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Actin-binding protein PDB id
1aoa
Jmol
Contents
Protein chain
247 a.a. *
Waters ×20
* Residue conservation analysis
PDB id:
1aoa
Name: Actin-binding protein
Title: N-terminal actin-crosslinking domain from human fimbrin
Structure: T-fimbrin. Chain: a. Fragment: abd1
Source: Homo sapiens. Human. Organism_taxid: 9606
Resolution:
2.40Å     R-factor:   0.186     R-free:   0.285
Authors: S.C.Goldsmith,N.Pokala,W.Shen,A.A.Fedorov,P.Matsudaira, S.C.Almo
Key ref: S.C.Goldsmith et al. (1997). The structure of an actin-crosslinking domain from human fimbrin. Nat Struct Biol, 4, 708-712. PubMed id: 9302997 DOI: 10.1038/nsb0997-708
Date:
30-Jun-97     Release date:   31-Dec-97    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P13797  (PLST_HUMAN) -  Plastin-3
Seq:
Struc: 		 
Seq:
Struc: 		630 a.a.
247 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Biochemical function     actin binding     1 term  

 

 
DOI no: 10.1038/nsb0997-708 Nat Struct Biol 4:708-712 (1997)
PubMed id: 9302997  
 
 
The structure of an actin-crosslinking domain from human fimbrin.
S.C.Goldsmith, N.Pokala, W.Shen, A.A.Fedorov, P.Matsudaira, S.C.Almo.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
20446344 S.H.Lee, and R.Dominguez (2010).
Regulation of actin cytoskeleton dynamics in cells.
  Mol Cells, 29, 311-325.  
20696926 S.M.Singh, N.Kongari, J.Cabello-Villegas, and K.M.Mallela (2010).
Missense mutations in dystrophin that trigger muscular dystrophy decrease protein stability and lead to cross-beta aggregates.
  Proc Natl Acad Sci U S A, 107, 15069-15074.  
18952167 B.Sjöblom, J.Ylänne, and K.Djinović-Carugo (2008).
Novel structural insights into F-actin-binding and novel functions of calponin homology domains.
  Curr Opin Struct Biol, 18, 702-708.  
19436497 E.H.Egelman (2008).
Problems in fitting high resolution structures into electron microscopic reconstructions.
  HFSP J, 2, 324-331.  
17921200 K.S.Kolahi, and M.R.Mofrad (2008).
Molecular mechanics of filamin's rod domain.
  Biophys J, 94, 1075-1083.  
18269770 R.W.Washington, and D.A.Knecht (2008).
Actin binding domains direct actin-binding proteins to different cytoskeletal locations.
  BMC Cell Biol, 9, 10.  
18164029 S.H.Lee, A.Weins, D.B.Hayes, M.R.Pollak, and R.Dominguez (2008).
Crystal structure of the actin-binding domain of alpha-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis.
  J Mol Biol, 376, 317-324.
PDB code: 2r0o
17222516 C.Antolik, D.H.Catino, A.M.O'Neill, W.G.Resneck, J.A.Ursitti, and R.J.Bloch (2007).
The actin binding domain of ACF7 binds directly to the tetratricopeptide repeat domains of rapsyn.
  Neuroscience, 145, 56-65.  
17195848 R.R.Wei, J.Al-Bassam, and S.C.Harrison (2007).
The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment.
  Nat Struct Mol Biol, 14, 54-59.
PDB code: 2igp
16959963 J.B.Moseley, and B.L.Goode (2006).
The yeast actin cytoskeleton: from cellular function to biochemical mechanism.
  Microbiol Mol Biol Rev, 70, 605-645.  
16109370 I.Hayashi, A.Wilde, T.K.Mal, and M.Ikura (2005).
Structural basis for the activation of microtubule assembly by the EB1 and p150Glued complex.
  Mol Cell, 19, 449-460.
PDB code: 1txq
15826935 I.N.Rybakova, and J.M.Ervasti (2005).
Identification of spectrin-like repeats required for high affinity utrophin-actin interaction.
