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Contents |
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274 a.a.
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100 a.a.
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115 a.a.
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209 a.a.
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* Residue conservation analysis
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PDB id:
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| Name: |
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Complex (mhc/viral peptide/receptor)
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Title:
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Complex between human t-cell receptor, viral peptide (tax), and hla-a 0201
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Structure:
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Hla-a 0201. Chain: a. Fragment: extracellular domains alpha 1, alpha 2, alpha 3. Synonym: hla-a2 heavy chain. Engineered: yes. Beta-2 microglobulin. Chain: b. Engineered: yes. Mutation: yes.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Organ: plasma. Cellular_location: plasma membrane. Gene: hla-a 0201. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Biol. unit:
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Pentamer (from
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Resolution:
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2.60Å
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R-factor:
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0.245
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R-free:
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0.320
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Authors:
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D.N.Garboczi,P.Ghosh,U.Utz,Q.R.Fan,W.E.Biddison,D.C.Wiley
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Key ref:
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D.N.Garboczi
et al.
(1996).
Structure of the complex between human T-cell receptor, viral peptide and HLA-A2.
Nature,
384,
134-141.
PubMed id:
DOI:
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Date:
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21-Jul-97
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Release date:
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17-Sep-97
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PROCHECK
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Headers
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References
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P01892
(1A02_HUMAN) -
HLA class I histocompatibility antigen, A-2 alpha chain
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Seq:
Struc:
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365 a.a.
274 a.a.
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P61769
(B2MG_HUMAN) -
Beta-2-microglobulin
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Seq:
Struc:
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119 a.a.
100 a.a.*
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Gene Ontology (GO) functional annotation
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Cellular component
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extracellular region
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8 terms
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Biological process
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immune response
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8 terms
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Biochemical function
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protein binding
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1 term
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DOI no:
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Nature
384:134-141
(1996)
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PubMed id:
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Structure of the complex between human T-cell receptor, viral peptide and HLA-A2.
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D.N.Garboczi,
P.Ghosh,
U.Utz,
Q.R.Fan,
W.E.Biddison,
D.C.Wiley.
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ABSTRACT
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Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a major
histocompatibility complex (MHC) molecule occurs through variable loops in the
TCR structure which bury almost all the available peptide and a much larger area
of the MHC molecule. The TCR fits diagonally across the MHC peptide-binding site
in a surface feature common to all class I and class II MHC molecules, providing
evidence that the nature of binding is general. A broadly applicable binding
mode has implications for the mechanism of repertoire selection and the
magnitude of alloreactions.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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|
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B.Loll,
C.Rückert,
C.S.Hee,
W.Saenger,
B.Uchanska-Ziegler,
and
A.Ziegler
(2011).
Loss of recognition by cross-reactive T cells and its relation to a C-terminus-induced conformational reorientation of an HLA-B*2705-bound peptide.
|
| |
Protein Sci, 20,
278-290.
|
|
|
|
|
|
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D.H.Aggen,
A.S.Chervin,
F.K.Insaidoo,
K.H.Piepenbrink,
B.M.Baker,
and
D.M.Kranz
(2011).
Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors.
|
| |
Protein Eng Des Sel, 24,
361-372.
|
|
|
|
|
|
|
D.K.Sethi,
D.A.Schubert,
A.K.Anders,
A.Heroux,
D.A.Bonsor,
C.P.Thomas,
E.J.Sundberg,
J.Pyrdol,
and
K.W.Wucherpfennig
(2011).
A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC.
|
| |
J Exp Med, 208,
91.
|
|
|
PDB code:
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|
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|
|
J.M.Khan,
and
S.Ranganathan
(2011).
Understanding TR Binding to pMHC Complexes: How Does a TR Scan Many pMHC Complexes yet Preferentially Bind to One.
|
| |
PLoS One, 6,
e17194.
|
|
|
|
|
|
|
K.W.Wucherpfennig,
and
D.Sethi
(2011).
T cell receptor recognition of self and foreign antigens in the induction of autoimmunity.
|
| |
Semin Immunol, 23,
84-91.
|
|
|
|
|
|
|
R.L.Wong,
B.Liu,
X.Zhu,
L.You,
L.Kong,
K.P.Han,
H.I.Lee,
P.A.Chavaillaz,
M.Jin,
Y.Wang,
P.R.Rhode,
and
H.C.Wong
(2011).
Interleukin-15:Interleukin-15 receptor {alpha} scaffold for creation of multivalent targeted immune molecules.
|
| |
Protein Eng Des Sel, 24,
373-383.
|
|
|
|
|
|
|
S.Gras,
L.Kjer-Nielsen,
Z.Chen,
J.Rossjohn,
and
J.McCluskey
(2011).
The structural bases of direct T-cell allorecognition: implications for T-cell-mediated transplant rejection.
|
| |
Immunol Cell Biol, 89,
388-395.
|
|
|
|
|
|
|
T.Mallevaey,
A.J.Clarke,
J.P.Scott-Browne,
M.H.Young,
L.C.Roisman,
D.G.Pellicci,
O.Patel,
J.P.Vivian,
J.L.Matsuda,
J.McCluskey,
D.I.Godfrey,
P.Marrack,
J.Rossjohn,
and
L.Gapin
(2011).
A molecular basis for NKT cell recognition of CD1d-self-antigen.
|
| |
Immunity, 34,
315-326.
|
|
|
|
|
|
|
A.J.Czaja
(2010).
Emerging opportunities for site-specific molecular and cellular interventions in autoimmune hepatitis.
|
| |
Dig Dis Sci, 55,
2712-2726.
|
|
|
|
|
|
|
A.K.Chakraborty,
and
A.Kosmrlj
(2010).
Statistical mechanical concepts in immunology.
|
| |
Annu Rev Phys Chem, 61,
283-303.
|
|
|
|
|
|
|
C.Bluemel,
S.Hausmann,
P.Fluhr,
M.Sriskandarajah,
W.B.Stallcup,
P.A.Baeuerle,
and
P.Kufer
(2010).
Epitope distance to the target cell membrane and antigen size determine the potency of T cell-mediated lysis by BiTE antibodies specific for a large melanoma surface antigen.
|
| |
Cancer Immunol Immunother, 59,
1197-1209.
|
|
|
|
|
|
|
D.K.Cole,
E.S.Edwards,
K.K.Wynn,
M.Clement,
J.J.Miles,
K.Ladell,
J.Ekeruche,
E.Gostick,
K.J.Adams,
A.Skowera,
M.Peakman,
L.Wooldridge,
D.A.Price,
and
A.K.Sewell
(2010).
Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition.
|
| |
J Immunol, 185,
2600-2610.
|
|
|
|
|
|
|
G.I.van Boxel,
S.Holmes,
L.Fugger,
and
E.Y.Jones
(2010).
An alternative conformation of the T-cell receptor alpha constant region.
|
| |
J Mol Biol, 400,
828-837.
|
|
|
|
|
|
|
J.J.Miles,
A.M.Bulek,
D.K.Cole,
E.Gostick,
A.J.Schauenburg,
G.Dolton,
V.Venturi,
M.P.Davenport,
M.P.Tan,
S.R.Burrows,
L.Wooldridge,
D.A.Price,
P.J.Rizkallah,
and
A.K.Sewell
(2010).
Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection.
|
| |
PLoS Pathog, 6,
e1001198.
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PDB code:
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K.W.Wucherpfennig,
E.Gagnon,
M.J.Call,
E.S.Huseby,
and
M.E.Call
(2010).
Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.
|
| |
Cold Spring Harb Perspect Biol, 2,
a005140.
|
|
|
|
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|
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S.A.Valkenburg,
E.B.Day,
N.G.Swan,
H.A.Croom,
F.R.Carbone,
P.C.Doherty,
S.J.Turner,
and
K.Kedzierska
(2010).
