PDBsum entry 1n72

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protein links
Transferase PDB id
Protein chain
115 a.a. *
* Residue conservation analysis
PDB id:
Name: Transferase
Title: Structure and ligand of a histone acetyltransferase bromodomain
Structure: Histone acetyltransferase. Chain: a. Fragment: bromodomain. Synonym: p300/cbp-associated factor, p/caf, histone acetylase pcaf. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pcaf. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
NMR struc: 1 models
Authors: C.Dhalluin,J.E.Carlson,L.Zeng,C.He,A.K.Aggarwal,M.-M.Zhou
Key ref:
C.Dhalluin et al. (1999). Structure and ligand of a histone acetyltransferase bromodomain. Nature, 399, 491-496. PubMed id: 10365964 DOI: 10.1038/20974
12-Nov-02     Release date:   11-Dec-02    
Supersedes: 1b91
Go to PROCHECK summary

Protein chain
Pfam   ArchSchema ?
Q92831  (KAT2B_HUMAN) -  Histone acetyltransferase KAT2B
832 a.a.
115 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.  - Histone acetyltransferase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Acetyl-CoA + [histone] = CoA + acetyl-[histone]
+ [histone]
= CoA
+ acetyl-[histone]
Molecule diagrams generated from .mol files obtained from the KEGG ftp site


    Added reference    
DOI no: 10.1038/20974 Nature 399:491-496 (1999)
PubMed id: 10365964  
Structure and ligand of a histone acetyltransferase bromodomain.
C.Dhalluin, J.E.Carlson, L.Zeng, C.He, A.K.Aggarwal, M.M.Zhou.
Histone acetylation is important in chromatin remodelling and gene activation. Nearly all known histone-acetyltransferase (HAT)-associated transcriptional co-activators contain bromodomains, which are approximately 110-amino-acid modules found in many chromatin-associated proteins. Despite the wide occurrence of these bromodomains, their three-dimensional structure and binding partners remain unknown. Here we report the solution structure of the bromodomain of the HAT co-activator P/CAF (p300/CBP-associated factor). The structure reveals an unusual left-handed up-and-down four-helix bundle. In addition, we show by a combination of structural and site-directed mutagenesis studies that bromodomains can interact specifically with acetylated lysine, making them the first known protein modules to do so. The nature of the recognition of acetyl-lysine by the P/CAF bromodomain is similar to that of acetyl-CoA by histone acetyltransferase. Thus, the bromodomain is functionally linked to the HAT activity of co-activators in the regulation of gene transcription.
  Selected figure(s)  
Figure 3.
Figure 3: Binding of the P/CAF bromodomain to AcK. a, Superimposed region of the 2D ^15N-HSQC spectra of the bromodomain ( 0.5 mM) in its free form (red) and complexed to the AcK-containing H4 peptide (molar ratio 1:6) (black). b, Ribbon and dotted-surface diagram of the bromodomain depicting the location of the lysine-acetylated H4 peptide-binding site. The colour coding reflects the chemicalshift changes ( ) of the backbone amide ^1H and ^15N resonances upon binding to the AcK peptide as observed in the ^15N-HSQC spectra. The normalized weighted average of the chemical shift changes was calculated by [av]/ [max] = [( ^2[NH] + ^2[N]/25)/2]^1/2/ [max], where [max] is the maximum weighted chemical shift difference observed for Tyr 809 (0.16 ppm). The backbone atoms are colour-coded in red, yellow or green for residues that have [av]/ [max] of >0.6 (Tyr 809, Glu 808, Asn 803 and Ala 757), 0.2–0.6 (Ala 813, Tyr 802, Tyr 760 and Val 752) or <0.2 (Cys 812, Ser 807, Cys 799, Phe 796 and Phe 748), respectively. The non-perturbed residues are shown in blue. c, Chemical structures of acetyl-lysine, acetyl-histamine, and acetyl-histidine.
Figure 4.
Figure 4: The acetyl-lysine binding pocket. Ribbons^29 depiction of a portion of the P/CAF bromodomain complexed with acetyl-histamine. The ligand is colour-coded by atom type.
  The above figures are reprinted by permission from Macmillan Publishers Ltd: Nature (1999, 399, 491-496) copyright 1999.  
  Figures were selected by an automated process.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
22722403 A.C.Belkina, and G.V.Denis (2012).
BET domain co-regulators in obesity, inflammation and cancer.
  Nat Rev Cancer, 12, 465-477.  
23211769 C.A.Musselman, M.E.Lalonde, J.Côté, and T.G.Kutateladze (2012).
Perceiving the epigenetic landscape through histone readers.
  Nat Struct Mol Biol, 19, 1218-1227.  
22307274 D.Su, Q.Hu, Q.Li, J.R.Thompson, G.Cui, A.Fazly, B.A.Davies, M.V.Botuyan, Z.Zhang, and G.Mer (2012).
Structural basis for recognition of H3K56-acetylated histone H3-H4 by the chaperone Rtt106.
  Nature, 483, 104-107.
PDB codes: 2lh0 3fss 3tvv 3tw1
21234331 A.Masumi (2011).
Histone acetyltransferases as regulators of nonhistone proteins: the role of interferon regulatory factor acetylation on gene transcription.
  J Biomed Biotechnol, 2011, 640610.  
21326359 C.Barnett, and J.E.Krebs (2011).
WSTF does it all: a multifunctional protein in transcription, repair, and replication.
  Biochem Cell Biol, 89, 12-23.  
21105876 C.Soldati, A.Bithell, P.Conforti, E.Cattaneo, and N.J.Buckley (2011).
Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington's disease.
  J Neurochem, 116, 415-425.  
21197572 F.D.Piaz, A.Vassallo, O.C.Rubio, S.Castellano, G.Sbardella, and N.De Tommasi (2011).
Chemical biology of Histone acetyltransferase natural compounds modulators.
  Mol Divers, 15, 401-416.  
21513889 J.C.Borah, S.Mujtaba, I.Karakikes, L.Zeng, M.Muller, J.Patel, N.Moshkina, K.Morohashi, W.Zhang, G.Gerona-Navarro, R.J.Hajjar, and M.M.Zhou (2011).
A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes.
  Chem Biol, 18, 531-541.
PDB codes: 2l84 2l85
  21371315 J.Patel, R.R.Pathak, and S.Mujtaba (2011).
The biology of lysine acetylation integrates transcriptional programming and metabolism.
  Nutr Metab (Lond), 8, 12.  
21423274 M.Yun, J.Wu, J.L.Workman, and B.Li (2011).
Readers of histone modifications.
  Cell Res, 21, 564-578.  
21243712 P.Voigt, and D.Reinberg (2011).
Histone tails: ideal motifs for probing epigenetics through chemical biology approaches.
  Chembiochem, 12, 236-252.  
21513886 T.Ito, T.Umehara, K.Sasaki, Y.Nakamura, N.Nishino, T.Terada, M.Shirouzu, B.Padmanabhan, S.Yokoyama, A.Ito, and M.Yoshida (2011).
Real-time imaging of histone H4K12-specific acetylation determines the modes of action of histone deacetylase and bromodomain inhibitors.
  Chem Biol, 18, 495-507.
PDB code: 3aqa
21243719 Y.Y.Yang, and H.C.Hang (2011).
Chemical approaches for the detection and synthesis of acetylated proteins.
  Chembiochem, 12, 314-322.  
20032077 C.A.Airoldi, F.D.Rovere, G.Falasca, G.Marino, M.Kooiker, M.M.Altamura, S.Citterio, and M.M.Kater (2010).
The Arabidopsis BET bromodomain factor GTE4 is involved in maintenance of the mitotic cell cycle during plant development.
  Plant Physiol, 152, 1320-1334.  
20862720 D.Schwarzer (2010).
Chemical tools in chromatin research.
  J Pept Sci, 16, 530-537.  
  21189220 G.V.Denis (2010).
Bromodomain coactivators in cancer, obesity, type 2 diabetes, and inflammation.
  Discov Med, 10, 489-499.  
19917722 J.Luo, X.Xu, H.Hall, E.M.Hyland, J.D.Boeke, T.Hazbun, and M.H.Kuo (2010).
Histone h3 exerts a key function in mitotic checkpoint control.
  Mol Cell Biol, 30, 537-549.  
20923397 K.L.Yap, and M.M.Zhou (2010).
Keeping it in the family: diverse histone recognition by conserved structural folds.
  Crit Rev Biochem Mol Biol, 45, 488-505.  
20491580 L.M.Bergner, F.E.Hickman, K.H.Wood, C.M.Wakeman, H.H.Stone, T.J.Campbell, S.B.Lightcap, S.M.Favors, A.C.Aldridge, and K.G.Hales (2010).
A novel predicted bromodomain-related protein affects coordination between meiosis and spermiogenesis in Drosophila and is required for male meiotic cytokinesis.
  DNA Cell Biol, 29, 487-498.  
20962278 L.Ma, J.S.Gao, Y.Guan, X.Shi, H.Zhang, M.K.Ayrapetov, Z.Zhang, L.Xu, Y.M.Hyun, M.Kim, S.Zhuang, and Y.E.Chin (2010).
Acetylation modulates prolactin receptor dimerization.
  Proc Natl Acad Sci U S A, 107, 19314-19319.  
20613843 L.Zeng, Q.Zhang, S.Li, A.N.Plotnikov, M.J.Walsh, and M.M.Zhou (2010).
Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b.
  Nature, 466, 258-262.
PDB codes: 2kwj 2kwk 2kwn 2kwo
19836960 M.Billur, H.D.Bartunik, and P.B.Singh (2010).
The essential function of HP1 beta: a case of the tail wagging the dog?
  Trends Biochem Sci, 35, 115-123.  
20131086 M.Dalvai, and K.Bystricky (2010).
The role of histone modifications and variants in regulating gene expression in breast cancer.
  J Mammary Gland Biol Neoplasia, 15, 19-33.  
20204433 M.N.Cruickshank, P.Besant, and D.Ulgiati (2010).
The impact of histone post-translational modifications on developmental gene regulation.
  Amino Acids, 39, 1087-1105.  
20126658 Q.Zhang, S.Chakravarty, D.Ghersi, L.Zeng, A.N.Plotnikov, R.Sanchez, and M.M.Zhou (2010).
Biochemical profiling of histone binding selectivity of the yeast bromodomain family.
  PLoS One, 5, e8903.  
  20621284 S.D.McCullough, and P.A.Grant (2010).
Histone acetylation, acetyltransferases, and ataxia-alteration of histone acetylation and chromatin dynamics is implicated in the pathogenesis of polyglutamine-expansion disorders.
  Adv Protein Chem Struct Biol, 79, 165-203.  
