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Signal transduction
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PDB id
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1a4o
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Contents |
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* Residue conservation analysis
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PDB id:
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| Name: |
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Signal transduction
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Title:
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14-3-3 protein zeta isoform
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Structure:
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14-3-3 protein zeta. Chain: a, b, c, d. Engineered: yes
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Source:
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Bos taurus. Cattle. Organism_taxid: 9913. Expressed in: escherichia coli. Expression_system_taxid: 562
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Biol. unit:
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Dimer (from
)
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Resolution:
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2.80Å
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R-factor:
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0.310
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R-free:
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0.345
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Authors:
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D.Liu,J.Bienkowska,C.Petosa,R.J.Collier,H.Fu,R.C.Liddington
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Key ref:
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D.Liu
et al.
(1995).
Crystal structure of the zeta isoform of the 14-3-3 protein.
Nature,
376,
191-194.
PubMed id:
DOI:
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Date:
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01-Feb-98
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Release date:
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02-Mar-99
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PROCHECK
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Headers
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References
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P63103
(1433Z_BOVIN) -
14-3-3 protein zeta/delta
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Seq:
Struc:
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245 a.a.
197 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Gene Ontology (GO) functional annotation
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Cellular component
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cytoplasm
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4 terms
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Biological process
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protein targeting
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1 term
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Biochemical function
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transcription factor binding
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2 terms
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DOI no:
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Nature
376:191-194
(1995)
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PubMed id:
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| |
|
Crystal structure of the zeta isoform of the 14-3-3 protein.
|
|
D.Liu,
J.Bienkowska,
C.Petosa,
R.J.Collier,
H.Fu,
R.Liddington.
|
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| |
ABSTRACT
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The 14-3-3 family of proteins have recently been identified as regulatory
elements in intracellular signalling pathways: 14-3-3 proteins bind to oncogene
and proto-oncogene products, including c-Raf-1 (refs 2-5), c-Bcr (ref. 6) and
polyomavirus middle-T antigen; overexpression of 14-3-3 activates Raf kinase in
yeast and induces meiotic maturation in Xenopus oocytes. Here we report the
crystal structure of the major isoform of mammalian 14-3-3 proteins at 2.9 A
resolution. Each subunit of the dimeric protein consists of a bundle of nine
antiparallel helices that form a palisade around an amphipathic groove. The
groove is large enough to accommodate a tenth helix, and we propose that binding
to an amphipathic helix represents a general mechanism for the interaction of
14-3-3 with diverse cellular proteins. The residues in the dimer interface and
the putative ligand-binding surface are invariant among vertebrates, yeast and
plants, suggesting a conservation of structure and function throughout the
14-3-3 family.
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Literature references that cite this PDB file's key reference
|
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| |
PubMed id
|
|
Reference
|
|
|
|
|
|
O.Barbash,
E.K.Lee,
and
J.A.Diehl
(2011).
Phosphorylation-dependent regulation of SCF(Fbx4) dimerization and activity involves a novel component, 14-3-3É›.
|
| |
Oncogene, 30,
1995-2002.
|
|
|
|
|
|
|
S.Cockcroft,
and
K.Garner
(2011).
Function of the phosphatidylinositol transfer protein gene family: is phosphatidylinositol transfer the mechanism of action?
|
| |
Crit Rev Biochem Mol Biol, 46,
89.
|
|
|
|
|
|
|
G.Messaritou,
S.Grammenoudi,
and
E.M.Skoulakis
(2010).
Dimerization is essential for 14-3-3zeta stability and function in vivo.
|
| |
J Biol Chem, 285,
1692-1700.
|
|
|
|
|
|
|
G.Shen,
S.Kuppu,
S.Venkataramani,
J.Wang,
J.Yan,
X.Qiu,
and
H.Zhang
(2010).
