PDBsum entry 1j9u

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protein links
Cytokine PDB id
Protein chain
109 a.a.
Theoretical model
PDB id:
Name: Cytokine
Title: Theoretical structure of human interleukin-13
Structure: Interleukin-13. Chain: a
Source: Homo sapiens. Human
Authors: J.Zuegg,D.C.Webb,P.S.Foster,M.G.Casarotto
Key ref: J.Zuegg et al. (2001). Structural model of human IL-13 defines the spatial interactions with the IL-13Ralpha/IL-4Ralpha receptor. Immunol Cell Biol, 79, 332-339. PubMed id: 11488979
29-May-01     Release date:   13-Jun-01    
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Protein chain
Pfam   ArchSchema ?
P35225  (IL13_HUMAN) -  Interleukin-13
146 a.a.
109 a.a.
Key:    PfamA domain  Secondary structure


Immunol Cell Biol 79:332-339 (2001)
PubMed id: 11488979  
Structural model of human IL-13 defines the spatial interactions with the IL-13Ralpha/IL-4Ralpha receptor.
J.Zuegg, D.C.Webb, P.S.Foster, M.G.Casarotto.
Interleukin-13 (IL-13) plays a key role in immune responses and inflammation. A structural model of human IL-13 (HuIL-13) based on the nuclear magnetic resonance and X-ray structure of IL-4 is put forward. Unlike previous models, this model is based on new sequence alignments that take into account the formation of the two disulfide linkages that have been determined experimentally. The proposed structure of human IL-13 is similar to IL-4, consisting of a four helix bundle with hydrophobic residues lining the core of the molecule and surface polar residues showing a high degree of solvent accessibility. Regions of HuIL-13 that are critical for the interaction with its receptors are explored and discussed in relation to existing mutagenic studies. From these studies we predict that helices A and C of HuIL-13 interact with the IL-4 receptor alpha (IL-4Ralpha) region and helix D is responsible for the interaction with the IL-13 receptor alpha 1 (IL-13Ralpha1) receptor.

Literature references that cite this PDB file's key reference

  PubMed id Reference
19546866 F.A.Hellenthal, W.A.Buurman, W.K.Wodzig, and G.W.Schurink (2009).
Biomarkers of abdominal aortic aneurysm progression. Part 2: inflammation.
  Nat Rev Cardiol, 6, 543-552.  
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