20048151 T.Umehara, Y.Nakamura, M.K.Jang, K.Nakano, A.Tanaka, K.Ozato, B.Padmanabhan, and S.Yokoyama (2010).
Structural basis for acetylated histone H4 recognition by the human BRD2 bromodomain.
  J Biol Chem, 285, 7610-7618.
PDB codes: 2dvq 2dvr 2dvs
20300640 V.Dumeaux, K.S.Olsen, G.Nuel, R.H.Paulssen, A.L.Børresen-Dale, and E.Lund (2010).
Deciphering normal blood gene expression variation--The NOWAC Postgenome Study.
  PLoS Genet, 6, e1000873.  
20974913 W.R.Luebben, N.Sharma, and J.K.Nyborg (2010).
Nucleosome eviction and activated transcription require p300 acetylation of histone H3 lysine 14.
  Proc Natl Acad Sci U S A, 107, 19254-19259.  
20393127 Y.Akai, N.Adachi, Y.Hayashi, M.Eitoku, N.Sano, R.Natsume, N.Kudo, M.Tanokura, T.Senda, and M.Horikoshi (2010).
Structure of the histone chaperone CIA/ASF1-double bromodomain complex linking histone modifications and site-specific histone eviction.
  Proc Natl Acad Sci U S A, 107, 8153-8158.
PDB code: 3aad
20368734 Z.Charlop-Powers, L.Zeng, Q.Zhang, and M.M.Zhou (2010).
Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2.
  Cell Res, 20, 529-538.
PDB codes: 2ktb 3ljw
19581291 A.Gradolatto, S.K.Smart, S.Byrum, L.P.Blair, R.S.Rogers, E.A.Kolar, H.Lavender, S.K.Larson, J.D.Aitchison, S.D.Taverna, and A.J.Tackett (2009).
A noncanonical bromodomain in the AAA ATPase protein Yta7 directs chromosomal positioning and barrier chromatin activity.
  Mol Cell Biol, 29, 4604-4611.  
19362612 A.Gyuris, D.J.Donovan, K.A.Seymour, L.A.Lovasco, N.R.Smilowitz, A.L.Halperin, J.E.Klysik, and R.N.Freiman (2009).
The chromatin-targeting protein Brd2 is required for neural tube closure and embryogenesis.
  Biochim Biophys Acta, 1789, 413-421.  
19103749 B.Huang, X.D.Yang, M.M.Zhou, K.Ozato, and L.F.Chen (2009).
Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA.
  Mol Cell Biol, 29, 1375-1387.  
19189962 D.Baniulis, E.Yamashita, J.P.Whitelegge, A.I.Zatsman, M.P.Hendrich, S.S.Hasan, C.M.Ryan, and W.A.Cramer (2009).
Structure-Function, Stability, and Chemical Modification of the Cyanobacterial Cytochrome b6f Complex from Nostoc sp. PCC 7120.
  J Biol Chem, 284, 9861-9869.
PDB code: 2zt9
19337993 D.W.Chan, Y.Wang, M.Wu, J.Wong, J.Qin, and Y.Zhao (2009).
Unbiased proteomic screen for binding proteins to modified lysines on histone H3.
  Proteomics, 9, 2343-2354.  
19828451 F.Vollmuth, W.Blankenfeldt, and M.Geyer (2009).
Structures of the dual bromodomains of the P-TEFb-activating protein Brd4 at atomic resolution.
  J Biol Chem, 284, 36547-36556.
PDB codes: 3jvj 3jvk 3jvl 3jvm
19818718 H.Neumann, S.M.Hancock, R.Buning, A.Routh, L.Chapman, J.Somers, T.Owen-Hughes, J.van Noort, D.Rhodes, and J.W.Chin (2009).
A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation.
  Mol Cell, 36, 153-163.  
19223581 I.D'Orso, and A.D.Frankel (2009).
Tat acetylation modulates assembly of a viral-host RNA-protein transcription complex.
  Proc Natl Acad Sci U S A, 106, 3101-3106.  
19358899 M.H.Kuo, X.J.Xu, H.A.Bolck, and D.Guo (2009).
Functional connection between histone acetyltransferase Gcn5p and methyltransferase Hmt1p.
  Biochim Biophys Acta, 1789, 395-402.  
19407817 M.Pinskaya, S.Gourvennec, and A.Morillon (2009).
H3 lysine 4 di- and tri-methylation deposited by cryptic transcription attenuates promoter activation.
  EMBO J, 28, 1697-1707.  
19903202 M.Sakamoto, S.Noguchi, S.Kawashima, Y.Okada, T.Enomoto, M.Seki, and M.Horikoshi (2009).
Global analysis of mutual interaction surfaces of nucleosomes with comprehensive point mutants.
  Genes Cells, 14, 1271-1330.  
19084573 M.Thompson (2009).
Polybromo-1: the chromatin targeting subunit of the PBAF complex.
  Biochimie, 91, 309-319.  
19419532 M.W.Yaish, M.Peng, and S.J.Rothstein (2009).
AtMBD9 modulates Arabidopsis development through the dual epigenetic pathways of DNA methylation and histone acetylation.
  Plant J, 59, 123-135.  
19184981 P.V.Peña, C.A.Musselman, A.J.Kuo, O.Gozani, and T.G.Kutateladze (2009).
NMR assignments and histone specificity of the ING2 PHD finger.
  Magn Reson Chem, 47, 352-358.  
19250906 R.J.Loomis, Y.Naoe, J.B.Parker, V.Savic, M.R.Bozovsky, T.Macfarlan, J.L.Manley, and D.Chakravarti (2009).
Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation.
  Mol Cell, 33, 450-461.  
  19736624 R.Sanchez, and M.M.Zhou (2009).
The role of human bromodomains in chromatin biology and gene transcription.
  Curr Opin Drug Discov Devel, 12, 659-665.  
19218239 S.Li, and M.A.Shogren-Knaak (2009).
The Gcn5 bromodomain of the SAGA complex facilitates cooperative and cross-tail acetylation of nucleosomes.
  J Biol Chem, 284, 9411-9417.  
18718879 S.M.Fuchs, R.N.Laribee, and B.D.Strahl (2009).
Protein modifications in transcription elongation.
  Biochim Biophys Acta, 1789, 26-36.  
18804549 S.Spange, T.Wagner, T.Heinzel, and O.H.Krämer (2009).
Acetylation of non-histone proteins modulates cellular signalling at multiple levels.
  Int J Biochem Cell Biol, 41, 185-198.  
19139074 T.K.Pandita, and C.Richardson (2009).
Chromatin remodeling finds its place in the DNA double-strand break response.
  Nucleic Acids Res, 37, 1363-1377.  
19369410 T.N.Siegel, D.R.Hekstra, L.E.Kemp, L.M.Figueiredo, J.E.Lowell, D.Fenyo, X.Wang, S.Dewell, and G.A.Cross (2009).
Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma brucei.
  Genes Dev, 23, 1063-1076.  
19698979 Z.Wang, C.Zang, K.Cui, D.E.Schones, A.Barski, W.Peng, and K.Zhao (2009).
Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes.
  Cell, 138, 1019-1031.  
18264999 B.L.Florence, and D.V.Faller (2008).
Drosophila female sterile (1) homeotic is a multifunctional transcriptional regulator that is modulated by Ras signaling.
  Dev Dyn, 237, 554-564.  
18984594 B.Sun, J.Hong, P.Zhang, X.Dong, X.Shen, D.Lin, and J.Ding (2008).
Molecular basis of the interaction of Saccharomyces cerevisiae Eaf3 chromo domain with methylated H3K36.
  J Biol Chem, 283, 36504-36512.
PDB codes: 3e9f 3e9g
18263619 C.Buerki, K.M.Rothgiesser, T.Valovka, H.R.Owen, H.Rehrauer, M.Fey, W.S.Lane, and M.O.Hottiger (2008).
Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65.
  Nucleic Acids Res, 36, 1665-1680.  
18406326 G.LeRoy, B.Rickards, and S.J.Flint (2008).
The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription.
  Mol Cell, 30, 51-60.  
18339539 J.Huang, and S.L.Berger (2008).
The emerging field of dynamic lysine methylation of non-histone proteins.
  Curr Opin Genet Dev, 18, 152-158.  
18406149 J.Peng, and J.Wysocka (2008).
It takes a PHD to SUMO.
  Trends Biochem Sci, 33, 191-194.  
18344520 K.H.Brettingham-Moore, O.R.Sprod, X.Chen, P.Oakford, M.F.Shannon, and A.F.Holloway (2008).
Determinants of a transcriptionally competent environment at the GM-CSF promoter.
  Nucleic Acids Res, 36, 2639-2653.  
18488044 L.Zeng, K.L.Yap, A.V.Ivanov, X.Wang, S.Mujtaba, O.Plotnikova, F.J.Rauscher, and M.M.Zhou (2008).
Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing.
  Nat Struct Mol Biol, 15, 626-633.
PDB code: 2ro1
18400184 L.Zeng, Q.Zhang, G.Gerona-Navarro, N.Moshkina, and M.M.Zhou (2008).
Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300.
  Structure, 16, 643-652.
PDB codes: 2rnw 2rnx 2rny
18323811 M.Brand, S.Rampalli, C.P.Chaturvedi, and F.J.Dilworth (2008).
Analysis of epigenetic modifications of chromatin at specific gene loci by native chromatin immunoprecipitation of nucleosomes isolated using hydroxyapatite chromatography.
  Nat Protoc, 3, 398-409.  
18319736 M.M.Brent, and R.Marmorstein (2008).
Ankyrin for methylated lysines.
  Nat Struct Mol Biol, 15, 221-222.  
18191465 M.Thompson, and R.Chandrasekaran (2008).
Thermodynamic analysis of acetylation-dependent Pb1 bromodomain-histone H3 interactions.
  Anal Biochem, 374, 304-312.  
18784729 R.J.Sims, and D.Reinberg (2008).
Is there a code embedded in proteins that is based on post-translational modifications?
  Nat Rev Mol Cell Biol, 9, 815-820.  
18498094 R.Toyama, M.L.Rebbert, A.Dey, K.Ozato, and I.B.Dawid (2008).
Brd4 associates with mitotic chromosomes throughout early zebrafish embryogenesis.
  Dev Dyn, 237, 1636-1644.  
18837912 S.Awad, and A.H.Hassan (2008).
The Swi2/Snf2 bromodomain is important for the full binding and remodeling activity of the SWI/SNF complex on H3- and H4-acetylated nucleosomes.
  Ann N Y Acad Sci, 1138, 366-375.  
19188699 S.Misri, S.Pandita, R.Kumar, and T.K.Pandita (2008).
Telomeres, histone code, and DNA damage response.
  Cytogenet Genome Res, 122, 297-307.  
