonation state.
  Biochemistry, 42, 12400-12408.  
11900550 A.G.Roberts, M.K.Bowman, and D.M.Kramer (2002).
Certain metal ions are inhibitors of cytochrome b6f complex 'Rieske' iron-sulfur protein domain movements.
  Biochemistry, 41, 4070-4079.  
11880631 C.Lange, and C.Hunte (2002).
Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c.
  Proc Natl Acad Sci U S A, 99, 2800-2805.
PDB code: 1kyo
12377760 E.B.Gutierrez-Cirlos, T.Merbitz-Zahradnik, and B.L.Trumpower (2002).
Failure to insert the iron-sulfur cluster into the Rieske iron-sulfur protein impairs both center N and center P of the cytochrome bc1 complex.
  J Biol Chem, 277, 50703-50709.  
11796719 F.Zito, J.Vinh, J.L.Popot, and G.Finazzi (2002).
Chimeric fusions of subunit IV and PetL in the b6f complex of Chlamydomonas reinhardtii: structural implications and consequences on state transitions.
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12045199 G.Engstrom, K.Xiao, C.A.Yu, L.Yu, B.Durham, and F.Millett (2002).
Photoinduced electron transfer between the Rieske iron-sulfur protein and cytochrome c(1) in the Rhodobacter sphaeroides cytochrome bc(1) complex. Effects of pH, temperature, and driving force.
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12044181 G.Finazzi (2002).
Redox-coupled proton pumping activity in cytochrome b6f, as evidenced by the pH dependence of electron transfer in whole cells of Chlamydomonas reinhardtii.
  Biochemistry, 41, 7475-7482.  
12207018 G.M.Soriano, L.W.Guo, C.De Vitry, T.Kallas, and W.A.Cramer (2002).
Electron transfer from the Rieske iron-sulfur protein (ISP) to cytochrome f in vitro. Is a guided trajectory of the ISP necessary for competent docking?
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12237311 J.St-Pierre, J.A.Buckingham, S.J.Roebuck, and M.D.Brand (2002).
Topology of superoxide production from different sites in the mitochondrial electron transport chain.
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12454467 M.A.Rosenow, C.L.Magee, J.C.Williams, and J.P.Allen (2002).
The influence of detergents on the solubility of membrane proteins.
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11756429 M.Jones, F.Talfournier, A.Bobrov, J.G.Grossmann, N.Vekshin, M.J.Sutcliffe, and N.S.Scrutton (2002).
Electron transfer and conformational change in complexes of trimethylamine dehydrogenase and electron transferring flavoprotein.
  J Biol Chem, 277, 8457-8465.  
12438637 N.Ivashkina, B.Wölk, V.Lohmann, R.Bartenschlager, H.E.Blum, F.Penin, and D.Moradpour (2002).
The hepatitis C virus RNA-dependent RNA polymerase membrane insertion sequence is a transmembrane segment.
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11748214 R.I.Samoilova, D.Kolling, T.Uzawa, T.Iwasaki, A.R.Crofts, and S.A.Dikanov (2002).
The interaction of the Rieske iron-sulfur protein with occupants of the Qo-site of the bc1 complex, probed by electron spin echo envelope modulation.
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12081951 S.Ouchane, I.Agalidis, and C.Astier (2002).
Natural resistance to inhibitors of the ubiquinol cytochrome c oxidoreductase of Rubrivivax gelatinosus: sequence and functional analysis of the cytochrome bc(1) complex.
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11850430 T.M.Iverson, C.Luna-Chavez, L.R.Croal, G.Cecchini, and D.C.Rees (2002).
Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site.
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PDB codes: 1kf6 1kfy 1l0v
12384503 Y.Saint-Georges, N.Bonnefoy, J.P.di Rago, S.Chiron, and G.Dujardin (2002).
A pathogenic cytochrome b mutation reveals new interactions between subunits of the mitochondrial bc1 complex.
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12057198 Z.W.Chen, K.Matsushita, T.Yamashita, T.A.Fujii, H.Toyama, O.Adachi, H.D.Bellamy, and F.S.Mathews (2002).
Structure at 1.9 A resolution of a quinohemoprotein alcohol dehydrogenase from Pseudomonas putida HK5.
