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Contents |
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442 a.a.
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406 a.a.
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379 a.a.
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241 a.a.
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196 a.a.
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100 a.a.
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78 a.a.
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66 a.a.
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33 a.a.
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59 a.a.
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* Residue conservation analysis
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PDB id:
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| Name: |
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Oxidoreductase
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Title:
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Cytochrome bc1 complex from chicken
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Structure:
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Ubiquinol cytochromE C oxidoreductase. Chain: a. Synonym: cytochrome bc1 complex, complex iii. Other_details: model includes ubiquinone and phospholipids. Ubiquinol cytochromE C oxidoreductase. Chain: b. Synonym: cytochrome bc1 complex, complex iii. Other_details: model includes ubiquinone and phospholipids. Ubiquinol cytochromE C oxidoreductase.
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Source:
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Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Tissue: muscle. Organelle: mitochondria. Cellular_location: mitochondrial inner membrane. Other_details: isolated from natural heart muscle tissue. Other_details: isolated from natural heart muscle tissue
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Biol. unit:
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Dimer (from PDB file)
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Resolution:
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3.16Å
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R-factor:
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0.270
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R-free:
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0.310
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Authors:
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Z.Zhang,L.Huang,V.M.Shulmeister,Y.-I.Chi,K.K.Kim,L.-W.Hung, A.R.Crofts,E.A.Berry,S.-H.Kim
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Key ref:
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Z.Zhang
et al.
(1998).
Electron transfer by domain movement in cytochrome bc1.
Nature,
392,
677-684.
PubMed id:
DOI:
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Date:
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23-Mar-98
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Release date:
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19-Aug-98
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PROCHECK
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Headers
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References
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P31800
(QCR1_BOVIN) -
Cytochrome b-c1 complex subunit 1, mitochondrial
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Seq:
Struc:
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480 a.a.
442 a.a.*
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P23004
(QCR2_BOVIN) -
Cytochrome b-c1 complex subunit 2, mitochondrial
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Seq:
Struc:
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453 a.a.
406 a.a.*
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P18946
(CYB_CHICK) -
Cytochrome b
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Seq:
Struc:
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380 a.a.
379 a.a.
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P00125
(CY1_BOVIN) -
Cytochrome c1, heme protein, mitochondrial
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Seq:
Struc:
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325 a.a.
241 a.a.*
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P13272
(UCRI_BOVIN) -
Cytochrome b-c1 complex subunit Rieske, mitochondrial
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Seq:
Struc:
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274 a.a.
196 a.a.*
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P00129
(QCR7_BOVIN) -
Cytochrome b-c1 complex subunit 7
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Seq:
Struc:
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111 a.a.
100 a.a.*
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P13271
(QCR8_BOVIN) -
Cytochrome b-c1 complex subunit 8
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Seq:
Struc:
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82 a.a.
78 a.a.*
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P00126
(QCR6_BOVIN) -
Cytochrome b-c1 complex subunit 6, mitochondrial
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Seq:
Struc:
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91 a.a.
66 a.a.*
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Enzyme class:
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Chain E:
E.C.1.10.2.2
- Ubiquinol--cytochrome-c reductase.
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Reaction:
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QH2 + 2 ferricytochrome c = Q + 2 ferrocytochrome c + 2 H+
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QH(2)
Bound ligand (Het Group name = )
matches with 62.50% similarity
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+
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2
×
ferricytochrome c
Bound ligand (Het Group name = )
matches with 63.64% similarity
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=
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Q
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+
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2
×
ferrocytochrome c
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+
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2
×
H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Gene Ontology (GO) functional annotation
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Cellular component
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membrane
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7 terms
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Biological process
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oxidation-reduction process
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14 terms
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Biochemical function
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catalytic activity
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11 terms
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DOI no:
|
Nature
392:677-684
(1998)
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PubMed id:
|
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|
|
|
| |
|
Electron transfer by domain movement in cytochrome bc1.
|
|
Z.Zhang,
L.Huang,
V.M.Shulmeister,
Y.I.Chi,
K.K.Kim,
L.W.Hung,
A.R.Crofts,
E.A.Berry,
S.H.Kim.
|
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| |
ABSTRACT
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| |
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The cytochrome bc1 is one of the three major respiratory enzyme complexes
residing in the inner mitochondrial membrane. Cytochrome bc1 transfers electrons
from ubiquinol to cytochrome c and uses the energy thus released to form an
electrochemical gradient across the inner membrane. Our X-ray crystal structures
of the complex from chicken, cow and rabbit in both the presence and absence of
inhibitors of quinone oxidation, reveal two different locations for the
extrinsic domain of one component of the enzyme, an iron-sulphur protein. One
location is close enough to the supposed quinol oxidation site to allow
reduction of the Fe-S protein by ubiquinol. The other site is close enough to
cytochrome c1 to allow oxidation of the Fe-S protein by the cytochrome. As
neither location will allow both reactions to proceed at a suitable rate, the
reaction mechanism must involve movement of the extrinsic domain of the Fe-S
component in order to shuttle electrons from ubiquinol to cytochrome c1. Such a
mechanism has not previously been observed in redox protein complexes.
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Selected figure(s)
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Figure 3.
Figure 3 Structure of the intermembrane (external surface)
domains of the chicken bc[1] complex. This is viewed from within
the membrane, with the transmembrane helices truncated at
roughly the membrane surface. Ball-and-stick models represent
the haem group of cytochrome c[1], the Rieske iron-sulphur
cluster, and the disulphide cysteines of subunit 8. SU, subunit;
cyt, cytochrome.
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|
Figure 6.
Figure 6 Relative positions of the redox centres in the two
different conformations of the bc[1] complex dimer. a, b, Iron
centres revealed by anomalous scattering near the iron edge. The
net is a Bivoet difference map with X-ray wavelength 7,131 eV
phased with experimental phases improved by averaging, and
contoured at 4.5  .
c, d, Schematic drawing representing the cofactors. a, c,
Results from a native crystal, with the iron-sulphur cluster of
the Rieske protein in the distal position (from the
low-potential haem group of cytochrome b). b, d, Results from a
crystal containing bound stigmatellin, with the cluster in the
proximal position.
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| |
The above figures are
reprinted
by permission from Macmillan Publishers Ltd:
Nature
(1998,
392,
677-684)
copyright 1998.
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| |
Figures were
selected
by the author.
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Literature references that cite this PDB file's key reference
|
|
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| |
PubMed id
|
|
Reference
|
|
|
|
|
|
J.Hovers,
M.Potschies,
A.Polidori,
B.Pucci,
S.Raynal,
F.Bonneté,
M.J.Serrano-Vega,
C.G.Tate,
D.Picot,
Y.Pierre,
J.L.Popot,
R.Nehmé,
M.Bidet,
I.Mus-Veteau,
H.Busskamp,
K.H.Jung,
A.Marx,
P.A.Timmins,
and
W.Welte
(2011).
