PDBsum entry 1dlh

Go to PDB code: 
protein ligands Protein-protein interface(s) links
Histocompatibility antigen PDB id
Protein chains
180 a.a. *
188 a.a. *
13 a.a. *
NAG ×2
NDG ×2
Waters ×153
* Residue conservation analysis
PDB id:
Name: Histocompatibility antigen
Title: Crystal structure of the human class ii mhc protein hla-dr1 with an influenza virus peptide
Structure: Class ii histocompatibility antigen (hla-dr1) (al chain). Chain: a, d. Engineered: yes. Class ii histocompatibility antigen (hla-dr1) (be chain: b, e. Engineered: yes. Enterotoxin type b precursor. Chain: c, f.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera. Expression_system_taxid: 7106.
Biol. unit: Hexamer (from PQS)
2.80Å     R-factor:   0.205     R-free:   0.304
Authors: L.J.Stern
Key ref: L.J.Stern et al. (1994). Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature, 368, 215-221. PubMed id: 8145819
15-Feb-94     Release date:   22-Jun-94    
Go to PROCHECK summary

Protein chains
Pfam   ArchSchema ?
P01903  (DRA_HUMAN) -  HLA class II histocompatibility antigen, DR alpha chain
254 a.a.
180 a.a.
Protein chains
Pfam   ArchSchema ?
P04229  (2B11_HUMAN) -  HLA class II histocompatibility antigen, DRB1-1 beta chain
266 a.a.
188 a.a.
Protein chains
Pfam   ArchSchema ?
P04664  (HEMA_I69A0) -  Hemagglutinin (Fragment)
328 a.a.
13 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   2 terms 
  Biological process     immune response   2 terms 


Nature 368:215-221 (1994)
PubMed id: 8145819  
Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide.
L.J.Stern, J.H.Brown, T.S.Jardetzky, J.C.Gorga, R.G.Urban, J.L.Strominger, D.C.Wiley.
An influenza virus peptide binds to HLA-DR1 in an extended conformation with a pronounced twist. Thirty-five per cent of the peptide surface is accessible to solvent and potentially available for interaction with the antigen receptor on T cells. Pockets in the peptide-binding site accommodate five of the thirteen side chains of the bound peptide, and explain the peptide specificity of HLA-DR1. Twelve hydrogen bonds between conserved HLA-DR1 residues and the main chain of the peptide provide a universal mode of peptide binding, distinct from the strategy used by class I histocompatibility proteins.

Literature references that cite this PDB file's key reference

  PubMed id Reference
23051753 L.Kjer-Nielsen, O.Patel, A.J.Corbett, J.Le Nours, B.Meehan, L.Liu, M.Bhati, Z.Chen, L.Kostenko, R.Reantragoon, N.A.Williamson, A.W.Purcell, N.L.Dudek, M.J.McConville, R.A.O'Hair, G.N.Khairallah, D.I.Godfrey, D.P.Fairlie, J.Rossjohn, and J.McCluskey (2012).
MR1 presents microbial vitamin B metabolites to MAIT cells.
  Nature, 491, 717-723.
PDB code: 4gup
21131964 A.K.Anders, M.J.Call, M.S.Schulze, K.D.Fowler, D.A.Schubert, N.P.Seth, E.J.Sundberg, and K.W.Wucherpfennig (2011).
HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide.
  Nat Immunol, 12, 54-61.  
21349321 B.A.Akhoon, P.S.Slathia, P.Sharma, S.K.Gupta, and V.Verma (2011).
In silico identification of novel protective VSG antigens expressed by Trypanosoma brucei and an effort for designing a highly immunogenic DNA vaccine using IL-12 as adjuvant.
  Microb Pathog, 51, 77-87.  
21299528 B.E.Hansen, C.H.Nielsen, H.O.Madsen, L.P.Ryder, B.K.Jakobsen, and A.Svejgaard (2011).
The HLA-DP2 protein binds the immunodominant epitope from myelin basic protein, MBP85-99, with high affinity.
  Tissue Antigens, 77, 229-234.  
20823902 D.Cížková, J.Gouy de Bellocq, S.J.Baird, J.Piálek, and J.Bryja (2011).
Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations.
  Heredity, 106, 727-740.  
21305276 J.Greenbaum, J.Sidney, J.Chung, C.Brander, B.Peters, and A.Sette (2011).
Functional classification of class II human leukocyte antigen (HLA) molecules reveals seven different supertypes and a surprising degree of repertoire sharing across supertypes.
  Immunogenetics, 63, 325-335.  
20924575 V.Srithayakumar, S.Castillo, R.C.Rosatte, and C.J.Kyle (2011).
MHC class II DRB diversity in raccoons (Procyon lotor) reveals associations with raccoon rabies virus (Lyssavirus).
  Immunogenetics, 63, 103-113.  
21116684 Zaheer-ul-Haq, and W.Khan (2011).
Molecular and structural determinants of adamantyl susceptibility to HLA-DRs allelic variants: an in silico approach to understand the mechanism of MLEs.
  J Comput Aided Mol Des, 25, 81.  
20936494 C.Cárdenas, A.Bidon-Chanal, P.Conejeros, G.Arenas, S.Marshall, and F.J.Luque (2010).
Molecular modeling of class I and II alleles of the major histocompatibility complex in Salmo salar.
  J Comput Aided Mol Des, 24, 1035-1051.  
20007533 C.K.Baumgartner, A.Ferrante, M.Nagaoka, J.Gorski, and L.P.Malherbe (2010).
Peptide-MHC class II complex stability governs CD4 T cell clonal selection.
  J Immunol, 184, 573-581.  
21067545 C.Lundegaard, I.Hoof, O.Lund, and M.Nielsen (2010).
State of the art and challenges in sequence based T-cell epitope prediction.
  Immunome Res, 6, S3.  
20521040 D.Gómez, P.Conejeros, S.H.Marshall, and S.Consuegra (2010).
MHC evolution in three salmonid species: a comparison between class II alpha and beta genes.
  Immunogenetics, 62, 531-542.  
20155490 D.S.Rosa, S.P.Ribeiro, and E.Cunha-Neto (2010).
CD4+ T cell epitope discovery and rational vaccine design.
  Arch Immunol Ther Exp (Warsz), 58, 121-130.  
20379596 G.King, and A.M.Dixon (2010).
Evidence for role of transmembrane helix-helix interactions in the assembly of the Class II major histocompatibility complex.
  Mol Biosyst, 6, 1650-1661.  
20875153 J.M.Khan, and S.Ranganathan (2010).
pDOCK: a new technique for rapid and accurate docking of peptide ligands to Major Histocompatibility Complexes.
  Immunome Res, 6, S2.  
20139279 J.Sidney, A.Steen, C.Moore, S.Ngo, J.Chung, B.Peters, and A.Sette (2010).
Five HLA-DP molecules frequently expressed in the worldwide human population share a common HLA supertypic binding specificity.
  J Immunol, 184, 2492-2503.  
20372886 K.Wei, Z.Zhang, X.Wang, W.Zhang, X.Xu, F.Shen, and B.Yue (2010).
Lineage pattern, trans-species polymorphism, and selection pressure among the major lineages of feline MHC-DRB peptide-binding region.
  Immunogenetics, 62, 307-317.  
20333301 M.A.Patarroyo, A.Bermúdez, C.López, G.Yepes, and M.E.Patarroyo (2010).
3D analysis of the TCR/pMHCII complex formation in monkeys vaccinated with the first peptide inducing sterilizing immunity against human malaria.
  PLoS One, 5, e9771.  
20618518 M.J.Chen, C.C.Chu, M.H.Shyr, C.L.Lin, P.Y.Lin, and K.L.Yang (2010).
Identification of a novel HLA-DQB1 allele, DQB1*0326, in a College of American Pathologists 2009 survey specimen.
  Int J Immunogenet, 37, 455-457.  
20979635 M.J.Ejsmond, W.Babik, and J.Radwan (2010).
MHC allele frequency distributions under parasite-driven selection: A simulation model.
  BMC Evol Biol, 10, 332.  
21081917 M.Saline, K.E.Rödström, G.Fischer, V.Y.Orekhov, B.G.Karlsson, and K.Lindkvist-Petersson (2010).
The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation.
  Nat Commun, 1, 119.
PDB codes: 2xn9 2xna
  20536985 R.A.Ettinger, E.A.James, W.W.Kwok, A.R.Thompson, and K.P.Pratt (2010).
HLA-DR-restricted T-cell responses to factor VIII epitopes in a mild haemophilia A family with missense substitution A2201P.
  Haemophilia, 16, 44-55.  
20706587 S.Castillo, V.Srithayakumar, V.Meunier, and C.J.Kyle (2010).
Characterization of major histocompatibility complex (MHC) DRB exon 2 and DRA exon 3 fragments in a primary terrestrial rabies vector (Procyon lotor).
  PLoS One, 5, e12066.  
20356827 S.Dai, G.A.Murphy, F.Crawford, D.G.Mack, M.T.Falta, P.Marrack, J.W.Kappler, and A.P.Fontenot (2010).
Crystal structure of HLA-DP2 and implications for chronic beryllium disease.
  Proc Natl Acad Sci U S A, 107, 7425-7430.
PDB code: 3lqz
20066513 S.Sadegh-Nasseri, S.Natarajan, C.L.Chou, I.Z.Hartman, K.Narayan, and A.Kim (2010).
Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection.
  Immunol Res, 47, 56-64.  
20306469 V.Cecconi, M.Moro, S.Del Mare, J.Sidney, A.Bachi, R.Longhi, A.Sette, M.P.Protti, P.Dellabona, and G.Casorati (2010).
The CD4+ T-cell epitope-binding register is a critical parameter when generating functional HLA-DR tetramers with promiscuous peptides.
  Eur J Immunol, 40, 1603-1616.  
20622157 W.Jiang, and E.T.Boder (2010).
High-throughput engineering and analysis of peptide binding to class II MHC.
  Proc Natl Acad Sci U S A, 107, 13258-13263.  
19583822 B.Waters, and D.Lillicrap (2009).
The molecular mechanisms of immunomodulation and tolerance induction to factor VIII.
  J Thromb Haemost, 7, 1446-1456.  
19450129 C.Bowman, and O.Delrieu (2009).
Immunogenetics of drug-induced skin blistering disorders. Part II: synthesis.
  Pharmacogenomics, 10, 779-816.  
19500310 C.C.Chu, H.L.Lee, and M.Lin (2009).
A novel HLA-DRB1 allele, DRB*1611, is identified in two Taiwanese individuals.
  Tissue Antigens, 74, 175-176.  
19243543 C.C.Chu, H.T.Ho, H.L.Lee, Y.S.Chan, F.J.Chang, C.L.Wang, and M.Lin (2009).
Anti-"Mi a" immunization is associated with HLA-DRB1*0901.
  Transfusion, 49, 472-478.  
19702653 C.Picard, C.Frassati, A.Basire, S.Buhler, V.Galicher, V.Ferrera, D.Reviron, J.P.Zappitelli, P.Bailly, and J.Chiaroni (2009).
Positive association of DRB1 04 and DRB1 15 alleles with Fya immunization in a Southern European population.
  Transfusion, 49, 2412-2417.  
19126865 D.Vassilakos, A.Natoli, M.Dahlheim, and A.R.Hoelzel (2009).
Balancing and directional selection at exon-2 of the MHC DQB1 locus among populations of odontocete cetaceans.
  Mol Biol Evol, 26, 681-689.  
19319519 E.F.Kikkawa, T.T.Tsuda, D.Sumiyama, T.K.Naruse, M.Fukuda, M.Kurita, R.P.Wilson, Y.LeMaho, G.D.Miller, M.Tsuda, K.Murata, J.K.Kulski, and H.Inoko (2009).