18539634 S.Padilla-Parra, N.Audugé, M.Coppey-Moisan, and M.Tramier (2008).
Quantitative FRET analysis by fast acquisition time domain FLIM at high spatial resolution in living cells.
  Biophys J, 95, 2976-2988.  
18174544 S.Rajendrasozhan, S.R.Yang, V.L.Kinnula, and I.Rahman (2008).
SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease.
  Am J Respir Crit Care Med, 177, 861-870.  
19050719 S.Till, K.Diamantara, and A.G.Ladurner (2008).
PARP: a transferase by any other name.
  Nat Struct Mol Biol, 15, 1243-1244.  
18782771 T.Hou, S.Ray, C.Lee, and A.R.Brasier (2008).
The STAT3 NH2-terminal Domain Stabilizes Enhanceosome Assembly by Interacting with the p300 Bromodomain.
  J Biol Chem, 283, 30725-30734.  
18327268 T.Suganuma, J.L.Gutiérrez, B.Li, L.Florens, S.K.Swanson, M.P.Washburn, S.M.Abmayr, and J.L.Workman (2008).
ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding.
  Nat Struct Mol Biol, 15, 364-372.  
18343834 W.Gad, and Y.Kim (2008).
A viral histone H4 encoded by Cotesia plutellae bracovirus inhibits haemocyte-spreading behaviour of the diamondback moth, Plutella xylostella.
  J Gen Virol, 89, 931-938.  
18470998 Z.A.Gurard-Levin, and M.Mrksich (2008).
The activity of HDAC8 depends on local and distal sequences of its peptide substrates.
  Biochemistry, 47, 6242-6250.  
17905638 A.Cvekl, and M.K.Duncan (2007).
Genetic and epigenetic mechanisms of gene regulation during lens development.
  Prog Retin Eye Res, 26, 555-597.  
17996705 A.G.Li, L.G.Piluso, X.Cai, B.J.Gadd, A.G.Ladurner, and X.Liu (2007).
An acetylation switch in p53 mediates holo-TFIID recruitment.
  Mol Cell, 28, 408-421.  
18037899 A.J.Ruthenburg, H.Li, D.J.Patel, and C.D.Allis (2007).
Multivalent engagement of chromatin modifications by linked binding modules.
  Nat Rev Mol Cell Biol, 8, 983-994.  
17893736 A.Keuling, F.Yang, S.Hanna, H.Wang, T.Tully, A.Burnham, J.Locke, and H.E.McDermid (2007).
Mutation analysis of Drosophila dikar/CG32394, homologue of the chromatin-remodelling gene CECR2.
  Genome, 50, 767-777.  
17602165 A.P.Mogal, R.van der Meer, P.S.Crooke, and S.A.Abdulkadir (2007).
Haploinsufficient prostate tumor suppression by Nkx3.1: a role for chromatin accessibility in dosage-sensitive gene regulation.
  J Biol Chem, 282, 25790-25800.  
17723105 B.Duncan, and K.Zhao (2007).
HMGA1 mediates the activation of the CRYAB promoter by BRG1.
  DNA Cell Biol, 26, 745-752.  
17198977 D.M.Heery, and P.M.Fischer (2007).
Pharmacological targeting of lysine acetyltransferases in human disease: a progress report.
  Drug Discov Today, 12, 88-99.  
17101790 F.Escaffit, O.Vaute, M.Chevillard-Briet, B.Segui, Y.Takami, T.Nakayama, and D.Trouche (2007).
Cleavage and cytoplasmic relocalization of histone deacetylase 3 are important for apoptosis progression.
  Mol Cell Biol, 27, 554-567.  
17848202 H.Huang, J.Zhang, W.Shen, X.Wang, J.Wu, J.Wu, and Y.Shi (2007).
Solution structure of the second bromodomain of Brd2 and its specific interaction with acetylated histone tails.
  BMC Struct Biol, 7, 57.  
17111193 J.Peng, W.Dong, L.Chen, T.Zou, Y.Qi, and Y.Liu (2007).
Brd2 is a TBP-associated protein and recruits TBP into E2F-1 transcriptional complex in response to serum stimulation.
  Mol Cell Biochem, 294, 45-54.  
17380162 K.K.Lee, and J.L.Workman (2007).
Histone acetyltransferase complexes: one size doesn't fit all.
  Nat Rev Mol Cell Biol, 8, 284-295.  
17898061 K.Kalantidis, M.A.Denti, S.Tzortzakaki, E.Marinou, M.Tabler, and M.Tsagris (2007).
Virp1 is a host protein with a major role in Potato spindle tuber viroid infection in Nicotiana plants.
  J Virol, 81, 12872-12880.  
17705707 M.B.Trelle, and O.N.Jensen (2007).
Functional proteomics in histone research and epigenetics.
  Expert Rev Proteomics, 4, 491-503.  
17362198 M.D.Shahbazian, and M.Grunstein (2007).
Functions of site-specific histone acetylation and deacetylation.
  Annu Rev Biochem, 76, 75.  
17526728 M.Durant, and B.F.Pugh (2007).
NuA4-directed chromatin transactions throughout the Saccharomyces cerevisiae genome.
  Mol Cell Biol, 27, 5327-5335.  
17166848 M.E.Lenburg, A.Sinha, D.V.Faller, and G.V.Denis (2007).
Tumor-specific and proliferation-specific gene expression typifies murine transgenic B cell lymphomagenesis.
  J Biol Chem, 282, 4803-4811.  
17668385 M.Field, P.S.Tarpey, R.Smith, S.Edkins, S.O'Meara, C.Stevens, C.Tofts, J.Teague, A.Butler, E.Dicks, S.Barthorpe, G.Buck, J.Cole, K.Gray, K.Halliday, K.Hills, A.Jenkinson, D.Jones, A.Menzies, T.Mironenko, J.Perry, K.Raine, D.Richardson, R.Shepherd, A.Small, J.Varian, S.West, S.Widaa, U.Mallya, R.Wooster, J.Moon, Y.Luo, H.Hughes, M.Shaw, K.L.Friend, M.Corbett, G.Turner, M.Partington, J.Mulley, M.Bobrow, C.Schwartz, R.Stevenson, J.Gecz, M.R.Stratton, P.A.Futreal, and F.L.Raymond (2007).
Mutations in the BRWD3 gene cause X-linked mental retardation associated with macrocephaly.
  Am J Hum Genet, 81, 367-374.  
17151888 M.J.Gao, D.D.Hegedus, A.G.Sharpe, S.J.Robinson, D.J.Lydiate, and A.Hannoufa (2007).
Isolation and characterization of a GCN5-interacting protein from Arabidopsis thaliana.
  Planta, 225, 1367-1379.  
17582821 M.Singh, G.M.Popowicz, M.Krajewski, and T.A.Holak (2007).
Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein, a central ATPase of the SWI/SNF remodeling complex.
  Chembiochem, 8, 1308-1316.
PDB code: 2grc
17340003 N.Jamonnak, D.G.Fatkins, L.Wei, and W.Zheng (2007).
N(epsilon)-methanesulfonyl-lysine as a non-hydrolyzable functional surrogate for N(epsilon)-acetyl-lysine.
  Org Biomol Chem, 5, 892-896.  
17504018 P.Stavropoulos, and A.Hoelz (2007).
Lysine-specific demethylase 1 as a potential therapeutic target.
  Expert Opin Ther Targets, 11, 809-820.  
17618463 R.J.Tseng, K.R.Armstrong, X.Wang, and H.M.Chamberlin (2007).
The bromodomain protein LEX-1 acts with TAM-1 to modulate gene expression in C. elegans.
  Mol Genet Genomics, 278, 507-518.  
17694078 R.Murr, T.Vaissière, C.Sawan, V.Shukla, and Z.Herceg (2007).
Orchestration of chromatin-based processes: mind the TRRAP.
  Oncogene, 26, 5358-5372.  
17387179 R.Xu, V.A.Spencer, and M.J.Bissell (2007).
Extracellular matrix-regulated gene expression requires cooperation of SWI/SNF and transcription factors.
  J Biol Chem, 282, 14992-14999.  
17984965 S.D.Taverna, H.Li, A.J.Ruthenburg, C.D.Allis, and D.J.Patel (2007).
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers.
  Nat Struct Mol Biol, 14, 1025-1040.  
17934485 S.I.Kim, and E.H.Bresnick (2007).
Transcriptional control of erythropoiesis: emerging mechanisms and principles.
  Oncogene, 26, 6777-6794.  
17144897 S.K.Han, J.D.Song, Y.S.Noh, and B.Noh (2007).
Role of plant CBP/p300-like genes in the regulation of flowering time.
  Plant J, 49, 103-114.  
17522673 S.L.Berger (2007).
The complex language of chromatin regulation during transcription.
  Nature, 447, 407-412.  
17984971 S.Lall (2007).
Primers on chromatin.
  Nat Struct Mol Biol, 14, 1110-1115.  
17694091 S.Mujtaba, L.Zeng, and M.M.Zhou (2007).
Structure and acetyl-lysine recognition of the bromodomain.
  Oncogene, 26, 5521-5527.  
18025461 S.Ramón-Maiques, A.J.Kuo, D.Carney, A.G.Matthews, M.A.Oettinger, O.Gozani, and W.Yang (2007).
The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2.
  Proc Natl Acad Sci U S A, 104, 18993-18998.
PDB codes: 2v83 2v85 2v86 2v87 2v88
17694080 S.Rea, G.Xouri, and A.Akhtar (2007).
Males absent on the first (MOF): from flies to humans.
  Oncogene, 26, 5385-5394.  
17391015 S.Vucetic, H.Xie, L.M.Iakoucheva, C.J.Oldfield, A.K.Dunker, Z.Obradovic, and V.N.Uversky (2007).
Functional anthology of intrinsic disorder. 2. Cellular components, domains, technical terms, developmental processes, and coding sequence diversities correlated with long disordered regions.
  J Proteome Res, 6, 1899-1916.  
17371436 T.Rothhammer, and A.K.Bosserhoff (2007).
Epigenetic events in malignant melanoma.
  Pigment Cell Res, 20, 92.  
17306844 V.K.Gangaraju, and B.Bartholomew (2007).
Mechanisms of ATP dependent chromatin remodeling.
  Mutat Res, 618, 3.  
17526731 Y.L.Chang, B.King, S.C.Lin, J.A.Kennison, and D.H.Huang (2007).
A double-bromodomain protein, FSH-S, activates the homeotic gene ultrabithorax through a critical promoter-proximal region.
  Mol Cell Biol, 27, 5486-5498.  
17148447 Y.Nakamura, T.Umehara, K.Nakano, M.K.Jang, M.Shirouzu, S.Morita, H.Uda-Tochio, H.Hamana, T.Terada, N.Adachi, T.Matsumoto, A.Tanaka, M.Horikoshi, K.Ozato, B.Padmanabhan, and S.Yokoyama (2007).