A class of mild surfactants that keep integral membrane proteins water-soluble for functional studies and crystallization.
|
| |
Mol Membr Biol, 28,
171-181.
|
|
|
|
|
|
|
B.Malyarchuk,
M.Derenko,
D.Berman,
M.Perkova,
T.Grzybowski,
A.Lejrikh,
and
N.Bulakhova
(2010).
Phylogeography and molecular adaptation of Siberian salamander Salamandrella keyserlingii based on mitochondrial DNA variation.
|
| |
Mol Phylogenet Evol, 56,
562-571.
|
|
|
|
|
|
|
D.W.Urry,
K.D.Urry,
W.Szaflarski,
and
M.Nowicki
(2010).
Elastic-contractile model proteins: Physical chemistry, protein function and drug design and delivery.
|
| |
Adv Drug Deliv Rev, 62,
1404-1455.
|
|
|
|
|
|
|
E.A.Berry,
L.S.Huang,
D.W.Lee,
F.Daldal,
K.Nagai,
and
N.Minagawa
(2010).
Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex.
|
| |
Biochim Biophys Acta, 1797,
360-370.
|
|
|
PDB code:
|
|
|
|
|
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|
|
E.L.Seifert,
C.Estey,
J.Y.Xuan,
and
M.E.Harper
(2010).
Electron transport chain-dependent and -independent mechanisms of mitochondrial H2O2 emission during long-chain fatty acid oxidation.
|
| |
J Biol Chem, 285,
5748-5758.
|
|
|
|
|
|
|
F.Baymann,
and
W.Nitschke
(2010).
Heliobacterial Rieske/cytb complex.
|
| |
Photosynth Res, 104,
177-187.
|
|
|
|
|
|
|
K.L.Hsueh,
W.M.Westler,
and
J.L.Markley
(2010).
NMR investigations of the Rieske protein from Thermus thermophilus support a coupled proton and electron transfer mechanism.
|
| |
J Am Chem Soc, 132,
7908-7918.
|
|
|
|
|
|
|
K.McLuskey,
A.W.Roszak,
Y.Zhu,
and
N.W.Isaacs
(2010).
Crystal structures of all-alpha type membrane proteins.
|
| |
Eur Biophys J, 39,
723-755.
|
|
|
|
|
|
|
M.Castellani,
R.Covian,
T.Kleinschroth,
O.Anderka,
B.Ludwig,
and
B.L.Trumpower
(2010).
Direct demonstration of half-of-the-sites reactivity in the dimeric cytochrome bc1 complex: enzyme with one inactive monomer is fully active but unable to activate the second ubiquinol oxidation site in response to ligand binding at the ubiquinone reduction site.
|
| |
J Biol Chem, 285,
502-510.
|
|
|
|
|
|
|
S.Lemeille,
and
J.D.Rochaix
(2010).
State transitions at the crossroad of thylakoid signalling pathways.
|
| |
Photosynth Res, 106,
33-46.
|
|
|
|
|
|
|
A.S.Walker,
C.Auclair,
M.Gredt,
and
P.Leroux
(2009).
First occurrence of resistance to strobilurin fungicides in Microdochium nivale and Microdochium majus from French naturally infected wheat grains.
|
| |
Pest Manag Sci, 65,
906-915.
|
|
|
|
|
|
|
D.R.Kolling,
R.I.Samoilova,
A.A.Shubin,
A.R.Crofts,
and
S.A.Dikanov
(2009).
Proton environment of reduced Rieske iron-sulfur cluster probed by two-dimensional ESEEM spectroscopy.
|
| |
J Phys Chem A, 113,
653-667.
|
|
|
|
|
|
|
F.Millett,
and
B.Durham
(2009).
Chapter 5 Use of ruthenium photooxidation techniques to study electron transfer in the cytochrome bc1 complex.
|
| |
Methods Enzymol, 456,
95.
|
|
|
|
|
|
|
H.B.Gray,
and
J.R.Winkler
(2009).
Electron Flow through Proteins.
|
| |
Chem Phys Lett, 483,
1-9.
|
|
|
|
|
|
|
J.W.Cooley,
D.W.Lee,
and
F.Daldal
(2009).
Across membrane communication between the Q(o) and Q(i) active sites of cytochrome bc(1).
|
| |
Biochemistry, 48,
1888-1899.
|
|
|
|
|
|
|
L.Zhao,
J.W.Pridgeon,
J.J.Becnel,
G.G.Clark,
and
K.J.Linthicum
(2009).
Mitochondrial gene cytochrome b developmental and environmental expression in Aedes aegypti (Diptera: Culicidae).
|
| |
J Med Entomol, 46,
1361-1369.
|
|
|
|
|
|
|
M.S.Albury,
C.Elliott,
and
A.L.Moore
(2009).
Towards a structural elucidation of the alternative oxidase in plants.
|
| |
Physiol Plant, 137,
316-327.
|
|
|
|
|
|
|
M.Sarewicz,
M.Dutka,
W.Froncisz,
and
A.Osyczka
(2009).
Magnetic interactions sense changes in distance between heme b(L) and the iron-sulfur cluster in cytochrome bc(1).
|
| |
Biochemistry, 48,
5708-5720.
|
|
|
|
|
|
|
P.Van Nieuwenhuyse,
T.Van Leeuwen,
J.Khajehali,
B.Vanholme,
and
L.Tirry
(2009).
Mutations in the mitochondrial cytochrome b of Tetranychus urticae Koch (Acari: Tetranychidae) confer cross-resistance between bifenazate and acequinocyl.
|
| |
Pest Manag Sci, 65,
404-412.
|
|
|
|
|
|
|
Q.L.Chen,
X.S.Tang,
W.J.Yao,
and
S.Q.Lu
(2009).
Bioinformatics analysis of the complete sequences of cytochrome b of Takydromus sylvaticus and modeling the tertiary structure of encoded protein.
|
| |
Int J Biol Sci, 5,
596-602.
|
|
|
|
|
|
|
R.Covian,
and
B.L.Trumpower
(2009).
Ilicicolin Inhibition and Binding at Center N of the Dimeric Cytochrome bc1 Complex Reveal Electron Transfer and Regulatory Interactions between Monomers.
|
| |
J Biol Chem, 284,
8614-8620.
|
|
|
|
|
|
|
R.E.Berry,
M.N.Shokhirev,
A.Y.Ho,
F.Yang,
T.K.Shokhireva,
H.Zhang,
A.Weichsel,
W.R.Montfort,
and
F.A.Walker
(2009).
Effect of mutation of carboxyl side-chain amino acids near the heme on the midpoint potentials and ligand binding constants of nitrophorin 2 and its NO, histamine, and imidazole complexes.
|
| |
J Am Chem Soc, 131,
2313-2327.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
S.Lemeille,
A.Willig,
N.Depège-Fargeix,
C.Delessert,
R.Bassi,
and
J.D.Rochaix
(2009).