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PDB code: 1kv9
11526320 A.Camara-Artigas, C.L.Magee, J.C.Williams, and J.P.Allen (2001).
Individual interactions influence the crystalline order for membrane proteins.
  Acta Crystallogr D Biol Crystallogr, 57, 1281-1286.
PDB codes: 1jgw 1jgx 1jgy 1jgz 1jh0
11331012 A.M.Grosset, B.R.Gibney, F.Rabanal, C.C.Moser, and P.L.Dutton (2001).
Proof of principle in a de novo designed protein maquette: an allosterically regulated, charge-activated conformational switch in a tetra-alpha-helix bundle.
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11340051 B.E.Schultz, and S.I.Chan (2001).
Structures and proton-pumping strategies of mitochondrial respiratory enzymes.
  Annu Rev Biophys Biomol Struct, 30, 23-65.  
11726495 C.Lange, J.H.Nett, B.L.Trumpower, and C.Hunte (2001).
Specific roles of protein-phospholipid interactions in the yeast cytochrome bc1 complex structure.
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PDB code: 1kb9
11440857 E.Darrouzet, C.C.Moser, P.L.Dutton, and F.Daldal (2001).
Large scale domain movement in cytochrome bc(1): a new device for electron transfer in proteins.
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11447103 F.A.Wollman (2001).
State transitions reveal the dynamics and flexibility of the photosynthetic apparatus.
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11698372 J.A.Zahn, D.J.Bergmann, J.M.Boyd, R.C.Kunz, and A.A.DiSpirito (2001).
Membrane-associated quinoprotein formaldehyde dehydrogenase from Methylococcus capsulatus Bath.
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11329288 J.E.McLean, E.A.Neidhardt, T.H.Grossman, and L.Hedstrom (2001).
Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase.
  Biochemistry, 40, 2194-2200.  
11435171 J.F.Allen, and J.Forsberg (2001).
Molecular recognition in thylakoid structure and function.
  Trends Plant Sci, 6, 317-326.  
11562368 K.Xiao, A.Chandrasekaran, L.Yu, and C.A.Yu (2001).
Evidence for the intertwined dimer of the cytochrome bc(1) complex in solution.
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11334619 M.B.Ulmschneider, and M.S.Sansom (2001).
Amino acid distributions in integral membrane protein structures.
  Biochim Biophys Acta, 1512, 1.  
11148026 M.Ghosh, Y.Wang, C.E.Ebert, S.Vadlamuri, and D.S.Beattie (2001).
Substituting leucine for alanine-86 in the tether region of the iron-sulfur protein of the cytochrome bc1 complex affects the mobility of the [2Fe2S] domain.
  Biochemistry, 40, 327-335.  
11231266 N.Fisher, and B.Meunier (2001).
Effects of mutations in mitochondrial cytochrome b in yeast and man. Deficiency, compensation and disease.
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11722564 R.Covián, and R.Moreno-Sánchez (2001).
Role of protonatable groups of bovine heart bc(1) complex in ubiquinol binding and oxidation.
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11746826 R.J.Bienstock, and J.C.Barrett (2001).
KAI1, a prostate metastasis suppressor: prediction of solvated structure and interactions with binding partners; integrins, cadherins, and cell-surface receptor proteins.
  Mol Carcinog, 32, 139-153.  
11468350 S.Dastmalchi, M.B.Morris, and W.B.Church (2001).
Modeling of the structural features of integral-membrane proteins reverse-environment prediction of integral membrane protein structure (REPIMPS).
  Protein Sci, 10, 1529-1538.  
11714918 T.J.Stevens, and I.T.Arkin (2001).
Substitution rates in alpha-helical transmembrane proteins.
  Protein Sci, 10, 2507-2517.  
11245788 T.Lee, S.U.Metzger, Y.S.Cho, J.Whitmarsh, and T.Kallas (2001).
Modification of inhibitor binding sites in the cytochrome bf complex by directed mutagenesis of cytochrome b(6) in Synechococcus sp. PCC 7002.
  Biochim Biophys Acta, 1504, 235-247.  
11722777 Y.Munekage, S.Takeda, T.Endo, P.Jahns, T.Hashimoto, and T.Shikanai (2001).
Cytochrome b(6)f mutation specifically affects thermal dissipation of absorbed light energy in Arabidopsis.