Crystal structure of the human BRD2 bromodomain: insights into dimerization and recognition of acetylated histone H4.
  J Biol Chem, 282, 4193-4201.  
17694077 Z.Nagy, and L.Tora (2007).
Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation.
  Oncogene, 26, 5341-5357.  
16732329 A.A.Wani, N.Sharma, Y.S.Shouche, and S.A.Bapat (2006).
Nuclear-mitochondrial genomic profiling reveals a pattern of evolution in epithelial ovarian tumor stem cells.
  Oncogene, 25, 6336-6344.  
17018288 A.G.Ladurner (2006).
Rheostat control of gene expression by metabolites.
  Mol Cell, 24, 1.  
16648632 A.H.Hassan, S.Awad, and P.Prochasson (2006).
The Swi2/Snf2 bromodomain is required for the displacement of SAGA and the octamer transfer of SAGA-acetylated nucleosomes.
  J Biol Chem, 281, 18126-18134.  
16936819 A.Morillon (2006).
Is histone loss a common feature of DNA metabolism regulation?
  Biochem Cell Biol, 84, 450-462.  
16543223 C.B.Millar, F.Xu, K.Zhang, and M.Grunstein (2006).
Acetylation of H2AZ Lys 14 is associated with genome-wide gene activity in yeast.
  Genes Dev, 20, 711-722.  
16912715 C.B.Millar, and M.Grunstein (2006).
Genome-wide patterns of histone modifications in yeast.
  Nat Rev Mol Cell Biol, 7, 657-666.  
16265664 C.Peng, J.Zhou, H.Y.Liu, M.Zhou, L.L.Wang, Q.H.Zhang, Y.X.Yang, W.Xiong, S.R.Shen, X.L.Li, and G.Y.Li (2006).
The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain.
  J Cell Biochem, 97, 882-892.  
16923967 D.G.Martin, K.Baetz, X.Shi, K.L.Walter, V.E.MacDonald, M.J.Wlodarski, O.Gozani, P.Hieter, and L.Howe (2006).
The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3.
  Mol Cell Biol, 26, 7871-7879.  
16598039 D.Nathan, K.Ingvarsdottir, D.E.Sterner, G.R.Bylebyl, M.Dokmanovic, J.A.Dorsey, K.A.Whelan, M.Krsmanovic, W.S.Lane, P.B.Meluh, E.S.Johnson, and S.L.Berger (2006).
Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications.
  Genes Dev, 20, 966-976.  
16877755 D.Zhang, C.J.Martyniuk, and V.L.Trudeau (2006).
SANTA domain: a novel conserved protein module in Eukaryota with potential involvement in chromatin regulation.
  Bioinformatics, 22, 2459-2462.  
17121596 E.Agricola, L.Verdone, E.Di Mauro, and M.Caserta (2006).
H4 acetylation does not replace H3 acetylation in chromatin remodelling and transcription activation of Adr1-dependent genes.
  Mol Microbiol, 62, 1433-1446.  
16699007 F.Lu, L.Day, S.J.Gao, and P.M.Lieberman (2006).
Acetylation of the latency-associated nuclear antigen regulates repression of Kaposi's sarcoma-associated herpesvirus lytic transcription.
  J Virol, 80, 5273-5282.  
16180204 F.Pizzitutti, A.Giansanti, P.Ballario, P.Ornaghi, P.Torreri, G.Ciccotti, and P.Filetici (2006).
The role of loop ZA and Pro371 in the function of yeast Gcn5p bromodomain revealed through molecular dynamics and experiment.
  J Mol Recognit, 19, 1-9.  
16461455 G.Da, J.Lenkart, K.Zhao, R.Shiekhattar, B.R.Cairns, and R.Marmorstein (2006).
Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes.
  Proc Natl Acad Sci U S A, 103, 2057-2062.
PDB code: 2fq3
16512664 G.V.Denis, M.E.McComb, D.V.Faller, A.Sinha, P.B.Romesser, and C.E.Costello (2006).
Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines.
  J Proteome Res, 5, 502-511.  
16935875 H.Dürr, A.Flaus, T.Owen-Hughes, and K.P.Hopfner (2006).
Snf2 family ATPases and DExx box helicases: differences and unifying concepts from high-resolution crystal structures.
  Nucleic Acids Res, 34, 4160-4167.  
16728978 H.Li, S.Ilin, W.Wang, E.M.Duncan, J.Wysocka, C.D.Allis, and D.J.Patel (2006).
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF.
  Nature, 442, 91-95.
PDB codes: 2f6j 2f6n 2fsa 2fui 2fuu
16412250 J.Perry (2006).
The Epc-N domain: a predicted protein-protein interaction domain found in select chromatin associated proteins.
  BMC Genomics, 7, 6.  
16896218 J.S.Fillingham, J.Garg, N.Tsao, N.Vythilingum, T.Nishikawa, and R.E.Pearlman (2006).
Molecular genetic analysis of an SNF2/brahma-related gene in Tetrahymena thermophila suggests roles in growth and nuclear development.
  Eukaryot Cell, 5, 1347-1359.  
16728976 J.Wysocka, T.Swigut, H.Xiao, T.A.Milne, S.Y.Kwon, J.Landry, M.Kauer, A.J.Tackett, B.T.Chait, P.Badenhorst, C.Wu, and C.D.Allis (2006).
A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling.
  Nature, 442, 86-90.  
17030999 M.Chandy, J.L.Gutiérrez, P.Prochasson, and J.L.Workman (2006).
SWI/SNF displaces SAGA-acetylated nucleosomes.
  Eukaryot Cell, 5, 1738-1747.  
16648099 M.Herranz, and M.Esteller (2006).
New therapeutic targets in cancer: the epigenetic connection.
  Clin Transl Oncol, 8, 242-249.  
16400169 M.M.Bhatti, M.Livingston, N.Mullapudi, and W.J.Sullivan (2006).
Pair of unusual GCN5 histone acetyltransferases and ADA2 homologues in the protozoan parasite Toxoplasma gondii.
  Eukaryot Cell, 5, 62-76.  
17081121 M.Singh, L.D'Silva, and T.A.Holak (2006).
DNA-binding properties of the recombinant high-mobility-group-like AT-hook-containing region from human BRG1 protein.
  Biol Chem, 387, 1469-1478.  
17014737 M.Yoshino, T.Mizutani, K.Yamada, T.Yazawa, H.Ogata-Kawata, T.Sekiguchi, T.Kajitani, and K.Miyamoto (2006).
Co-activator p120 is increased by gonadotropins in the rat ovary and enhances progesterone receptor activity.
  Reprod Biol Endocrinol, 4, 50.  
16728977 P.V.Peña, F.Davrazou, X.Shi, K.L.Walter, V.V.Verkhusha, O.Gozani, R.Zhao, and T.G.Kutateladze (2006).
Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2.
  Nature, 442, 100-103.
PDB code: 2g6q
16368686 Q.Yu, J.Sandmeier, H.Xu, Y.Zou, and X.Bi (2006).
Mechanism of the long range anti-silencing function of targeted histone acetyltransferases in yeast.
  J Biol Chem, 281, 3980-3988.  
16954381 S.P.Sripathy, J.Stevens, and D.C.Schultz (2006).
The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repression.
  Mol Cell Biol, 26, 8623-8638.  
16362936 S.Pantano, A.Marcello, A.Ferrari, D.Gaudiosi, A.Sabò, V.Pellegrini, F.Beltram, M.Giacca, and P.Carloni (2006).
Insights on HIV-1 Tat:P/CAF bromodomain molecular recognition from in vivo experiments and molecular dynamics simulations.
  Proteins, 62, 1062-1073.  
16857008 T.Jenuwein (2006).
The epigenetic magic of histone lysine methylation.
  FEBS J, 273, 3121-3135.  
17015479 T.Y.Erkina, and A.M.Erkine (2006).
Displacement of histones at promoters of Saccharomyces cerevisiae heat shock genes is differentially associated with histone H3 acetylation.
  Mol Cell Biol, 26, 7587-7600.  
16339282 X.Guo, K.Tatsuoka, and R.Liu (2006).
Histone acetylation and transcriptional regulation in the genome of Saccharomyces cerevisiae.
  Bioinformatics, 22, 392-399.  
16601153 Y.Huang, J.Fang, M.T.Bedford, Y.Zhang, and R.M.Xu (2006).
Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A.
  Science, 312, 748-751.
PDB codes: 2gf7 2gfa
16826231 Y.Zhang (2006).
It takes a PHD to interpret histone methylation.
  Nat Struct Mol Biol, 13, 572-574.  
15858614 A.Melnick (2005).
Predicting the effect of transcription therapy in hematologic malignancies.
  Leukemia, 19, 1109-1117.  
16275642 A.R.Colina, and D.Young (2005).
Raf60, a novel component of the Rpd3 histone deacetylase complex required for Rpd3 activity in Saccharomyces cerevisiae.
  J Biol Chem, 280, 42552-42556.  
16099183 C.A.Berkes, and S.J.Tapscott (2005).
MyoD and the transcriptional control of myogenesis.
  Semin Cell Dev Biol, 16, 585-595.  
16135811 C.Carré, D.Szymczak, J.Pidoux, and C.Antoniewski (2005).
The histone H3 acetylase dGcn5 is a key player in Drosophila melanogaster metamorphosis.
  Mol Cell Biol, 25, 8228-8238.  
16122352 C.L.Liu, T.Kaplan, M.Kim, S.Buratowski, S.L.Schreiber, N.Friedman, and O.J.Rando (2005).
Single-nucleosome mapping of histone modifications in S. cerevisiae.
  PLoS Biol, 3, e328.  
16261189 C.Martin, and Y.Zhang (2005).
The diverse functions of histone lysine methylation.
  Nat Rev Mol Cell Biol, 6, 838-849.  
16094444 C.N.Johnson, N.L.Adkins, and P.Georgel (2005).
Chromatin remodeling complexes: ATP-dependent machines in action.
  Biochem Cell Biol, 83, 405-417.  
16227593 D.J.Eastburn, and M.Han (2005).
A gain-of-function allele of cbp-1, the Caenorhabditis elegans ortholog of the mammalian CBP/p300 gene, causes an increase in histone acetyltransferase activity and antagonism of activated Ras.
  Mol Cell Biol, 25, 9427-9434.  
15870728 E.Lejeune, and A.G.Ladurner (2005).
Hitting transcription in all the right places.
  Nat Struct Mol Biol, 12, 390-392.  
15870268 E.Y.Shim, J.L.Ma, J.H.Oum, Y.Yanez, and S.E.Lee (2005).
The yeast chromatin remodeler RSC complex facilitates end joining repair of DNA double-strand breaks.