Trans-species polymorphism of the Mhc class II DRB-like gene in banded penguins (genus Spheniscus).
  Immunogenetics, 61, 341-352.  
19812023 E.Varga, A.Petró, R.Jáger, and L.Varga (2009).
[Two faces of an illness: ankylosing spondylitis developed after rheumatoid arthritis]
  Orv Hetil, 150, 2000-2003.  
19528258 J.D.Campbell, K.F.Buckland, S.J.McMillan, J.Kearley, W.L.Oldfield, L.J.Stern, H.Grönlund, M.van Hage, C.J.Reynolds, R.J.Boyton, S.P.Cobbold, A.B.Kay, D.M.Altmann, C.M.Lloyd, and M.Larché (2009).
Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression.
  J Exp Med, 206, 1535-1547.  
19647320 K.Narayan, K.W.Su, C.L.Chou, S.Khoruzhenko, and S.Sadegh-Nasseri (2009).
HLA-DM mediates peptide exchange by interacting transiently and repeatedly with HLA-DR1.
  Mol Immunol, 46, 3157-3162.  
19718029 L.E.Fallang, E.Bergseng, K.Hotta, A.Berg-Larsen, C.Y.Kim, and L.M.Sollid (2009).
Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation.
  Nat Immunol, 10, 1096-1101.  
19414787 M.J.Call, X.Xing, G.D.Cuny, N.P.Seth, D.M.Altmann, L.Fugger, M.Krogsgaard, R.L.Stein, and K.W.Wucherpfennig (2009).
In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange.
  J Immunol, 182, 6342-6352.  
19845906 M.Wurm, S.Tischer, S.Immenschuh, R.Blasczyk, and B.Eiz-Vesper (2009).
The predicted protein structures of the novel DRB1*0717 and DRB1*0701 are highly related.
  Tissue Antigens, 74, 460-462.  
20477508 N.Kumar, G.Kaur, and N.Mehra (2009).
Genetic determinants of type 1 diabetes: immune response genes.
  Biomark Med, 3, 153-173.  
18767126 R.Yaneva, S.Springer, and M.Zacharias (2009).
Flexibility of the MHC class II peptide binding cleft in the bound, partially filled, and empty states: A molecular dynamics simulation study.
  Biopolymers, 91, 14-27.  
19225081 S.Gaseitsiwe, D.Valentini, R.Ahmed, S.Mahdavifar, I.Magalhaes, J.Zerweck, M.Schutkowski, E.Gautherot, F.Montero, A.Ehrnst, M.Reilly, and M.Maeurer (2009).
Major histocompatibility complex class II molecule-human immunodeficiency virus peptide analysis using a microarray chip.
  Clin Vaccine Immunol, 16, 567-573.  
19811074 U.Gowthaman, and J.N.Agrewala (2009).
In silico methods for predicting T-cell epitopes: Dr Jekyll or Mr Hyde?
  Expert Rev Proteomics, 6, 527-537.  
18987854 U.Jüse, B.Fleckenstein, E.Bergseng, and L.M.Sollid (2009).
Soluble HLA-DQ2 expressed in S2 cells copurifies with a high affinity insect cell derived protein.
  Immunogenetics, 61, 81-89.  
19132105 W.A.Agudelo, J.F.Galindo, M.Ortiz, J.L.Villaveces, E.E.Daza, and M.E.Patarroyo (2009).
Variations in the electrostatic landscape of class II human leukocyte antigen molecule induced by modifications in the myelin basic protein peptide: a theoretical approach.
  PLoS ONE, 4, e4164.  
19767569 Z.Zhou, K.A.Callaway, D.A.Weber, and P.E.Jensen (2009).
Cutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexes.
  J Immunol, 183, 4187-4191.  
19005572 A.Ferrante, M.W.Anderson, C.S.Klug, and J.Gorski (2008).
HLA-DM mediates epitope selection by a "compare-exchange" mechanism when a potential peptide pool is available.
  PLoS ONE, 3, e3722.  
18384488 A.Palikhe, M.L.Lokki, P.J.Pussinen, S.Paju, J.Ahlberg, S.Asikainen, M.Seppänen, V.Valtonen, M.S.Nieminen, and J.Sinisalo (2008).
Lymphotoxin alpha LTA+496C allele is a risk factor for periodontitis in patients with coronary artery disease.
  Tissue Antigens, 71, 530-537.  
18438843 A.W.Morgan, L.Haroon-Rashid, S.G.Martin, H.C.Gooi, J.Worthington, W.Thomson, J.H.Barrett, and P.Emery (2008).
The shared epitope hypothesis in rheumatoid arthritis: evaluation of alternative classification criteria in a large UK Caucasian cohort.
  Arthritis Rheum, 58, 1275-1283.  
18525076 B.A.Cobb, and D.L.Kasper (2008).
Characteristics of carbohydrate antigen binding to the presentation protein HLA-DR.
  Glycobiology, 18, 707-718.  
18545669 C.A.Painter, A.Cruz, G.E.López, L.J.Stern, and Z.Zavala-Ruiz (2008).
Model for the peptide-free conformation of class II MHC proteins.
  PLoS ONE, 3, e2403.  
19036163 C.O'Brien, D.R.Flower, and C.Feighery (2008).
Peptide length significantly influences in vitro affinity for MHC class II molecules.
  Immunome Res, 4, 6.  
18276010 E.A.James, A.K.Moustakas, D.Berger, L.Huston, G.K.Papadopoulos, and W.W.Kwok (2008).
Definition of the peptide binding motif within DRB1*1401 restricted epitopes by peptide competition and structural modeling.
  Mol Immunol, 45, 2651-2659.  
18315850 G.L.Zhang, A.M.Khan, K.N.Srinivasan, A.Heiny, K.Lee, C.K.Kwoh, J.T.August, and V.Brusic (2008).
Hotspot Hunter: a computational system for large-scale screening and selection of candidate immunological hotspots in pathogen proteomes.
  BMC Bioinformatics, 9, S19.  
19091022 H.H.Lin, G.L.Zhang, S.Tongchusak, E.L.Reinherz, and V.Brusic (2008).
Evaluation of MHC-II peptide binding prediction servers: applications for vaccine research.
  BMC Bioinformatics, 9, S22.  
19046299 H.L.Lee, C.C.Chu, J.A.Trejaut, K.L.Yang, and M.Lin (2008).
Identification of two novel HLA-DRB1 alleles, HLA-DRB1*1214 and HLA-DRB1*1215, in two Taiwanese individuals.
  Int J Immunogenet, 35, 423-426.  
18512783 I.Alvarez, J.Collado, X.Daura, N.Colomé, M.Rodríguez-García, T.Gallart, F.Canals, and D.Jaraquemada (2008).
The rheumatoid arthritis-associated allele HLA-DR10 (DRB1*1001) shares part of its repertoire with HLA-DR1 (DRB1*0101) and HLA-DR4 (DRB*0401).
  Arthritis Rheum, 58, 1630-1639.  
18315854 L.Kong, and S.Ranganathan (2008).
Tandem duplication, circular permutation, molecular adaptation: how Solanaceae resist pests via inhibitors.
  BMC Bioinformatics, 9, S22.  
18797863 L.M.Herrmann-Hoesing, S.N.White, M.R.Mousel, G.S.Lewis, and D.P.Knowles (2008).
Ovine progressive pneumonia provirus levels associate with breed and Ovar-DRB1.
  Immunogenetics, 60, 749-758.  
18573126 M.A.Juliarena, M.Poli, L.Sala, C.Ceriani, S.Gutierrez, G.Dolcini, E.M.Rodríguez, B.Mariño, C.Rodríguez-Dubra, and E.N.Esteban (2008).
Association of BLV infection profiles with alleles of the BoLA-DRB3.2 gene.
  Anim Genet, 39, 432-438.  
18544021 M.Cadogan, B.Austen, J.L.Heeney, and A.G.Dalgleish (2008).
HLA homology within the C5 domain promotes peptide binding by HIV type 1 gp120.
  AIDS Res Hum Retroviruses, 24, 845-855.  
18603471 M.Halling-Brown, C.E.Sansom, M.Davies, R.W.Titball, and D.S.Moss (2008).
Are bacterial vaccine antigens T-cell epitope depleted?
  Trends Immunol, 29, 374-379.  
18304006 P.Marrack, J.P.Scott-Browne, S.Dai, L.Gapin, and J.W.Kappler (2008).
Evolutionarily conserved amino acids that control TCR-MHC interaction.
  Annu Rev Immunol, 26, 171-203.  
18389056 P.Wang, J.Sidney, C.Dow, B.Mothé, A.Sette, and B.Peters (2008).
A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach.
  PLoS Comput Biol, 4, e1000048.  
18513924 R.Etzensperger, R.M.McMahon, E.Y.Jones, and L.Fugger (2008).
Dissection of the multiple sclerosis associated DR2 haplotype.
  J Autoimmun, 31, 201-207.  
18347751 R.F.Furlong, and Z.Yang (2008).
Diversifying and purifying selection in the peptide binding region of DRB in mammals.
  J Mol Evol, 66, 384-394.  
18350151 S.Gupta, S.Höpner, B.Rupp, S.Günther, K.Dickhaut, N.Agarwal, M.C.Cardoso, R.Kühne, K.H.Wiesmüller, G.Jung, K.Falk, and O.Rötzschke (2008).
Anchor side chains of short peptide fragments trigger ligand-exchange of class II MHC molecules.
  PLoS ONE, 3, e1814.  
18261958 S.Sadegh-Nasseri, M.Chen, K.Narayan, and M.Bouvier (2008).
The convergent roles of tapasin and HLA-DM in antigen presentation.
  Trends Immunol, 29, 141-147.  
18481255 T.L.Cheng, and S.Roffler (2008).
Membrane-tethered proteins for basic research, imaging, and therapy.
  Med Res Rev, 28, 885-928.  
18331522 Y.Serov, G.Hommel-Berrey, and A.Lobashevsky (2008).
Identification of a novel HLA-DRB1 allele, DRB1*116502, by sequence-based typing in an African-American individual.
  Tissue Antigens, 71, 489-490.  
17727623 A.Munguia-Vega, Y.Esquer-Garrigos, L.Rojas-Bracho, R.Vazquez-Juarez, A.Castro-Prieto, and S.Flores-Ramirez (2007).
Genetic drift vs. natural selection in a long-term small isolated population: major histocompatibility complex class II variation in the Gulf of California endemic porpoise (Phocoena sinus).
  Mol Ecol, 16, 4051-4065.  
17668896 A.Pajot, A.Schnuriger, A.Moris, A.Rodallec, D.M.Ojcius, B.Autran, F.A.Lemonnier, and Y.C.Lone (2007).
The Th1 immune response against HIV-1 Gag p24-derived peptides in mice expressing HLA-A02.01 and HLA-DR1.
  Eur J Immunol, 37, 2635-2644.  
17573956 B.Aydinli, I.Pirim, K.Y.Polat, N.Gursan, S.S.Atamanalp, M.Ezer, and R.Donmez (2007).
Association between hepatic alveolar echinococcosis and frequency of human leukocyte antigen class I and II alleles in Turkish patients.
  Hepatol Res, 37, 806-810.  
17389030 C.C.Chu, C.Y.Lin, J.A.Trejaut, M.M.Wu, and M.Lin (2007).
HLA-DQB1*0317 is a novel allele with an unusual DR-DQ haplotype.
  Tissue Antigens, 69, 370-372.  