  J Biol Chem, 280, 23018-23023.  
15960882 V.Delanote, J.Vandekerckhove, and J.Gettemans (2005).
Plastins: versatile modulators of actin organization in (patho)physiological cellular processes.
  Acta Pharmacol Sin, 26, 769-779.  
15272162 C.H.Wang, M.K.Balasubramanian, and T.Dokland (2004).
Structure, crystal packing and molecular dynamics of the calponin-homology domain of Schizosaccharomyces pombe Rng2.
  Acta Crystallogr D Biol Crystallogr, 60, 1396-1403.
PDB codes: 1p2x 1p5s
15274909 E.H.Egelman (2004).
More insights into structural plasticity of actin binding proteins.
  Structure, 12, 909-910.  
15128297 J.Sevcík, L.Urbániková, J.Kost'an, L.Janda, and G.Wiche (2004).
Actin-binding domain of mouse plectin. Crystal structure and binding to vimentin.
  Eur J Biochem, 271, 1873-1884.
PDB codes: 1sh5 1sh6
15274920 M.G.Klein, W.Shi, U.Ramagopal, Y.Tseng, D.Wirtz, D.R.Kovar, C.J.Staiger, and S.C.Almo (2004).
Structure of the actin crosslinking core of fimbrin.
  Structure, 12, 999.
PDB codes: 1pxy 1rt8
15548864 W.Lehman, R.Craig, J.Kendrick-Jones, and A.J.Sutherland-Smith (2004).
An open or closed case for the conformation of calponin homology domains on F-actin?
  J Muscle Res Cell Motil, 25, 351-358.  
12857735 I.Hayashi, and M.Ikura (2003).
Crystal structure of the amino-terminal microtubule-binding domain of end-binding protein 1 (EB1).
  J Biol Chem, 278, 36430-36434.
PDB codes: 1pa7 1ueg
12517699 S.J.Winder (2003).
Structural insights into actin-binding, branching and bundling proteins.
  Curr Opin Cell Biol, 15, 14-22.  
12058056 H.Yin, L.You, D.Pasqualone, K.M.Kopski, and T.C.Huffaker (2002).
Stu1p is physically associated with beta-tubulin and is required for structural integrity of the mitotic spindle.
  Mol Biol Cell, 13, 1881-1892.  
12237450 M.Novatchkova, and F.Eisenhaber (2002).
A CH domain-containing N terminus in NuMA?
  Protein Sci, 11, 2281-2284.  
12378542 N.Daudet, and M.C.Lebart (2002).
Transient expression of the t-isoform of plastins/fimbrin in the stereocilia of developing auditory hair cells.
  Cell Motil Cytoskeleton, 53, 326-336.  
11956227 V.E.Galkin, A.Orlova, M.S.VanLoock, I.N.Rybakova, J.M.Ervasti, and E.H.Egelman (2002).
The utrophin actin-binding domain binds F-actin in two different modes: implications for the spectrin superfamily of proteins.
  J Cell Biol, 157, 243-251.  
11732068 D.W.McCurdy, D.R.Kovar, and C.J.Staiger (2001).
Actin and actin-binding proteins in higher plants.
  Protoplasma, 215, 89.  
11381081 N.Volkmann, D.DeRosier, P.Matsudaira, and D.Hanein (2001).
An atomic model of actin filaments cross-linked by fimbrin and its implications for bundle assembly and function.
  J Cell Biol, 153, 947-956.  
10891857 C.A.Moores, and J.Kendrick-Jones (2000).
Biochemical characterisation of the actin-binding properties of utrophin.
  Cell Motil Cytoskeleton, 46, 116-128.  
  10801490 F.L.Norwood, A.J.Sutherland-Smith, N.H.Keep, and J.Kendrick-Jones (2000).
The structure of the N-terminal actin-binding domain of human dystrophin and how mutations in this domain may cause Duchenne or Becker muscular dystrophy.
  Structure, 8, 481-491.
PDB code: 1dxx
11134073 S.N.Nikolopoulos, and C.E.Turner (2000).
Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion.