  Mol Cell Biol, 25, 3934-3944.  
15902274 G.I.Karras, G.Kustatscher, H.R.Buhecha, M.D.Allen, C.Pugieux, F.Sait, M.Bycroft, and A.G.Ladurner (2005).
The macro domain is an ADP-ribose binding module.
  EMBO J, 24, 1911-1920.
PDB codes: 2bfq 2bfr
15831453 H.Qiu, C.Hu, F.Zhang, G.J.Hwang, M.J.Swanson, C.Boonchird, and A.G.Hinnebusch (2005).
Interdependent recruitment of SAGA and Srb mediator by transcriptional activator Gcn4p.
  Mol Cell Biol, 25, 3461-3474.  
16230526 I.Ivanovska, T.Khandan, T.Ito, and T.L.Orr-Weaver (2005).
A histone code in meiosis: the histone kinase, NHK-1, is required for proper chromosomal architecture in Drosophila oocytes.
  Genes Dev, 19, 2571-2582.  
15834423 J.H.Kim, E.J.Cho, S.T.Kim, and H.D.Youn (2005).
CtBP represses p300-mediated transcriptional activation by direct association with its bromodomain.
  Nat Struct Mol Biol, 12, 423-428.  
15788094 L.Chen, and H.Zhao (2005).
Gene expression analysis reveals that histone deacetylation sites may serve as partitions of chromatin gene expression domains.
  BMC Genomics, 6, 44.  
15898057 M.Biel, V.Wascholowski, and A.Giannis (2005).
Epigenetics--an epicenter of gene regulation: histones and histone-modifying enzymes.
  Angew Chem Int Ed Engl, 44, 3186-3216.  
15840568 M.Bulger (2005).
Hyperacetylated chromatin domains: lessons from heterochromatin.
  J Biol Chem, 280, 21689-21692.  
15767660 M.D.Stewart, J.Li, and J.Wong (2005).
Relationship between histone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment.
  Mol Cell Biol, 25, 2525-2538.  
15795371 M.F.Dion, S.J.Altschuler, L.F.Wu, and O.J.Rando (2005).
Genomic characterization reveals a simple histone H4 acetylation code.
  Proc Natl Acad Sci U S A, 102, 5501-5506.  
15951563 M.Fu, C.Wang, M.Rao, X.Wu, T.Bouras, X.Zhang, Z.Li, X.Jiao, J.Yang, A.Li, N.D.Perkins, B.Thimmapaya, A.L.Kung, A.Munoz, A.Giordano, M.P.Lisanti, and R.G.Pestell (2005).
Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism.
  J Biol Chem, 280, 29728-29742.  
16109376 M.K.Jang, K.Mochizuki, M.Zhou, H.S.Jeong, J.N.Brady, and K.Ozato (2005).
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.
  Mol Cell, 19, 523-534.  
16079223 N.Jambunathan, A.W.Martinez, E.C.Robert, N.B.Agochukwu, M.E.Ibos, S.L.Dugas, and D.Donze (2005).
Multiple bromodomain genes are involved in restricting the spread of heterochromatic silencing at the Saccharomyces cerevisiae HMR-tRNA boundary.
  Genetics, 171, 913-922.  
16246723 N.Macdonald, J.P.Welburn, M.E.Noble, A.Nguyen, M.B.Yaffe, D.Clynes, J.G.Moggs, G.Orphanides, S.Thomson, J.W.Edmunds, A.L.Clayton, J.A.Endicott, and L.C.Mahadevan (2005).
Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3.
  Mol Cell, 20, 199-211.
PDB codes: 2c1j 2c1n
16252006 R.Fujiki, M.S.Kim, Y.Sasaki, K.Yoshimura, H.Kitagawa, and S.Kato (2005).
Ligand-induced transrepression by VDR through association of WSTF with acetylated histones.
  EMBO J, 24, 3881-3894.  
15779005 R.Popovic, and N.J.Zeleznik-Le (2005).
MLL: how complex does it get?
  J Cell Biochem, 95, 234-242.  
15632193 T.Bouras, M.Fu, A.A.Sauve, F.Wang, A.A.Quong, N.D.Perkins, R.T.Hay, W.Gu, and R.G.Pestell (2005).
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.
  J Biol Chem, 280, 10264-10276.  
15706033 T.Y.Roh, S.Cuddapah, and K.Zhao (2005).
Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping.
  Genes Dev, 19, 542-552.  
15666348 la Cruz, S.Lois, S.Sánchez-Molina, and M.A.Martínez-Balbás (2005).
Do protein motifs read the histone code?
  Bioessays, 27, 164-175.  
16166385 Y.L.Chua, S.Channelière, E.Mott, and J.C.Gray (2005).
The bromodomain protein GTE6 controls leaf development in Arabidopsis by histone acetylation at ASYMMETRIC LEAVES1.
  Genes Dev, 19, 2245-2254.  
16287868 Y.Liu, X.Xu, S.Singh-Rodriguez, Y.Zhao, and M.H.Kuo (2005).
Histone H3 Ser10 phosphorylation-independent function of Snf1 and Reg1 proteins rescues a gcn5- mutant in HIS3 expression.
  Mol Cell Biol, 25, 10566-10579.  
15456879 A.Farina, M.Hattori, J.Qin, Y.Nakatani, N.Minato, and K.Ozato (2004).
Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization.
  Mol Cell Biol, 24, 9059-9069.  
15183183 A.Loyola, and G.Almouzni (2004).
Bromodomains in living cells participate in deciphering the histone code.
  Trends Cell Biol, 14, 279-281.  
15284898 A.M.Erkine (2004).
Activation domains of gene-specific transcription factors: are histones among their targets?
  Biochem Cell Biol, 82, 453-459.  
15289613 B.Y.Hamaoka, C.E.Dann, B.V.Geisbrecht, and D.J.Leahy (2004).
Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A.
  Proc Natl Acad Sci U S A, 101, 11673-11678.
PDB code: 1szh
16117649 C.B.Millar, S.K.Kurdistani, and M.Grunstein (2004).
Acetylation of yeast histone H4 lysine 16: a switch for protein interactions in heterochromatin and euchromatin.
  Cold Spring Harb Symp Quant Biol, 69, 193-200.  
16117652 C.J.Fry, M.A.Shogren-Knaak, and C.L.Peterson (2004).
Histone H3 amino-terminal tail phosphorylation and acetylation: synergistic or independent transcriptional regulatory marks?
  Cold Spring Harb Symp Quant Biol, 69, 219-226.  
14597626 C.M.Kiekhaefer, M.E.Boyer, K.D.Johnson, and E.H.Bresnick (2004).
A WW domain-binding motif within the activation domain of the hematopoietic transcription factor NF-E2 is essential for establishment of a tissue-specific histone modification pattern.
  J Biol Chem, 279, 7456-7461.  
15225549 C.Martinez-Campa, P.Politis, J.L.Moreau, N.Kent, J.Goodall, J.Mellor, and C.R.Goding (2004).
Precise nucleosome positioning and the TATA box dictate requirements for the histone H4 tail and the bromodomain factor Bdf1.
  Mol Cell, 15, 69-81.  
15289617 F.J.Dilworth, K.J.Seaver, A.L.Fishburn, S.L.Htet, and S.J.Tapscott (2004).
In vitro transcription system delineates the distinct roles of the coactivators pCAF and p300 during MyoD/E47-dependent transactivation.
  Proc Natl Acad Sci U S A, 101, 11593-11598.  
15347669 F.Wang, R.Zhang, T.V.Beischlag, C.Muchardt, M.Yaniv, and O.Hankinson (2004).
Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene.
  J Biol Chem, 279, 46733-46741.  
15291802 G.Mitterbauer-Hohendanner, and C.Mannhalter (2004).
The biological and clinical significance of MLL abnormalities in haematological malignancies.
  Eur J Clin Invest, 34, 12-24.  
15118322 H.Koyama, T.A.Nagao, T.Inai, K.Miyahara, Y.Hayasida, K.Shirahige, and E.Tsuchiya (2004).
RSC Nucleosome-remodeling complex plays prominent roles in transcriptional regulation throughout budding yeast gametogenesis.
  Biosci Biotechnol Biochem, 68, 909-919.  
14701747 J.L.Reid, Z.Moqtaderi, and K.Struhl (2004).
Eaf3 regulates the global pattern of histone acetylation in Saccharomyces cerevisiae.
  Mol Cell Biol, 24, 757-764.  
15121865 K.Cui, P.Tailor, H.Liu, X.Chen, K.Ozato, and K.Zhao (2004).
The chromatin-remodeling BAF complex mediates cellular antiviral activities by promoter priming.
  Mol Cell Biol, 24, 4476-4486.  
15210580 K.Ishihara, J.Hong, O.Zee, and K.Ohuchi (2004).
Possible mechanism of action of the histone deacetylase inhibitors for the induction of differentiation of HL-60 clone 15 cells into eosinophils.
  Br J Pharmacol, 142, 1020-1030.  
15308641 K.Narayanan, R.Srinivas, M.C.Peterson, A.Ramachandran, J.Hao, B.Thimmapaya, P.E.Scherer, and A.George (2004).
Transcriptional regulation of dentin matrix protein 1 by JunB and p300 during osteoblast differentiation.
  J Biol Chem, 279, 44294-44302.  
15060156 K.W.Trotter, and T.K.Archer (2004).
Reconstitution of glucocorticoid receptor-dependent transcription in vivo.
  Mol Cell Biol, 24, 3347-3358.  
15040448 L.A.Boyer, R.R.Latek, and C.L.Peterson (2004).
The SANT domain: a unique histone-tail-binding module?
  Nat Rev Mol Cell Biol, 5, 158-163.  
15184976 M.J.Bottomley (2004).
Structures of protein domains that create or recognize histone modifications.
  EMBO Rep, 5, 464-469.  
15014446 M.Kasten, H.Szerlong, H.Erdjument-Bromage, P.Tempst, M.Werner, and B.R.Cairns (2004).
Tandem bromodomains in the chromatin remodeler RSC recognize acetylated histone H3 Lys14.
  EMBO J, 23, 1348-1359.  
14563639 R.J.Greenwald, J.R.Tumang, A.Sinha, N.Currier, R.D.Cardiff, T.L.Rothstein, D.V.Faller, and G.V.Denis (2004).
E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia.
  Blood, 103, 1475-1484.  
15155140 R.Kristeleit, L.Stimson, P.Workman, and W.Aherne (2004).
Histone modification enzymes: novel targets for cancer drugs.
  Expert Opin Emerg Drugs, 9, 135-154.  
15082762 S.Ahmed, C.Palermo, S.Wan, and N.C.Walworth (2004).
A novel protein with similarities to Rb binding protein 2 compensates for loss of Chk1 function and affects histone modification in fission yeast.