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10632705 A.Kapazoglou, R.M.Mould, and J.C.Gray (2000).
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10715139 A.V.Veselov, J.P.Osborne, R.B.Gennis, and C.P.Scholes (2000).
Q-band ENDOR (electron nuclear double resonance) of the high-affinity ubisemiquinone center in cytochrome bo3 from Escherichia coli.
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10727220 B.K.Rao, A.M.Tyryshkin, A.G.Roberts, M.K.Bowman, and D.M.Kramer (2000).
Inhibitory copper binding site on the spinach cytochrome b6f complex: implications for Qo site catalysis.
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10681499 B.Schoepp, E.Chabaud, C.Breyton, A.Verméglio, and J.L.Popot (2000).
On the spatial organization of hemes and chlorophyll in cytochrome b(6)f. A linear and circular dichroism study.
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Relative orientation of the hemes of the cytochrome bc(1) complexes from Rhodobacter sphaeroides, Rhodospirillum rubrum, and beef heart mitochondria. A linear dichroism study.
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Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment.
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11074596 C.M.Perks, C.McCaig, and J.M.Holly (2000).
Differential insulin-like growth factor (IGF)-independent interactions of IGF binding protein-3 and IGF binding protein-5 on apoptosis in human breast cancer cells. Involvement of the mitochondria.
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10632712 C.Schwarze, A.V.Carluccio, G.Venturoli, and A.Labahn (2000).
Photo-induced cyclic electron transfer involving cytochrome bc1 complex and reaction center in the obligate aerobic phototroph Roseobacter denitrificans.
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11106766 D.A.Berthold, M.E.Andersson, and P.Nordlund (2000).
New insight into the structure and function of the alternative oxidase.
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10966481 E.A.Berry, M.Guergova-Kuras, L.S.Huang, and A.R.Crofts (2000).
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11004461 E.A.Berry, Z.Zhang, H.D.Bellamy, and L.Huang (2000).
Crystallographic location of two Zn(2+)-binding sites in the avian cytochrome bc(1) complex.
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PDB code: 3h1k
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Uncovering the [2Fe2S] domain movement in cytochrome bc1 and its implications for energy conversion.
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Probing the role of the Fe-S subunit hinge region during Q(o) site catalysis in Rhodobacter capsulatus bc(1) complex.
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10734109 H.Tian, R.Sadoski, L.Zhang, C.A.Yu, L.Yu, B.Durham, and F.Millett (2000).
Definition of the interaction domain for cytochrome c on the cytochrome bc(1) complex. Steady-state and rapid kinetic analysis of electron transfer between cytochrome c and Rhodobacter sphaeroides cytochrome bc(1) surface mutants.
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10837495 J.Illerhaus, L.Altschmied, J.Reichert, E.Zak, R.G.Herrmann, and W.Haehnel (2000).
Dynamic interaction of plastocyanin with the cytochrome bf complex.
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10966478 J.L.Popot, and D.M.Engelman (2000).
Helical membrane protein folding, stability, and evolution.
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11101297 J.M.Shifman, B.R.Gibney, R.E.Sharp, and P.L.Dutton (2000).
Heme redox potential control in de novo designed four-alpha-helix bundle proteins.
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10627300 K.C.Hansen, B.E.Schultz, G.Wang, and S.I.Chan (2000).
Reaction of Escherichia coli cytochrome bo(3) and mitochondrial cytochrome bc(1) with a photoreleasable decylubiquinol.
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11112550 K.Kobayashi, S.Tagawa, and T.Mogi (2000).
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10852722 L.A.Sazanov, S.Y.Peak-Chew, I.M.Fearnley, and J.E.Walker (2000).
Resolution of the membrane domain of bovine complex I into subcomplexes: implications for the structural organization of the enzyme.
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10713075 L.Zhang, C.H.Tai, L.Yu, and C.A.Yu (2000).
pH-induced intramolecular electron transfer between the iron-sulfur protein and cytochrome c(1) in bovine cytochrome bc(1) complex.
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A spectroscopic method for observing the domain movement of the Rieske iron-sulfur protein.