Fixing an irrelevant TCR alpha chain reveals the importance of TCR beta diversity for optimal TCR alpha beta pairing and function of virus-specific CD8+ T cells.
|
| |
Eur J Immunol, 40,
2470-2481.
|
|
|
|
|
|
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D.Hatherley,
S.C.Graham,
K.Harlos,
D.I.Stuart,
and
A.N.Barclay
(2009).
Structure of signal-regulatory protein alpha: a link to antigen receptor evolution.
|
| |
J Biol Chem, 284,
26613-26619.
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PDB code:
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|
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D.K.Cole,
F.Yuan,
P.J.Rizkallah,
J.J.Miles,
E.Gostick,
D.A.Price,
G.F.Gao,
B.K.Jakobsen,
and
A.K.Sewell
(2009).
Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor.
|
| |
J Biol Chem, 284,
27281-27289.
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PDB code:
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J.J.Cragnolini,
N.García-Medel,
and
J.A.de Castro
(2009).
Endogenous processing and presentation of T-cell epitopes from Chlamydia trachomatis with relevance in HLA-B27-associated reactive arthritis.
|
| |
Mol Cell Proteomics, 8,
1850-1859.
|
|
|
|
|
|
|
J.N.Haidar,
B.Pierce,
Y.Yu,
W.Tong,
M.Li,
and
Z.Weng
(2009).
Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC.
|
| |
Proteins, 74,
948-960.
|
|
|
|
|
|
|
J.Petersen,
S.J.Wurzbacher,
N.A.Williamson,
S.H.Ramarathinam,
H.H.Reid,
A.K.Nair,
A.Y.Zhao,
R.Nastovska,
G.Rudge,
J.Rossjohn,
and
A.W.Purcell
(2009).
Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes.
|
| |
Proc Natl Acad Sci U S A, 106,
2776-2781.
|
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PDB codes:
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K.C.Garcia,
J.J.Adams,
D.Feng,
and
L.K.Ely
(2009).
The molecular basis of TCR germline bias for MHC is surprisingly simple.
|
| |
Nat Immunol, 10,
143-147.
|
|
|
|
|
|
|
K.H.Piepenbrink,
O.Y.Borbulevych,
R.F.Sommese,
J.Clemens,
K.M.Armstrong,
C.Desmond,
P.Do,
and
B.M.Baker
(2009).
Fluorine substitutions in an antigenic peptide selectively modulate T-cell receptor binding in a minimally perturbing manner.
|
| |
Biochem J, 423,
353-361.
|
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|
PDB codes:
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|
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O.Y.Borbulevych,
K.H.Piepenbrink,
B.E.Gloor,
D.R.Scott,
R.F.Sommese,
D.K.Cole,
A.K.Sewell,
and
B.M.Baker
(2009).
T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility.
|
| |
Immunity, 31,
885-896.
|
|
|
PDB codes:
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P.Kumar,
A.Vahedi-Faridi,
W.Saenger,
A.Ziegler,
and
B.Uchanska-Ziegler
(2009).
Conformational changes within the HLA-A1:MAGE-A1 complex induced by binding of a recombinant antibody fragment with TCR-like specificity.
|
| |
Protein Sci, 18,
37-49.
|
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PDB code:
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|
|
P.Tolar,
and
S.K.Pierce
(2009).
Change we can believe in--of the conformational type. Workshop on the Initiation of Antigen Receptor Signaling.
|
| |
EMBO Rep, 10,
331-336.
|
|
|
|
|
|
|
S.A.Richman,
D.H.Aggen,
M.L.Dossett,
D.L.Donermeyer,
P.M.Allen,
P.D.Greenberg,
and
D.M.Kranz
(2009).
Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain ValphaVbeta fragments.
|
| |
Mol Immunol, 46,
902-916.
|
|
|
|
|
|
|
T.Connelley,
J.Aerts,
A.Law,
and
W.I.Morrison
(2009).
Genomic analysis reveals extensive gene duplication within the bovine TRB locus.
|
| |
BMC Genomics, 10,
192.
|
|
|
|
|
|
|
X.Shang,
L.Wang,
W.Niu,
G.Meng,
X.Fu,
B.Ni,
Z.Lin,
Z.Yang,
X.Chen,
and
Y.Wu
(2009).
Rational optimization of tumor epitopes using in silico analysis-assisted substitution of TCR contact residues.
|
| |
Eur J Immunol, 39,
2248-2258.
|
|
|
|
|
|
|
Y.Chen,
Y.Shi,
H.Cheng,
Y.Q.An,
and
G.F.Gao
(2009).
Structural immunology and crystallography help immunologists see the immune system in action: how T and NK cells touch their ligands.
|
| |
IUBMB Life, 61,
579-590.
|
|
|
|
|
|
|
D.I.Godfrey,
J.Rossjohn,
and
J.McCluskey
(2008).
The fidelity, occasional promiscuity, and versatility of T cell receptor recognition.
|
| |
Immunity, 28,
304-314.
|
|
|
|
|
|
|
E.J.Adams,
P.Strop,
S.Shin,
Y.H.Chien,
and
K.C.Garcia
(2008).
An autonomous CDR3delta is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by gammadelta T cells.
|
| |
Nat Immunol, 9,
777-784.
|
|
|
|
|
|
|
E.J.Collins,
and
D.S.Riddle
(2008).
TCR-MHC docking orientation: natural selection, or thymic selection?
|
| |
Immunol Res, 41,
267-294.
|
|
|
|
|
|
|
J.Ishizuka,
G.B.Stewart-Jones,
A.van der Merwe,
J.I.Bell,
A.J.McMichael,
and
E.Y.Jones
(2008).
The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain.
|
| |
Immunity, 28,
171-182.
|
|
|
PDB codes:
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K.Kedzierska,
N.L.La Gruta,
J.Stambas,
S.J.Turner,
and
P.C.Doherty
(2008).
Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity.
|
| |
Mol Immunol, 45,
607-618.
|
|
|
|
|
|
|
K.M.Armstrong,
K.H.Piepenbrink,
and
B.M.Baker
(2008).
Conformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes.
|
| |
Biochem J, 415,
183-196.
|
|
|
|
|
|
|
M.A.Cuendet,
and
O.Michielin
(2008).
Protein-protein interaction investigated by steered molecular dynamics: the TCR-pMHC complex.
|
| |
Biophys J, 95,
3575-3590.
|
|
|
|
|
|
|
M.A.Exley,
R.Hou,
A.Shaulov,
E.Tonti,
P.Dellabona,
G.Casorati,
O.Akbari,
H.O.Akman,
E.A.Greenfield,
J.E.Gumperz,
J.E.Boyson,
S.P.Balk,
and
S.B.Wilson
(2008).
Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop.
|
| |
Eur J Immunol, 38,
1756-1766.
|
|
|
|
|
|
|
M.Cohn
(2008).
An in depth analysis of the concept of "polyspecificity" assumed to characterize TCR/BCR recognition.
|
| |
Immunol Res, 40,
128-147.
|
|
|
|
|
|
|
M.Cohn
(2008).
The Tritope Model for restrictive recognition of antigen by T-cells II. Implications for ontogeny, evolution and physiology.
|
| |
Mol Immunol, 45,
632-652.
|
|
|
|
|
|
|
M.L.Dustin
(2008).
T-cell activation through immunological synapses and kinapses.
|
| |
Immunol Rev, 221,
77-89.
|
|
|
|
|
|
|
M.L.Dustin
(2008).
Hunter to gatherer and back: immunological synapses and kinapses as variations on the theme of amoeboid locomotion.
|
| |
Annu Rev Cell Dev Biol, 24,
577-596.
|
|
|
|
|
|
|
P.Marrack,
J.P.Scott-Browne,
S.Dai,
L.Gapin,
and
J.W.Kappler
(2008).