17559577 C.E.Voorter, M.Amicosante, F.Berretta, L.Groeneveld, M.Drent, and E.M.van den Berg-Loonen (2007).
HLA class II amino acid epitopes as susceptibility markers of sarcoidosis.
  Tissue Antigens, 70, 18-27.  
17475008 C.Li, and Q.Wu (2007).
Adaptive evolution of multiple-variable exons and structural diversity of drug-metabolizing enzymes.
  BMC Evol Biol, 7, 69.  
17182688 E.Lofgren, N.H.Fefferman, Y.N.Naumov, J.Gorski, and E.N.Naumova (2007).
Influenza seasonality: underlying causes and modeling theories.
  J Virol, 81, 5429-5436.  
17525157 G.M.Grotenbreg, M.J.Nicholson, K.D.Fowler, K.Wilbuer, L.Octavio, M.Yang, A.K.Chakraborty, H.L.Ploegh, and K.W.Wucherpfennig (2007).
Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association.
  J Biol Chem, 282, 21425-21436.  
17497145 G.P.Bondinas, A.K.Moustakas, and G.K.Papadopoulos (2007).
The spectrum of HLA-DQ and HLA-DR alleles, 2006: a listing correlating sequence and structure with function.
  Immunogenetics, 59, 539-553.  
17937498 J.M.Calvo-Calle, I.Strug, M.D.Nastke, S.P.Baker, and L.J.Stern (2007).
Human CD4+ T cell epitopes from vaccinia virus induced by vaccination or infection.
  PLoS Pathog, 3, 1511-1529.  
17406862 J.S.Hauswaldt, H.Stuckas, S.Pfautsch, and R.Tiedemann (2007).
Molecular characterization of MHC class II in a nonmodel anuran species, the fire-bellied toad Bombina bombina.
  Immunogenetics, 59, 479-491.  
17629515 K.N.Henderson, J.A.Tye-Din, H.H.Reid, Z.Chen, N.A.Borg, T.Beissbarth, A.Tatham, S.I.Mannering, A.W.Purcell, N.L.Dudek, D.A.van Heel, J.McCluskey, J.Rossjohn, and R.P.Anderson (2007).
A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease.
  Immunity, 27, 23-34.
PDB code: 2nna
17143275 K.Narayan, C.L.Chou, A.Kim, I.Z.Hartman, S.Dalai, S.Khoruzhenko, and S.Sadegh-Nasseri (2007).
HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes.
  Nat Immunol, 8, 92.  
17398114 K.W.Wucherpfennig, P.M.Allen, F.Celada, I.R.Cohen, R.De Boer, K.C.Garcia, B.Goldstein, R.Greenspan, D.Hafler, P.Hodgkin, E.S.Huseby, D.C.Krakauer, D.Nemazee, A.S.Perelson, C.Pinilla, R.K.Strong, and E.E.Sercarz (2007).
Polyspecificity of T cell and B cell receptor recognition.
  Semin Immunol, 19, 216-224.  
17211830 K.Y.Chang, A.Suri, and E.R.Unanue (2007).
Predicting peptides bound to I-Ag7 class II histocompatibility molecules using a novel expectation-maximization alignment algorithm.
  Proteomics, 7, 367-377.  
17445206 M.Singh, A.Balamurugan, K.Katoch, S.K.Sharma, and N.K.Mehra (2007).
Immunogenetics of mycobacterial infections in the North Indian population.
  Tissue Antigens, 69, 228-230.  
17351628 P.Venkatraman, T.T.Nguyen, M.Sainlos, O.Bilsel, S.Chitta, B.Imperiali, and L.J.Stern (2007).
Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells.
  Nat Chem Biol, 3, 222-228.
PDB code: 2ipk
17486336 S.Xu, P.Sun, K.Zhou, and G.Yang (2007).
Sequence variability at three MHC loci of finless porpoises (Neophocaena phocaenoides).
  Immunogenetics, 59, 581-592.  
17972349 T.W.Mak (2007).
The T cell antigen receptor: "The Hunting of the Snark".
  Eur J Immunol, 37, S83-S93.  
16639700 A.Kosmopoulou, M.Vlassi, A.Stavrakoudis, C.Sakarellos, and M.Sakarellos-Daitsiotis (2006).
T-cell epitopes of the La/SSB autoantigen: prediction based on the homology modeling of HLA-DQ2/DQ7 with the insulin-B peptide/HLA-DQ8 complex.
  J Comput Chem, 27, 1033-1044.  
16791623 C.F.Suárez, M.E.Patarroyo, E.Trujillo, M.Estupiñán, J.E.Baquero, C.Parra, and R.Rodriguez (2006).
Owl monkey MHC-DRB exon 2 reveals high similarity with several HLA-DRB lineages.
  Immunogenetics, 58, 542-558.  
16441501 C.H.Song, J.Y.Baek, Y.S.Heo, K.Kwack, and O.J.Kwon (2006).
Identification of a novel HLA-DRB1*09 allele, DRB1*0904, in the Korean population, by sequence-based typing.
  Tissue Antigens, 67, 179-180.  
16467040 C.I.Joung, J.B.Jun, W.T.Chung, G.G.Song, J.Y.Choe, H.K.Chang, and D.H.Yoo (2006).
Association between the HLA-DRB1 gene and clinical features of systemic sclerosis in Korea.
  Scand J Rheumatol, 35, 39-43.  
16565072 C.Parra-López, J.M.Calvo-Calle, T.O.Cameron, L.E.Vargas, L.M.Salazar, M.E.Patarroyo, E.Nardin, and L.J.Stern (2006).
Major histocompatibility complex and T cell interactions of a universal T cell epitope from Plasmodium falciparum circumsporozoite protein.
  J Biol Chem, 281, 14907-14917.  
16557259 E.Y.Jones, L.Fugger, J.L.Strominger, and C.Siebold (2006).
MHC class II proteins and disease: a structural perspective.
  Nat Rev Immunol, 6, 271-282.  
16091932 I.K.Egorov (2006).
Mouse models of efficient and inefficient anti-tumor immunity, with emphasis on minimal residual disease and tumor escape.
  Cancer Immunol Immunother, 55, 1.  
16409303 J.Chiaroni, I.Dettori, V.Ferrera, D.Legrand, M.Touinssi, P.Mercier, Micco, and D.Reviron (2006).
HLA-DRB1 polymorphism is associated with Kell immunisation.
  Br J Haematol, 132, 374-378.  
16551242 J.L.Strominger, and J.L.Strominger (2006).
The tortuous journey of a biochemist to immunoland and what he found there.
  Annu Rev Immunol, 24, 1.  
16671948 L.Bowen, B.M.Aldridge, A.K.Miles, and J.L.Stott (2006).
Expressed MHC class II genes in sea otters (Enhydra lutris) from geographically disparate populations.
  Tissue Antigens, 67, 402-408.  
16791622 M.E.Patarroyo, G.Cifuentes, and J.Baquero (2006).
Comparative molecular and three-dimensional analysis of the peptide-MHC II binding region in both human and Aotus MHC-DRB molecules confirms their usefulness in antimalarial vaccine development.
  Immunogenetics, 58, 598-606.  
16829512 M.M.Fernández, R.Guan, C.P.Swaminathan, E.L.Malchiodi, and R.A.Mariuzza (2006).
Crystal structure of staphylococcal enterotoxin I (SEI) in complex with a human major histocompatibility complex class II molecule.
  J Biol Chem, 281, 25356-25364.
PDB code: 2g9h
17010587 M.Sospedra, and R.Martin (2006).
When T cells recognize a pattern, they might cause trouble.
  Curr Opin Immunol, 18, 697-703.  
20476978 N.Mehra, and G.Kaur (2006).
HLA genetics and disease with particular reference to Type 1 diabetes and HIV infection in Asian Indians.
  Expert Rev Clin Immunol, 2, 901-913.  
16634878 P.A.Horn, J.Zingsem, R.Eckstein, and R.Blasczyk (2006).
Novel HLA-DRB1*1370 allele identified in a cord blood donor and her mother.
  Tissue Antigens, 67, 345-347.  
16941709 P.T.Donaldson, A.Baragiotta, M.A.Heneghan, A.Floreani, C.Venturi, J.A.Underhill, D.E.Jones, O.F.James, and M.F.Bassendine (2006).
HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: a large-scale study.
  Hepatology, 44, 667-674.  
17005558 S.Höpner, K.Dickhaut, M.Hofstätter, H.Krämer, D.Rückerl, J.A.Söderhäll, S.Gupta, V.Marin-Esteban, R.Kühne, C.Freund, G.Jung, K.Falk, and O.Rötzschke (2006).
Small organic compounds enhance antigen loading of class II major histocompatibility complex proteins by targeting the polymorphic P1 pocket.
  J Biol Chem, 281, 38535-38542.  
16519730 S.L.Fernando, and W.J.Britton (2006).
Genetic susceptibility to mycobacterial disease in humans.
  Immunol Cell Biol, 84, 125-137.  
16451200 X.Li, R.Li, and Z.Li (2006).
Inhibitory effects on HLA-DR1-specific T-cell activation by influenza virus haemagglutinin-derived peptides.
  Tissue Antigens, 67, 45-52.  
16982003 Y.Sakurai, D.D.Brand, B.Tang, E.F.Rosloniec, J.M.Stuart, A.H.Kang, and L.K.Myers (2006).
Analog peptides of type II collagen can suppress arthritis in HLA-DR4 (DRB1*0401) transgenic mice.
  Arthritis Res Ther, 8, R150.  
16530013 Ã.˜.Molberg, and L.M.Sollid (2006).
A gut feeling for joint inflammation - using coeliac disease to understand rheumatoid arthritis.
  Trends Immunol, 27, 188-194.  
15958261 A.Dubaniewicz, G.Moszkowska, and Z.Szczerkowska (2005).
Frequency of DRB1-DQB1 two-locus haplotypes in tuberculosis: preliminary report.
  Tuberculosis (Edinb), 85, 259-267.  
15915462 A.Godkin, M.Davenport, and A.V.Hill (2005).
Molecular analysis of HLA class II associations with hepatitis B virus clearance and vaccine nonresponsiveness.
  Hepatology, 41, 1383-1390.  
15934994 D.Reviron, I.Dettori, V.Ferrera, D.Legrand, M.Touinssi, P.Mercier, Micco, and J.Chiaroni (2005).
HLA-DRB1 alleles and Jk(a) immunization.
  Transfusion, 45, 956-959.  
15826953 E.Bergseng, J.Xia, C.Y.Kim, C.Khosla, and L.M.Sollid (2005).
Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule.
  J Biol Chem, 280, 21791-21796.  
  17491695 E.Biros, M.A.Jordan, and A.G.Baxter (2005).
Genes mediating environment interactions in type 1 diabetes.
  Rev Diabet Stud, 2, 192-207.  
15980449 G.L.Zhang, A.M.Khan, K.N.Srinivasan, J.T.August, and V.Brusic (2005).
MULTIPRED: a computational system for prediction of promiscuous HLA binding peptides.
  Nucleic Acids Res, 33, W172-W179.  
16178362 G.Sayers, B.Good, J.P.Hanrahan, M.Ryan, J.M.Angles, and T.Sweeney (2005).
Major histocompatibility complex DRB1 gene: its role in nematode resistance in Suffolk and Texel sheep breeds.
  Parasitology, 131, 403-409.  
16583780 G.Sayers, and T.Sweeney (2005).
Gastrointestinal nematode infection in sheep--a review of the alternatives to anthelmintics in parasite control.
  Anim Health Res Rev, 6, 159-171.  
15711804 H.Duyar, J.Dengjel, Graaf, K.H.Wiesmüller, S.Stevanović, and R.Weissert (2005).
Peptide motif for the rat MHC class II molecule RT1.Da: similarities to the multiple sclerosis-associated HLA-DRB1*1501 molecule.
