spacer
spacer

PDBsum entry 1j9u

Go to PDB code: 
protein links
Cytokine PDB id
1j9u
Jmol
Contents
Protein chain
109 a.a.
Theoretical model
PDB id:
1j9u
Name: Cytokine
Title: Theoretical structure of human interleukin-13
Structure: Interleukin-13. Chain: a
Source: Homo sapiens. Human
Authors: J.Zuegg,D.C.Webb,P.S.Foster,M.G.Casarotto
Key ref: J.Zuegg et al. (2001). Structural model of human IL-13 defines the spatial interactions with the IL-13Ralpha/IL-4Ralpha receptor. Immunol Cell Biol, 79, 332-339. PubMed id: 11488979
Date:
29-May-01     Release date:   13-Jun-01    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P35225  (IL13_HUMAN) -  Interleukin-13
Seq:
Struc:
146 a.a.
109 a.a.
Key:    PfamA domain  Secondary structure

 

 
Immunol Cell Biol 79:332-339 (2001)
PubMed id: 11488979  
 
 
Structural model of human IL-13 defines the spatial interactions with the IL-13Ralpha/IL-4Ralpha receptor.
J.Zuegg, D.C.Webb, P.S.Foster, M.G.Casarotto.
 
  ABSTRACT  
 
Interleukin-13 (IL-13) plays a key role in immune responses and inflammation. A structural model of human IL-13 (HuIL-13) based on the nuclear magnetic resonance and X-ray structure of IL-4 is put forward. Unlike previous models, this model is based on new sequence alignments that take into account the formation of the two disulfide linkages that have been determined experimentally. The proposed structure of human IL-13 is similar to IL-4, consisting of a four helix bundle with hydrophobic residues lining the core of the molecule and surface polar residues showing a high degree of solvent accessibility. Regions of HuIL-13 that are critical for the interaction with its receptors are explored and discussed in relation to existing mutagenic studies. From these studies we predict that helices A and C of HuIL-13 interact with the IL-4 receptor alpha (IL-4Ralpha) region and helix D is responsible for the interaction with the IL-13 receptor alpha 1 (IL-13Ralpha1) receptor.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
19546866 F.A.Hellenthal, W.A.Buurman, W.K.Wodzig, and G.W.Schurink (2009).
Biomarkers of abdominal aortic aneurysm progression. Part 2: inflammation.
  Nat Rev Cardiol, 6, 543-552.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.