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Actin binding protein
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PDB id
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1ahq
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Contents |
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* Residue conservation analysis
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Gene Ontology (GO) functional annotation
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Cellular component
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intracellular
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2 terms
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Biochemical function
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actin binding
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1 term
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DOI no:
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Nat Struct Biol
4:369-373
(1997)
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PubMed id:
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Crystal structure of the actin-binding protein actophorin from Acanthamoeba.
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S.A.Leonard,
A.G.Gittis,
E.C.Petrella,
T.D.Pollard,
E.E.Lattman.
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ABSTRACT
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Actophorin is a member of the actin-depolymerizing factor/cofilin family. It
severs actin filaments and sequesters actin monomers. The crystal structure of
actophorin will help to elucidate actin-ADF/cofilin interactions.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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S.Mehta,
and
L.D.Sibley
(2010).
Toxoplasma gondii actin depolymerizing factor acts primarily to sequester G-actin.
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J Biol Chem, 285,
6835-6847.
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H.Schüler,
A.K.Mueller,
and
K.Matuschewski
(2005).
A Plasmodium actin-depolymerizing factor that binds exclusively to actin monomers.
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| |
Mol Biol Cell, 16,
4013-4023.
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O.Quintero-Monzon,
A.A.Rodal,
B.Strokopytov,
S.C.Almo,
and
B.L.Goode
(2005).
Structural and functional dissection of the Abp1 ADFH actin-binding domain reveals versatile in vivo adapter functions.
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| |
Mol Biol Cell, 16,
3128-3139.
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B.J.Pope,
K.M.Zierler-Gould,
R.Kühne,
A.G.Weeds,
and
L.J.Ball
(2004).
Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor.
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J Biol Chem, 279,
4840-4848.
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PDB codes:
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E.J.McGhie,
R.D.Hayward,
and
V.Koronakis
(2004).
Control of actin turnover by a salmonella invasion protein.
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Mol Cell, 13,
497-510.
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|
R.Dominguez
(2004).
Actin-binding proteins--a unifying hypothesis.
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Trends Biochem Sci, 29,
572-578.
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X.Li,
X.Liu,
Z.Lou,
X.Duan,
H.Wu,
Y.Liu,
and
Z.Rao
(2004).
Crystal structure of human coactosin-like protein at 1.9 A resolution.
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Protein Sci, 13,
2845-2851.
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PDB code:
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S.J.Winder
(2003).
Structural insights into actin-binding, branching and bundling proteins.
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Curr Opin Cell Biol, 15,
14-22.
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S.Ono
(2003).
Regulation of actin filament dynamics by actin depolymerizing factor/cofilin and actin-interacting protein 1: new blades for twisted filaments.
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| |
Biochemistry, 42,
13363-13370.
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S.K.Maciver,
and
P.J.Hussey
(2002).
The ADF/cofilin family: actin-remodeling proteins.
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Genome Biol, 3,
reviews3007.
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V.O.Paavilainen,
M.C.Merckel,
S.Falck,
P.J.Ojala,
E.Pohl,
M.Wilmanns,
and
P.Lappalainen
(2002).
Structural conservation between the actin monomer-binding sites of twinfilin and actin-depolymerizing factor (ADF)/cofilin.
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J Biol Chem, 277,
43089-43095.
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PDB code:
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L.Blondin,
V.Sapountzi,
S.K.Maciver,
C.Renoult,
Y.Benyamin,
and
C.Roustan
(2001).
The second ADF/cofilin actin-binding site exists in F-actin, the cofilin-G-actin complex, but not in G-actin.
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Eur J Biochem, 268,
6426-6434.
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G.D.Bowman,
I.M.Nodelman,
Y.Hong,
N.H.Chua,
U.Lindberg,
and
C.E.Schutt
(2000).
A comparative structural analysis of the ADF/cofilin family.
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Proteins, 41,
374-384.
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PDB code:
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M.Van Troys,
D.Dewitte,
J.L.Verschelde,
M.Goethals,
J.Vandekerckhove,
and
C.Ampe
(2000).
The competitive interaction of actin and PIP2 with actophorin is based on overlapping target sites: design of a gain-of-function mutant.
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Biochemistry, 39,
12181-12189.
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C.Renoult,
D.Ternent,
S.K.Maciver,
A.Fattoum,
C.Astier,
Y.Benyamin,
and
C.Roustan
(1999).
The identification of a second cofilin binding site on actin suggests a novel, intercalated arrangement of F-actin binding.
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| |
J Biol Chem, 274,
28893-28899.
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H.N.Higgs,
and
T.D.Pollard
(1999).