Analysis of the chloroplast protein kinase Stt7 during state transitions.
|
| |
PLoS Biol, 7,
e45.
|
|
|
|
|
|
|
V.Zara,
L.Conte,
and
B.L.Trumpower
(2009).
Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane.
|
| |
FEBS J, 276,
1900-1914.
|
|
|
|
|
|
|
A.P.Komarov,
O.W.Rokhlin,
C.A.Yu,
and
A.V.Gudkov
(2008).
Functional genetic screening reveals the role of mitochondrial cytochrome b as a mediator of FAS-induced apoptosis.
|
| |
Proc Natl Acad Sci U S A, 105,
14453-14458.
|
|
|
|
|
|
|
A.R.Crofts,
J.T.Holland,
D.Victoria,
D.R.Kolling,
S.A.Dikanov,
R.Gilbreth,
S.Lhee,
R.Kuras,
and
M.G.Kuras
(2008).
The Q-cycle reviewed: How well does a monomeric mechanism of the bc(1) complex account for the function of a dimeric complex?
|
| |
Biochim Biophys Acta, 1777,
1001-1019.
|
|
|
|
|
|
|
B.Gurung,
L.Yu,
and
C.A.Yu
(2008).
Stigmatellin Induces Reduction of Iron-Sulfur Protein in the Oxidized Cytochrome bc1 Complex.
|
| |
J Biol Chem, 283,
28087-28094.
|
|
|
|
|
|
|
D.Fernández-Ortuño,
J.A.Torés,
A.de Vicente,
and
A.Pérez-García
(2008).
Field resistance to QoI fungicides in Podosphaera fusca is not supported by typical mutations in the mitochondrial cytochrome b gene.
|
| |
Pest Manag Sci, 64,
694-702.
|
|
|
|
|
|
|
D.Xia,
L.Esser,
M.Elberry,
F.Zhou,
L.Yu,
and
C.A.Yu
(2008).
The road to the crystal structure of the cytochrome bc (1) complex from the anoxigenic, photosynthetic bacterium Rhodobacter sphaeroides.
|
| |
J Bioenerg Biomembr, 40,
485-492.
|
|
|
|
|
|
|
E.A.Berry,
and
F.A.Walker
(2008).
Bis-histidine-coordinated hemes in four-helix bundles: how the geometry of the bundle controls the axial imidazole plane orientations in transmembrane cytochromes of mitochondrial complexes II and III and related proteins.
|
| |
J Biol Inorg Chem, 13,
481-498.
|
|
|
|
|
|
|
F.A.Rotsaert,
M.G.Ding,
and
B.L.Trumpower
(2008).
Differential efficacy of inhibition of mitochondrial and bacterial cytochrome bc1 complexes by center N inhibitors antimycin, ilicicolin H and funiculosin.
|
| |
Biochim Biophys Acta, 1777,
211-219.
|
|
|
|
|
|
|
G.J.Workun,
K.Moquin,
R.A.Rothery,
and
J.H.Weiner
(2008).
Evolutionary persistence of the molybdopyranopterin-containing sulfite oxidase protein fold.
|
| |
Microbiol Mol Biol Rev, 72,
228.
|
|
|
|
|
|
|
H.W.Ma,
S.Yang,
L.Yu,
and
C.A.Yu
(2008).
Formation of engineered intersubunit disulfide bond in cytochrome bc1 complex disrupts electron transfer activity in the complex.
|
| |
Biochim Biophys Acta, 1777,
317-326.
|
|
|
|
|
|
|
L.Esser,
M.Elberry,
F.Zhou,
C.A.Yu,
L.Yu,
and
D.Xia
(2008).
Inhibitor-complexed Structures of the Cytochrome bc1 from the Photosynthetic Bacterium Rhodobacter sphaeroides.
|
| |
J Biol Chem, 283,
2846-2857.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
L.Zhao,
J.W.Pridgeon,
J.J.Becnel,
G.G.Clark,
and
K.J.Linthicum
(2008).
Cytochrome c gene and protein expression: developmental regulation, environmental response, and pesticide sensitivity in Aedes aegypti.
|
| |
J Med Entomol, 45,
401-408.
|
|
|
|
|
|
|
M.V.Petoukhov,
J.B.Vicente,
P.B.Crowley,
M.A.Carrondo,
M.Teixeira,
and
D.I.Svergun
(2008).
Quaternary structure of flavorubredoxin as revealed by synchrotron radiation small-angle X-ray scattering.
|
| |
Structure, 16,
1428-1436.
|
|
|
|
|
|
|
N.Fisher,
and
B.Meunier
(2008).
Molecular basis of resistance to cytochrome bc1 inhibitors.
|
| |
FEMS Yeast Res, 8,
183-192.
|
|
|
|
|
|
|
O.A.Ulanovskaya,
J.Janjic,
M.Suzuki,
S.S.Sabharwal,
P.T.Schumacker,
S.J.Kron,
and
S.A.Kozmin
(2008).
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide.
|
| |
Nat Chem Biol, 4,
418-424.
|
|
|
|
|
|
|
P.J.Crowley,
E.A.Berry,
T.Cromartie,
F.Daldal,
C.R.Godfrey,
D.W.Lee,
J.E.Phillips,
A.Taylor,
and
R.Viner
(2008).
The role of molecular modeling in the design of analogues of the fungicidal natural products crocacins A and D.
|
| |
Bioorg Med Chem, 16,
10345-10355.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
R.Covian,
and
B.L.Trumpower
(2008).
The dimeric structure of the cytochrome bc(1) complex prevents center P inhibition by reverse reactions at center N.
|
| |
Biochim Biophys Acta, 1777,
1044-1052.
|
|
|
|
|
|
|
R.Covian,
and
B.L.Trumpower
(2008).
Regulatory interactions in the dimeric cytochrome bc(1) complex: the advantages of being a twin.
|
| |
Biochim Biophys Acta, 1777,
1079-1091.
|
|
|
|
|
|
|
S.R.Solmaz,
and
C.Hunte
(2008).
Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer.
|
| |
J Biol Chem, 283,
17542-17549.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
S.Yang,
H.W.Ma,
L.Yu,
and
C.A.Yu
(2008).
On the Mechanism of Quinol Oxidation at the QP Site in the Cytochrome bc1 Complex: STUDIED USING MUTANTS LACKING CYTOCHROME bL OR bH.
|
| |
J Biol Chem, 283,
28767-28776.
|
|
|
|
|
|
|
T.Kleinschroth,
O.Anderka,
M.Ritter,
A.Stocker,
T.A.Link,
B.Ludwig,
and
P.Hellwig
(2008).
Characterization of mutations in crucial residues around the Q(o) binding site of the cytochrome bc complex from Paracoccus denitrificans.
|
| |
FEBS J, 275,
4773-4785.
|
|
|
|
|
|
|
A.Bresell,
and
B.Persson
(2007).
Characterization of oligopeptide patterns in large protein sets.
|
| |
BMC Genomics, 8,
346.
|
|
|
|
|
|
|
A.R.Crofts
(2007).