  J Cell Biol, 151, 1435-1448.  
9867810 A.Richardson, S.M.van der Vies, F.Keppel, A.Taher, S.J.Landry, and C.Georgopoulos (1999).
Compensatory changes in GroEL/Gp31 affinity as a mechanism for allele-specific genetic interaction.
  J Biol Chem, 274, 52-58.  
10508161 A.Stock, M.O.Steinmetz, P.A.Janmey, U.Aebi, G.Gerisch, R.A.Kammerer, I.Weber, and J.Faix (1999).
Domain analysis of cortexillin I: actin-bundling, PIP(2)-binding and the rescue of cytokinesis.
  EMBO J, 18, 5274-5284.  
10585942 B.Leinweber, J.X.Tang, W.F.Stafford, and J.M.Chalovich (1999).
Calponin interaction with alpha-actinin-actin: evidence for a structural role for calponin.
  Biophys J, 77, 3208-3217.  
10468582 D.Zhou, M.S.Mooseker, and J.E.Galán (1999).
An invasion-associated Salmonella protein modulates the actin-bundling activity of plastin.
  Proc Natl Acad Sci U S A, 96, 10176-10181.  
10459017 I.Correia, D.Chu, Y.H.Chou, R.D.Goldman, and P.Matsudaira (1999).
Integrating the actin and vimentin cytoskeletons. adhesion-dependent formation of fimbrin-vimentin complexes in macrophages.
  J Cell Biol, 146, 831-842.  
9990286 M.Van Troys, J.Vandekerckhove, and C.Ampe (1999).
Structural modules in actin-binding proteins: towards a new classification.
  Biochim Biophys Acta, 1448, 323-348.  
  10647184 N.H.Keep, S.J.Winder, C.A.Moores, S.Walke, F.L.Norwood, and J.Kendrick-Jones (1999).
Crystal structure of the actin-binding region of utrophin reveals a head-to-tail dimer.
  Structure, 7, 1539-1546.
PDB code: 1qag
9631289 A.McGough (1998).
F-actin-binding proteins.
  Curr Opin Struct Biol, 8, 166-176.  
9700162 F.Rivero, A.Kuspa, R.Brokamp, M.Matzner, and A.A.Noegel (1998).
Interaptin, an actin-binding protein of the alpha-actinin superfamily in Dictyostelium discoideum, is developmentally and cAMP-regulated and associates with intracellular membrane compartments.
  J Cell Biol, 142, 735-750.  
9763424 J.R.Bartles, L.Zheng, A.Li, A.Wierda, and B.Chen (1998).
Small espin: a third actin-bundling protein and potential forked protein ortholog in brush border microvilli.
  J Cell Biol, 143, 107-119.  
9545287 J.Xu, D.Wirtz, and T.D.Pollard (1998).
Dynamic cross-linking by alpha-actinin determines the mechanical properties of actin filament networks.
  J Biol Chem, 273, 9570-9576.  
9545201 K.M.Pang, E.Lee, and D.A.Knecht (1998).
Use of a fusion protein between GFP and an actin-binding domain to visualize transient filamentous-actin structures.
  Curr Biol, 8, 405-408.  
  9817844 S.Bañuelos, M.Saraste, and K.Djinović Carugo (1998).
Structural comparisons of calponin homology domains: implications for actin binding.
  Structure, 6, 1419-1431.
PDB code: 1bkr
9484592 Y.A.Puius, N.M.Mahoney, and S.C.Almo (1998).
The modular structure of actin-regulatory proteins.
  Curr Opin Cell Biol, 10, 23-34.  
9334343 D.Hanein, P.Matsudaira, and D.J.DeRosier (1997).
Evidence for a conformational change in actin induced by fimbrin (N375) binding.
  J Cell Biol, 139, 387-396.  
  9409826 T.M.Sandrock, J.L.O'Dell, and A.E.Adams (1997).
Allele-specific suppression by formation of new protein-protein interactions in yeast.
  Genetics, 147, 1635-1642.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.