  Mol Cell Biol, 24, 3660-3669.  
15024082 S.Molinari, F.Relaix, M.Lemonnier, B.Kirschbaum, B.Schäfer, and M.Buckingham (2004).
A novel complex regulates cardiac actin gene expression through interaction of Emb, a class VI POU domain protein, MEF2D, and the histone transacetylase p300.
  Mol Cell Biol, 24, 2944-2957.  
14759370 S.Mujtaba, Y.He, L.Zeng, S.Yan, O.Plotnikova, Sachchidanand, R.Sanchez, N.J.Zeleznik-Le, Z.Ronai, and M.M.Zhou (2004).
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
  Mol Cell, 13, 251-263.
PDB code: 1jsp
15136563 S.N.Kutney, R.Hong, T.Macfarlan, and D.Chakravarti (2004).
A signaling role of histone-binding proteins and INHAT subunits pp32 and Set/TAF-Ibeta in integrating chromatin hypoacetylation and transcriptional repression.
  J Biol Chem, 279, 30850-30855.  
14960713 X.J.Yang (2004).
The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases.
  Nucleic Acids Res, 32, 959-976.  
15382140 X.J.Yang (2004).
Lysine acetylation and the bromodomain: a new partnership for signaling.
  Bioessays, 26, 1076-1087.  
15147721 Y.J.Li, X.H.Fu, D.P.Liu, and C.C.Liang (2004).
Opening the chromatin for transcription.
  Int J Biochem Cell Biol, 36, 1411-1423.  
15601824 Z.Wang, W.Zhai, J.A.Richardson, E.N.Olson, J.J.Meneses, M.T.Firpo, C.Kang, W.C.Skarnes, and R.Tjian (2004).
Polybromo protein BAF180 functions in mammalian cardiac chamber maturation.
  Genes Dev, 18, 3106-3116.  
12840145 A.Dey, F.Chitsaz, A.Abbasi, T.Misteli, and K.Ozato (2003).
The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis.
  Proc Natl Acad Sci U S A, 100, 8758-8763.  
12620225 A.G.Ladurner, C.Inouye, R.Jain, and R.Tjian (2003).
Bromodomains mediate an acetyl-histone encoded antisilencing function at heterochromatin boundaries.
  Mol Cell, 11, 365-376.  
12917345 A.Goel, and R.Janknecht (2003).
Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu.
  Mol Cell Biol, 23, 6243-6254.  
12861021 C.Pivot-Pajot, C.Caron, J.Govin, A.Vion, S.Rousseaux, and S.Khochbin (2003).
Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein.
  Mol Cell Biol, 23, 5354-5365.  
12604594 H.Im, C.Park, Q.Feng, K.D.Johnson, C.M.Kiekhaefer, K.Choi, Y.Zhang, and E.H.Bresnick (2003).
Dynamic regulation of histone H3 methylated at lysine 79 within a tissue-specific chromatin domain.
  J Biol Chem, 278, 18346-18352.  
12820972 H.Reinke, and W.Hörz (2003).
Histones are first hyperacetylated and then lose contact with the activated PHO5 promoter.
  Mol Cell, 11, 1599-1607.  
12878007 I.Davidson (2003).
The genetics of TBP and TBP-related factors.
  Trends Biochem Sci, 28, 391-398.  
12923526 I.Grummt, and C.S.Pikaard (2003).
Epigenetic silencing of RNA polymerase I transcription.
  Nat Rev Mol Cell Biol, 4, 641-649.  
12672490 J.A.Martens, and F.Winston (2003).
Recent advances in understanding chromatin remodeling by Swi/Snf complexes.
  Curr Opin Genet Dev, 13, 136-142.  
12840002 J.Yu, Y.Li, T.Ishizuka, M.G.Guenther, and M.A.Lazar (2003).
A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation.
  EMBO J, 22, 3403-3410.  
12887902 K.Kaehlcke, A.Dorr, C.Hetzer-Egger, V.Kiermer, P.Henklein, M.Schnoelzer, E.Loret, P.A.Cole, E.Verdin, and M.Ott (2003).
Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation.
  Mol Cell, 12, 167-176.  
12474222 M.H.Schmidt, R.Broll, H.P.Bruch, O.Bögler, and M.Duchrow (2003).
The proliferation marker pKi-67 organizes the nucleolus during the cell cycle depending on Ran and cyclin B.
  J Pathol, 199, 18-27.  
12672492 M.Iizuka, and M.M.Smith (2003).
Functional consequences of histone modifications.
  Curr Opin Genet Dev, 13, 154-160.  
14555466 M.S.Hung, and C.K.Shen (2003).
Eukaryotic methyl-CpG-binding domain proteins and chromatin modification.
  Eukaryot Cell, 2, 841-846.  
12620224 O.Matangkasombut, and S.Buratowski (2003).
Different sensitivities of bromodomain factors 1 and 2 to histone H4 acetylation.
  Mol Cell, 11, 353-363.  
14580348 P.Prochasson, K.E.Neely, A.H.Hassan, B.Li, and J.L.Workman (2003).
Targeting activity is required for SWI/SNF function in vivo and is accomplished through two partially redundant activator-interaction domains.
  Mol Cell, 12, 983-990.  
12665578 Q.Ren, and M.A.Gorovsky (2003).
The nonessential H2A N-terminal tail can function as an essential charge patch on the H2A.Z variant N-terminal tail.
  Mol Cell Biol, 23, 2778-2789.  
12724405 S.Barbaric, H.Reinke, and W.Hörz (2003).
Multiple mechanistically distinct functions of SAGA at the PHO5 promoter.
  Mol Cell Biol, 23, 3468-3476.  
12845608 S.Boa, C.Coert, and H.G.Patterton (2003).
Saccharomyces cerevisiae Set1p is a methyltransferase specific for lysine 4 of histone H3 and is required for efficient gene expression.
  Yeast, 20, 827-835.  
12671650 S.K.Kurdistani, and M.Grunstein (2003).
Histone acetylation and deacetylation in yeast.
  Nat Rev Mol Cell Biol, 4, 276-284.  
12421817 W.An, and R.G.Roeder (2003).
Direct association of p300 with unmodified H3 and H4 N termini modulates p300-dependent acetylation and transcription of nucleosomal templates.
  J Biol Chem, 278, 1504-1510.  
12757711 W.L.Cheung, K.Ajiro, K.Samejima, M.Kloc, P.Cheung, C.A.Mizzen, A.Beeser, L.D.Etkin, J.Chernoff, W.C.Earnshaw, and C.D.Allis (2003).
Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.
  Cell, 113, 507-517.  
12665567 Z.Deng, C.J.Chen, M.Chamberlin, F.Lu, G.A.Blobel, D.Speicher, L.A.Cirillo, K.S.Zaret, and P.M.Lieberman (2003).
The CBP bromodomain and nucleosome targeting are required for Zta-directed nucleosome acetylation and transcription activation.
  Mol Cell Biol, 23, 2633-2644.  
12032084 A.Dorr, V.Kiermer, A.Pedal, H.R.Rackwitz, P.Henklein, U.Schubert, M.M.Zhou, E.Verdin, and M.Ott (2002).
Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain.
  EMBO J, 21, 2715-2723.  
12419247 A.H.Hassan, P.Prochasson, K.E.Neely, S.C.Galasinski, M.Chandy, M.J.Carrozza, and J.L.Workman (2002).
Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes.
  Cell, 111, 369-379.  
12410229 A.Kimura, T.Umehara, and M.Horikoshi (2002).
Chromosomal gradient of histone acetylation established by Sas2p and Sir2p functions as a shield against gene silencing.
  Nat Genet, 32, 370-377.  
12232854 B.Coffee, F.Zhang, S.Ceman, S.T.Warren, and D.Reines (2002).
Histone modifications depict an aberrantly heterochromatinized FMR1 gene in fragile x syndrome.
  Am J Hum Genet, 71, 923-932.  
  12049668 B.Polevoda, and F.Sherman (2002).
The diversity of acetylated proteins.
  Genome Biol, 3, reviews0006.  
12242305 C.L.Zhang, T.A.McKinsey, and E.N.Olson (2002).
Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation.
  Mol Cell Biol, 22, 7302-7312.  
12379744 C.M.Kiekhaefer, J.A.Grass, K.D.Johnson, M.E.Boyer, and E.H.Bresnick (2002).
Hematopoietic-specific activators establish an overlapping pattern of histone acetylation and methylation within a mammalian chromatin domain.
  Proc Natl Acad Sci U S A, 99, 14309-14314.  
11836534 C.Qiu, K.Sawada, X.Zhang, and X.Cheng (2002).
The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds.
  Nat Struct Biol, 9, 217-224.
PDB code: 1khc
11809876 C.R.Clapier, K.P.Nightingale, and P.B.Becker (2002).
A critical epitope for substrate recognition by the nucleosome remodeling ATPase ISWI.
  Nucleic Acids Res, 30, 649-655.  
12242698 D.C.Daniel (2002).
Highlight: BRCA1 and BRCA2 proteins in breast cancer.
  Microsc Res Tech, 59, 68-83.  
11777910 D.E.Sterner, X.Wang, M.H.Bloom, G.M.Simon, and S.L.Berger (2002).
The SANT domain of Ada2 is required for normal acetylation of histones by the yeast SAGA complex.
  J Biol Chem, 277, 8178-8186.  
11997514 D.Houzelstein, S.L.Bullock, D.E.Lynch, E.F.Grigorieva, V.A.Wilson, and R.S.Beddington (2002).
Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4.
  Mol Cell Biol, 22, 3794-3802.  
12034878 D.Sharma, and J.D.Fondell (2002).
Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo.
  Proc Natl Acad Sci U S A, 99, 7934-7939.  
12192034 D.V.Fyodorov, and J.T.Kadonaga (2002).
Binding of Acf1 to DNA involves a WAC motif and is important for ACF-mediated chromatin assembly.
  Mol Cell Biol, 22, 6344-6353.  
11818058 D.Wagner, and E.M.Meyerowitz (2002).
SPLAYED, a novel SWI/SNF ATPase homolog, controls reproductive development in Arabidopsis.
  Curr Biol, 12, 85-94.  
11909520 E.J.Richards, and S.C.Elgin (2002).
Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects.
  Cell, 108, 489-500.  
11884585 E.Kalkhoven, H.Teunissen, A.Houweling, C.P.Verrijzer, and A.Zantema (2002).
The PHD type zinc finger is an integral part of the CBP acetyltransferase domain.
  Mol Cell Biol, 22, 1961-1970.  
12384511 E.Remboutsika, K.Yamamoto, M.Harbers, and M.Schmutz (2002).
The bromodomain mediates transcriptional intermediary factor 1alpha -nucleosome interactions.
  J Biol Chem, 277, 50318-50325.  