Life, Information, Entropy, and Time: Vehicles for Semantic Inheritance.
|
| |
Complexity, 13,
14-50.
|
|
|
|
|
|
|
A.Y.Mulkidjanian
(2007).
Proton translocation by the cytochrome bc1 complexes of phototrophic bacteria: introducing the activated Q-cycle.
|
| |
Photochem Photobiol Sci, 6,
19-34.
|
|
|
|
|
|
|
D.J.Kolling,
J.S.Brunzelle,
S.Lhee,
A.R.Crofts,
and
S.K.Nair
(2007).
Atomic resolution structures of rieske iron-sulfur protein: role of hydrogen bonds in tuning the redox potential of iron-sulfur clusters.
|
| |
Structure, 15,
29-38.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
D.Xia,
L.Esser,
L.Yu,
and
C.A.Yu
(2007).
Structural basis for the mechanism of electron bifurcation at the quinol oxidation site of the cytochrome bc1 complex.
|
| |
Photosynth Res, 92,
17-34.
|
|
|
|
|
|
|
E.Yamashita,
H.Zhang,
and
W.A.Cramer
(2007).
Structure of the cytochrome b6f complex: quinone analogue inhibitors as ligands of heme cn.
|
| |
J Mol Biol, 370,
39-52.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.Heinemeyer,
H.P.Braun,
E.J.Boekema,
and
R.Kouril
(2007).
A structural model of the cytochrome C reductase/oxidase supercomplex from yeast mitochondria.
|
| |
J Biol Chem, 282,
12240-12248.
|
|
|
|
|
|
|
J.J.Perry,
L.Fan,
and
J.A.Tainer
(2007).
Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair.
|
| |
Neuroscience, 145,
1280-1299.
|
|
|
|
|
|
|
J.Zhu,
T.Egawa,
S.R.Yeh,
L.Yu,
and
C.A.Yu
(2007).
Simultaneous reduction of iron-sulfur protein and cytochrome b(L) during ubiquinol oxidation in cytochrome bc(1) complex.
|
| |
Proc Natl Acad Sci U S A, 104,
4864-4869.
|
|
|
|
|
|
|
L.Giachini,
F.Francia,
G.Veronesi,
D.W.Lee,
F.Daldal,
L.S.Huang,
E.A.Berry,
T.Cocco,
S.Papa,
F.Boscherini,
and
G.Venturoli
(2007).
X-Ray absorption studies of Zn2+ binding sites in bacterial, avian, and bovine cytochrome bc1 complexes.
|
| |
Biophys J, 93,
2934-2951.
|
|
|
|
|
|
|
M.S.Chae,
C.C.Lin,
K.E.Kessler,
C.E.Nargang,
L.L.Tanton,
L.B.Hahn,
and
F.E.Nargang
(2007).
Identification of an alternative oxidase induction motif in the promoter region of the aod-1 gene in Neurospora crassa.
|
| |
Genetics, 175,
1597-1606.
|
|
|
|
|
|
|
R.Covian,
K.Zwicker,
F.A.Rotsaert,
and
B.L.Trumpower
(2007).
Asymmetric and redox-specific binding of quinone and quinol at center N of the dimeric yeast cytochrome bc1 complex. Consequences for semiquinone stabilization.
|
| |
J Biol Chem, 282,
24198-24208.
|
|
|
|
|
|
|
R.Covian,
T.Kleinschroth,
B.Ludwig,
and
B.L.Trumpower
(2007).
Asymmetric binding of stigmatellin to the dimeric Paracoccus denitrificans bc1 complex: evidence for anti-cooperative ubiquinol oxidation and communication between center P ubiquinol oxidation sites.
|
| |
J Biol Chem, 282,
22289-22297.
|
|
|
|
|
|
|
R.Kuras,
D.Saint-Marcoux,
F.A.Wollman,
and
C.de Vitry
(2007).
A specific c-type cytochrome maturation system is required for oxygenic photosynthesis.
|
| |
Proc Natl Acad Sci U S A, 104,
9906-9910.
|
|
|
|
|
|
|
S.A.Dikanov,
J.T.Holland,
B.Endeward,
D.R.Kolling,
R.I.Samoilova,
T.F.Prisner,
and
A.R.Crofts
(2007).
Hydrogen bonds between nitrogen donors and the semiquinone in the Qi-site of the bc1 complex.
|
| |
J Biol Chem, 282,
25831-25841.
|
|
|
|
|
|
|
S.Devanathan,
Z.Salamon,
G.Tollin,
J.C.Fitch,
T.E.Meyer,
E.A.Berry,
and
M.A.Cusanovich
(2007).
Plasmon waveguide resonance spectroscopic evidence for differential binding of oxidized and reduced Rhodobacter capsulatus cytochrome c2 to the cytochrome bc1 complex mediated by the conformation of the Rieske iron-sulfur protein.
|
| |
Biochemistry, 46,
7138-7145.
|
|
|
|
|
|
|
S.Rajagukguk,
S.Yang,
C.A.Yu,
L.Yu,
B.Durham,
and
F.Millett
(2007).
Effect of mutations in the cytochrome b ef loop on the electron-transfer reactions of the Rieske iron-sulfur protein in the cytochrome bc1 complex.
|
| |
Biochemistry, 46,
1791-1798.
|
|
|
|
|
|
|
V.P.Shinkarev,
and
C.A.Wraight
(2007).
Intermonomer electron transfer in the bc1 complex dimer is controlled by the energized state and by impaired electron transfer between low and high potential hemes.
|
| |
FEBS Lett, 581,
1535-1541.
|
|
|
|
|
|
|
V.Zara,
L.Conte,
and
B.L.Trumpower
(2007).
Identification and characterization of cytochrome bc(1) subcomplexes in mitochondria from yeast with single and double deletions of genes encoding cytochrome bc(1) subunits.
|
| |
FEBS J, 274,
4526-4539.
|
|
|
|
|
|
|
Y.R.Chen,
C.L.Chen,
D.R.Pfeiffer,
and
J.L.Zweier
(2007).
Mitochondrial complex II in the post-ischemic heart: oxidative injury and the role of protein S-glutathionylation.
|
| |
J Biol Chem, 282,
32640-32654.
|
|
|
|
|
|
|
C.S.Willett
(2006).
Deleterious epistatic interactions between electron transport system protein-coding loci in the copepod Tigriopus californicus.
|
| |
Genetics, 173,
1465-1477.
|
|
|
|
|
|
|
E.J.Haddadian,
and
E.L.Gross
(2006).
A Brownian dynamics study of the interactions of the luminal domains of the cytochrome b6f complex with plastocyanin and cytochrome c6: the effects of the Rieske FeS protein on the interactions.
|
| |
Biophys J, 91,
2589-2600.
|
|
|
|
|
|
|
E.Schäfer,
H.Seelert,
N.H.Reifschneider,
F.Krause,
N.A.Dencher,
and
J.Vonck
(2006).