  Immunogenetics, 57, 69-76.  
16013435 J.D.Hayball, and R.A.Lake (2005).
The immune function of MHC class II molecules mutated in the putative superdimer interface.
  Mol Cell Biochem, 273, 1-9.  
15834022 J.M.Greer, and M.P.Pender (2005).
The presence of glutamic acid at positions 71 or 74 in pocket 4 of the HLA-DRbeta1 chain is associated with the clinical course of multiple sclerosis.
  J Neurol Neurosurg Psychiatry, 76, 656-662.  
16160911 J.Yang, L.Huston, D.Berger, N.A.Danke, A.W.Liu, M.L.Disis, and W.W.Kwok (2005).
Expression of HLA-DP0401 molecules for identification of DP0401 restricted antigen specific T cells.
  J Clin Immunol, 25, 428-436.  
16010587 K.L.Knutson, and M.L.Disis (2005).
Tumor antigen-specific T helper cells in cancer immunity and immunotherapy.
  Cancer Immunol Immunother, 54, 721-728.  
15556932 R.Baggio, G.J.Carven, A.Chiulli, M.Palmer, L.J.Stern, and J.E.Arenas (2005).
Induced fit of an epitope peptide to a monoclonal antibody probed with a novel parallel surface plasmon resonance assay.
  J Biol Chem, 280, 4188-4194.  
15726347 S.Consuegra, H.J.Megens, K.Leon, R.J.Stet, and W.C.Jordan (2005).
Patterns of variability at the major histocompatibility class II alpha locus in Atlantic salmon contrast with those at the class I locus.
  Immunogenetics, 57, 16-24.  
15898991 T.Sone, K.Dairiki, K.Morikubo, K.Shimizu, H.Tsunoo, T.Mori, and K.Kino (2005).
Identification of human T cell epitopes in Japanese cypress pollen allergen, Cha o 1, elucidates the intrinsic mechanism of cross-allergenicity between Cha o 1 and Cry j 1, the major allergen of Japanese cedar pollen, at the T cell level.
  Clin Exp Allergy, 35, 664-671.  
15787743 Y.J.Cheng, Q.Zhou, and Z.G.Li (2005).
The inhibitory effect of altered collagen II peptide on HLA-DRB1-restricted T-cell activation.
  Scand J Immunol, 61, 260-265.  
15075536 A.Gayà, A.Esteve, J.Casabona, J.J.McCarthy, J.Martorell, T.F.Schulz, and D.Whitby (2004).
Amino acid residue at position 13 in HLA-DR beta chain plays a critical role in the development of Kaposi's sarcoma in AIDS patients.
  AIDS, 18, 199-204.  
14989720 C.C.Chu, H.L.Lee, and M.Lin (2004).
Identification of a new HLA-DRB1 allele, HLA-DRB1*0436.
  Tissue Antigens, 63, 279-281.  
15020763 C.Y.Kim, H.Quarsten, E.Bergseng, C.Khosla, and L.M.Sollid (2004).
Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease.
  Proc Natl Acad Sci U S A, 101, 4175-4179.
PDB code: 1s9v
15501399 E.E.Drouin, L.J.Glickstein, and A.C.Steere (2004).
Molecular characterization of the OspA(161-175) T cell epitope associated with treatment-resistant Lyme arthritis: differences among the three pathogenic species of Borrelia burgdorferi sensu lato.
  J Autoimmun, 23, 281-292.  
15245378 E.Garino, M.Berrino, G.Mazzola, M.Boccadoro, B.Bruno, F.Bertinetto, L.Bertola, P.Caropreso, E.Frisaldi, F.Marin, M.L.Panniello, F.Tondat, and A.M.Dall'Omo (2004).
Identification of a new HLA-DRB1 allele in three members of an Italian family.
  Tissue Antigens, 64, 210-212.  
14757758 G.J.Carven, S.Chitta, I.Hilgert, M.M.Rushe, R.F.Baggio, M.Palmer, J.E.Arenas, J.L.Strominger, V.Horejsi, L.Santambrogio, and L.J.Stern (2004).
Monoclonal antibodies specific for the empty conformation of HLA-DR1 reveal aspects of the conformational change associated with peptide binding.
  J Biol Chem, 279, 16561-16570.  
15550021 G.L.Hu, D.K.Okita, and B.M.Conti-Fine (2004).
T cell recognition of the A2 domain of coagulation factor VIII in hemophilia patients and healthy subjects.
  J Thromb Haemost, 2, 1908-1917.  
14748001 H.D.Schafroth, and C.A.Floudas (2004).
Predicting peptide binding to MHC pockets via molecular modeling, implicit solvation, and global optimization.
  Proteins, 54, 534-556.  
15549775 J.A.Gebe, S.A.Masewicz, S.A.Kochik, H.Reijonen, and G.T.Nepom (2004).
Inhibition of altered peptide ligand-mediated antagonism of human GAD65-responsive CD4+ T cells by non-antagonizable T cells.
  Eur J Immunol, 34, 3337-3345.  
15322290 J.C.Tong, T.W.Tan, and S.Ranganathan (2004).
Modeling the structure of bound peptide ligands to major histocompatibility complex.
  Protein Sci, 13, 2523-2532.  
15213134 K.M.Williams, and E.C.Bigley (2004).
Identification of an I-Ed-restricted T-cell epitope of Escherichia coli outer membrane protein F.
  Infect Immun, 72, 3907-3913.  
14734520 K.W.Wucherpfennig (2004).
Presentation of a self-peptide in two distinct conformations by a disease-associated HLA-B27 subtype.
  J Exp Med, 199, 151-154.  
15180759 M.Raulf-Heimsoth, P.Rozynek, T.Brüning, and H.P.Rihs (2004).
Characterization of B- and T-cell responses and HLA-DR4 binding motifs of the latex allergen Hev b 6.01 (prohevein) and its post-transcriptionally formed proteins Hev b 6.02 and Hev b 6.03.
  Allergy, 59, 724-733.  
15304045 M.T.Reding, D.K.Okita, B.M.Diethelm-Okita, T.A.Anderson, and B.M.Conti-Fine (2004).
Epitope repertoire of human CD4(+) T cells on the A3 domain of coagulation factor VIII.
  J Thromb Haemost, 2, 1385-1394.  
15140028 N.Leuchte, N.Berry, B.Köhler, N.Almond, R.LeGrand, R.Thorstensson, F.Titti, and U.Sauermann (2004).
MhcDRB-sequences from cynomolgus macaques (Macaca fascicularis) of different origin.
  Tissue Antigens, 63, 529-537.  
15517241 R.A.Ettinger, A.K.Moustakas, and S.D.Lobaton (2004).
Open reading frame sequencing and structure-based alignment of polypeptides encoded by RT1-Bb, RT1-Ba, RT1-Db, and RT1-Da alleles.
  Immunogenetics, 56, 585-596.  
15364925 R.Thai, G.Moine, M.Desmadril, D.Servent, J.L.Tarride, A.Ménez, and M.Léonetti (2004).
Antigen stability controls antigen presentation.
  J Biol Chem, 279, 50257-50266.  
14747723 Y.Zhao, Z.Li, S.Drozd, Y.Guo, R.Stack, C.Hauer, and H.Li (2004).
Crystallization and preliminary crystallographic analysis of Mycoplasma arthritidis-derived mitogen complexed with peptide/MHC class II antigen.
  Acta Crystallogr D Biol Crystallogr, 60, 353-356.  
14962388 Y.Zhao, Z.Li, S.J.Drozd, Y.Guo, W.Mourad, and H.Li (2004).
Crystal structure of Mycoplasma arthritidis mitogen complexed with HLA-DR1 reveals a novel superantigen fold and a dimerized superantigen-MHC complex.
  Structure, 12, 277-288.
PDB code: 1r5i
15084275 Z.Pu, S.B.Lovitch, E.K.Bikoff, and E.R.Unanue (2004).
T cells distinguish MHC-peptide complexes formed in separate vesicles and edited by H2-DM.
  Immunity, 20, 467-476.  
15304013 Z.X.Chen, S.G.Tsan, C.W.Dang, C.C.Chu, M.Lin, and Y.J.Lee (2004).
Identification of two new HLA-DRB1 alleles: HLA-DRB1*1350 and DRB1*140502.
  Tissue Antigens, 64, 300-303.  
15331779 Z.Zavala-Ruiz, I.Strug, B.D.Walker, P.J.Norris, and L.J.Stern (2004).
A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition.
  Proc Natl Acad Sci U S A, 101, 13279-13284.
PDB codes: 1sje 1sjh
15489166 Z.Zavala-Ruiz, I.Strug, M.W.Anderson, J.Gorski, and L.J.Stern (2004).
A polymorphic pocket at the P10 position contributes to peptide binding specificity in class II MHC proteins.
  Chem Biol, 11, 1395-1402.
PDB codes: 1t5w 1t5x
12571864 A.C.Steere, B.Falk, E.E.Drouin, L.A.Baxter-Lowe, J.Hammer, and G.T.Nepom (2003).
Binding of outer surface protein A and human lymphocyte function-associated antigen 1 peptides to HLA-DR molecules associated with antibiotic treatment-resistant Lyme arthritis.
  Arthritis Rheum, 48, 534-540.  
14514946 A.Dubaniewicz, G.Moszkowska, Z.Szczerkowska, and A.Hoppe (2003).
Analysis of DQB1 allele frequencies in pulmonary tuberculosis: preliminary report.
  Thorax, 58, 890-891.  
14617028 A.P.Fontenot, and B.L.Kotzin (2003).
Chronic beryllium disease: immune-mediated destruction with implications for organ-specific autoimmunity.
  Tissue Antigens, 62, 449-458.  
12753659 C.E.Voorter, B.G.Hepkema, S.P.Lems, and E.M.van den Berg-Loonen (2003).
Identification of three new DRB1 alleles, DRB1*0107, *0425 and *13012 and confirmation of DRB4*01033.
  Tissue Antigens, 61, 398-402.  
14521599 G.L.Hu, D.K.Okita, B.M.Diethelm-Okita, and B.M.Conti-Fine (2003).
Recognition of coagulation factor VIII by CD4+ T cells of healthy humans.
  J Thromb Haemost, 1, 2159-2166.  
12748655 G.S.Firestein (2003).
Evolving concepts of rheumatoid arthritis.
  Nature, 423, 356-361.  
12913229 H.Nojima, M.Takeda-Shitaka, Y.Kurihara, K.Kamiya, and H.Umeyama (2003).
Dynamic flexibility of a peptide-binding groove of human HLA-DR1 class II MHC molecules: normal mode analysis of the antigen peptide-class II MHC complex.
  Chem Pharm Bull (Tokyo), 51, 923-928.  
12740374 I.Potolicchio, L.Santambrogio, and J.L.Strominger (2003).
Molecular interaction and enzymatic activity of macrophage migration inhibitory factor with immunorelevant peptides.
  J Biol Chem, 278, 30889-30895.  
12615896 J.Loh, and J.Fraser (2003).
Metal-derivatized major histocompatibility complex: zeroing in on contact hypersensitivity.
  J Exp Med, 197, 549-552.  
12674501 J.M.Lozano, M.P.Alba, M.Vanegas, Y.Silva, J.L.Torres-Castellanos, and M.E.Patarroyo (2003).
MSP-1 malaria pseudopeptide analogs: biological and immunological significance and three-dimensional structure.
  Biol Chem, 384, 71-82.  
14679046 K.W.Wucherpfennig (2003).
MHC-linked susceptibility to type 1 diabetes: a structural perspective.