Regulation of actin polymerization by Arp2/3 complex and WASp/Scar proteins.
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| |
J Biol Chem, 274,
32531-32534.
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J.R.Bamburg
(1999).
Proteins of the ADF/cofilin family: essential regulators of actin dynamics.
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Annu Rev Cell Dev Biol, 15,
185-230.
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J.R.Bamburg,
A.McGough,
and
S.Ono
(1999).
Putting a new twist on actin: ADF/cofilins modulate actin dynamics.
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| |
Trends Cell Biol, 9,
364-370.
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K.Moriyama,
and
I.Yahara
(1999).
Two activities of cofilin, severing and accelerating directional depolymerization of actin filaments, are affected differentially by mutations around the actin-binding helix.
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| |
EMBO J, 18,
6752-6761.
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M.F.Carlier,
F.Ressad,
and
D.Pantaloni
(1999).
Control of actin dynamics in cell motility. Role of ADF/cofilin.
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| |
J Biol Chem, 274,
33827-33830.
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M.Van Troys,
J.Vandekerckhove,
and
C.Ampe
(1999).
Structural modules in actin-binding proteins: towards a new classification.
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| |
Biochim Biophys Acta, 1448,
323-348.
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S.Ono,
D.L.Baillie,
and
G.M.Benian
(1999).
UNC-60B, an ADF/cofilin family protein, is required for proper assembly of actin into myofibrils in Caenorhabditis elegans body wall muscle.
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| |
J Cell Biol, 145,
491-502.
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|
A.McGough
(1998).
F-actin-binding proteins.
|
| |
Curr Opin Struct Biol, 8,
166-176.
|
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|
|
|
|
A.P.Smertenko,
C.J.Jiang,
N.J.Simmons,
A.G.Weeds,
D.R.Davies,
and
P.J.Hussey
(1998).
Ser6 in the maize actin-depolymerizing factor, ZmADF3, is phosphorylated by a calcium-stimulated protein kinase and is essential for the control of functional activity.
|
| |
Plant J, 14,
187-193.
|
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|
|
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|
|
F.Ressad,
D.Didry,
G.X.Xia,
Y.Hong,
N.H.Chua,
D.Pantaloni,
and
M.F.Carlier
(1998).
Kinetic analysis of the interaction of actin-depolymerizing factor (ADF)/cofilin with G- and F-actins. Comparison of plant and human ADFs and effect of phosphorylation.
|
| |
J Biol Chem, 273,
20894-20902.
|
|
|
|
|
|
|
L.Blanchoin,
and
T.D.Pollard
(1998).
Interaction of actin monomers with Acanthamoeba actophorin (ADF/cofilin) and profilin.
|
| |
J Biol Chem, 273,
25106-25111.
|
|
|
PDB code:
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|
|
P.Lappalainen,
M.M.Kessels,
M.J.Cope,
and
D.G.Drubin
(1998).
The ADF homology (ADF-H) domain: a highly exploited actin-binding module.
|
| |
Mol Biol Cell, 9,
1951-1959.
|
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|
|
Y.A.Puius,
N.M.Mahoney,
and
S.C.Almo
(1998).
The modular structure of actin-regulatory proteins.
|
| |
Curr Opin Cell Biol, 10,
23-34.
|
|
|
|
|
|
|
A.McGough,
B.Pope,
W.Chiu,
and
A.Weeds
(1997).
Cofilin changes the twist of F-actin: implications for actin filament dynamics and cellular function.
|
| |
J Cell Biol, 138,
771-781.
|
|
|
|
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|
|
C.J.Jiang,
A.G.Weeds,
S.Khan,
and
P.J.Hussey
(1997).
F-actin and G-actin binding are uncoupled by mutation of conserved tyrosine residues in maize actin depolymerizing factor (ZmADF).
|
| |
Proc Natl Acad Sci U S A, 94,
9973-9978.
|
|
|
|
|
|
|
M.Van Troys,
D.Dewitte,
J.L.Verschelde,
M.Goethals,
J.Vandekerckhove,
and
C.Ampe
(1997).
Analogous F-actin binding by cofilin and gelsolin segment 2 substantiates their structural relationship.
|
| |
J Biol Chem, 272,
32750-32758.
|
|
|
|
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|
|
P.Lappalainen,
E.V.Fedorov,
A.A.Fedorov,
S.C.Almo,
and
D.G.Drubin
(1997).
Essential functions and actin-binding surfaces of yeast cofilin revealed by systematic mutagenesis.
|
| |
EMBO J, 16,
5520-5530.
|
|
|
|
|
|
The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