ANKYRIN REPEAT-CONTAINING PROTEIN 2A is an essential molecular chaperone for peroxisomal membrane-bound ASCORBATE PEROXIDASE3 in Arabidopsis.
|
| |
Plant Cell, 22,
811-831.
|
|
|
|
|
|
|
K.Kasahara,
H.Goto,
M.Enomoto,
Y.Tomono,
T.Kiyono,
and
M.Inagaki
(2010).
14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage.
|
| |
EMBO J, 29,
2802-2812.
|
|
|
|
|
|
|
M.Inoue,
K.Yasuda,
H.Uemura,
N.Yasaka,
H.Inoue,
Y.Sei,
N.Horikoshi,
and
T.Fukuma
(2010).
Phosphorylation-dependent protein interaction with Trypanosoma brucei 14-3-3 proteins that display atypical target recognition.
|
| |
PLoS One, 5,
e15566.
|
|
|
|
|
|
|
Z.T.Zhang,
Y.Zhou,
Y.Li,
S.Q.Shao,
B.Y.Li,
H.Y.Shi,
and
X.B.Li
(2010).
Interactome analysis of the six cotton 14-3-3s that are preferentially expressed in fibres and involved in cell elongation.
|
| |
J Exp Bot, 61,
3331-3344.
|
|
|
|
|
|
|
B.Kostelecky,
A.T.Saurin,
A.Purkiss,
P.J.Parker,
and
N.Q.McDonald
(2009).
Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon.
|
| |
EMBO Rep, 10,
983-989.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
D.Chevalier,
E.R.Morris,
and
J.C.Walker
(2009).
14-3-3 and FHA domains mediate phosphoprotein interactions.
|
| |
Annu Rev Plant Biol, 60,
67-91.
|
|
|
|
|
|
|
E.Rampakakis,
D.N.Arvanitis,
D.Di Paola,
and
M.Zannis-Hadjopoulos
(2009).
Metazoan origins of DNA replication: regulation through dynamic chromatin structure.
|
| |
J Cell Biochem, 106,
512-520.
|
|
|
|
|
|
|
K.Kligys,
J.Yao,
D.Yu,
and
J.C.Jones
(2009).
14-3-3zeta/tau heterodimers regulate Slingshot activity in migrating keratinocytes.
|
| |
Biochem Biophys Res Commun, 383,
450-454.
|
|
|
|
|
|
|
R.Kobayashi,
M.Deavers,
R.Patenia,
T.Rice-Stitt,
J.Halbe,
S.Gallardo,
and
R.S.Freedman
(2009).
14-3-3 zeta protein secreted by tumor associated monocytes/macrophages from ascites of epithelial ovarian cancer patients.
|
| |
Cancer Immunol Immunother, 58,
247-258.
|
|
|
|
|
|
|
S.Sun,
E.W.Wong,
M.W.Li,
W.M.Lee,
and
C.Y.Cheng
(2009).
14-3-3 and its binding partners are regulators of protein-protein interactions during spermatogenesis.
|
| |
J Endocrinol, 202,
327-336.
|
|
|
|
|
|
|
A.L.Paul,
K.M.Folta,
and
R.J.Ferl
(2008).
14-3-3 proteins, red light and photoperiodic flowering: A point of connection?
|
| |
Plant Signal Behav, 3,
511-515.
|
|
|
|
|
|
|
D.L.Bolton,
R.A.Barnitz,
K.Sakai,
and
M.J.Lenardo
(2008).
14-3-3 theta binding to cell cycle regulatory factors is enhanced by HIV-1 Vpr.
|
| |
Biol Direct, 3,
17.
|
|
|
|
|
|
|
H.Sakiyama,
R.M.Wynn,
W.R.Lee,
M.Fukasawa,
H.Mizuguchi,
K.H.Gardner,
J.J.Repa,
and
K.Uyeda
(2008).