  Ann N Y Acad Sci, 1005, 119-127.  
12560454 M.A.Kelly, M.L.Rayner, C.H.Mijovic, and A.H.Barnett (2003).
Molecular aspects of type 1 diabetes.
  Mol Pathol, 56, 1.  
12828552 M.L.Diegel, F.Chen, R.Laus, T.J.Graddis, and D.Vidovic (2003).
Major histocompatibility complex class I-restricted presentation of protein antigens without prior intracellular processing.
  Scand J Immunol, 58, 1-8.  
12911593 M.T.Reding, D.K.Okita, B.M.Diethelm-Okita, T.A.Anderson, and B.M.Conti-Fine (2003).
Human CD4+ T-cell epitope repertoire on the C2 domain of coagulation factor VIII.
  J Thromb Haemost, 1, 1777-1784.  
12767128 S.L.Lam, and V.L.Hsu (2003).
NMR identification of left-handed polyproline type II helices.
  Biopolymers, 69, 270-281.  
12473669 W.Swietnicki, A.M.Barnie, B.K.Dyas, and R.G.Ulrich (2003).
Zinc binding and dimerization of Streptococcus pyogenes pyrogenic exotoxin C are not essential for T-cell stimulation.
  J Biol Chem, 278, 9885-9895.  
12952957 Z.Zavala-Ruiz, E.J.Sundberg, J.D.Stone, D.B.DeOliveira, I.C.Chan, J.Svendsen, R.A.Mariuzza, and L.J.Stern (2003).
Exploration of the P6/P7 region of the peptide-binding site of the human class II major histocompatability complex protein HLA-DR1.
  J Biol Chem, 278, 44904-44912.
PDB code: 1pyw
11866281 A.J.Czaja, P.T.Donaldson, and A.W.Lohse (2002).
Antibodies to soluble liver antigen/liver pancreas and HLA risk factors for type 1 autoimmune hepatitis.
  Am J Gastroenterol, 97, 413-419.  
12116175 A.K.Moustakas, and G.K.Papadopoulos (2002).
Molecular properties of HLA-DQ alleles conferring susceptibility to or protection from insulin-dependent diabetes mellitus: keys to the fate of islet beta-cells.
  Am J Med Genet, 115, 37-47.  
12395395 B.Bochicchio, and A.M.Tamburro (2002).
Polyproline II structure in proteins: identification by chiroptical spectroscopies, stability, and functions.
  Chirality, 14, 782-792.  
12144808 B.Catchpole, F.J.Ward, A.S.Hamblin, and N.A.Staines (2002).
Autoreactivity in collagen-induced arthritis of rats: a potential role for T cell responses to self MHC peptides.
  J Autoimmun, 18, 271-280.  
11857638 B.J.McFarland, and C.Beeson (2002).
Binding interactions between peptides and proteins of the class II major histocompatibility complex.
  Med Res Rev, 22, 168-203.  
12516563 C.Texier, S.Pouvelle-Moratille, C.Buhot, F.A.Castelli, C.Pecquet, A.Ménez, F.Leynadier, and B.Maillère (2002).
Emerging principles for the design of promiscuous HLA-DR-restricted peptides: an example from the major bee venom allergen.
  Eur J Immunol, 32, 3699-3707.  
11956295 D.H.Fremont, S.Dai, H.Chiang, F.Crawford, P.Marrack, and J.Kappler (2002).
Structural basis of cytochrome c presentation by IE(k).
  J Exp Med, 195, 1043-1052.
PDB codes: 1kt2 1ktd
12190925 E.R.Unanue (2002).
Perspective on antigen processing and presentation.
  Immunol Rev, 185, 86.  
16233301 H.Noguchi, R.Kato, T.Hanai, Y.Matsubara, H.Honda, V.Brusic, and T.Kobayashi (2002).
Hidden Markov model-based prediction of antigenic peptides that interact with MHC class II molecules.
  J Biosci Bioeng, 94, 264-270.  
12324465 I.Parrot, P.C.Huang, and C.Khosla (2002).
Circular dichroism and nuclear magnetic resonance spectroscopic analysis of immunogenic gluten peptides and their analogs.
  J Biol Chem, 277, 45572-45578.  
11877480 J.Hennecke, and D.C.Wiley (2002).
Structure of a complex of the human alpha/beta T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB1*0401): insight into TCR cross-restriction and alloreactivity.
  J Exp Med, 195, 571-581.
PDB code: 1j8h
12190663 K.Suzuki, R.Inoue, H.Sakaguchi, M.Aoki, Z.Kato, H.Kaneko, S.Matsushita, and N.Kondo (2002).
The correlation between ovomucoid-derived peptides, human leucocyte antigen class II molecules and T cell receptor-complementarity determining region 3 compositions in patients with egg-white allergy.
  Clin Exp Allergy, 32, 1223-1230.  
  12070311 M.Fridkis-Hareli, L.Santambrogio, J.N.Stern, L.Fugger, C.Brosnan, and J.L.Strominger (2002).
Novel synthetic amino acid copolymers that inhibit autoantigen-specific T cell responses and suppress experimental autoimmune encephalomyelitis.
  J Clin Invest, 109, 1635-1643.  
12124299 M.J.Kogan, I.Dalcol, P.Gorostiza, C.Lopez-Iglesias, R.Pons, M.Pons, F.Sanz, and E.Giralt (2002).
Supramolecular properties of the proline-rich gamma-Zein N-terminal domain.
  Biophys J, 83, 1194-1204.  
11864610 M.M.Mullen, K.M.Haan, R.Longnecker, and T.S.Jardetzky (2002).
Structure of the Epstein-Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1.
  Mol Cell, 9, 375-385.
PDB code: 1kg0
11748166 M.Panigada, T.Sturniolo, G.Besozzi, M.G.Boccieri, F.Sinigaglia, G.G.Grassi, and F.Grassi (2002).
Identification of a promiscuous T-cell epitope in Mycobacterium tuberculosis Mce proteins.
  Infect Immun, 70, 79-85.  
12471156 O.Rötzschke, J.M.Lau, M.Hofstätter, K.Falk, and J.L.Strominger (2002).
A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules.
  Proc Natl Acad Sci U S A, 99, 16946-16950.  
12010576 P.E.Adrian, G.Rajaseger, V.S.Mathura, M.K.Sakharkar, and P.Kangueane (2002).
Types of inter-atomic interactions at the MHC-peptide interface: identifying commonality from accumulated data.
  BMC Struct Biol, 2, 2.  
11754003 P.Etongué-Mayer, M.A.Langlois, M.Ouellette, H.Li, S.Younes, R.Al-Daccak, and W.Mourad (2002).
Involvement of zinc in the binding of Mycoplasma arthritidis-derived mitogen to the proximity of the HLA-DR binding groove regardless of histidine 81 of the beta chain.
  Eur J Immunol, 32, 50-58.  
12432567 S.L.Cunliffe, J.R.Wyer, J.K.Sutton, M.Lucas, G.Harcourt, P.Klenerman, A.J.McMichael, and A.D.Kelleher (2002).
Optimization of peptide linker length in production of MHC class II/peptide tetrameric complexes increases yield and stability, and allows identification of antigen-specific CD4+T cells in peripheral blood mononuclear cells.
  Eur J Immunol, 32, 3366-3375.  
12402950 T.D.Lockey, S.Surman, S.Brown, K.S.Slobod, C.Coleclough, P.C.Doherty, and J.L.Hurwitz (2002).
A five-residue HIV envelope helper T cell determinant: does this peptide-MHC interaction leave the binding groove half empty?
  AIDS Res Hum Retroviruses, 18, 1141-1144.  
12084926 X.Liu, S.Dai, F.Crawford, R.Fruge, P.Marrack, and J.Kappler (2002).
Alternate interactions define the binding of peptides to the MHC molecule IA(b).
  Proc Natl Acad Sci U S A, 99, 8820-8825.
PDB code: 1lnu
11433380 C.Texier, S.Pouvelle-Moratille, M.Busson, D.Charron, A.Ménez, and B.Maillère (2001).
Complementarity and redundancy of the binding specificity of HLA-DRB1, -DRB3, -DRB4 and -DRB5 molecules.
  Eur J Immunol, 31, 1837-1846.  
11263767 D.Reviron, A.Perdriger, E.Toussirot, D.Wendling, N.Balandraud, S.Guis, G.Semana, P.Tiberghien, P.Mercier, and J.Roudier (2001).
Influence of shared epitope-negative HLA-DRB1 alleles on genetic susceptibility to rheumatoid arthritis.
  Arthritis Rheum, 44, 535-540.  
11334484 E.Maverakis, P.van den Elzen, and E.E.Sercarz (2001).
Self-reactive T cells and degeneracy of T cell recognition: evolving concepts-from sequence homology to shape mimicry and TCR flexibility.
  J Autoimmun, 16, 201-209.  
11580857 H.A.Elsner, K.Kotsch, and R.Blasczyk (2001).
Identification of the novel allele HLA-DRB1*1137 which probably originated from DRB1*11011: implications for mismatch with its ancestor allele at bone marrow transplantation.
  Tissue Antigens, 58, 47-49.  
11405221 K.H.Wiesmüller, B.Fleckenstein, and G.Jung (2001).
Peptide vaccines and peptide libraries.
  Biol Chem, 382, 571-579.  
11432818 K.Petersson, M.Håkansson, H.Nilsson, G.Forsberg, L.A.Svensson, A.Liljas, and B.Walse (2001).
Crystal structure of a superantigen bound to MHC class II displays zinc and peptide dependence.
  EMBO J, 20, 3306-3312.
PDB code: 1hxy
11677085 K.W.Wucherpfennig (2001).
Insights into autoimmunity gained from structural analysis of MHC-peptide complexes.
  Curr Opin Immunol, 13, 650-656.  
11334495 K.W.Wucherpfennig (2001).
Structural basis of molecular mimicry.
  J Autoimmun, 16, 293-302.  
11180120 M.Kalbus, B.T.Fleckenstein, M.Offenhäusser, M.Blüggel, A.Melms, H.E.Meyer, H.G.Rammensee, R.Martin, G.Jung, and N.Sommer (2001).
Ligand motif of the autoimmune disease-associated mouse MHC class II molecule H2-A(s).
  Eur J Immunol, 31, 551-562.  
11556969 M.Minohara, H.Ochi, S.Matsushita, A.Irie, Y.Nishimura, and J.Kira (2001).
Differences between T-cell reactivities to major myelin protein-derived peptides in opticospinal and conventional forms of multiple sclerosis and healthy controls.
  Tissue Antigens, 57, 447-456.  
11536359 O.Schueler-Furman, Y.Altuvia, and H.Margalit (2001).
Examination of possible structural constraints of MHC-binding peptides by assessment of their native structure within their source proteins.
  Proteins, 45, 47-54.  
11592376 P.Cacoub, C.Renou, G.Kerr, S.Hüe, E.Rosenthal, P.Cohen, G.Kaplanski, F.Charlotte, V.Thibault, P.Ghillani, J.C.Piette, and S.Caillat-Zucman (2001).
Influence of HLA-DR phenotype on the risk of hepatitis C virus-associated mixed cryoglobulinemia.
  Arthritis Rheum, 44, 2118-2124.  
11380954 S.Wu, Y.M.Shiao, C.Y.Lai, S.M.Lai, S.P.Chen, D.A.Sidebottom, W.H.Hildebrand, M.G.Tilanus, F.C.Chou, and M.F.Tsai (2001).
Polymorphism of human HLA-DRB1 antigens generated by genetic exchange between DR2 (DRB1*15011) and DR6 (DRB1*1405) alleles: a novel DRB1 allele (DRB1*1437) identified in a Paiwan tribe member of Taiwan.