Architecture of active mammalian respiratory chain supercomplexes.
|
| |
J Biol Chem, 281,
15370-15375.
|
|
|
|
|
|
|
F.A.Walker
(2006).
The heme environment of mouse neuroglobin: histidine imidazole plane orientations obtained from solution NMR and EPR spectroscopy as compared with X-ray crystallography.
|
| |
J Biol Inorg Chem, 11,
391-397.
|
|
|
|
|
|
|
I.Forquer,
R.Covian,
M.K.Bowman,
B.L.Trumpower,
and
D.M.Kramer
(2006).
Similar transition states mediate the Q-cycle and superoxide production by the cytochrome bc1 complex.
|
| |
J Biol Chem, 281,
38459-38465.
|
|
|
|
|
|
|
J.Bachmann,
B.Bauer,
K.Zwicker,
B.Ludwig,
and
O.Anderka
(2006).
The Rieske protein from Paracoccus denitrificans is inserted into the cytoplasmic membrane by the twin-arginine translocase.
|
| |
FEBS J, 273,
4817-4830.
|
|
|
|
|
|
|
J.L.Cape,
M.K.Bowman,
and
D.M.Kramer
(2006).
Understanding the cytochrome bc complexes by what they don't do. The Q-cycle at 30.
|
| |
Trends Plant Sci, 11,
46-55.
|
|
|
|
|
|
|
J.Yan,
G.Kurisu,
and
W.A.Cramer
(2006).
Intraprotein transfer of the quinone analogue inhibitor 2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone in the cytochrome b6f complex.
|
| |
Proc Natl Acad Sci U S A, 103,
69-74.
|
|
|
|
|
|
|
J.Zhang,
F.E.Frerman,
and
J.J.Kim
(2006).
Structure of electron transfer flavoprotein-ubiquinone oxidoreductase and electron transfer to the mitochondrial ubiquinone pool.
|
| |
Proc Natl Acad Sci U S A, 103,
16212-16217.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
L.Esser,
X.Gong,
S.Yang,
L.Yu,
C.A.Yu,
and
D.Xia
(2006).
Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex.
|
| |
Proc Natl Acad Sci U S A, 103,
13045-13050.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
R.Covian,
and
B.L.Trumpower
(2006).
Regulatory interactions between ubiquinol oxidation and ubiquinone reduction sites in the dimeric cytochrome bc1 complex.
|
| |
J Biol Chem, 281,
30925-30932.
|
|
|
|
|
|
|
S.Balakumar,
P.Thanasekaran,
E.Rajkumar,
K.J.Adaikalasamy,
S.Rajagopal,
R.Ramaraj,
T.Rajendran,
B.Manimaran,
and
K.L.Lu
(2006).
Micellar catalysis on the electron transfer reactions of iron(III)-polypyridyl complexes with organic sulfides-importance of hydrophobic interactions.
|
| |
Org Biomol Chem, 4,
352-358.
|
|
|
|
|
|
|
T.M.Iverson
(2006).
Evolution and unique bioenergetic mechanisms in oxygenic photosynthesis.
|
| |
Curr Opin Chem Biol, 10,
91.
|
|
|
|
|
|
|
T.Teschner,
L.Yatsunyk,
V.Schünemann,
H.Paulsen,
H.Winkler,
C.Hu,
W.R.Scheidt,
F.A.Walker,
and
A.X.Trautwein
(2006).
Models of the membrane-bound cytochromes: mössbauer spectra of crystalline low-spin ferriheme complexes having axial ligand plane dihedral angles ranging from 0 degree to 90 degrees.
|
| |
J Am Chem Soc, 128,
1379-1389.
|
|
|
|
|
|
|
W.A.Cramer,
H.Zhang,
J.Yan,
G.Kurisu,
and
J.L.Smith
(2006).
Transmembrane traffic in the cytochrome b6f complex.
|
| |
Annu Rev Biochem, 75,
769-790.
|
|
|
|
|
|
|
A.J.Watson,
A.V.Hughes,
P.K.Fyfe,
M.C.Wakeham,
K.Holden-Dye,
P.Heathcote,
and
M.R.Jones
(2005).
On the role of basic residues in adapting the reaction centre-LH1 complex for growth at elevated temperatures in purple bacteria.
|
| |
Photosynth Res, 86,
81.
|
|
|
|
|
|
|
A.Osyczka,
C.C.Moser,
and
P.L.Dutton
(2005).
Fixing the Q cycle.
|
| |
Trends Biochem Sci, 30,
176-182.
|
|
|
|
|
|
|
A.Y.Andreyev,
Y.E.Kushnareva,
and
A.A.Starkov
(2005).
Mitochondrial metabolism of reactive oxygen species.
|
| |
Biochemistry (Mosc), 70,
200-214.
|
|
|
|
|
|
|
B.Gurung,
L.Yu,
D.Xia,
and
C.A.Yu
(2005).
The iron-sulfur cluster of the Rieske iron-sulfur protein functions as a proton-exiting gate in the cytochrome bc(1) complex.
|
| |
J Biol Chem, 280,
24895-24902.
|
|
|
|
|
|
|
F.Musiani,
A.Dikiy,
A.Y.Semenov,
and
S.Ciurli
(2005).
Structure of the intermolecular complex between plastocyanin and cytochrome f from spinach.
|
| |
J Biol Chem, 280,
18833-18841.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
F.Sun,
X.Huo,
Y.Zhai,
A.Wang,
J.Xu,
D.Su,
M.Bartlam,
and
Z.Rao
(2005).
Crystal structure of mitochondrial respiratory membrane protein complex II.
|
| |
Cell, 121,
1043-1057.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
H.Leonov,
and
I.T.Arkin
(2005).
A periodicity analysis of transmembrane helices.
|
| |
Bioinformatics, 21,
2604-2610.
|
|
|
|
|
|
|
J.N.Forkey,
M.E.Quinlan,
and
Y.E.Goldman
(2005).
Measurement of single macromolecule orientation by total internal reflection fluorescence polarization microscopy.
|
| |
Biophys J, 89,
1261-1271.
|
|
|
|
|
|
|
J.W.Cooley,
T.Ohnishi,
and
F.Daldal
(2005).
Binding dynamics at the quinone reduction (Qi) site influence the equilibrium interactions of the iron sulfur protein and hydroquinone oxidation (Qo) site of the cytochrome bc1 complex.
|
| |
Biochemistry, 44,
10520-10532.
|
|
|
|
|
|
|
L.S.Huang,
D.Cobessi,
E.Y.Tung,
and
E.A.Berry
(2005).
Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern.
|
| |
J Mol Biol, 351,
573-597.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
M.E.Nelson,
G.Finazzi,
Q.J.Wang,
K.A.Middleton-Zarka,
J.Whitmarsh,
and
T.Kallas
(2005).