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10823938 M.Eilers, S.C.Shekar, T.Shieh, S.O.Smith, and P.J.Fleming (2000).
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10858292 M.Guergova-Kuras, R.Kuras, N.Ugulava, I.Hadad, and A.R.Crofts (2000).
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11093219 M.H.Huynh, P.S.White, and T.J.Meyer (2000).
Proton-Coupled Electron Transfer from Sulfur: A S-H/S-D Kinetic Isotope Effect of >/=31.1 We are grateful to the U.S. Department of Energy for financial support.
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10898682 M.Korsinczky, N.Chen, B.Kotecka, A.Saul, K.Rieckmann, and Q.Cheng (2000).
Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site.
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11079541 M.Rana, I.de Coo, F.Diaz, H.Smeets, and C.T.Moraes (2000).
An out-of-frame cytochrome b gene deletion from a patient with parkinsonism is associated with impaired complex III assembly and an increase in free radical production.
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11056038 M.Suwa, H.T.Yudate, Y.Masuho, and S.Mitaku (2000).
A novel measure characterized by a polar energy surface approximation for recognition and classification of transmembrane protein structures.
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11112534 M.Valkova-Valchanova, E.Darrouzet, C.R.Moomaw, C.A.Slaughter, and F.Daldal (2000).
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10757970 R.C.Sadoski, G.Engstrom, H.Tian, L.Zhang, C.A.Yu, L.Yu, B.Durham, and F.Millett (2000).
Use of a photoactivated ruthenium dimer complex to measure electron transfer between the Rieske iron-sulfur protein and cytochrome c(1) in the cytochrome bc(1) complex.
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10861933 S.Jiang, and I.A.Vakser (2000).
Side chains in transmembrane helices are shorter at helix-helix interfaces.
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10848994 S.Rodgers, C.Moser, M.Martinez-Julvez, and I.Sinning (2000).
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10981634 T.M.Iverson, C.Luna-Chavez, I.Schröder, G.Cecchini, and D.C.Rees (2000).
Analyzing your complexes: structure of the quinol-fumarate reductase respiratory complex.
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Simple redox-linked proton-transfer design: new insights from structures of quinol-fumarate reductase.
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10733991 U.A.van der Heide, S.C.Hopkins, and Y.E.Goldman (2000).
A maximum entropy analysis of protein orientations using fluorescence polarization data from multiple probes.
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10692548 V.H.Obungu, Y.Wang, S.M.Amyot, C.B.Gocke, and D.S.Beattie (2000).
Mutations in the tether region of the iron-sulfur protein affect the activity and assembly of the cytochrome bc(1) complex of yeast mitochondria.
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11123950 V.P.Shinkarev, N.B.Ugulava, A.R.Crofts, and C.A.Wraight (2000).
DCCD inhibits the reactions of the iron-sulfur protein in Rhodobacter sphaeroides chromatophores.
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11087372 V.P.Shinkarev, N.B.Ugulava, E.Takahashi, A.R.Crofts, and C.A.Wraight (2000).
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10869174 Y.I.Chi, L.S.Huang, Z.Zhang, J.G.Fernández-Velasco, and E.A.Berry (2000).
X-ray structure of a truncated form of cytochrome f from chlamydomonas reinhardtii.
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Ubiquinol:cytochrome c oxidoreductase. Effects of inhibitors on reverse electron transfer from the iron-sulfur protein to cytochrome b.
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Pathways for proton release during ubihydroquinone oxidation by the bc(1) complex.
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An engineered cytochrome b6c1 complex with a split cytochrome b is able to support photosynthetic growth of Rhodobacter capsulatus.
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10413476 B.Gomez, and N.C.Robinson (1999).
Phospholipase digestion of bound cardiolipin reversibly inactivates bovine cytochrome bc1.
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Histidine placement in de novo-designed heme proteins.
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Structure and reaction mechanisms of multifunctional mitochondrial cytochrome bc1 complex.
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Ubiquinone at center N is responsible for triphasic reduction of cytochrome b in the cytochrome bc(1) complex.
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9927413 C.Jungas, J.L.Ranck, J.L.Rigaud, P.Joliot, and A.Verméglio (1999).
Supramolecular organization of the photosynthetic apparatus of Rhodobacter sphaeroides.