Regulation of Nuclear Import/Export of Carbohydrate Response Element-binding Protein (ChREBP): INTERACTION OF AN {alpha}-HELIX OF ChREBP WITH THE 14-3-3 PROTEINS AND REGULATION BY PHOSPHORYLATION.
|
| |
J Biol Chem, 283,
24899-24908.
|
|
|
|
|
|
|
H.Takala,
E.Nurminen,
S.M.Nurmi,
M.Aatonen,
T.Strandin,
M.Takatalo,
T.Kiema,
C.G.Gahmberg,
J.Ylänne,
and
S.C.Fagerholm
(2008).
Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding.
|
| |
Blood, 112,
1853-1862.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
K.Omi,
N.S.Hachiya,
M.Tanaka,
K.Tokunaga,
and
K.Kaneko
(2008).
14-3-3zeta is indispensable for aggregate formation of polyglutamine-expanded huntingtin protein.
|
| |
Neurosci Lett, 431,
45-50.
|
|
|
|
|
|
|
M.Zannis-Hadjopoulos,
W.Yahyaoui,
and
M.Callejo
(2008).
14-3-3 cruciform-binding proteins as regulators of eukaryotic DNA replication.
|
| |
Trends Biochem Sci, 33,
44-50.
|
|
|
|
|
|
|
S.Visconti,
L.Camoni,
M.Marra,
and
P.Aducci
(2008).
Role of the 14-3-3 C-terminal region in the interaction with the plasma membrane H+-ATPase.
|
| |
Plant Cell Physiol, 49,
1887-1897.
|
|
|
|
|
|
|
T.Obsil,
and
V.Obsilova
(2008).
Structure/function relationships underlying regulation of FOXO transcription factors.
|
| |
Oncogene, 27,
2263-2275.
|
|
|
|
|
|
|
X.Liang,
M.B.Butterworth,
K.W.Peters,
W.H.Walker,
and
R.A.Frizzell
(2008).
An Obligatory Heterodimer of 14-3-3{beta} and 14-3-3{epsilon} Is Required for Aldosterone Regulation of the Epithelial Sodium Channel.
|
| |
J Biol Chem, 283,
27418-27425.
|
|
|
|
|
|
|
C.Ottmann,
L.Yasmin,
M.Weyand,
J.L.Veesenmeyer,
M.H.Diaz,
R.H.Palmer,
M.S.Francis,
A.R.Hauser,
A.Wittinghofer,
and
B.Hallberg
(2007).
Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis.
|
| |
EMBO J, 26,
902-913.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.S.Kim,
B.A.Diebold,
B.M.Babior,
U.G.Knaus,
and
G.M.Bokoch
(2007).
Regulation of Nox1 activity via protein kinase A-mediated phosphorylation of NoxA1 and 14-3-3 binding.
|
| |
J Biol Chem, 282,
34787-34800.
|
|
|
|
|
|
|
O.Gileadi,
S.Knapp,
W.H.Lee,
B.D.Marsden,
S.Müller,
F.H.Niesen,
K.L.Kavanagh,
L.J.Ball,
F.von Delft,
D.A.Doyle,
U.C.Oppermann,
and
M.Sundström
(2007).
The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins.
|
| |
J Struct Funct Genomics, 8,
107-119.
|
|
|
|
|
|
|
Y.Li,
X.Lin,
R.T.Kilani,
J.C.Jones,
and
A.Ghahary
(2007).
14-3-3 sigma isoform interacts with the cytoplasmic domain of the transmembrane BP180 in keratinocytes.
|
| |
J Cell Physiol, 212,
675-681.
|
|
|
|
|
|
|
A.Aitken
(2006).
14-3-3 proteins: a historic overview.
|
| |
Semin Cancer Biol, 16,
162-172.
|
|
|
|
|
|
|
A.K.Gardino,
S.J.Smerdon,
and
M.B.Yaffe
(2006).