Evolutionarily conserved amino acids that control TCR-MHC interaction.
|
| |
Annu Rev Immunol, 26,
171-203.
|
|
|
|
|
|
|
P.Marrack,
K.Rubtsova,
J.Scott-Browne,
and
J.W.Kappler
(2008).
T cell receptor specificity for major histocompatibility complex proteins.
|
| |
Curr Opin Immunol, 20,
203-207.
|
|
|
|
|
|
|
S.Dai,
E.S.Huseby,
K.Rubtsova,
J.Scott-Browne,
F.Crawford,
W.A.Macdonald,
P.Marrack,
and
J.W.Kappler
(2008).
Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules.
|
| |
Immunity, 28,
324-334.
|
|
|
PDB codes:
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|
|
|
|
|
|
|
Z.Kato,
J.N.Stern,
H.K.Nakamura,
K.Kuwata,
N.Kondo,
and
J.L.Strominger
(2008).
Positioning of autoimmune TCR-Ob.2F3 and TCR-Ob.3D1 on the MBP85-99/HLA-DR2 complex.
|
| |
Proc Natl Acad Sci U S A, 105,
15523-15528.
|
|
|
|
|
|
|
Z.Ma,
K.A.Sharp,
P.A.Janmey,
and
T.H.Finkel
(2008).
Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity.
|
| |
PLoS Biol, 6,
e43.
|
|
|
|
|
|
|
A.de Jong,
E.C.Arce,
T.Y.Cheng,
R.P.van Summeren,
B.L.Feringa,
V.Dudkin,
D.Crich,
I.Matsunaga,
A.J.Minnaard,
and
D.B.Moody
(2007).
CD1c presentation of synthetic glycolipid antigens with foreign alkyl branching motifs.
|
| |
Chem Biol, 14,
1232-1242.
|
|
|
|
|
|
|
D.Feng,
C.J.Bond,
L.K.Ely,
J.Maynard,
and
K.C.Garcia
(2007).
Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'.
|
| |
Nat Immunol, 8,
975-983.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
D.Hatherley,
K.Harlos,
D.C.Dunlop,
D.I.Stuart,
and
A.N.Barclay
(2007).
The structure of the macrophage signal regulatory protein alpha (SIRPalpha) inhibitory receptor reveals a binding face reminiscent of that used by T cell receptors.
|
| |
J Biol Chem, 282,
14567-14575.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
D.Masopust,
V.Vezys,
E.J.Wherry,
and
R.Ahmed
(2007).
A brief history of CD8 T cells.
|
| |
Eur J Immunol, 37,
S103-S110.
|
|
|
|
|
|
|
E.Evensen,
D.Joseph-McCarthy,
G.A.Weiss,
S.L.Schreiber,
and
M.Karplus
(2007).
Ligand design by a combinatorial approach based on modeling and experiment: application to HLA-DR4.
|
| |
J Comput Aided Mol Des, 21,
395-418.
|
|
|
|
|
|
|
F.E.Tynan,
H.H.Reid,
L.Kjer-Nielsen,
J.J.Miles,
M.C.Wilce,
L.Kostenko,
N.A.Borg,
N.A.Williamson,
T.Beddoe,
A.W.Purcell,
S.R.Burrows,
J.McCluskey,
and
J.Rossjohn
(2007).
A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule.
|
| |
Nat Immunol, 8,
268-276.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.Kuball,
M.L.Dossett,
M.Wolfl,
W.Y.Ho,
R.H.Voss,
C.Fowler,
and
P.D.Greenberg
(2007).
Facilitating matched pairing and expression of TCR chains introduced into human T cells.
|
| |
Blood, 109,
2331-2338.
|
|
|
|
|
|
|
K.M.Armstrong,
and
B.M.Baker
(2007).
A comprehensive calorimetric investigation of an entropically driven T cell receptor-peptide/major histocompatibility complex interaction.
|
| |
Biophys J, 93,
597-609.
|
|
|
|
|
|
|
K.R.Jun,
S.E.Choi,
C.H.Cha,
H.B.Oh,
Y.S.Heo,
H.Y.Ahn,
and
K.J.Lee
(2007).
Meta-analysis of the association between HLA-DRB1 allele and rheumatoid arthritis susceptibility in Asian populations.
|
| |
J Korean Med Sci, 22,
973-980.
|
|
|
|
|
|
|
K.W.Wucherpfennig,
P.M.Allen,
F.Celada,
I.R.Cohen,
R.De Boer,
K.C.Garcia,
B.Goldstein,
R.Greenspan,
D.Hafler,
P.Hodgkin,
E.S.Huseby,
D.C.Krakauer,
D.Nemazee,
A.S.Perelson,
C.Pinilla,
R.K.Strong,
and
E.E.Sercarz
(2007).
Polyspecificity of T cell and B cell receptor recognition.
|
| |
Semin Immunol, 19,
216-224.
|
|
|
|
|
|
|
M.A.Cuendet,
and
W.F.van Gunsteren
(2007).
On the calculation of velocity-dependent properties in molecular dynamics simulations using the leapfrog integration algorithm.
|
| |
J Chem Phys, 127,
184102.
|
|
|
|
|
|
|
M.Herget,
and
R.Tampé
(2007).
Intracellular peptide transporters in human--compartmentalization of the "peptidome".
|
| |
Pflugers Arch, 453,
591-600.
|
|
|
|
|
|
|
O.Y.Borbulevych,
F.K.Insaidoo,
T.K.Baxter,
D.J.Powell,
L.A.Johnson,
N.P.Restifo,
and
B.M.Baker
(2007).
Structures of MART-126/27-35 Peptide/HLA-A2 complexes reveal a remarkable disconnect between antigen structural homology and T cell recognition.
|
| |
J Mol Biol, 372,
1123-1136.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
P.J.Miller,
Y.Pazy,
B.Conti,
D.Riddle,
E.Appella,
and
E.J.Collins
(2007).
Single MHC mutation eliminates enthalpy associated with T cell receptor binding.
|
| |
J Mol Biol, 373,
315-327.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
S.Minguet,
M.Swamy,
B.Alarcón,
I.F.Luescher,
and
W.W.Schamel
(2007).
Full activation of the T cell receptor requires both clustering and conformational changes at CD3.
|
| |
Immunity, 26,
43-54.
|
|
|
|
|
|
|
Y.H.Chien,
and
Y.Konigshofer
(2007).
Antigen recognition by gammadelta T cells.
|
| |
Immunol Rev, 215,
46-58.
|
|
|
|
|
|
|
Y.Nakagawa,
H.Kikuchi,
and
H.Takahashi
(2007).
Molecular analysis of TCR and peptide/MHC interaction using P18-I10-derived peptides with a single D-amino acid substitution.
|
| |
Biophys J, 92,
2570-2582.
|
|
|
|
|
|
|
Y.Sun,
F.Kong,
S.Ren,
F.Yuan,
F.Liang,
N.Liu,
L.Jin,
and
Y.Xi
(2007).
Severe acute graft-vs-host disease in a patient with acute monocytic leukemia having a recombination event between HLA-A/B loci from a multiple recombinant family.
|
| |
Tissue Antigens, 70,
499-505.
|
|
|
|
|
|
|
A.K.Iversen,
G.Stewart-Jones,
G.H.Learn,
N.Christie,
C.Sylvester-Hviid,
A.E.Armitage,
R.Kaul,
T.Beattie,
J.K.Lee,
Y.Li,
P.Chotiyarnwong,
T.Dong,
X.Xu,
M.A.Luscher,
K.MacDonald,
H.Ullum,
B.Klarlund-Pedersen,
P.Skinhøj,
L.Fugger,
S.Buus,
J.I.Mullins,
E.Y.Jones,
P.A.van der Merwe,
and
A.J.McMichael
(2006).
Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope.
|
| |
Nat Immunol, 7,
179-189.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
C.Douat-Casassus,
N.Marchand-Geneste,
E.Diez,
C.Aznar,
P.Picard,
S.Geoffre,
A.Huet,
M.L.Bourguet-Kondracki,
N.Gervois,
F.Jotereau,
and
S.Quideau
(2006).
Covalent modification of a melanoma-derived antigenic peptide with a natural quinone methide. Preliminary chemical, molecular modelling and immunological evaluation studies.
|
| |
Mol Biosyst, 2,
240-249.
|
|
|
|
|
|
|
C.Rückert,
M.T.Fiorillo,
B.Loll,
R.Moretti,
J.Biesiadka,
W.Saenger,
A.Ziegler,
R.Sorrentino,
and
B.Uchanska-Ziegler
(2006).
Conformational dimorphism of self-peptides and molecular mimicry in a disease-associated HLA-B27 subtype.
|
| |
J Biol Chem, 281,
2306-2316.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
C.S.Clements,
M.A.Dunstone,
W.A.Macdonald,
J.McCluskey,
and
J.Rossjohn
(2006).
Specificity on a knife-edge: the alphabeta T cell receptor.
|
| |
Curr Opin Struct Biol, 16,
787-795.
|
|
|
|
|
|
|
C.Thilo,
P.Berglund,
S.E.Applequist,
J.W.Yewdell,
H.G.Ljunggren,
and
A.Achour
(2006).
Dissection of the interaction of the human cytomegalovirus-derived US2 protein with major histocompatibility complex class I molecules: prominent role of a single arginine residue in human leukocyte antigen-A2.
|
| |
J Biol Chem, 281,
8950-8957.
|
|
|
|
|
|
|
C.Xu,
M.E.Call,
and
K.W.Wucherpfennig
(2006).
A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor.
|
| |
J Biol Chem, 281,
36977-36984.
|
|
|
|
|
|
|
D.H.Bos,
and
B.Waldman
(2006).
Polymorphism, natural selection, and structural modeling of class Ia MHC in the African clawed frog (Xenopus laevis).
|
| |
Immunogenetics, 58,
433-442.
|
|
|
|
|
|
|
D.K.Cole,
P.J.Rizkallah,
F.Gao,
N.I.Watson,
J.M.Boulter,
J.I.Bell,
M.Sami,
G.F.Gao,
and
B.K.Jakobsen
(2006).
Crystal structure of HLA-A*2402 complexed with a telomerase peptide.
|
| |
Eur J Immunol, 36,
170-179.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
E.Martinez-Hackert,
N.Anikeeva,
S.A.Kalams,
B.D.Walker,
W.A.Hendrickson,
and
Y.Sykulev
(2006).
Structural basis for degenerate recognition of natural HIV peptide variants by cytotoxic lymphocytes.
|
| |
J Biol Chem, 281,
20205-20212.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
H.J.Wallny,
D.Avila,
L.G.Hunt,
T.J.Powell,
P.Riegert,
J.Salomonsen,
K.Skjødt,
O.Vainio,
F.Vilbois,
M.V.Wiles,
and
J.Kaufman
(2006).
Peptide motifs of the single dominantly expressed class I molecule explain the striking MHC-determined response to Rous sarcoma virus in chickens.
|
| |
Proc Natl Acad Sci U S A, 103,
1434-1439.
|
|
|
|
|
|
|
K.Hoelsch,
I.Lenggeler,
H.Knabe,
K.Hartel,
H.G.Klein,
and
A.Woelpl
(2006).
Identification of a novel HLA-B*44 variant (B*4441) in three unrelated Caucasian individuals.
|
| |
Tissue Antigens, 67,
247-249.
|
|
|
|
|
|
|
K.Kedzierska,
N.L.La Gruta,
S.J.Turner,
and
P.C.Doherty
(2006).
Establishment and recall of CD8+ T-cell memory in a model of localized transient infection.
|
| |
Immunol Rev, 211,
133-145.
|
|
|
|
|
|
|
L.K.Ely,
T.Beddoe,
C.S.Clements,
J.M.Matthews,
A.W.Purcell,
L.Kjer-Nielsen,
J.McCluskey,
and
J.Rossjohn
(2006).
Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction.
|
| |
Proc Natl Acad Sci U S A, 103,
6641-6646.
|
|
|
|
|
|
|
M.G.Rudolph,
R.L.Stanfield,
and
I.A.Wilson
(2006).
How TCRs bind MHCs, peptides, and coreceptors.
|
| |
Annu Rev Immunol, 24,
419-466.
|
|
|
|
|
|
|
M.H.Andersen,
D.Schrama,
P.Thor Straten,
and
J.C.Becker
(2006).
Cytotoxic T cells.
|
| |
J Invest Dermatol, 126,
32-41.
|
|
|
|
|
|
|
M.Sospedra,
and
R.Martin
(2006).
Molecular mimicry in multiple sclerosis.
|
| |
Autoimmunity, 39,
3-8.
|
|
|
|
|
|
|
M.Sospedra,
and
R.Martin
(2006).
When T cells recognize a pattern, they might cause trouble.
|
| |
Curr Opin Immunol, 18,
697-703.
|
|
|
|
|
|
|
P.D.Baum,
and
J.M.McCune
(2006).
Direct measurement of T-cell receptor repertoire diversity with AmpliCot.
|
| |
Nat Methods, 3,
895-901.
|
|
|
|
|
|
|
P.Dokouhaki,
R.Moghadam,
F.Akbariasbagh,
A.Zarnani,
M.G.Novin,
A.Razavi,
and
M.Jeddi-Tehrani
(2006).
Expression profile and clonality of T-cell receptor beta variable genes in normal human endometrium.
|
| |
Am J Reprod Immunol, 55,
349-359.
|
|
|
|
|
|
|
P.J.Bjorkman
(2006).
Finding the groove.
|
| |
Nat Immunol, 7,
787-789.
|
|
|
|
|
|
|
S.D.Gadola,
M.Koch,
J.Marles-Wright,
N.M.Lissin,
D.Shepherd,
G.Matulis,
K.Harlos,
P.M.Villiger,
D.I.Stuart,
B.K.Jakobsen,
V.Cerundolo,
and
E.Y.Jones
(2006).
Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors.
|
| |
J Exp Med, 203,
699-710.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
S.J.Davis,
and
P.A.van der Merwe
(2006).
The kinetic-segregation model: TCR triggering and beyond.
|
| |
Nat Immunol, 7,
803-809.
|
|
|
|
|
|
|
S.J.Turner,
P.C.Doherty,
J.McCluskey,
and
J.Rossjohn
(2006).
Structural determinants of T-cell receptor bias in immunity.
|
| |
Nat Rev Immunol, 6,
883-894.
|
|
|
|
|
|
|
S.M.Dunn,
P.J.Rizkallah,
E.Baston,
T.Mahon,
B.Cameron,
R.Moysey,
F.Gao,
M.Sami,
J.Boulter,
Y.Li,
and
B.K.Jakobsen
(2006).
Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.
|
| |
Protein Sci, 15,
710-721.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
Y.Tanaka
(2006).
Human gamma delta T cells and tumor immunotherapy.
|
| |
J Clin Exp Hematop, 46,
11-23.
|
|
|
|
|
|
|
Y.Xin-Sheng,
X.Zheng-Jun,
M.Li,
S.Wan-Bang,
Z.Wei-Yang,
W.Qian,
H.Zhi-Ming,
M.Min-Jie,
L.Ying,
W.Zhen-Qiang,
H.Xiao-Wei,
W.Ju-Fang,
and
W.Xiao-Ning
(2006).