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10508156 C.M.Cruciat, K.Hell, H.Fölsch, W.Neupert, and R.A.Stuart (1999).
Bcs1p, an AAA-family member, is a chaperone for the assembly of the cytochrome bc(1) complex.
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10433117 C.de Vitry, and O.Vallon (1999).
Mutants of Chlamydomonas: tools to study thylakoid membrane structure, function and biogenesis.
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10387032 E.Darrouzet, S.Mandaci, J.Li, H.Qin, D.B.Knaff, and F.Daldal (1999).
Substitution of the sixth axial ligand of Rhodobacter capsulatus cytochrome c1 heme yields novel cytochrome c1 variants with unusual properties.
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10082948 F.Gao, H.Qin, D.B.Knaff, L.Zhang, L.Yu, C.A.Yu, K.A.Gray, F.Daldal, and M.R.Ondrias (1999).
Q-Band resonance Raman investigation of turnip cytochrome f and Rhodobacter capsulatus cytochrome c1.
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10357809 F.Zito, G.Finazzi, R.Delosme, W.Nitschke, D.Picot, and F.A.Wollman (1999).
The Qo site of cytochrome b6f complexes controls the activation of the LHCII kinase.
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The cytochrome bc1 complex from Rhodovulum sulfidophilum is a dimer with six quinones per monomer and an additional 6-kDa component.
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  10477309 G.Schäfer, M.Engelhard, and V.Müller (1999).
Bioenergetics of the Archaea.
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10066773 H.Tian, S.White, L.Yu, and C.A.Yu (1999).
Evidence for the head domain movement of the rieske iron-sulfur protein in electron transfer reaction of the cytochrome bc1 complex.
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9880536 H.Zhang, D.Huang, and W.A.Cramer (1999).
Stoichiometrically bound beta-carotene in the cytochrome b6f complex of oxygenic photosynthesis protects against oxygen damage.
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10447880 I.K.Srivastava, J.M.Morrisey, E.Darrouzet, F.Daldal, and A.B.Vaidya (1999).
Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites.
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9915790 J.G.Okun, P.Lümmen, and U.Brandt (1999).
Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase).
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10092599 J.H.Nett, and B.L.Trumpower (1999).
Intermediate length Rieske iron-sulfur protein is present and functionally active in the cytochrome bc1 complex of Saccharomyces cerevisiae.
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10404600 J.Lubkowski, F.Hennecke, A.Plückthun, and A.Wlodawer (1999).
Filamentous phage infection: crystal structure of g3p in complex with its coreceptor, the C-terminal domain of TolA.
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Helix-bundle membrane protein fold templates.
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10611277 K.E.McAuley, P.K.Fyfe, J.P.Ridge, N.W.Isaacs, R.J.Cogdell, and M.R.Jones (1999).
Structural details of an interaction between cardiolipin and an integral membrane protein.
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PDB code: 1qov
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Thermolysin and mitochondrial processing peptidase: how far structure-functional convergence goes.
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10358018 M.Brugna, W.Nitschke, M.Asso, B.Guigliarelli, D.Lemesle-Meunier, and C.Schmidt (1999).
Redox components of cytochrome bc-type enzymes in acidophilic prokaryotes. II. The Rieske protein of phylogenetically distant acidophilic organisms.
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9930987 M.M.Pereira, J.N.Carita, and M.Teixeira (1999).
Membrane-bound electron transfer chain of the thermohalophilic bacterium Rhodothermus marinus: a novel multihemic cytochrome bc, a new complex III.
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10409625 M.R.de Planque, J.A.Kruijtzer, R.M.Liskamp, D.Marsh, D.V.Greathouse, R.E.Koeppe, B.de Kruijff, and J.A.Killian (1999).
Different membrane anchoring positions of tryptophan and lysine in synthetic transmembrane alpha-helical peptides.
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10066163 M.Saraste (1999).
Oxidative phosphorylation at the fin de siècle.
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Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 A resolution.
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Ubiquinone binding capacity of the Rhodobacter capsulatus cytochrome bc1 complex: effect of diphenylamine, a weak binding QO site inhibitor.