  Tissue Antigens, 57, 384-387.  
11703831 T.A.Dunn, B.A.Iglehart, and M.S.Leffell (2001).
Identification of a novel DR4 allele, DRB1*0442.
  Tissue Antigens, 58, 198-200.  
11090155 A.H.Choi, M.Basu, M.M.McNeal, J.Flint, J.L.VanCott, J.D.Clements, and R.L.Ward (2000).
Functional mapping of protective domains and epitopes in the rotavirus VP6 protein.
  J Virol, 74, 11574-11580.  
10636922 A.K.Sato, J.A.Zarutskie, M.M.Rushe, A.Lomakin, S.K.Natarajan, S.Sadegh-Nasseri, G.B.Benedek, and L.J.Stern (2000).
Determinants of the peptide-induced conformational change in the human class II major histocompatibility complex protein HLA-DR1.
  J Biol Chem, 275, 2165-2173.  
11050177 A.P.Fontenot, M.Torres, W.H.Marshall, L.S.Newman, and B.L.Kotzin (2000).
Beryllium presentation to CD4+ T cells underlies disease-susceptibility HLA-DP alleles in chronic beryllium disease.
  Proc Natl Acad Sci U S A, 97, 12717-12722.  
10981968 A.Shamshiev, A.Donda, T.I.Prigozy, L.Mori, V.Chigorno, C.A.Benedict, L.Kappos, S.Sonnino, M.Kronenberg, and G.De Libero (2000).
The alphabeta T cell response to self-glycolipids shows a novel mechanism of CD1b loading and a requirement for complex oligosaccharides.
  Immunity, 13, 255-264.  
11053110 A.Simon, Z.Dosztányi, E.Rajnavölgyi, and I.Simon (2000).
Function-related regulation of the stability of MHC proteins.
  Biophys J, 79, 2305-2313.  
10837054 C.Alfonso, and L.Karlsson (2000).
Nonclassical MHC class II molecules.
  Annu Rev Immunol, 18, 113-142.  
11058219 C.E.Schutt, and U.Lindberg (2000).
Forthcoming topics
  Anat Rec, 261, 216.  
11120767 C.L.Chou, and S.Sadegh-Nasseri (2000).
HLA-DM recognizes the flexible conformation of major histocompatibility complex class II.
  J Exp Med, 192, 1697-1706.  
10894170 D.Scott, C.Addey, P.Ellis, E.James, M.J.Mitchell, N.Saut, S.Jurcevic, and E.Simpson (2000).
Dendritic cells permit identification of genes encoding MHC class II-restricted epitopes of transplantation antigens.
  Immunity, 12, 711-720.  
11828419 E.Wellner, T.Gustafsson, J.Bäcklund, R.Holmdahl, and J.Kihlberg (2000).
Synthesis of a C-glycoside analogue of beta-D-galactosyl hydroxynorvaline and its use in immunological studies.
  Chembiochem, 1, 272-280.  
10713985 G.J.Gatto, B.V.Geisbrecht, S.J.Gould, and J.M.Berg (2000).
A proposed model for the PEX5-peroxisomal targeting signal-1 recognition complex.
  Proteins, 38, 241-246.  
11060013 J.Hennecke, A.Carfi, and D.C.Wiley (2000).
Structure of a covalently stabilized complex of a human alphabeta T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1.
  EMBO J, 19, 5611-5624.
PDB code: 1fyt
10859331 J.M.Blander, D.B.Sant'Angelo, K.Bottomly, and C.A.Janeway (2000).
Alteration at a single amino acid residue in the T cell receptor alpha chain complementarity determining region 2 changes the differentiation of naive CD4 T cells in response to antigen from T helper cell type 1 (Th1) to Th2.
  J Exp Med, 191, 2065-2074.  
10980449 J.R.Cochran, and L.J.Stern (2000).
A diverse set of oligomeric class II MHC-peptide complexes for probing T-cell receptor interactions.
  Chem Biol, 7, 683-696.  
10755611 J.R.Cochran, T.O.Cameron, and L.J.Stern (2000).
The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers.
  Immunity, 12, 241-250.  
10972222 L.Frasca, A.Tamir, S.Jurcevic, B.Marinari, A.Monizio, R.Sorrentino, M.Carbonari, E.Piccolella, R.I.Lechler, and G.Lombardi (2000).
Peptide analogues as a strategy to induce tolerance in T cells with indirect allospecificity.
  Transplantation, 70, 631-640.  
10782527 M.J.Torres-Galván, J.Quiralte, C.Blanco, R.Castillo, T.Carrillo, P.Pérez-Aciego, and F.Sánchez-García (2000).
Pocket 4 in the HLA-DRB1 antigen-binding groove: an association with atopy.
  Allergy, 55, 398-401.  
11098933 M.Kuwana, J.Kaburaki, J.P.Pandey, M.Murata, Y.Kawakami, H.Inoko, and Y.Ikeda (2000).
HLA class II alleles in Japanese patients with immune thrombocytopenic purpura. Associations with anti-platelet glycoprotein autoantibodies and responses to splenectomy.
  Tissue Antigens, 56, 337-343.  
10653650 P.M.Kasson, J.D.Rabinowitz, L.Schmitt, M.M.Davis, and H.M.McConnell (2000).
Kinetics of peptide binding to the class II MHC protein I-Ek.
  Biochemistry, 39, 1048-1058.  
10689356 P.V.Lehmann (2000).
Selective peptidomimetic blockers of autoantigen presentation: a novel therapeutic approach to autoimmune disease.
  Trends Pharmacol Sci, 21, 79-80.  
10894169 R.R.Latek, A.Suri, S.J.Petzold, C.A.Nelson, O.Kanagawa, E.R.Unanue, and D.H.Fremont (2000).
Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice.
  Immunity, 12, 699-710.
PDB code: 1f3j
10736175 R.V.Joshi, J.A.Zarutskie, and L.J.Stern (2000).
A three-step kinetic mechanism for peptide binding to MHC class II proteins.
  Biochemistry, 39, 3751-3762.  
  10833487 S.M.McKiernan, R.Hagan, M.Curry, G.S.McDonald, N.Nolan, J.Crowley, J.Hegarty, E.Lawlor, and D.Kelleher (2000).
The MHC is a major determinant of viral status, but not fibrotic stage, in individuals infected with hepatitis C.
  Gastroenterology, 118, 1124-1130.  
10906388 U.Grimholt, A.Getahun, T.Hermsen, and R.J.Stet (2000).
The major histocompatibility class II alpha chain in salmonid fishes.
  Dev Comp Immunol, 24, 751-763.  
11106392 Y.Wang, W.M.Kalka-Moll, M.H.Roehrl, and D.L.Kasper (2000).
Structural basis of the abscess-modulating polysaccharide A2 from Bacteroides fragilis.
  Proc Natl Acad Sci U S A, 97, 13478-13483.  
10450992 A.B.Jones, J.J.Acton, A.D.Adams, W.Yuen, E.A.Nichols, C.D.Schwartz, L.S.Wicker, and J.D.Hermes (1999).
Tetrapeptide derived inhibitors of complexation of a class II MHC: fully unnatural ligands.
  Bioorg Med Chem Lett, 9, 2115-2118.  
10625593 A.B.Vogt, S.O.Arndt, G.J.Hämmerling, and H.Kropshofer (1999).
Quality control of MHC class II associated peptides by HLA-DM/H2-M.
  Semin Immunol, 11, 391-403.  
10403279 A.P.Cope, S.D.Patel, F.Hall, M.Congia, H.A.Hubers, G.F.Verheijden, A.M.Boots, R.Menon, M.Trucco, A.W.Rijnders, and G.Sønderstrup (1999).
T cell responses to a human cartilage autoantigen in the context of rheumatoid arthritis-associated and nonassociated HLA-DR4 alleles.
  Arthritis Rheum, 42, 1497-1507.  
10625594 B.Fleckenstein, G.Jung, and K.H.Wiesmüller (1999).
Quantitative analysis of peptide-MHC class II interaction.
  Semin Immunol, 11, 405-416.  
9874795 C.I.Pearson, A.M.Gautam, I.C.Rulifson, R.S.Liblau, and H.O.McDevitt (1999).
A small number of residues in the class II molecule I-Au confer the ability to bind the myelin basic protein peptide Ac1-11.
  Proc Natl Acad Sci U S A, 96, 197-202.  
  10614738 C.M.Weyand, and J.J.Goronzy (1999).
HLA polymorphisms and T cells in rheumatoid arthritis.
  Int Rev Immunol, 18, 37-59.  
10322159 C.Pinilla, R.Martin, B.Gran, J.R.Appel, C.Boggiano, D.B.Wilson, and R.A.Houghten (1999).
Exploring immunological specificity using synthetic peptide combinatorial libraries.
  Curr Opin Immunol, 11, 193-202.  
10068910 C.Seidl, U.R.Kässer, B.Fischer, U.Koch, L.Meier, P.Fischer, H.M.Wisseler, G.Faust-Tinnefeldt, G.Bach, D.Maas, W.W.Bolten, K.Badenhoop, E.Seifried, and J.P.Kaltwasser (1999).
HLA-DR/DQ interaction in patients with erosive rheumatoid arthritis presenting articular and extraarticular disease manifestations.
  Eur J Immunogenet, 26, 19-27.  
10488742 C.Yun, S.Senju, H.Fujita, Y.Tsuji, A.Irie, S.Matsushita, and Y.Nishimura (1999).
Augmentation of immune response by altered peptide ligands of the antigenic peptide in a human CD4+ T-cell clone reacting to TEL/AML1 fusion protein.
  Tissue Antigens, 54, 153-161.  
10359576 D.H.Hausmann, B.Yu, S.Hausmann, and K.W.Wucherpfennig (1999).
pH-dependent peptide binding properties of the type I diabetes-associated I-Ag7 molecule: rapid release of CLIP at an endosomal pH.
  J Exp Med, 189, 1723-1734.  
10023765 D.N.Garboczi, and W.E.Biddison (1999).
Shapes of MHC restriction.
  Immunity, 10, 1-7.  
10606632 E.J.Novak, A.W.Liu, G.T.Nepom, and W.W.Kwok (1999).
MHC class II tetramers identify peptide-specific human CD4(+) T cells proliferating in response to influenza A antigen.
  J Clin Invest, 104, R63-R67.  
  10079241 E.R.Unanue (1999).
Rous-Whipple Award Lecture. Chemical features of peptide selection by the class II histocompatibility molecules.
  Am J Pathol, 154, 651-664.  
10097129 G.A.Snyder, A.G.Brooks, and P.D.Sun (1999).
Crystal structure of the HLA-Cw3 allotype-specific killer cell inhibitory receptor KIR2DL2.
  Proc Natl Acad Sci U S A, 96, 3864-3869.
PDB codes: 2dl2 2dli
10540160 G.P.Uko, L.Y.Lu, M.A.Asuquo, D.Fici, S.Mahan, Z.Awdeh, E.R.Udim, W.Ding, U.Umana, T.Adewole, and P.A.Fraser (1999).
HLA-DRB1 leprogenic motifs in nigerian population groups.
  Clin Exp Immunol, 118, 56-62.  
10319257 H.A.Lewin, G.C.Russell, and E.J.Glass (1999).
Comparative organization and function of the major histocompatibility complex of domesticated cattle.
  Immunol Rev, 167, 145-158.  
10092094 H.I.Russell, I.A.York, K.L.Rock, and J.J.Monaco (1999).
Class II antigen processing defects in two H2d mouse cell lines are caused by point mutations in the H2-DMa gene.
  Eur J Immunol, 29, 905-911.  