Analysis of the CDR3 region of alpha/beta T-cell receptors (TCRs) and TCR BD gene double-stranded recombination signal sequence breaks end in peripheral blood mononuclear cells of T-lineage acute lymphoblastic leukemia.
|
| |
Clin Lab Haematol, 28,
405-415.
|
|
|
|
|
|
|
B.Laugel,
J.M.Boulter,
N.Lissin,
A.Vuidepot,
Y.Li,
E.Gostick,
L.E.Crotty,
D.C.Douek,
J.Hemelaar,
D.A.Price,
B.K.Jakobsen,
and
A.K.Sewell
(2005).
Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition.
|
| |
J Biol Chem, 280,
1882-1892.
|
|
|
|
|
|
|
C.Bade-Doeding,
B.Eiz-Vesper,
C.Figueiredo,
A.Seltsam,
H.A.Elsner,
and
R.Blasczyk
(2005).
Peptide-binding motif of HLA-A*6603.
|
| |
Immunogenetics, 56,
769-772.
|
|
|
|
|
|
|
C.Barassi,
E.Soprana,
C.Pastori,
R.Longhi,
E.Buratti,
F.Lillo,
C.Marenzi,
A.Lazzarin,
A.G.Siccardi,
and
L.Lopalco
(2005).
Induction of murine mucosal CCR5-reactive antibodies as an anti-human immunodeficiency virus strategy.
|
| |
J Virol, 79,
6848-6858.
|
|
|
|
|
|
|
D.B.Moody,
D.M.Zajonc,
and
I.A.Wilson
(2005).
Anatomy of CD1-lipid antigen complexes.
|
| |
Nat Rev Immunol, 5,
387-399.
|
|
|
|
|
|
|
D.M.Zajonc,
M.D.Crispin,
T.A.Bowden,
D.C.Young,
T.Y.Cheng,
J.Hu,
C.E.Costello,
P.M.Rudd,
R.A.Dwek,
M.J.Miller,
M.B.Brenner,
D.B.Moody,
and
I.A.Wilson
(2005).
Molecular mechanism of lipopeptide presentation by CD1a.
|
| |
Immunity, 22,
209-219.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
E.F.Houston,
T.Connelley,
K.Parsons,
N.D.MacHugh,
and
W.I.Morrison
(2005).
Analysis of T-cell receptor BV gene sequences in cattle reveals extensive duplication within the BV9 and BV20 subgroups.
|
| |
Immunogenetics, 57,
674-681.
|
|
|
|
|
|
|
E.J.Adams,
Y.H.Chien,
and
K.C.Garcia
(2005).
Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22.
|
| |
Science, 308,
227-231.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
E.Y.Jones
(2005).
Favorite flavors of surfaces.
|
| |
Nat Immunol, 6,
365-366.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
F.E.Tynan,
S.R.Burrows,
A.M.Buckle,
C.S.Clements,
N.A.Borg,
J.J.Miles,
T.Beddoe,
J.C.Whisstock,
M.C.Wilce,
S.L.Silins,
J.M.Burrows,
L.Kjer-Nielsen,
L.Kostenko,
A.W.Purcell,
J.McCluskey,
and
J.Rossjohn
(2005).
T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide.
|
| |
Nat Immunol, 6,
1114-1122.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
H.Li,
S.Van Vranken,
Y.Zhao,
Z.Li,
Y.Guo,
L.Eisele,
and
Y.Li
(2005).
Crystal structures of T cell receptor (beta) chains related to rheumatoid arthritis.
|
| |
Protein Sci, 14,
3025-3038.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
H.Thude,
C.Hardt,
U.Schorner,
S.Ferencik,
C.Helfricht,
and
D.Barz
(2005).
Identification of a new HLA-B allele, HLA-B*4443, in a German family.
|
| |
Tissue Antigens, 66,
696-699.
|
|
|
|
|
|
|
I.Van Rhijn,
D.M.Zajonc,
I.A.Wilson,
and
D.B.Moody
(2005).
T-cell activation by lipopeptide antigens.
|
| |
Curr Opin Immunol, 17,
222-229.
|
|
|
|
|
|
|
J.C.Huang,
R.J.Ober,
and
E.S.Ward
(2005).
The central residues of a T cell receptor sequence motif are key determinants of autoantigen recognition in murine experimental autoimmune encephalomyelitis.
|
| |
Eur J Immunol, 35,
299-304.
|
|
|
|
|
|
|
J.D.Hayball,
and
R.A.Lake
(2005).
The immune function of MHC class II molecules mutated in the putative superdimer interface.
|
| |
Mol Cell Biochem, 273,
1-9.
|
|
|
|
|
|
|
J.L.Chen,
G.Stewart-Jones,
G.Bossi,
N.M.Lissin,
L.Wooldridge,
E.M.Choi,
G.Held,
P.R.Dunbar,
R.M.Esnouf,
M.Sami,
J.M.Boulter,
P.Rizkallah,
C.Renner,
A.Sewell,
P.A.van der Merwe,
B.K.Jakobsen,
G.Griffiths,
E.Y.Jones,
and
V.Cerundolo
(2005).
Structural and kinetic basis for heightened immunogenicity of T cell vaccines.
|
| |
J Exp Med, 201,
1243-1255.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
K.Choudhuri,
D.Wiseman,
M.H.Brown,
K.Gould,
and
P.A.van der Merwe
(2005).
T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand.
|
| |
Nature, 436,
578-582.
|
|
|
|
|
|
|
K.Oved,
A.Lev,
R.Noy,
D.Segal,
and
Y.Reiter
(2005).
Antibody-mediated targeting of human single-chain class I MHC with covalently linked peptides induces efficient killing of tumor cells by tumor or viral-specific cytotoxic T lymphocytes.
|
| |
Cancer Immunol Immunother, 54,
867-879.
|
|
|
|
|
|
|
M.E.Call,
and
K.W.Wucherpfennig
(2005).
The T cell receptor: critical role of the membrane environment in receptor assembly and function.
|
| |
Annu Rev Immunol, 23,
101-125.
|
|
|
|
|
|
|
M.Hahn,
M.J.Nicholson,
J.Pyrdol,
and
K.W.Wucherpfennig
(2005).
Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor.
|
| |
Nat Immunol, 6,
490-496.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
M.Krogsgaard,
and
M.M.Davis
(2005).
How T cells 'see' antigen.
|
| |
Nat Immunol, 6,
239-245.
|
|
|
|
|
|
|
M.Schmitt-Haendle,
O.Bachmann,
E.Harrer,
B.Schmidt,
M.Bäuerle,
and
T.Harrer
(2005).
Recognition patterns of HLA-A2-restricted human immunodeficiency virus-1-specific cytotoxic T-lymphocytes in a cohort of HIV-1-infected individuals.
|
| |
Viral Immunol, 18,
627-636.
|
|
|
|
|
|
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M.Shuh,
and
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The human T-cell leukemia virus type 1 (HTLV-1): new insights into the clinical aspects and molecular pathogenesis of adult T-cell leukemia/lymphoma (ATLL) and tropical spastic paraparesis/HTLV-associated myelopathy (TSP/HAM).
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Microsc Res Tech, 68,
176-196.
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M.T.Fiorillo,
C.Rückert,
M.Hülsmeyer,
R.Sorrentino,
W.Saenger,
A.Ziegler,
and
B.Uchanska-Ziegler
(2005).
Allele-dependent similarity between viral and self-peptide presentation by HLA-B27 subtypes.
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| |
J Biol Chem, 280,
2962-2971.
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|
|
PDB codes:
|
|
|
|
|
|
|
|
N.A.Borg,
L.K.Ely,
T.Beddoe,
W.A.Macdonald,
H.H.Reid,
C.S.Clements,
A.W.Purcell,
L.Kjer-Nielsen,
J.J.Miles,
S.R.Burrows,
J.McCluskey,
and
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The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition.
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| |
Nat Immunol, 6,
171-180.
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|
O.J.Kwon,
S.H.Hwang,
S.S.Hur,
M.N.Lee,
and
H.B.Oh
(2005).