Cytochrome b6 arginine 214 of Synechococcus sp. PCC 7002, a key residue for quinone-reductase site function and turnover of the cytochrome bf complex.
|
| |
J Biol Chem, 280,
10395-10402.
|
|
|
|
|
|
|
M.W.Mather,
E.Darrouzet,
M.Valkova-Valchanova,
J.W.Cooley,
M.T.McIntosh,
F.Daldal,
and
A.B.Vaidya
(2005).
Uncovering the molecular mode of action of the antimalarial drug atovaquone using a bacterial system.
|
| |
J Biol Chem, 280,
27458-27465.
|
|
|
|
|
|
|
N.Dashdorj,
H.Zhang,
H.Kim,
J.Yan,
W.A.Cramer,
and
S.Savikhin
(2005).
The single chlorophyll a molecule in the cytochrome b6f complex: unusual optical properties protect the complex against singlet oxygen.
|
| |
Biophys J, 88,
4178-4187.
|
|
|
|
|
|
|
O.Zafra,
F.Cava,
F.Blasco,
A.Magalon,
and
J.Berenguer
(2005).
Membrane-associated maturation of the heterotetrameric nitrate reductase of Thermus thermophilus.
|
| |
J Bacteriol, 187,
3990-3996.
|
|
|
|
|
|
|
R.Covian,
and
B.L.Trumpower
(2005).
Rapid electron transfer between monomers when the cytochrome bc1 complex dimer is reduced through center N.
|
| |
J Biol Chem, 280,
22732-22740.
|
|
|
|
|
|
|
S.Ouchane,
W.Nitschke,
P.Bianco,
A.Vermeglio,
and
C.Astier
(2005).
Multiple Rieske genes in prokaryotes: exchangeable Rieske subunits in the cytochrome bc-complex of Rubrivivax gelatinosus.
|
| |
Mol Microbiol, 57,
261-275.
|
|
|
|
|
|
|
X.Gong,
L.Yu,
D.Xia,
and
C.A.Yu
(2005).
Evidence for electron equilibrium between the two hemes bL in the dimeric cytochrome bc1 complex.
|
| |
J Biol Chem, 280,
9251-9257.
|
|
|
|
|
|
|
A.Kounosu,
Z.Li,
N.J.Cosper,
J.E.Shokes,
R.A.Scott,
T.Imai,
A.Urushiyama,
and
T.Iwasaki
(2004).
Engineering a three-cysteine, one-histidine ligand environment into a new hyperthermophilic archaeal Rieske-type [2Fe-2S] ferredoxin from Sulfolobus solfataricus.
|
| |
J Biol Chem, 279,
12519-12528.
|
|
|
|
|
|
|
A.Osyczka,
C.C.Moser,
F.Daldal,
and
P.L.Dutton
(2004).
Reversible redox energy coupling in electron transfer chains.
|
| |
Nature, 427,
607-612.
|
|
|
|
|
|
|
A.R.Crofts
(2004).
The cytochrome bc1 complex: function in the context of structure.
|
| |
Annu Rev Physiol, 66,
689-733.
|
|
|
|
|
|
|
A.Stroh,
O.Anderka,
K.Pfeiffer,
T.Yagi,
M.Finel,
B.Ludwig,
and
H.Schägger
(2004).
Assembly of respiratory complexes I, III, and IV into NADH oxidase supercomplex stabilizes complex I in Paracoccus denitrificans.
|
| |
J Biol Chem, 279,
5000-5007.
|
|
|
|
|
|
|
C.de Vitry,
Y.Ouyang,
G.Finazzi,
F.A.Wollman,
and
T.Kallas
(2004).
The chloroplast Rieske iron-sulfur protein. At the crossroad of electron transport and signal transduction.
|
| |
J Biol Chem, 279,
44621-44627.
|
|
|
|
|
|
|
D.Ghibaudo,
L.Cohen,
F.Penin,
and
A.Martin
(2004).
Characterization of GB virus B polyprotein processing reveals the existence of a novel 13-kDa protein with partial homology to hepatitis C virus p7 protein.
|
| |
J Biol Chem, 279,
24965-24975.
|
|
|
|
|
|
|
D.Moradpour,
V.Brass,
E.Bieck,
P.Friebe,
R.Gosert,
H.E.Blum,
R.Bartenschlager,
F.Penin,
and
V.Lohmann
(2004).
Membrane association of the RNA-dependent RNA polymerase is essential for hepatitis C virus RNA replication.
|
| |
J Virol, 78,
13278-13284.
|
|
|
|
|
|
|
D.Schneider,
S.Berry,
T.Volkmer,
A.Seidler,
and
M.Rögner
(2004).
PetC1 is the major Rieske iron-sulfur protein in the cytochrome b6f complex of Synechocystis sp. PCC 6803.
|
| |
J Biol Chem, 279,
39383-39388.
|
|
|
|
|
|
|
E.B.Gutierrez-Cirlos,
T.Merbitz-Zahradnik,
and
B.L.Trumpower
(2004).
Inhibition of the yeast cytochrome bc1 complex by ilicicolin H, a novel inhibitor that acts at the Qn site of the bc1 complex.
|
| |
J Biol Chem, 279,
8708-8714.
|
|
|
|
|
|
|
E.D.Garcin,
C.M.Bruns,
S.J.Lloyd,
D.J.Hosfield,
M.Tiso,
R.Gachhui,
D.J.Stuehr,
J.A.Tainer,
and
E.D.Getzoff
(2004).
Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase.
|
| |
J Biol Chem, 279,
37918-37927.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
F.Baymann,
E.Lebrun,
and
W.Nitschke
(2004).
Mitochondrial cytochrome c1 is a collapsed di-heme cytochrome.
|
| |
Proc Natl Acad Sci U S A, 101,
17737-17740.
|
|
|
|
|
|
|
F.L.Muller,
Y.Liu,
and
H.Van Remmen
(2004).
Complex III releases superoxide to both sides of the inner mitochondrial membrane.
|
| |
J Biol Chem, 279,
49064-49073.
|
|
|
|
|
|
|
G.Brasseur,
D.Lemesle-Meunier,
F.Reinaud,
and
B.Meunier
(2004).
QO site deficiency can be compensated by extragenic mutations in the hinge region of the iron-sulfur protein in the bc1 complex of Saccharomyces cerevisiae.
|
| |
J Biol Chem, 279,
24203-24211.
|
|
|
|
|
|
|
H.S.Toogood,
A.van Thiel,
J.Basran,
M.J.Sutcliffe,
N.S.Scrutton,
and
D.Leys
(2004).
Extensive domain motion and electron transfer in the human electron transferring flavoprotein.medium chain Acyl-CoA dehydrogenase complex.
|
| |
J Biol Chem, 279,
32904-32912.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.L.Smith,
H.Zhang,
J.Yan,
G.Kurisu,
and
W.A.Cramer
(2004).