10631952 H.Kropshofer, G.J.Hämmerling, and A.B.Vogt (1999).
The impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC class II molecules.
  Immunol Rev, 172, 267-278.  
10518213 H.Ye, Y.C.Park, M.Kreishman, E.Kieff, and H.Wu (1999).
The structural basis for the recognition of diverse receptor sequences by TRAF2.
  Mol Cell, 4, 321-330.
PDB codes: 1czy 1czz 1d00 1d01 1d0a 1d0j
10427976 I.Potolicchio, A.Festucci, P.Hausler, and R.Sorrentino (1999).
HLA-DP molecules bind cobalt: a possible explanation for the genetic association with hard metal disease.
  Eur J Immunol, 29, 2140-2147.  
10231540 J.A.Zarutskie, A.K.Sato, M.M.Rushe, I.C.Chan, A.Lomakin, G.B.Benedek, and L.J.Stern (1999).
A conformational change in the human major histocompatibility complex protein HLA-DR1 induced by peptide binding.
  Biochemistry, 38, 5878-5887.  
10382737 J.N.Agrewala, and R.J.Wilkinson (1999).
Influence of HLA-DR on the phenotype of CD4+ T lymphocytes specific for an epitope of the 16-kDa alpha-crystallin antigen of Mycobacterium tuberculosis.
  Eur J Immunol, 29, 1753-1761.  
9933100 K.Bartnes, F.Leon, J.P.Briand, P.J.Travers, and K.Hannestad (1999).
N-terminal elongation of a peptide determinant beyond the first primary anchor improves binding to H-2 I-Ad and HLA-DR1 by backbone-dependent and aromatic side chain-dependent interactions, respectively.
  Eur J Immunol, 29, 189-195.  
10358763 K.C.Garcia, L.Teyton, and I.A.Wilson (1999).
Structural basis of T cell recognition.
  Annu Rev Immunol, 17, 369-397.  
10607669 K.Maenaka, and E.Y.Jones (1999).
MHC superfamily structure and the immune system.
  Curr Opin Struct Biol, 9, 745-753.  
10064083 L.Raddrizzani, E.Bono, A.B.Vogt, H.Kropshofer, F.Gallazzi, T.Sturniolo, G.J.Hämmerling, F.Sinigaglia, and J.Hammer (1999).
Identification of destabilizing residues in HLA class II-selected bacteriophage display libraries edited by HLA-DM.
  Eur J Immunol, 29, 660-668.  
10611336 L.Santambrogio, A.K.Sato, F.R.Fischer, M.E.Dorf, and L.J.Stern (1999).
Abundant empty class II MHC molecules on the surface of immature dendritic cells.
  Proc Natl Acad Sci U S A, 96, 15050-15055.  
10573514 M.Pando, J.Larriba, G.C.Fernandez, H.Fainboim, M.Ciocca, M.Ramonet, I.Badia, J.Daruich, J.Findor, H.Tanno, C.Cañero-Velasco, and L.Fainboim (1999).
Pediatric and adult forms of type I autoimmune hepatitis in Argentina: evidence for differential genetic predisposition.
  Hepatology, 30, 1374-1380.  
10319250 M.Yeager, and A.L.Hughes (1999).
Evolution of the mammalian MHC: natural selection, recombination, and convergent evolution.
  Immunol Rev, 167, 45-58.  
10213634 N.R.Glover, and A.S.Tracey (1999).
Nuclear magnetic resonance and restrained molecular dynamics studies of the interaction of an epidermal growth factor-derived peptide with protein tyrosine phosphatase 1B.
  Biochemistry, 38, 5256-5271.  
10377434 O.Rötzschke, K.Falk, J.Mack, J.M.Lau, G.Jung, and J.L.Strominger (1999).
Conformational variants of class II MHC/peptide complexes induced by N- and C-terminal extensions of minimal peptide epitopes.
  Proc Natl Acad Sci U S A, 96, 7445-7450.  
10631949 P.E.Jensen, D.A.Weber, W.P.Thayer, L.E.Westerman, and C.T.Dao (1999).
Peptide exchange in MHC molecules.
  Immunol Rev, 172, 229-238.  
10353458 P.E.Jensen (1999).
Mechanisms of antigen presentation.
  Clin Chem Lab Med, 37, 179-186.  
10741860 P.E.Jensen, D.A.Weber, W.P.Thayer, X.Chen, and C.T.Dao (1999).
HLA-DM and the MHC class II antigen presentation pathway.
  Immunol Res, 20, 195-205.  
10406258 P.L.Bittencourt, A.C.Goldberg, E.L.Cançado, G.Porta, F.J.Carrilho, A.Q.Farias, S.A.Palacios, J.M.Chiarella, C.P.Abrantes-Lemos, V.L.Baggio, A.A.Laudanna, and J.Kalil (1999).
Genetic heterogeneity in susceptibility to autoimmune hepatitis types 1 and 2.
  Am J Gastroenterol, 94, 1906-1913.  
  10630789 R.Azoury-Ziadeh, K.Herd, G.J.Fernando, I.H.Frazer, and R.W.Tindle (1999).
T-helper epitopes identified within the E6 transforming protein of cervical cancer-associated human papillomavirus type 16.
  Viral Immunol, 12, 297-312.  
10571772 R.G.Phelps, and A.J.Rees (1999).
The HLA complex in Goodpasture's disease: a model for analyzing susceptibility to autoimmunity.
  Kidney Int, 56, 1638-1653.  
10455165 R.L.Rich, C.C.Deivanayagam, R.T.Owens, M.Carson, A.Höök, D.Moore, J.Symersky, V.W.Yang, S.V.Narayana, and M.Höök (1999).
Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, alpha(1)beta(1) integrin and Staphylococcus aureus cna MSCRAMM.
  J Biol Chem, 274, 24906-24913.
PDB code: 1qc5
10049939 R.Pieper, R.E.Christian, M.I.Gonzales, M.I.Nishimura, G.Gupta, R.E.Settlage, J.Shabanowitz, S.A.Rosenberg, D.F.Hunt, and S.L.Topalian (1999).
Biochemical identification of a mutated human melanoma antigen recognized by CD4(+) T cells.
  J Exp Med, 189, 757-766.  
10631948 R.R.Latek, and E.R.Unanue (1999).
Mechanisms and consequences of peptide selection by the I-Ak class II molecule.
  Immunol Rev, 172, 209-228.  
  10520901 R.Riechers, J.Grötzinger, and M.Hertl (1999).
HLA class II restriction of autoreactive T cell responses in pemphigus vulgaris: review of the literature and potential applications for the development of a specific immunotherapy.
  Autoimmunity, 30, 183-196.  
10631947 R.Wubbolts, and J.Neefjes (1999).
Intracellular transport and peptide loading of MHC class II molecules: regulation by chaperones and motors.
  Immunol Rev, 172, 189-208.  
10551417 S.Djoulah, M.Busson, T.Sasazuki, B.Maillere, S.Yasunaga, A.Kimura, D.Charron, and J.Hors (1999).
A new predictive model for insulin-dependent diabetes mellitus susceptibility based on combinations of molecular HLA-DRB1 and HLA-DQB1 pockets.
  Tissue Antigens, 54, 341-348.  
10323462 S.Hawke, H.Matsuo, M.Nicolle, P.Wordsworth, L.Corlett, E.Spack, S.Deshpande, P.C.Driscoll, and N.Willcox (1999).
Cross-restriction of a T cell clone to HLA-DR alleles associated with rheumatoid arthritis: clues to arthritogenic peptide motifs.
  Arthritis Rheum, 42, 1040-1050.  
  10614742 S.Macphail (1999).
Superantigens: mechanisms by which they may induce, exacerbate and control autoimmune diseases.
  Int Rev Immunol, 18, 141-180.  
10319881 S.Piyasirisilp, B.J.Schmeckpeper, D.Chandanayingyong, T.Hemachudha, and D.E.Griffin (1999).
Association of HLA and T-cell receptor gene polymorphisms with Semple rabies vaccine-induced autoimmune encephalomyelitis.
  Ann Neurol, 45, 595-600.  
10233712 T.Sai, M.Mine, M.Fukuoka, S.Koarada, and M.Kimoto (1999).
A mutational analysis of the Abetaz/Aalphad major histocompatibility complex class II molecule that restricts autoreactive T cells in (NZBxNZW)F1 mice. The critical influence of alanine at position 69 in the Aalphad chain.
  Immunology, 96, 325-332.  
10025914 U.Kurzik-Dumke, C.Schick, R.Rzepka, and I.Melchers (1999).
Overexpression of human homologs of the bacterial DnaJ chaperone in the synovial tissue of patients with rheumatoid arthritis.
  Arthritis Rheum, 42, 210-220.  
9836367 A.P.Cope, and G.Sønderstrup (1998).
Evaluating candidate autoantigens in rheumatoid arthritis.
  Springer Semin Immunopathol, 20, 23-39.  
9650099 B.Diethelm-Okita, G.B.Wells, A.Kuryatov, D.Okita, J.Howard, J.M.Lindstrom, and B.M.Conti-Fine (1998).
Response of CD4+ T cells from myasthenic patients and healthy subjects of biosynthetic and synthetic sequences of the nicotinic acetylcholine receptor.
  J Autoimmun, 11, 191-203.  
9668248 B.M.Conti-Fine, D.Navaneetham, P.I.Karachunski, R.Raju, B.Diethelm-Okita, D.Okita, J.Howard, and Z.Y.Wang (1998).
T cell recognition of the acetylcholine receptor in myasthenia gravis.
  Ann N Y Acad Sci, 841, 283-308.  
  9521118 C.A.Scott, K.C.Garcia, E.A.Stura, P.A.Peterson, I.A.Wilson, and L.Teyton (1998).
Engineering protein for X-ray crystallography: the murine Major Histocompatibility Complex class II molecule I-Ad.
  Protein Sci, 7, 413-418.  
9529149 C.A.Scott, P.A.Peterson, L.Teyton, and I.A.Wilson (1998).
Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues.
  Immunity, 8, 319-329.
PDB codes: 1iao 2iad
9620675 C.Daniel, S.Horvath, and P.M.Allen (1998).
A basis for alloreactivity: MHC helical residues broaden peptide recognition by the TCR.
  Immunity, 8, 543-552.  
9565642 C.Lee, M.N.Liang, K.M.Tate, J.D.Rabinowitz, C.Beeson, P.P.Jones, and H.M.McConnell (1998).
Evidence that the autoimmune antigen myelin basic protein (MBP) Ac1-9 binds towards one end of the major histocompatibility complex (MHC) cleft.
  J Exp Med, 187, 1505-1516.  
9836366 C.M.Weyand, P.A.Klimiuk, and J.J.Goronzy (1998).
Heterogeneity of rheumatoid arthritis: from phenotypes to genotypes.
  Springer Semin Immunopathol, 20, 5.  
9668262 D.Beeson, A.P.Bond, L.Corlett, S.J.Curnow, M.E.Hill, L.W.Jacobson, C.MacLennan, A.Meager, A.M.Moody, P.Moss, N.Nagvekar, J.Newsom-Davis, N.Pantic, I.Roxanis, E.G.Spack, A.Vincent, and N.Willcox (1998).
Thymus, thymoma, and specific T cells in myasthenia gravis.
  Ann N Y Acad Sci, 841, 371-387.  
9759354 D.Gerlier, M.C.Trescol-Biémont, L.Ettouati, J.Paris, and C.Rabourdin-Combe (1998).
An accessory peptide binding site with allosteric effect on the formation of peptide-MHC-II complexes?
  C R Acad Sci III, 321, 19-24.  