Novel HLA-Cw*01 allele, Cw*010203, identified by sequence-based typing*.
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| |
Tissue Antigens, 66,
240-241.
|
|
|
|
|
|
|
S.H.Hwang,
H.B.Oh,
S.S.Hur,
M.N.Lee,
S.A.Hong,
and
O.J.Kwon
(2005).
Novel HLA-A*31 allele, A*3111 identified by sequence-based typing.
|
| |
Tissue Antigens, 66,
145-147.
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|
|
|
|
|
|
S.J.Turner,
K.Kedzierska,
H.Komodromou,
N.L.La Gruta,
M.A.Dunstone,
A.I.Webb,
R.Webby,
H.Walden,
W.Xie,
J.McCluskey,
A.W.Purcell,
J.Rossjohn,
and
P.C.Doherty
(2005).
Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations.
|
| |
Nat Immunol, 6,
382-389.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
Y.Li,
R.Moysey,
P.E.Molloy,
A.L.Vuidepot,
T.Mahon,
E.Baston,
S.Dunn,
N.Liddy,
J.Jacob,
B.K.Jakobsen,
and
J.M.Boulter
(2005).
Directed evolution of human T-cell receptors with picomolar affinities by phage display.
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| |
Nat Biotechnol, 23,
349-354.
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|
Y.Li,
Y.Huang,
J.Lue,
J.A.Quandt,
R.Martin,
and
R.A.Mariuzza
(2005).
Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule.
|
| |
EMBO J, 24,
2968-2979.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
D.B.Moody,
D.C.Young,
T.Y.Cheng,
J.P.Rosat,
C.Roura-Mir,
P.B.O'Connor,
D.M.Zajonc,
A.Walz,
M.J.Miller,
S.B.Levery,
I.A.Wilson,
C.E.Costello,
and
M.B.Brenner
(2004).
T cell activation by lipopeptide antigens.
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| |
Science, 303,
527-531.
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|
J.E.Gumperz
(2004).
Antigen specificity of semi-invariant CD1d-restricted T cell receptors: the best of both worlds?
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| |
Immunol Cell Biol, 82,
285-294.
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|
J.K.Lee,
G.Stewart-Jones,
T.Dong,
K.Harlos,
K.Di Gleria,
L.Dorrell,
D.C.Douek,
P.A.van der Merwe,
E.Y.Jones,
and
A.J.McMichael
(2004).
T cell cross-reactivity and conformational changes during TCR engagement.
|
| |
J Exp Med, 200,
1455-1466.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.T.Pribila,
A.C.Quale,
K.L.Mueller,
and
Y.Shimizu
(2004).
Integrins and T cell-mediated immunity.
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| |
Annu Rev Immunol, 22,
157-180.
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K.Kedzierska,
S.J.Turner,
and
P.C.Doherty
(2004).
Conserved T cell receptor usage in primary and recall responses to an immunodominant influenza virus nucleoprotein epitope.
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| |
Proc Natl Acad Sci U S A, 101,
4942-4947.
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|
K.L.Arnett,
S.C.Harrison,
and
D.C.Wiley
(2004).
Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment.
|
| |
Proc Natl Acad Sci U S A, 101,
16268-16273.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
M.E.Call,
J.Pyrdol,
and
K.W.Wucherpfennig
(2004).
Stoichiometry of the T-cell receptor-CD3 complex and key intermediates assembled in the endoplasmic reticulum.
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| |
EMBO J, 23,
2348-2357.
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M.R.Haynes,
and
G.E.Wu
(2004).
Evolution of the variable gene segments and recombination signal sequences of the human T-cell receptor alpha/delta locus.
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| |
Immunogenetics, 56,
470-479.
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N.A.Watkins,
T.R.Dafforn,
M.Kuijpers,
C.Brown,
B.Javid,
P.J.Lehner,
C.Navarrete,
and
W.H.Ouwehand
(2004).
Molecular studies of anti-HLA-A2 using light-chain shuffling: a structural model for HLA antibody binding.
|
| |
Tissue Antigens, 63,
345-354.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
P.A.Wearsch,
C.A.Jakob,
A.Vallin,
R.A.Dwek,
P.M.Rudd,
and
P.Cresswell
(2004).
Major histocompatibility complex class I molecules expressed with monoglucosylated N-linked glycans bind calreticulin independently of their assembly status.
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| |
J Biol Chem, 279,
25112-25121.
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T.K.Baxter,
S.J.Gagnon,
R.L.Davis-Harrison,
J.C.Beck,
A.K.Binz,
R.V.Turner,
W.E.Biddison,
and
B.M.Baker
(2004).
Strategic mutations in the class I major histocompatibility complex HLA-A2 independently affect both peptide binding and T cell receptor recognition.
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| |
J Biol Chem, 279,
29175-29184.
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T.M.Razzaq,
P.Ozegbe,
E.C.Jury,
P.Sembi,
N.M.Blackwell,
and
P.S.Kabouridis
(2004).
Regulation of T-cell receptor signalling by membrane microdomains.
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| |
Immunology, 113,
413-426.
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A.Hamrouni,
A.Aublin,
P.Guillaume,
and
J.L.Maryanski
(2003).
T cell receptor gene rearrangement lineage analysis reveals clues for the origin of highly restricted antigen-specific repertoires.
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| |
J Exp Med, 197,
601-614.
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|
C.F.Suárez,
P.P.Cárdenas,
E.J.Llanos-Ballestas,
P.Martínez,
M.Obregón,
M.E.Patarroyo,
and
M.A.Patarroyo
(2003).
Alpha1 and alpha2 domains of Aotus MHC class I and Catarrhini MHC class Ia share similar characteristics.
|
| |
Tissue Antigens, 61,
362-373.
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D.G.Lim,
J.M.Slavik,
K.Bourcier,
K.J.Smith,
and
D.A.Hafler
(2003).
Allelic variation of MHC structure alters peptide ligands to induce atypical partial agonistic CD8+ T cell function.
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| |
J Exp Med, 198,
99.
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D.Garrigan,
and
P.W.Hedrick
(2003).
Perspective: detecting adaptive molecular polymorphism: lessons from the MHC.
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| |
Evolution Int J Org Evolution, 57,
1707-1722.
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H.Robertson,
and
J.A.Kirby
(2003).
Post-transplant renal tubulitis: the recruitment, differentiation and persistence of intra-epithelial T cells.
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| |
Am J Transplant, 3,
3.
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J.Buslepp,
H.Wang,
W.E.Biddison,
E.Appella,
and
E.J.Collins
(2003).
A correlation between TCR Valpha docking on MHC and CD8 dependence: implications for T cell selection.
|
| |
Immunity, 19,
595-606.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.W.Yewdell,
E.Reits,
and
J.Neefjes
(2003).
Making sense of mass destruction: quantitating MHC class I antigen presentation.
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| |
Nat Rev Immunol, 3,
952-961.
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K.Ogata,
A.Jaramillo,
W.Cohen,
J.P.Briand,
F.Connan,
J.Choppin,
S.Muller,
and
S.J.Wodak
(2003).
Automatic sequence design of major histocompatibility complex class I binding peptides impairing CD8+ T cell recognition.
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| |
J Biol Chem, 278,
1281-1290.
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L.Kjer-Nielsen,
C.S.Clements,
A.W.Purcell,
A.G.Brooks,
J.C.Whisstock,
S.R.Burrows,
J.McCluskey,
and
J.Rossjohn
(2003).
A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity.
|
| |
Immunity, 18,
53-64.
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|
|
PDB code:
|
|
|
|
|
|
|
|
M.Bak,
C.Hansen,
N.Tommerup,
and
L.A.Larsen
(2003).
The Hedgehog signaling pathway--implications for drug targets in cancer and neurodegenerative disorders.
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| |
Pharmacogenomics, 4,
411-429.
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|
P.A.van der Merwe,
and
S.J.Davis
(2003).