Cytochrome bc complexes: a common core of structure and function surrounded by diversity in the outlying provinces.
|
| |
Curr Opin Struct Biol, 14,
432-439.
|
|
|
|
|
|
|
J.S.Armstrong,
H.Yang,
W.Duan,
and
M.Whiteman
(2004).
Cytochrome bc(1) regulates the mitochondrial permeability transition by two distinct pathways.
|
| |
J Biol Chem, 279,
50420-50428.
|
|
|
|
|
|
|
M.D.Brand,
C.Affourtit,
T.C.Esteves,
K.Green,
A.J.Lambert,
S.Miwa,
J.L.Pakay,
and
N.Parker
(2004).
Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins.
|
| |
Free Radic Biol Med, 37,
755-767.
|
|
|
|
|
|
|
M.E.Harper,
L.Bevilacqua,
K.Hagopian,
R.Weindruch,
and
J.J.Ramsey
(2004).
Ageing, oxidative stress, and mitochondrial uncoupling.
|
| |
Acta Physiol Scand, 182,
321-331.
|
|
|
|
|
|
|
M.Lei,
M.I.Zavodszky,
L.A.Kuhn,
and
M.F.Thorpe
(2004).
Sampling protein conformations and pathways.
|
| |
J Comput Chem, 25,
1133-1148.
|
|
|
|
|
|
|
N.Fisher,
A.C.Brown,
G.Sexton,
A.Cook,
J.Windass,
and
B.Meunier
(2004).
Modeling the Qo site of crop pathogens in Saccharomyces cerevisiae cytochrome b.
|
| |
Eur J Biochem, 271,
2264-2271.
|
|
|
|
|
|
|
N.Nelson,
and
A.Ben-Shem
(2004).
The complex architecture of oxygenic photosynthesis.
|
| |
Nat Rev Mol Cell Biol, 5,
971-982.
|
|
|
|
|
|
|
P.Jeschke
(2004).
The unique role of fluorine in the design of active ingredients for modern crop protection.
|
| |
Chembiochem, 5,
571-589.
|
|
|
|
|
|
|
R.Covian,
E.B.Gutierrez-Cirlos,
and
B.L.Trumpower
(2004).
Anti-cooperative oxidation of ubiquinol by the yeast cytochrome bc1 complex.
|
| |
J Biol Chem, 279,
15040-15049.
|
|
|
|
|
|
|
T.Uchiyama,
A.Kounosu,
T.Sato,
N.Tanaka,
T.Iwasaki,
and
T.Kumasaka
(2004).
Crystallization and preliminary X-ray diffraction studies of the hyperthermophilic archaeal sulredoxin having the unique Rieske [2Fe-2S] cluster environment.
|
| |
Acta Crystallogr D Biol Crystallogr, 60,
1487-1489.
|
|
|
|
|
|
|
V.Zara,
I.Palmisano,
L.Conte,
and
B.L.Trumpower
(2004).
Further insights into the assembly of the yeast cytochrome bc1 complex based on analysis of single and double deletion mutants lacking supernumerary subunits and cytochrome b.
|
| |
Eur J Biochem, 271,
1209-1218.
|
|
|
|
|
|
|
A.R.Crofts,
V.P.Shinkarev,
D.R.Kolling,
and
S.Hong
(2003).
The modified Q-cycle explains the apparent mismatch between the kinetics of reduction of cytochromes c1 and bH in the bc1 complex.
|
| |
J Biol Chem, 278,
36191-36201.
|
|
|
|
|
|
|
C.Gissi,
and
G.Pesole
(2003).
Transcript mapping and genome annotation of ascidian mtDNA using EST data.
|
| |
Genome Res, 13,
2203-2212.
|
|
|
|
|
|
|
D.Leys,
J.Basran,
F.Talfournier,
M.J.Sutcliffe,
and
N.S.Scrutton
(2003).
Extensive conformational sampling in a ternary electron transfer complex.
|
| |
Nat Struct Biol, 10,
219-225.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
D.R.Kolling,
R.I.Samoilova,
J.T.Holland,
E.A.Berry,
S.A.Dikanov,
and
A.R.Crofts
(2003).
Exploration of ligands to the Qi site semiquinone in the bc1 complex using high-resolution EPR.
|
| |
J Biol Chem, 278,
39747-39754.
|
|
|
|
|
|
|
D.Stroebel,
Y.Choquet,
J.L.Popot,
and
D.Picot
(2003).
An atypical haem in the cytochrome b(6)f complex.
|
| |
Nature, 426,
413-418.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
E.C.Slater,
D.Keilin,
and
E.C.Slater
(2003).
Keilin, cytochrome, and the respiratory chain.
|
| |
J Biol Chem, 278,
16455-16461.
|
|
|
|
|
|
|
E.M.Aro,
and
I.Ohad
(2003).
Redox regulation of thylakoid protein phosphorylation.
|
| |
Antioxid Redox Signal, 5,
55-67.
|
|
|
|
|
|
|
F.Francia,
G.Palazzo,
A.Mallardi,
L.Cordone,
and
G.Venturoli
(2003).
Residual water modulates QA- -to-QB electron transfer in bacterial reaction centers embedded in trehalose amorphous matrices.
|
| |
Biophys J, 85,
2760-2775.
|
|
|
|
|
|
|
G.Kurisu,
H.Zhang,
J.L.Smith,
and
W.A.Cramer
(2003).
Structure of the cytochrome b6f complex of oxygenic photosynthesis: tuning the cavity.
|
| |
Science, 302,
1009-1014.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
H.Palsdottir,
C.G.Lojero,
B.L.Trumpower,
and
C.Hunte
(2003).
Structure of the yeast cytochrome bc1 complex with a hydroxyquinone anion Qo site inhibitor bound.
|
| |
J Biol Chem, 278,
31303-31311.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
H.Zhang,
G.Kurisu,
J.L.Smith,
and
W.A.Cramer
(2003).
A defined protein-detergent-lipid complex for crystallization of integral membrane proteins: The cytochrome b6f complex of oxygenic photosynthesis.
|
| |
Proc Natl Acad Sci U S A, 100,
5160-5163.
|
|
|
|
|
|
|
I.Schröder,
E.Johnson,
and
S.de Vries
(2003).
Microbial ferric iron reductases.
|
| |
FEMS Microbiol Rev, 27,
427-447.
|
|
|
|
|
|
|
J.S.Armstrong,
M.Whiteman,
P.Rose,
and
D.P.Jones
(2003).
The Coenzyme Q10 analog decylubiquinone inhibits the redox-activated mitochondrial permeability transition: role of mitcohondrial [correction mitochondrial] complex III.
|
| |
J Biol Chem, 278,
49079-49084.
|
|
|
|
|
|
|
J.Yan,
and
W.A.Cramer
(2003).
Functional insensitivity of the cytochrome b6f complex to structure changes in the hinge region of the Rieske iron-sulfur protein.
|
| |
J Biol Chem, 278,
20925-20933.
|
|
|
|
|
|
|
K.Xiao,
G.Engstrom,
S.Rajagukguk,
C.A.Yu,
L.Yu,
B.Durham,
and
F.Millett
(2003).
