PDBsum entry: 1af0

Complex (metalloprotease/inhibitor)

PDB-id: 1af0

Contents

Description

Header details

Header records

References

PROCHECK

Protein chain

470 a.a. *

Ligands

LEU-HMA

Metal ions

_CA ×7

_ZN

Waters ×206

* Residue conservation analysis

Tools

Clefts Calculation

PDB id:

1af0

Name:

Complex (metalloprotease/inhibitor)

Title:

Serratia protease in complex with inhibitor

Structure:

Serratia protease. Chain: a. Ec: 3.4.24.40

Source:

Serratia marcescens. Organism_taxid: 615. Strain: not known, probably sm6. Other_details: purchased from sigma

UniProt:

P23694 (PRZN_SERMA)

Seq:

Struc:

Seq:

487 a.a.

Struc:

470 a.a.*

Key:	PfamA domain
Secondary structure	CATH domain

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme class:

E.C.3.4.24.40   [IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

Reaction:

Preferential cleavage of bonds with hydrophobic residues in P1'.

Cofactor:

Zinc

Resolution:

1.80Å

R-factor:

0.183

R-free:

0.237

Authors:

U.Baumann

Key ref:

u.baumann Crystal Structure of the 50 kDa Metallo Protease from S. Marcescens in Complex with the Synthetic Inhibitor Cbz-Leu-Ala-Nhoh. To be Published, .

Date:

20-Mar-97

Release date:

25-Mar-98

Quick_links

Procheck

Clefts

Surface