Molecular interactions mediating T cell antigen recognition.
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| |
Annu Rev Immunol, 21,
659-684.
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|
P.Santamaria
(2003).
Kinetic evolution of a diabetogenic CD8+ T cell response.
|
| |
Ann N Y Acad Sci, 1005,
88-97.
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|
|
|
R.H.McMahan,
L.Watson,
R.Meza-Romero,
G.G.Burrows,
D.N.Bourdette,
and
A.C.Buenafe
(2003).
Production, characterization, and immunogenicity of a soluble rat single chain T cell receptor specific for an encephalitogenic peptide.
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| |
J Biol Chem, 278,
30961-30970.
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|
S.J.Lee,
Y.Hori,
and
A.K.Chakraborty
(2003).
Low T cell receptor expression and thermal fluctuations contribute to formation of dynamic multifocal synapses in thymocytes.
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| |
Proc Natl Acad Sci U S A, 100,
4383-4388.
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S.J.Turner,
G.Diaz,
R.Cross,
and
P.C.Doherty
(2003).
Analysis of clonotype distribution and persistence for an influenza virus-specific CD8+ T cell response.
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| |
Immunity, 18,
549-559.
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S.Radaev,
and
P.D.Sun
(2003).
Structure and function of natural killer cell surface receptors.
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| |
Annu Rev Biophys Biomol Struct, 32,
93.
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S.Raychaudhuri,
A.K.Chakraborty,
and
M.Kardar
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Effective membrane model of the immunological synapse.
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| |
Phys Rev Lett, 91,
208101.
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Z.Wang,
and
J.Moult
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Three-dimensional structural location and molecular functional effects of missense SNPs in the T cell receptor Vbeta domain.
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| |
Proteins, 53,
748-757.
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|
|
A.Achour,
J.Michaëlsson,
R.A.Harris,
J.Odeberg,
P.Grufman,
J.K.Sandberg,
V.Levitsky,
K.Kärre,
T.Sandalova,
and
G.Schneider
(2002).
A structural basis for LCMV immune evasion: subversion of H-2D(b) and H-2K(b) presentation of gp33 revealed by comparative crystal structure.Analyses.
|
| |
Immunity, 17,
757-768.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
A.Kawana-Tachikawa,
M.Tomizawa,
J.Nunoya,
T.Shioda,
A.Kato,
E.E.Nakayama,
T.Nakamura,
Y.Nagai,
and
A.Iwamoto
(2002).
An efficient and versatile mammalian viral vector system for major histocompatibility complex class I/peptide complexes.
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| |
J Virol, 76,
11982-11988.
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B.Holm,
J.Bäcklund,
M.A.Recio,
R.Holmdahl,
and
J.Kihlberg
(2002).
Glycopeptide specificity of helper T cells obtained in mouse models for rheumatoid arthritis.
|
| |
Chembiochem, 3,
1209-1222.
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|
|
|
|
|
|
C.S.Clements,
L.Kjer-Nielsen,
W.A.MacDonald,
A.G.Brooks,
A.W.Purcell,
J.McCluskey,
and
J.Rossjohn
(2002).
The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state.
|
| |
Acta Crystallogr D Biol Crystallogr, 58,
2131-2134.
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|
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|
|
D.H.Fremont,
S.Dai,
H.Chiang,
F.Crawford,
P.Marrack,
and
J.Kappler
(2002).
Structural basis of cytochrome c presentation by IE(k).
|
| |
J Exp Med, 195,
1043-1052.
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|
|
PDB codes:
|
|
|
|
|
|
|
|
E.May,
N.Dulphy,
E.Frauendorf,
R.Duchmann,
P.Bowness,
J.A.Lopez de Castro,
A.Toubert,
and
E.Märker-Hermann
(2002).
Conserved TCR beta chain usage in reactive arthritis; evidence for selection by a putative HLA-B27-associated autoantigen.
|
| |
Tissue Antigens, 60,
299-308.
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|
|
|
E.R.Unanue
(2002).
Perspective on antigen processing and presentation.
|
| |
Immunol Rev, 185,
86.
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F.E.McCann,
K.Suhling,
L.M.Carlin,
K.Eleme,
S.B.Taner,
K.Yanagi,
B.Vanherberghen,
P.M.French,
and
D.M.Davis
(2002).
Imaging immune surveillance by T cells and NK cells.
|
| |
Immunol Rev, 189,
179-192.
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H.A.Elsner,
and
R.Blasczyk
(2002).
Sequence similarity matching: proposal of a structure-based rating system for bone marrow transplantation.
|
| |
Eur J Immunogenet, 29,
229-236.
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|
H.I.Krupka,
B.W.Segelke,
R.G.Ulrich,
S.Ringhofer,
M.Knapp,
and
B.Rupp
(2002).
Structural basis for abrogated binding between staphylococcal enterotoxin A superantigen vaccine and MHC-IIalpha.
|
| |
Protein Sci, 11,
642-651.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
H.Sakaguchi,
R.Inoue,
H.Kaneko,
M.Watanabe,
K.Suzuki,
Z.Kato,
S.Matsushita,
and
N.Kondo
(2002).
Interaction among human leucocyte antigen-peptide-T cell receptor complexes in cow's milk allergy: the significance of human leucocyte antigen and T cell receptor-complementarity determining region 3 loops.
|
| |
Clin Exp Allergy, 32,
762-770.
|
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|
|
|
|
J.G.Luz,
M.Huang,
K.C.Garcia,
M.G.Rudolph,
V.Apostolopoulos,
L.Teyton,
and
I.A.Wilson
(2002).
Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions.
|
| |
J Exp Med, 195,
1175-1186.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.Hennecke,
and
D.C.Wiley
(2002).
Structure of a complex of the human alpha/beta T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB1*0401): insight into TCR cross-restriction and alloreactivity.
|
| |
J Exp Med, 195,
571-581.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
K.A.Smith
(2002).
Medical immunology: a new journal for a new subspecialty.
|
| |
Med Immunol, 1,
1.
|
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|
|
K.Natarajan,
N.Dimasi,
J.Wang,
R.A.Mariuzza,
and
D.H.Margulies
(2002).
Structure and function of natural killer cell receptors: multiple molecular solutions to self, nonself discrimination.
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| |
Annu Rev Immunol, 20,
853-885.
|
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|
|
K.Suzuki,
R.Inoue,
H.Sakaguchi,
M.Aoki,
Z.Kato,
H.Kaneko,
S.Matsushita,
and
N.Kondo
(2002).
The correlation between ovomucoid-derived peptides, human leucocyte antigen class II molecules and T cell receptor-complementarity determining region 3 compositions in patients with egg-white allergy.
|
| |
Clin Exp Allergy, 32,
1223-1230.
|
|
|
|
|
|
|
M.E.Call,
J.Pyrdol,
M.Wiedmann,
and
K.W.Wucherpfennig
(2002).
The organizing principle in the formation of the T cell receptor-CD3 complex.
|
| |
Cell, 111,
967-979.
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|
|
M.G.Rudolph,
and
I.A.Wilson
(2002).
The specificity of TCR/pMHC interaction.
|
| |
Curr Opin Immunol, 14,
52-65.
|
|
|
|
|
|
|
M.G.Rudolph,
J.G.Luz,
and
I.A.Wilson
(2002).
Structural and thermodynamic correlates of T cell signaling.
|
| |
Annu Rev Biophys Biomol Struct, 31,
121-149.
|
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|
|
|
|
M.Przemeck,
H.A.Elsner,
S.Sel,
L.T.Pastucha,
and
R.Blasczyk
(2002).
HLA-B*4431: a new HLA-B variant with a complex ancestral history involving HLA-B*44, B*40 and B*07 alleles.
|
| |
Tissue Antigens, 60,
91-94.
|
|
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|
|
M.Ramos,
I.Alvarez,
L.Sesma,
A.Logean,
D.Rognan,
and
J.A.López de Castro
(2002).