Structural determinants of 14-3-3 binding specificities and regulation of subcellular localization of 14-3-3-ligand complexes: a comparison of the X-ray crystal structures of all human 14-3-3 isoforms.
|
| |
Semin Cancer Biol, 16,
173-182.
|
|
|
|
|
|
|
A.Patel,
N.Cummings,
M.Batchelor,
P.J.Hill,
T.Dubois,
K.H.Mellits,
G.Frankel,
and
I.Connerton
(2006).
Host protein interactions with enteropathogenic Escherichia coli (EPEC): 14-3-3tau binds Tir and has a role in EPEC-induced actin polymerization.
|
| |
Cell Microbiol, 8,
55-71.
|
|
|
|
|
|
|
G.P.van Heusden,
and
H.Y.Steensma
(2006).
Yeast 14-3-3 proteins.
|
| |
Yeast, 23,
159-171.
|
|
|
|
|
|
|
G.W.Porter,
F.R.Khuri,
and
H.Fu
(2006).
Dynamic 14-3-3/client protein interactions integrate survival and apoptotic pathways.
|
| |
Semin Cancer Biol, 16,
193-202.
|
|
|
|
|
|
|
K.Chaithirayanon,
R.Grams,
S.Vichasri-Grams,
A.Hofmann,
G.Korge,
V.Viyanant,
E.S.Upatham,
and
P.Sobhon
(2006).
Molecular and immunological characterization of encoding gene and 14-3-3 protein 1 in Fasciola gigantica.
|
| |
Parasitology, 133,
763-775.
|
|
|
|
|
|
|
L.Yasmin,
A.L.Jansson,
T.Panahandeh,
R.H.Palmer,
M.S.Francis,
and
B.Hallberg
(2006).
Delineation of exoenzyme S residues that mediate the interaction with 14-3-3 and its biological activity.
|
| |
FEBS J, 273,
638-646.
|
|
|
|
|
|
|
M.Lalle,
A.M.Salzano,
M.Crescenzi,
and
E.Pozio
(2006).
The Giardia duodenalis 14-3-3 protein is post-translationally modified by phosphorylation and polyglycylation of the C-terminal tail.
|
| |
J Biol Chem, 281,
5137-5148.
|
|
|
|
|
|
|
W.F.Xu,
and
W.M.Shi
(2006).
Expression profiling of the 14-3-3 gene family in response to salt stress and potassium and iron deficiencies in young tomato (Solanum lycopersicum) roots: analysis by real-time RT-PCR.
|
| |
Ann Bot, 98,
965-974.
|
|
|
|
|
|
|
X.Yang,
W.H.Lee,
F.Sobott,
E.Papagrigoriou,
C.V.Robinson,
J.G.Grossmann,
M.Sundström,
D.A.Doyle,
and
J.M.Elkins
(2006).
Structural basis for protein-protein interactions in the 14-3-3 protein family.
|
| |
Proc Natl Acad Sci U S A, 103,
17237-17242.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
C.Faul,
S.Hüttelmaier,
J.Oh,
V.Hachet,
R.H.Singer,
and
P.Mundel
(2005).
Promotion of importin alpha-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3.
|
| |
J Cell Biol, 169,
415-424.
|
|
|
|
|
|
|
D.W.Powell,
W.M.Pierce,
and
K.R.McLeish
(2005).
Defining mitogen-activated protein kinase pathways with mass spectrometry-based approaches.
|
| |
Mass Spectrom Rev, 24,
847-864.
|
|
|
|
|
|
|
E.W.Wilker,
R.A.Grant,
S.C.Artim,
and
M.B.Yaffe
(2005).
A structural basis for 14-3-3sigma functional specificity.
|
| |
J Biol Chem, 280,
18891-18898.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
I.Jéru,
S.Papin,
S.L'hoste,
P.Duquesnoy,
C.Cazeneuve,
J.Camonis,
and
S.Amselem
(2005).