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10555979 R.E.Sharp, B.R.Gibney, A.Palmitessa, J.L.White, J.A.Dixon, C.C.Moser, F.Daldal, and P.L.Dutton (1999).
Effect of inhibitors on the ubiquinone binding capacity of the primary energy conversion site in the Rhodobacter capsulatus cytochrome bc(1) complex.
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10410805 S.H.White, and W.C.Wimley (1999).
Membrane protein folding and stability: physical principles.
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10567355 S.Hong, N.Ugulava, M.Guergova-Kuras, and A.R.Crofts (1999).
The energy landscape for ubihydroquinone oxidation at the Q(o) site of the bc(1) complex in Rhodobacter sphaeroides.
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10512801 S.Izrailev, A.R.Crofts, E.A.Berry, and K.Schulten (1999).
Steered molecular dynamics simulation of the Rieske subunit motion in the cytochrome bc(1) complex.
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10491129 S.van Wilpe, H.Boumans, G.Lobo-Hajdu, L.A.Grivell, and J.A.Berden (1999).
Functional complementation analysis of yeast bc1 mutants. A study of the mitochondrial import of heterologous and hybrid proteins.
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10373012 T.J.Stevens, and I.T.Arkin (1999).
Are membrane proteins "inside-out" proteins?
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10373108 T.M.Iverson, C.Luna-Chavez, G.Cecchini, and D.C.Rees (1999).
Structure of the Escherichia coli fumarate reductase respiratory complex.
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PDB code: 1fum
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Proton translocation in the respiratory chain involving ubiquinone--a hypothetical semiquinone switch mechanism for complex I.
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10413471 V.Schünemann, A.X.Trautwein, J.Illerhaus, and W.Haehnel (1999).
Mössbauer and electron paramagnetic resonance studies of the cytochrome bf complex.
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Energy transduction function of the quinone reactions in cytochrome bc complexes.
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Structure and function of the cytochrome bc1 complex of mitochondria and photosynthetic bacteria.
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Interactions between the cytochrome b, cytochrome c1, and Fe-S protein subunits at the ubihydroquinone oxidation site of the bc1 complex of Rhodobacter capsulatus.
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Protein phosphorylation and redox sensing in chloroplast thylakoids.
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Glu78, from the conserved PEWY sequence of subunit IV, has a key function in cytochrome b6f turnover.
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Inhibitor binding changes domain mobility in the iron-sulfur protein of the mitochondrial bc1 complex from bovine heart.
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Membrane-bound cytochrome cz couples quinol oxidoreductase to the P840 reaction center complex in isolated membranes of the green sulfur bacterium Chlorobium tepidum.
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Flexibility of the neck region of the rieske iron-sulfur protein is functionally important in the cytochrome bc1 complex.
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Large unit cells and cellular mechanics.
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Functionalized de novo designed proteins: mechanism of proton coupling to oxidation/reduction in heme protein maquettes.
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Isolation and characterization of a two-subunit cytochrome b-c1 subcomplex from Rhodobacter capsulatus and reconstitution of its ubihydroquinone oxidation (Qo) site with purified Fe-S protein subunit.
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Diversity of cytochrome bc complexes: example of the Rieske protein in green sulfur bacteria.
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Chlamydomonas genetics, a tool for the study of bioenergetic pathways.
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Conformational gating of the electron transfer reaction QA-.QB --> QAQB-. in bacterial reaction centers of Rhodobacter sphaeroides determined by a driving force assay.
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Perturbation of the internal water chain in cytochrome f of oxygenic photosynthesis: loss of the concerted reduction of cytochromes f and b6.
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In vivo analysis of the effect of dicyclohexylcarbodiimide on electron and proton transfers in cytochrome bf complex of Chlorella sorokiniana.
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Steps toward constructing a cytochrome b6 f complex in the purple bacterium Rhodobacter sphaeroides: an example of the structural plasticity of a membrane cytochrome.
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Membrane protein structures: the known world expands.
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Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex.
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PDB codes: 1be3 1bgy
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On the mechanism of quinol oxidation in the bc1 complex.
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9693740 U.Brandt (1998).
The chemistry and mechanics of ubihydroquinone oxidation at center P (Qo) of the cytochrome bc1 complex.
  Biochim Biophys Acta, 1365, 261-268.  
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