Molecular mimicry of an HLA-B27-derived ligand of arthritis-linked subtypes with chlamydial proteins.
|
| |
J Biol Chem, 277,
37573-37581.
|
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|
|
|
|
P.C.Doherty
(2002).
The pas de deux of viruses and CD8 T cells.
|
| |
Immunol Rev, 185,
39-49.
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P.E.Adrian,
G.Rajaseger,
V.S.Mathura,
M.K.Sakharkar,
and
P.Kangueane
(2002).
Types of inter-atomic interactions at the MHC-peptide interface: identifying commonality from accumulated data.
|
| |
BMC Struct Biol, 2,
2.
|
|
|
|
|
|
|
R.König
(2002).
Interactions between MHC molecules and co-receptors of the TCR.
|
| |
Curr Opin Immunol, 14,
75-83.
|
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|
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|
|
A.Franzke,
J.Buer,
M.Probst-Kepper,
C.Lindig,
M.Framzle,
A.J.Schrader,
A.Ganser,
and
J.Atzpodien
(2001).
HLA phenotype and cytokine-induced tumor control in advanced renal cell cancer.
|
| |
Cancer Biother Radiopharm, 16,
401-409.
|
|
|
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|
|
|
A.Guimezanes,
G.A.Barrett-Wilt,
P.Gulden-Thompson,
J.Shabanowitz,
V.H.Engelhard,
D.F.Hunt,
A.M.Schmitt-Verhulst,
and
V.H.Engelhardt
(2001).
Identification of endogenous peptides recognized by in vivo or in vitro generated alloreactive cytotoxic T lymphocytes: distinct characteristics correlated with CD8 dependence.
|
| |
Eur J Immunol, 31,
421-432.
|
|
|
|
|
|
|
A.Qadri,
and
E.S.Ward
(2001).
Activation of a T cell hybridoma by an alloligand results in differential effects on IL-2 secretion and activation-induced cell death.
|
| |
Eur J Immunol, 31,
3825-3832.
|
|
|
|
|
|
|
A.Quesnel,
A.Zerbib,
F.Connan,
J.G.Guillet,
J.P.Briand,
and
J.Choppin
(2001).
Synthesis and antigenic properties of reduced peptide bond analogues of an immunodominant epitope of the melanoma MART-1 protein.
|
| |
J Pept Sci, 7,
157-165.
|
|
|
|
|
|
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B.E.Gewurz,
R.Gaudet,
D.Tortorella,
E.W.Wang,
H.L.Ploegh,
and
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Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2.
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| |
Proc Natl Acad Sci U S A, 98,
6794-6799.
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PDB code:
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B.E.Gewurz,
R.Gaudet,
D.Tortorella,
E.W.Wang,
and
H.L.Ploegh
(2001).
Virus subversion of immunity: a structural perspective.
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| |
Curr Opin Immunol, 13,
442-450.
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B.K.Cho,
K.C.Lian,
P.Lee,
A.Brunmark,
C.McKinley,
J.Chen,
D.M.Kranz,
and
H.N.Eisen
(2001).
Differences in antigen recognition and cytolytic activity of CD8(+) and CD8(-) T cells that express the same antigen-specific receptor.
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| |
Proc Natl Acad Sci U S A, 98,
1723-1727.
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B.M.Baker,
R.V.Turner,
S.J.Gagnon,
D.C.Wiley,
and
W.E.Biddison
(2001).
Identification of a crucial energetic footprint on the alpha1 helix of human histocompatibility leukocyte antigen (HLA)-A2 that provides functional interactions for recognition by tax peptide/HLA-A2-specific T cell receptors.
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J Exp Med, 193,
551-562.
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C.B.Carpenter
(2001).
Why do we reject grafts?
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| |
Heart Dis, 3,
270-275.
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D.B.Moody,
and
G.S.Besra
(2001).
Glycolipid targets of CD1-mediated T-cell responses.
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| |
Immunology, 104,
243-251.
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G.R.Marshall
(2001).
Peptide interactions with G-protein coupled receptors.
|
| |
Biopolymers, 60,
246-277.
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J.Buslepp,
R.Zhao,
D.Donnini,
D.Loftus,
M.Saad,
E.Appella,
and
E.J.Collins
(2001).
T cell activity correlates with oligomeric peptide-major histocompatibility complex binding on T cell surface.
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| |
J Biol Chem, 276,
47320-47328.
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PDB codes:
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J.Hennecke,
and
D.C.Wiley
(2001).
T cell receptor-MHC interactions up close.
|
| |
Cell, 104,
1-4.
|
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J.Mack,
K.Falk,
O.Rötzschke,
T.Walk,
J.L.Strominger,
and
G.Jung
(2001).
Synthesis of linear and comb-like peptide constructs containing up to four copies of a T cell epitope and their capacity to stimulate T cells.
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| |
J Pept Sci, 7,
338-345.
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K.C.Garcia,
C.G.Radu,
J.Ho,
R.J.Ober,
and
E.S.Ward
(2001).
Kinetics and thermodynamics of T cell receptor- autoantigen interactions in murine experimental autoimmune encephalomyelitis.
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| |
Proc Natl Acad Sci U S A, 98,
6818-6823.
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K.D.Bourcier,
D.G.Lim,
Y.H.Ding,
K.J.Smith,
K.Wucherpfennig,
and
D.A.Hafler
(2001).
Conserved CDR3 regions in T-cell receptor (TCR) CD8(+) T cells that recognize the Tax11-19/HLA-A*0201 complex in a subject infected with human T-cell leukemia virus type 1: relationship of T-cell fine specificity and major histocompatibility complex/peptide/TCR crystal structure.
|
| |
J Virol, 75,
9836-9843.
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K.W.Wucherpfennig
(2001).
Structural basis of molecular mimicry.
|
| |
J Autoimmun, 16,
293-302.
|
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L.Subrahmanyan,
M.A.Eberle,
A.G.Clark,
L.Kruglyak,
and
D.A.Nickerson
(2001).
Sequence variation and linkage disequilibrium in the human T-cell receptor beta (TCRB) locus.
|
| |
Am J Hum Genet, 69,
381-395.
|
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M.G.Rudolph,
J.A.Speir,
A.Brunmark,
N.Mattsson,
M.R.Jackson,
P.A.Peterson,
L.Teyton,
and
I.A.Wilson
(2001).
The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivity.
|
| |
Immunity, 14,
231-242.
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PDB codes:
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M.Regner
(2001).
Cross-reactivity in T-cell antigen recognition.
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| |
Immunol Cell Biol, 79,
91.
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M.Saito,
G.P.Taylor,
A.Saito,
Y.Furukawa,
K.Usuku,
J.N.Weber,
M.Osame,
and
C.R.Bangham
(2001).
In vivo selection of T-cell receptor junctional region sequences by HLA-A2 human T-cell lymphotropic virus type 1 Tax11-19 peptide complexes.
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| |
J Virol, 75,
1065-1071.
|
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P.Kourilsky,
and
N.Fazilleau
(2001).
Self peptides and the peptidic self.
|
| |
Int Rev Immunol, 20,
575-591.
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P.M.Rudd,
T.Elliott,
P.Cresswell,
I.A.Wilson,
and
R.A.Dwek
(2001).
Glycosylation and the immune system.
|
| |
Science, 291,
2370-2376.
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R.R.Pogue-Caley,
and
M.G.McHeyzer-Williams
(2001).
Emergence of a type II collagen-specific helper T cell response.
|
| |
Eur J Immunol, 31,
2362-2372.
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S.Radaev,
B.Rostro,
A.G.Brooks,
M.Colonna,
and
P.D.Sun
(2001).
Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3.
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| |
Immunity, 15,
1039-1049.
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PDB code:
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