Interaction of pyrin with 14.3.3 in an isoform-specific and phosphorylation-dependent manner regulates its translocation to the nucleus.
|
| |
Arthritis Rheum, 52,
1848-1857.
|
|
|
|
|
|
|
I.M.Rienties,
J.Vink,
J.W.Borst,
E.Russinova,
and
S.C.de Vries
(2005).
The Arabidopsis SERK1 protein interacts with the AAA-ATPase AtCDC48, the 14-3-3 protein GF14lambda and the PP2C phosphatase KAPP.
|
| |
Planta, 221,
394-405.
|
|
|
|
|
|
|
J.Sunayama,
F.Tsuruta,
N.Masuyama,
and
Y.Gotoh
(2005).
JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3.
|
| |
J Cell Biol, 170,
295-304.
|
|
|
|
|
|
|
L.Baisamy,
N.Jurisch,
and
D.Diviani
(2005).
Leucine zipper-mediated homo-oligomerization regulates the Rho-GEF activity of AKAP-Lbc.
|
| |
J Biol Chem, 280,
15405-15412.
|
|
|
|
|
|
|
L.G.Rodriguez,
and
J.L.Guan
(2005).
14-3-3 regulation of cell spreading and migration requires a functional amphipathic groove.
|
| |
J Cell Physiol, 202,
285-294.
|
|
|
|
|
|
|
M.Inoue,
Y.Nakamura,
K.Yasuda,
N.Yasaka,
T.Hara,
A.Schnaufer,
K.Stuart,
and
T.Fukuma
(2005).
The 14-3-3 proteins of Trypanosoma brucei function in motility, cytokinesis, and cell cycle.
|
| |
J Biol Chem, 280,
14085-14096.
|
|
|
|
|
|
|
N.Macdonald,
J.P.Welburn,
M.E.Noble,
A.Nguyen,
M.B.Yaffe,
D.Clynes,
J.G.Moggs,
G.Orphanides,
S.Thomson,
J.W.Edmunds,
A.L.Clayton,
J.A.Endicott,
and
L.C.Mahadevan
(2005).
Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3.
|
| |
Mol Cell, 20,
199-211.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
Q.Li,
Q.Lu,
G.Estepa,
and
I.M.Verma
(2005).
Identification of 14-3-3sigma mutation causing cutaneous abnormality in repeated-epilation mutant mouse.
|
| |
Proc Natl Acad Sci U S A, 102,
15977-15982.
|
|
|
|
|
|
|
S.J.Clokie,
K.Y.Cheung,
S.Mackie,
R.Marquez,
A.H.Peden,
and
A.Aitken
(2005).
BCR kinase phosphorylates 14-3-3 Tau on residue 233.
|
| |
FEBS J, 272,
3767-3776.
|
|
|
|
|
|
|
S.Urschel,
F.Bassermann,
R.Y.Bai,
S.Münch,
C.Peschel,
and
J.Duyster
(2005).
Phosphorylation of grb10 regulates its interaction with 14-3-3.
|
| |
J Biol Chem, 280,
16987-16993.
|
|
|
|
|
|
|
W.Zheng,
D.Schwarzer,
A.Lebeau,
J.L.Weller,
D.C.Klein,
and
P.A.Cole
(2005).
Cellular stability of serotonin N-acetyltransferase conferred by phosphonodifluoromethylene alanine (Pfa) substitution for Ser-205.
|
| |
J Biol Chem, 280,
10462-10467.
|
|
|
|
|
|
|
A.Ulloa-Aguirre,
J.A.Janovick,
S.P.Brothers,
and
P.M.Conn
(2004).
Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease.
|
| |
Traffic, 5,
821-837.
|
|
|
|
|
|
|
D.Diviani,
L.Abuin,
S.Cotecchia,
and
L.Pansier
(2004).
Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex.
|
| |
EMBO J, 23,
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PDB code:
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M.L.Knetsch,
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Cell, 89,
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14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction.
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J Biol Chem, 272,
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14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain.
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