Effect of famoxadone on photoinduced electron transfer between the iron-sulfur center and cytochrome c1 in the cytochrome bc1 complex.
|
| |
J Biol Chem, 278,
11419-11426.
|
|
|
|
|
|
|
M.Ritter,
O.Anderka,
B.Ludwig,
W.Mäntele,
and
P.Hellwig
(2003).
Electrochemical and FTIR spectroscopic characterization of the cytochrome bc1 complex from Paracoccus denitrificans: evidence for protonation reactions coupled to quinone binding.
|
| |
Biochemistry, 42,
12391-12399.
|
|
|
|
|
|
|
M.T.Facciotti,
V.S.Cheung,
D.Nguyen,
S.Rouhani,
and
R.M.Glaeser
(2003).
Crystal structure of the bromide-bound D85S mutant of bacteriorhodopsin: principles of ion pumping.
|
| |
Biophys J, 85,
451-458.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
S.Miwa,
J.St-Pierre,
L.Partridge,
and
M.D.Brand
(2003).
Superoxide and hydrogen peroxide production by Drosophila mitochondria.
|
| |
Free Radic Biol Med, 35,
938-948.
|
|
|
|
|
|
|
Y.Zu,
M.M.Couture,
D.R.Kolling,
A.R.Crofts,
L.D.Eltis,
J.A.Fee,
and
J.Hirst
(2003).
Reduction potentials of Rieske clusters: importance of the coupling between oxidation state and histidine protonation state.
|
| |
Biochemistry, 42,
12400-12408.
|
|
|
|
|
|
|
A.G.Roberts,
M.K.Bowman,
and
D.M.Kramer
(2002).
Certain metal ions are inhibitors of cytochrome b6f complex 'Rieske' iron-sulfur protein domain movements.
|
| |
Biochemistry, 41,
4070-4079.
|
|
|
|
|
|
|
C.Lange,
and
C.Hunte
(2002).
Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c.
|
| |
Proc Natl Acad Sci U S A, 99,
2800-2805.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
E.B.Gutierrez-Cirlos,
T.Merbitz-Zahradnik,
and
B.L.Trumpower
(2002).
Failure to insert the iron-sulfur cluster into the Rieske iron-sulfur protein impairs both center N and center P of the cytochrome bc1 complex.
|
| |
J Biol Chem, 277,
50703-50709.
|
|
|
|
|
|
|
F.Zito,
J.Vinh,
J.L.Popot,
and
G.Finazzi
(2002).
Chimeric fusions of subunit IV and PetL in the b6f complex of Chlamydomonas reinhardtii: structural implications and consequences on state transitions.
|
| |
J Biol Chem, 277,
12446-12455.
|
|
|
|
|
|
|
G.Engstrom,
K.Xiao,
C.A.Yu,
L.Yu,
B.Durham,
and
F.Millett
(2002).
Photoinduced electron transfer between the Rieske iron-sulfur protein and cytochrome c(1) in the Rhodobacter sphaeroides cytochrome bc(1) complex. Effects of pH, temperature, and driving force.
|
| |
J Biol Chem, 277,
31072-31078.
|
|
|
|
|
|
|
G.Finazzi
(2002).
Redox-coupled proton pumping activity in cytochrome b6f, as evidenced by the pH dependence of electron transfer in whole cells of Chlamydomonas reinhardtii.
|
| |
Biochemistry, 41,
7475-7482.
|
|
|
|
|
|
|
G.M.Soriano,
L.W.Guo,
C.De Vitry,
T.Kallas,
and
W.A.Cramer
(2002).
Electron transfer from the Rieske iron-sulfur protein (ISP) to cytochrome f in vitro. Is a guided trajectory of the ISP necessary for competent docking?
|
| |
J Biol Chem, 277,
41865-41871.
|
|
|
|
|
|
|
J.St-Pierre,
J.A.Buckingham,
S.J.Roebuck,
and
M.D.Brand
(2002).
Topology of superoxide production from different sites in the mitochondrial electron transport chain.
|
| |
J Biol Chem, 277,
44784-44790.
|
|
|
|
|
|
|
M.A.Rosenow,
C.L.Magee,
J.C.Williams,
and
J.P.Allen
(2002).
The influence of detergents on the solubility of membrane proteins.
|
| |
Acta Crystallogr D Biol Crystallogr, 58,
2076-2081.
|
|
|
|
|
|
|
M.Jones,
F.Talfournier,
A.Bobrov,
J.G.Grossmann,
N.Vekshin,
M.J.Sutcliffe,
and
N.S.Scrutton
(2002).
Electron transfer and conformational change in complexes of trimethylamine dehydrogenase and electron transferring flavoprotein.
|
| |
J Biol Chem, 277,
8457-8465.
|
|
|
|
|
|
|
N.Ivashkina,
B.Wölk,
V.Lohmann,
R.Bartenschlager,
H.E.Blum,
F.Penin,
and
D.Moradpour
(2002).
The hepatitis C virus RNA-dependent RNA polymerase membrane insertion sequence is a transmembrane segment.
|
| |
J Virol, 76,
13088-13093.
|
|
|
|
|
|
|
R.I.Samoilova,
D.Kolling,
T.Uzawa,
T.Iwasaki,
A.R.Crofts,
and
S.A.Dikanov
(2002).
The interaction of the Rieske iron-sulfur protein with occupants of the Qo-site of the bc1 complex, probed by electron spin echo envelope modulation.
|
| |
J Biol Chem, 277,
4605-4608.
|
|
|
|
|
|
|
S.Ouchane,
I.Agalidis,
and
C.Astier
(2002).
Natural resistance to inhibitors of the ubiquinol cytochrome c oxidoreductase of Rubrivivax gelatinosus: sequence and functional analysis of the cytochrome bc(1) complex.
|
| |
J Bacteriol, 184,
3815-3822.
|
|
|
|
|
|
|
T.M.Iverson,
C.Luna-Chavez,
L.R.Croal,
G.Cecchini,
and
D.C.Rees
(2002).
Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site.
|
| |
J Biol Chem, 277,
16124-16130.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
Y.Saint-Georges,
N.Bonnefoy,
J.P.di Rago,
S.Chiron,
and
G.Dujardin
(2002).
A pathogenic cytochrome b mutation reveals new interactions between subunits of the mitochondrial bc1 complex.
|
| |
J Biol Chem, 277,
49397-49402.
|
|
|
|
|
|
|
Z.W.Chen,
K.Matsushita,
T.Yamashita,
T.A.Fujii,
H.Toyama,
O.Adachi,
H.D.Bellamy,
and
F.S.Mathews
(2002).
Structure at 1.9 A resolution of a quinohemoprotein alcohol dehydrogenase from Pseudomonas putida HK5.
|
| |
Structure, 10,
837-849.
|
|
|
PDB code:
|
|
|
|
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| | |
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