12080090 H.H.Ng, Q.Feng, H.Wang, H.Erdjument-Bromage, P.Tempst, Y.Zhang, and K.Struhl (2002).
Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association.
  Genes Dev, 16, 1518-1527.  
12356740 J.A.Armstrong, O.Papoulas, G.Daubresse, A.S.Sperling, J.T.Lis, M.P.Scott, and J.W.Tamkun (2002).
The Drosophila BRM complex facilitates global transcription by RNA polymerase II.
  EMBO J, 21, 5245-5254.  
11893495 J.A.Simon, and J.W.Tamkun (2002).
Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes.
  Curr Opin Genet Dev, 12, 210-218.  
12192044 J.Deckert, and K.Struhl (2002).
Targeted recruitment of Rpd3 histone deacetylase represses transcription by inhibiting recruitment of Swi/Snf, SAGA, and TATA binding protein.
  Mol Cell Biol, 22, 6458-6470.  
12123281 J.H.Waterborg, and T.Kapros (2002).
Kinetic analysis of histone acetylation turnover and Trichostatin A induced hyper- and hypoacetylation in alfalfa.
  Biochem Cell Biol, 80, 279-293.  
11972331 J.H.Yeh, S.Spicuglia, S.Kumar, A.Sanchez-Sevilla, P.Ferrier, and J.Imbert (2002).
Control of IL-2Ralpha gene expression: structural changes within the proximal enhancer/core promoter during T-cell development.
  Nucleic Acids Res, 30, 1944-1951.  
12193658 K.Noma, and S.I.Grewal (2002).
Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast.
  Proc Natl Acad Sci U S A, 99, 16438-16445.  
  12186646 L.Aravind, and L.M.Iyer (2002).
The SWIRM domain: a conserved module found in chromosomal proteins points to novel chromatin-modifying activities.
  Genome Biol, 3, RESEARCH0039.  
12456660 L.F.Chen, Y.Mu, and W.C.Greene (2002).
Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.
  EMBO J, 21, 6539-6548.  
11893490 M.Bulger, T.Sawado, D.Schübeler, and M.Groudine (2002).
ChIPs of the beta-globin locus: unraveling gene regulation within an active domain.
  Curr Opin Genet Dev, 12, 170-177.  
11893487 M.Featherstone (2002).
Coactivators in transcription initiation: here are your orders.
  Curr Opin Genet Dev, 12, 149-155.  
12486878 M.Fu, C.Wang, J.Wang, B.T.Zafonte, M.P.Lisanti, and R.G.Pestell (2002).
Acetylation in hormone signaling and the cell cycle.
  Cytokine Growth Factor Rev, 13, 259-276.  
12702296 M.Yukawa, H.Koyama, K.Miyahara, and E.Tsuchiya (2002).
Functional differences between RSC1 and RSC2, components of a for growth essential chromatin-remodeling complex of Saccharomyces cerevisiae, during the sporulation process.
  FEMS Yeast Res, 2, 87-91.  
12042701 P.Ernst, J.Wang, and S.J.Korsmeyer (2002).
The role of MLL in hematopoiesis and leukemia.
  Curr Opin Hematol, 9, 282-287.  
12504020 P.Hatzis, and I.Talianidis (2002).
Dynamics of enhancer-promoter communication during differentiation-induced gene activation.
  Mol Cell, 10, 1467-1477.  
11850414 P.Zegerman, B.Canas, D.Pappin, and T.Kouzarides (2002).
Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex.
  J Biol Chem, 277, 11621-11624.  
12466527 R.Pandey, A.Müller, C.A.Napoli, D.A.Selinger, C.S.Pikaard, E.J.Richards, J.Bender, D.W.Mount, and R.A.Jorgensen (2002).
Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes.
  Nucleic Acids Res, 30, 5036-5055.  
12082111 S.C.Tsai, and E.Seto (2002).
Regulation of histone deacetylase 2 by protein kinase CK2.
  J Biol Chem, 277, 31826-31833.  
11893486 S.L.Berger (2002).
Histone modifications in transcriptional regulation.
  Curr Opin Genet Dev, 12, 142-148.  
11931765 S.Mujtaba, Y.He, L.Zeng, A.Farooq, J.E.Carlson, M.Ott, E.Verdin, and M.M.Zhou (2002).
Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain.
  Mol Cell, 9, 575-586.
PDB code: 1jm4
11805098 S.Wang, and O.Hankinson (2002).
Functional involvement of the Brahma/SWI2-related gene 1 protein in cytochrome P4501A1 transcription mediated by the aryl hydrocarbon receptor complex.
  J Biol Chem, 277, 11821-11827.  
12419248 T.Agalioti, G.Chen, and D.Thanos (2002).
Deciphering the transcriptional histone acetylation code for a human gene.
  Cell, 111, 381-392.  
12093919 T.Chimura, T.Kuzuhara, and M.Horikoshi (2002).
Identification and characterization of CIA/ASF1 as an interactor of bromodomains associated with TFIID.
  Proc Natl Acad Sci U S A, 99, 9334-9339.  
12192049 T.Maruyama, A.Farina, A.Dey, J.Cheong, V.P.Bermudez, T.Tamura, S.Sciortino, J.Shuman, J.Hurwitz, and K.Ozato (2002).
A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase.
  Mol Cell Biol, 22, 6509-6520.  
12453419 T.Nakamura, T.Mori, S.Tada, W.Krajewski, T.Rozovskaia, R.Wassell, G.Dubois, A.Mazo, C.M.Croce, and E.Canaani (2002).
ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.
  Mol Cell, 10, 1119-1128.  
12237408 T.Suganuma, M.Kawabata, T.Ohshima, and M.A.Ikeda (2002).
Growth suppression of human carcinoma cells by reintroduction of the p300 coactivator.
  Proc Natl Acad Sci U S A, 99, 13073-13078.  
11889031 W.A.Bickmore, and H.G.Sutherland (2002).
Addressing protein localization within the nucleus.
  EMBO J, 21, 1248-1254.  
11983172 W.An, V.B.Palhan, M.A.Karymov, S.H.Leuba, and R.G.Roeder (2002).
Selective requirements for histone H3 and H4 N termini in p300-dependent transcriptional activation from chromatin.
  Mol Cell, 9, 811-821.  
11972045 Y.Dou, and M.A.Gorovsky (2002).
Regulation of transcription by H1 phosphorylation in Tetrahymena is position independent and requires clustered sites.
  Proc Natl Acad Sci U S A, 99, 6142-6146.  
12366783 Y.Matsuzaka, S.Makino, K.Okamoto, A.Oka, A.Tsujimura, K.Matsumiya, S.Takahara, A.Okuyama, M.Sada, R.Gotoh, T.Nakatani, M.Ota, Y.Katsuyama, G.Tamiya, and H.Inoko (2002).
Susceptibility locus for non-obstructive azoospermia is localized within the HLA-DR/DQ subregion: primary role of DQB1*0604.
  Tissue Antigens, 60, 53-63.  
11290320 A.H.Hassan, K.E.Neely, and J.L.Workman (2001).
Histone acetyltransferase complexes stabilize swi/snf binding to promoter nucleosomes.
  Cell, 104, 817-827.  
11173289 A.Lusser, D.Kölle, and P.Loidl (2001).
Histone acetylation: lessons from the plant kingdom.
  Trends Plant Sci, 6, 59-65.  
11395415 A.M.Näär, B.D.Lemon, and R.Tjian (2001).
Transcriptional coactivator complexes.
  Annu Rev Biochem, 70, 475-501.  
11463815 A.Polesskaya, I.Naguibneva, A.Duquet, E.Bengal, P.Robin, and A.Harel-Bellan (2001).
Interaction between acetylated MyoD and the bromodomain of CBP and/or p300.
  Mol Cell Biol, 21, 5312-5320.  
11250140 C.Müller, and A.Leutz (2001).
Chromatin remodeling in development and differentiation.
  Curr Opin Genet Dev, 11, 167-174.  
11154274 C.R.Clapier, G.Längst, D.F.Corona, P.B.Becker, and K.P.Nightingale (2001).
Critical role for the histone H4 N terminus in nucleosome remodeling by ISWI.
  Mol Cell Biol, 21, 875-883.  
11179888 C.W.Müller (2001).
Transcription factors: global and detailed views.
  Curr Opin Struct Biol, 11, 26-32.  
11230151 D.C.Schultz, J.R.Friedman, and F.J.Rauscher (2001).
Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD.
  Genes Dev, 15, 428-443.  
11561159 D.Liedman, and N.Zeleznik-Le (2001).
Retroviral transduction model of mixed lineage leukemia fused to CREB binding protein.
  Curr Opin Hematol, 8, 218-223.  
11536294 E.C.Forsberg, and E.H.Bresnick (2001).
Histone acetylation beyond promoters: long-range acetylation patterns in the chromatin world.
  Bioessays, 23, 820-830.  
11266554 E.J.Stockinger, Y.Mao, M.K.Regier, S.J.Triezenberg, and M.F.Thomashow (2001).
Transcriptional adaptor and histone acetyltransferase proteins in Arabidopsis and their interactions with CBF1, a transcriptional activator involved in cold-regulated gene expression.
  Nucleic Acids Res, 29, 1524-1533.  
11359896 E.T.Manning, T.Ikehara, T.Ito, J.T.Kadonaga, and W.L.Kraus (2001).
p300 forms a stable, template-committed complex with chromatin: role for the bromodomain.
  Mol Cell Biol, 21, 3876-3887.  
11352938 G.Csankovszki, A.Nagy, and R.Jaenisch (2001).
Synergism of Xist RNA, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivation.
  J Cell Biol, 153, 773-784.  
11487463 G.V.Denis (2001).
Duality in bromodomain-containing protein complexes.
  Front Biosci, 6, D849-D852.  
11463378 H.Reinke, P.D.Gregory, and W.Hörz (2001).
A transient histone hyperacetylation signal marks nucleosomes for remodeling at the PHO8 promoter in vivo.
  Mol Cell, 7, 529-538.  
11742995 I.Kitabayashi, Y.Aikawa, L.A.Nguyen, A.Yokoyama, and M.Ohki (2001).
Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein.
  EMBO J, 20, 7184-7196.  
11343896 J.C.Rice, and C.D.Allis (2001).
Histone methylation versus histone acetylation: new insights into epigenetic regulation.
  Curr Opin Cell Biol, 13, 263-273.  
11544176 K.R.Katsani, J.J.Arredondo, A.J.Kal, and C.P.Verrijzer (2001).
A homeotic mutation in the trithorax SET domain impedes histone binding.
  Genes Dev, 15, 2197-2202.  
11160878 L.Bordoli, M.Netsch, U.Lüthi, W.Lutz, and R.Eckner (2001).
Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins.
  Nucleic Acids Res, 29, 589-597.  
