PDBsum entry: 1af0

Hydrolase/hydrolase inhibitor

PDB id: 1af0

Contents

Protein chain

470 a.a. *

Ligands

0Z9

Metals

_ZN

_CA ×7

Waters ×206

* Residue conservation analysis

PDB id:

1af0

Name:

Hydrolase/hydrolase inhibitor

Title:

Serratia protease in complex with inhibitor

Structure:

Serratia protease. Chain: a. Ec: 3.4.24.40

Source:

Serratia marcescens. Organism_taxid: 615. Strain: not known, probably sm6. Other_details: purchased from sigma

Resolution:

1.80Å R-factor: 0.183 R-free: 0.237

Authors:

U.Baumann

Key ref:

U.Baumann Crystal structure of the 50 kda metallo protease from s. Marcescens in complex with the synthetic inhibitor cbz-Leu-Ala-Nhoh. To be published,

Date:

20-Mar-97 Release date: 25-Mar-98

Protein chain

P23694  (PRZN_SERMA) -  Serralysin

Seq: 487 a.a.

Struc: 470 a.a.*

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.4.24.40 - Serralysin.
• Reaction: Preferential cleavage of bonds with hydrophobic residues in P1'.
• Cofactor: Zinc

 Gene Ontology (GO) functional annotation 

• Cellular component: extracellular region (3 terms)
• Biological process: pathogenesis (2 terms)
• Biochemical function: hydrolase activity (7 terms)