11252719 L.Vandel, and D.Trouche (2001).
Physical association between the histone acetyl transferase CBP and a histone methyl transferase.
  EMBO Rep, 2, 21-26.  
11171966 M.Abrink, J.A.Ortiz, C.Mark, C.Sanchez, C.Looman, L.Hellman, P.Chambon, and R.Losson (2001).
Conserved interaction between distinct Krüppel-associated box domains and the transcriptional intermediary factor 1 beta.
  Proc Natl Acad Sci U S A, 98, 1422-1426.  
  11305943 P.A.Grant (2001).
A tale of histone modifications.
  Genome Biol, 2, REVIEWS0003.  
11250136 P.D.Gregory (2001).
Transcription and chromatin converge: lessons from yeast genetics.
  Curr Opin Genet Dev, 11, 142-147.  
11336699 R.Beckstead, J.A.Ortiz, C.Sanchez, S.N.Prokopenko, P.Chambon, R.Losson, and H.J.Bellen (2001).
Bonus, a Drosophila homolog of TIF1 proteins, interacts with nuclear receptors and can inhibit betaFTZ-F1-dependent transcription.
  Mol Cell, 7, 753-765.  
11250138 R.Marmorstein, and S.Y.Roth (2001).
Histone acetyltransferases: function, structure, and catalysis.
  Curr Opin Genet Dev, 11, 155-161.  
11502199 R.S.BelAiba, P.Baril, Y.Chebloune, E.Tabone, and H.Boukerche (2001).
Identification and cloning of an 85-kDa protein homologous to RING3 that is upregulated in proliferating endothelial cells.
  Eur J Biochem, 268, 4398-4407.  
11566886 S.A.Jacobs, S.D.Taverna, Y.Zhang, S.D.Briggs, J.Li, J.C.Eissenberg, C.D.Allis, and S.Khorasanizadeh (2001).
Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3.
  EMBO J, 20, 5232-5241.  
11331592 S.I.Hsu, C.M.Yang, K.G.Sim, D.M.Hentschel, E.O'Leary, and J.V.Bonventre (2001).
TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1.
  EMBO J, 20, 2273-2285.  
  11294220 S.L.Berger (2001).
Molecular biology. The histone modification circus.
  Science, 292, 64-65.  
11395403 S.Y.Roth, J.M.Denu, and C.D.Allis (2001).
Histone acetyltransferases.
  Annu Rev Biochem, 70, 81.  
11246006 T.Doerks, R.Copley, and P.Bork (2001).
DDT -- a novel domain in different transcription and chromosome remodeling factors.
  Trends Biochem Sci, 26, 145-146.  
11498575 T.Jenuwein, and C.D.Allis (2001).
Translating the histone code.
  Science, 293, 1074-1080.  
11259590 W.Zhang, S.Kadam, B.M.Emerson, and J.J.Bieker (2001).
Site-specific acetylation by p300 or CREB binding protein regulates erythroid Krüppel-like factor transcriptional activity via its interaction with the SWI-SNF complex.
  Mol Cell Biol, 21, 2413-2422.  
11295558 Y.G.Gangloff, C.Romier, S.Thuault, S.Werten, and I.Davidson (2001).
The histone fold is a key structural motif of transcription factor TFIID.
  Trends Biochem Sci, 26, 250-257.  
11438666 Y.G.Gangloff, J.C.Pointud, S.Thuault, L.Carré, C.Romier, S.Muratoglu, M.Brand, L.Tora, J.L.Couderc, and I.Davidson (2001).
The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger.
  Mol Cell Biol, 21, 5109-5121.  
10938129 A.Dey, J.Ellenberg, A.Farina, A.E.Coleman, T.Maruyama, S.Sciortino, J.Lippincott-Schwartz, and K.Ozato (2000).
A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition.
  Mol Cell Biol, 20, 6537-6549.  
11025449 A.Staal, J.M.Enserink, J.L.Stein, G.S.Stein, and A.J.van Wijnen (2000).
Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2.
  J Cell Physiol, 185, 269-279.  
10944586 B.M.Turner (2000).
Histone acetylation and an epigenetic code.
  Bioessays, 22, 836-845.  
11106353 C.A.Johnson (2000).
Chromatin modification and disease.
  J Med Genet, 37, 905-915.  
10970858 C.Lavau, C.Du, M.Thirman, and N.Zeleznik-Le (2000).
Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia.
  EMBO J, 19, 4655-4664.  
10655480 D.A.Bochar, J.Savard, W.Wang, D.W.Lafleur, P.Moore, J.Côté, and R.Shiekhattar (2000).
A family of chromatin remodeling factors related to Williams syndrome transcription factor.
  Proc Natl Acad Sci U S A, 97, 1038-1043.  
10655500 D.A.Wassarman, N.Aoyagi, L.A.Pile, and E.M.Schlag (2000).
TAF250 is required for multiple developmental events in Drosophila.
  Proc Natl Acad Sci U S A, 97, 1154-1159.  
10913195 D.B.Bloch, A.Nakajima, T.Gulick, J.D.Chiche, D.Orth, La Monte, and K.D.Bloch (2000).
Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator.
  Mol Cell Biol, 20, 6138-6146.  
10839822 D.E.Sterner, and S.L.Berger (2000).
Acetylation of histones and transcription-related factors.
  Microbiol Mol Biol Rev, 64, 435-459.  
11080160 D.J.Owen, P.Ornaghi, J.C.Yang, N.Lowe, P.R.Evans, P.Ballario, D.Neuhaus, P.Filetici, and A.A.Travers (2000).
The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p.
  EMBO J, 19, 6141-6149.
PDB code: 1e6i
11094082 F.Bantignies, R.H.Goodman, and S.M.Smolik (2000).
Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiers.
  Mol Cell Biol, 20, 9317-9330.  
10940244 F.Dyda, D.C.Klein, and A.B.Hickman (2000).
GCN5-related N-acetyltransferases: a structural overview.
  Annu Rev Biophys Biomol Struct, 29, 81.  
11003650 J.DiRenzo, Y.Shang, M.Phelan, S.Sif, M.Myers, R.Kingston, and M.Brown (2000).
BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation.
  Mol Cell Biol, 20, 7541-7549.  
11106735 K.Brubaker, S.M.Cowley, K.Huang, L.Loo, G.S.Yochum, D.E.Ayer, R.N.Eisenman, and I.Radhakrishnan (2000).
Solution structure of the interacting domains of the Mad-Sin3 complex: implications for recruitment of a chromatin-modifying complex.
  Cell, 103, 655-665.
PDB code: 1g1e
11009610 K.G.Tanner, M.R.Langer, and J.M.Denu (2000).
Kinetic mechanism of human histone acetyltransferase P/CAF.
  Biochemistry, 39, 11961-11969.  
10688638 M.Vignali, A.H.Hassan, K.E.Neely, and J.L.Workman (2000).
ATP-dependent chromatin-remodeling complexes.
  Mol Cell Biol, 20, 1899-1910.  
  10783167 O.Matangkasombut, R.M.Buratowski, N.W.Swilling, and S.Buratowski (2000).
Bromodomain factor 1 corresponds to a missing piece of yeast TFIID.
  Genes Dev, 14, 951-962.  
11057899 P.Cheung, C.D.Allis, and P.Sassone-Corsi (2000).
Signaling to chromatin through histone modifications.
  Cell, 103, 263-271.  
10904263 P.Sudarsanam, and F.Winston (2000).
The Swi/Snf family nucleosome-remodeling complexes and transcriptional control.
  Trends Genet, 16, 345-351.  
10882076 R.Deuring, L.Fanti, J.A.Armstrong, M.Sarte, O.Papoulas, M.Prestel, G.Daubresse, M.Verardo, S.L.Moseley, M.Berloco, T.Tsukiyama, C.Wu, S.Pimpinelli, and J.W.Tamkun (2000).
The ISWI chromatin-remodeling protein is required for gene expression and the maintenance of higher order chromatin structure in vivo.
  Mol Cell, 5, 355-365.  
10592260 S.A.Sullivan, L.Aravind, I.Makalowska, A.D.Baxevanis, and D.Landsman (2000).
The histone database: a comprehensive WWW resource for histones and histone fold-containing proteins.
  Nucleic Acids Res, 28, 320-322.  
11058129 S.Itoh, J.Ericsson, J.Nishikawa, C.H.Heldin, and P.ten Dijke (2000).
The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling.
  Nucleic Acids Res, 28, 4291-4298.  
11106736 T.Agalioti, S.Lomvardas, B.Parekh, J.Yie, T.Maniatis, and D.Thanos (2000).
Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter.
  Cell, 103, 667-678.  
10716917 T.Kouzarides (2000).
Acetylation: a regulatory modification to rival phosphorylation?
  EMBO J, 19, 1176-1179.  
10860993 T.Nakamura, J.Blechman, S.Tada, T.Rozovskaia, T.Itoyama, F.Bullrich, A.Mazo, C.M.Croce, B.Geiger, and E.Canaani (2000).
huASH1 protein, a putative transcription factor encoded by a human homologue of the Drosophila ash1 gene, localizes to both nuclei and cell-cell tight junctions.
  Proc Natl Acad Sci U S A, 97, 7284-7289.  
10801466 W.L.Cheung, S.D.Briggs, and C.D.Allis (2000).
Acetylation and chromosomal functions.
  Curr Opin Cell Biol, 12, 326-333.  
10911986 W.S.Lo, R.C.Trievel, J.R.Rojas, L.Duggan, J.Y.Hsu, C.D.Allis, R.Marmorstein, and S.L.Berger (2000).
Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14.
  Mol Cell, 5, 917-926.  
10891493 Y.Liu, A.L.Colosimo, X.J.Yang, and D.Liao (2000).
Adenovirus E1B 55-kilodalton oncoprotein inhibits p53 acetylation by PCAF.
  Mol Cell Biol, 20, 5540-5553.  
11078522 Y.Xue, J.C.Canman, C.S.Lee, Z.Nie, D.Yang, G.T.Moreno, M.K.Young, E.D.Salmon, and W.Wang (2000).
The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes.
  Proc Natl Acad Sci U S A, 97, 13015-13020.  
10619019 B.R.Cairns, A.Schlichter, H.Erdjument-Bromage, P.Tempst, R.D.Kornberg, and F.Winston (1999).
Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains.
  Mol Cell, 4, 715-723.  
10629113 J.R.Davie, and V.A.Spencer (1999).
Control of histone modifications.
  J Cell Biochem, (), 141-148.  
  10567538 W.L.Kraus, E.T.Manning, and J.T.Kadonaga (1999).
Biochemical analysis of distinct activation functions in p300 that enhance transcription initiation with chromatin templates.
  Mol Cell Biol, 19, 8123-8135.  
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