9529148 D.H.Fremont, D.Monnaie, C.A.Nelson, W.A.Hendrickson, and E.R.Unanue (1998).
Crystal structure of I-Ak in complex with a dominant epitope of lysozyme.
  Immunity, 8, 305-317.
PDB code: 1iak
  9765031 D.Ou, L.A.Mitchell, D.Décarie, A.J.Tingle, M.Lacroix, and M.Zrein (1998).
Point mutation of a rubella virus E1 protein T-cell epitope by substitution of single amino acid reversed the restrictive HLA-DR polymorphism: a possible mechanism maintaining HLA polymorphism.
  Viral Immunol, 11, 93.  
9636191 E.C.Andersson, B.E.Hansen, H.Jacobsen, L.S.Madsen, C.B.Andersen, J.Engberg, J.B.Rothbard, G.S.McDevitt, V.Malmström, R.Holmdahl, A.Svejgaard, and L.Fugger (1998).
Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice.
  Proc Natl Acad Sci U S A, 95, 7574-7579.  
9695948 E.Conti, M.Uy, L.Leighton, G.Blobel, and J.Kuriyan (1998).
Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha.
  Cell, 94, 193-204.
PDB codes: 1bk5 1bk6
9459499 F.E.L'Faqihi, C.Praud, B.Yassine-Diab, G.Enault, F.Lakhdar-Ghazal, Préval, and H.Coppin (1998).
Residue 67 in the DRbeta1*0101 and DRbeta1*0103 chains strongly influences antigen presentation and DR-peptide molecular complex conformation.
  Tissue Antigens, 51, 10-19.  
9815256 G.C.Harcourt, S.Garrard, M.P.Davenport, A.Edwards, and R.E.Phillips (1998).
HIV-1 variation diminishes CD4 T lymphocyte recognition.
  J Exp Med, 188, 1785-1793.  
9714471 G.Díaz, M.Catálfamo, M.T.Coiras, A.M.Alvarez, D.Jaraquemada, C.Nombela, M.Sánchez-Pérez, and J.Arroyo (1998).
HLA-DPbeta residue 69 plays a crucial role in allorecognition.
  Tissue Antigens, 52, 27-36.  
9824493 H.Senpuku, K.Yanagi, and T.Nisizawa (1998).
Identification of Streptococcus mutans PAc peptide motif binding with human MHC class II molecules (DRB1*0802, *1101, *1401 and *1405).
  Immunology, 95, 322-330.  
9506435 H.U.Weltzien, and E.Padovan (1998).
Molecular features of penicillin allergy.
  J Invest Dermatol, 110, 203-206.  
9523114 I.A.Wilson, and P.J.Bjorkman (1998).
Unusual MHC-like molecules: CD1, Fc receptor, the hemochromatosis gene product, and viral homologs.
  Curr Opin Immunol, 10, 67-73.  
9700498 I.D.Campbell (1998).
The modular architecture of leukocyte cell-surface receptors.
  Immunol Rev, 163, 11-18.  
  9609134 I.Durinovic-Belló (1998).
Autoimmune diabetes: the role of T cells, MHC molecules and autoantigens.
  Autoimmunity, 27, 159-177.  
9842927 I.Khalil-Daher, F.Boisgérault, J.P.Feugeas, V.Tieng, A.Toubert, and D.Charron (1998).
Naturally processed peptides from HLA-DQ7 (alpha1*0501-beta1*0301): influence of both alpha and beta chain polymorphism in the HLA-DQ peptide binding specificity.
  Eur J Immunol, 28, 3840-3849.  
9844827 J.Alexander, J.Fikes, S.Hoffman, E.Franke, J.Sacci, E.Appella, F.V.Chisari, L.G.Guidotti, R.W.Chesnut, B.Livingston, and A.Sette (1998).
The optimization of helper T lymphocyte (HTL) function in vaccine development.
  Immunol Res, 18, 79-92.  
9846491 J.D.Rabinowitz, M.Vrljic, P.M.Kasson, M.N.Liang, R.Busch, J.J.Boniface, M.M.Davis, and H.M.McConnell (1998).
Formation of a highly peptide-receptive state of class II MHC.
  Immunity, 9, 699-709.  
9645372 J.M.Bach, H.Otto, G.Jung, H.Cohen, C.Boitard, J.F.Bach, and P.M.van Endert (1998).
Identification of mimicry peptides based on sequential motifs of epitopes derived from 65-kDa glutamic acid decarboxylase.
  Eur J Immunol, 28, 1902-1910.  
9782128 K.J.Smith, J.Pyrdol, L.Gauthier, D.C.Wiley, and K.W.Wucherpfennig (1998).
Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein.
  J Exp Med, 188, 1511-1520.
PDB code: 1bx2
9751750 L.Gauthier, K.J.Smith, J.Pyrdol, A.Kalandadze, J.L.Strominger, D.C.Wiley, and K.W.Wucherpfennig (1998).
Expression and crystallization of the complex of HLA-DR2 (DRA, DRB1*1501) and an immunodominant peptide of human myelin basic protein.
  Proc Natl Acad Sci U S A, 95, 11828-11833.  
9768757 L.Mosyak, D.M.Zaller, and D.C.Wiley (1998).
The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation.
  Immunity, 9, 377-383.
PDB code: 1hdm
9520453 M.Congia, S.Patel, A.P.Cope, S.De Virgiliis, and G.Sønderstrup (1998).
T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin.
  Proc Natl Acad Sci U S A, 95, 3833-3838.  
  9525574 M.E.Grigg, C.W.McMahon, S.Morkowski, A.Y.Rudensky, and A.M.Pullen (1998).
Mtv-1 superantigen trafficks independently of major histocompatibility complex class II directly to the B-cell surface by the exocytic pathway.
  J Virol, 72, 2577-2588.  
9802608 M.F.González-Escribano, G.Jiménez, K.Walter, M.Montes, A.M.Perez-Bernal, M.R.Rodríguez, J.S.Conejo-Mir, and A.Núñez-Roldán (1998).
Distribution of HLA class II alleles among Spanish patients with pemphigus vulgaris.
  Tissue Antigens, 52, 275-278.  
9824474 M.Feng, D.Chou, Y.Liaw, and M.Lai (1998).
Conserved T-cell receptor class II major histocompatibility complex contact detected in a T-lymphocyte population.
  Immunology, 95, 185-192.  
9770519 M.Fridkis-Hareli, E.F.Rosloniec, L.Fugger, and J.L.Strominger (1998).
Synthetic amino acid copolymers that bind to HLA-DR proteins and inhibit type II collagen-reactive T cell clones.
  Proc Natl Acad Sci U S A, 95, 12528-12531.  
9543084 M.Raulf-Heimsoth, Z.Chen, H.P.Rihs, H.Kalbacher, V.Liebers, and X.Baur (1998).
Analysis of T-cell reactive regions and HLA-DR4 binding motifs on the latex allergen Hev b 1 (rubber elongation factor).
  Clin Exp Allergy, 28, 339-348.  
9665697 M.S.Hasson, A.Muscate, M.J.McLeish, L.S.Polovnikova, J.A.Gerlt, G.L.Kenyon, G.A.Petsko, and D.Ringe (1998).
The crystal structure of benzoylformate decarboxylase at 1.6 A resolution: diversity of catalytic residues in thiamin diphosphate-dependent enzymes.
  Biochemistry, 37, 9918-9930.
PDB code: 1bfd
9511982 M.Zamani, and J.J.Cassiman (1998).
Reevaluation of the importance of polymorphic HLA class II alleles and amino acids in the susceptibility of individuals of different populations to type I diabetes.
  Am J Med Genet, 76, 183-194.  
9762356 N.Katunuma, Y.Matsunaga, A.Matsui, H.Kakegawa, K.Endo, T.Inubushi, T.Saibara, Y.Ohba, and T.Kakiuchi (1998).
Novel physiological functions of cathepsins B and L on antigen processing and osteoclastic bone resorption.
  Adv Enzyme Regul, 38, 235-251.  
9643627 P.J.Fairchild (1998).
Presentation of antigenic peptides by products of the major histocompatibility complex.
  J Pept Sci, 4, 182-194.  
9521085 P.Kjellén, U.Brunsberg, J.Broddefalk, B.Hansen, M.Vestberg, I.Ivarsson, A.Engström, A.Svejgaard, J.Kihlberg, L.Fugger, and R.Holmdahl (1998).
The structural basis of MHC control of collagen-induced arthritis; binding of the immunodominant type II collagen 256-270 glycopeptide to H-2Aq and H-2Ap molecules.
  Eur J Immunol, 28, 755-767.  
  10072085 R.R.Mallios (1998).
Iterative stepwise discriminant analysis: a meta-algorithm for detecting quantitative sequence motifs.
  J Comput Biol, 5, 703-711.  
9841927 S.Ceman, S.Wu, T.S.Jardetzky, and A.J.Sant (1998).
Alteration of a single hydrogen bond between class II molecules and peptide results in rapid degradation of class II molecules after invariant chain removal.
  J Exp Med, 188, 2139-2149.  
9990359 S.H.Jee, T.F.Tsai, W.L.Tsai, S.H.Liaw, C.H.Chang, and C.Y.Hu (1998).
HLA-DRB1*0701 and DRB1*1401 are associated with genetic susceptibility to psoriasis vulgaris in a Taiwanese population.
  Br J Dermatol, 139, 978-983.  
9668090 S.Krebs, J.R.Lamas, S.Poenaru, G.Folkers, Castro, D.Seebach, and D.Rognan (1998).
Substituting nonpeptidic spacers for the T cell receptor-binding part of class I major histocompatibility complex-binding peptides.
  J Biol Chem, 273, 19072-19079.  
9843387 S.Nishimura, H.Kandori, and A.Maeda (1998).
Interaction between photoactivated rhodopsin and the C-terminal peptide of transducin alpha-subunit studied by FTIR spectroscopy.
  Biochemistry, 37, 15816-15824.  
9862341 T.Gyotoku, Y.Fukui, and T.Sasazuki (1998).
An endogenously processed self peptide and the corresponding exogenous peptide bound to the same MHC class II molecule could be distinct ligands for TCR with different kinetic stability.
  Eur J Immunol, 28, 4050-4061.  
9756400 T.H.Eiermann, F.Bettens, P.Tiberghien, K.Schmitz, I.Beurton, S.Bresson-Hadni, R.W.Ammann, S.F.Goldmann, D.A.Vuitton, B.Gottstein, and P.Kern (1998).
HLA and alveolar echinococcosis.
  Tissue Antigens, 52, 124-129.  
9811813 T.L.Benzinger, D.M.Gregory, T.S.Burkoth, H.Miller-Auer, D.G.Lynn, R.E.Botto, and S.C.Meredith (1998).
Propagating structure of Alzheimer's beta-amyloid(10-35) is parallel beta-sheet with residues in exact register.
  Proc Natl Acad Sci U S A, 95, 13407-13412.  
9707600 Y.Ghendler, M.K.Teng, J.H.Liu, T.Witte, J.Liu, K.S.Kim, P.Kern, H.C.Chang, J.H.Wang, and E.L.Reinherz (1998).
Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands.
  Proc Natl Acad Sci U S A, 95, 10061-10066.
PDB code: 1osz
  10036633 Y.Nishimura, M.Oiso, S.Fujisao, T.Kanai, J.Kira, Y.Z.Chen, and S.Matsushita (1998).
Peptide-based molecular analyses of HLA class II-associated susceptibility to autoimmune diseases.
  Int Rev Immunol, 17, 229-262.  
  9307981 A.Brack, A.Geisler, V.M.Martinez-Taboada, B.R.Younge, J.J.Goronzy, and C.M.Weyand (1997).
Giant cell vasculitis is a T cell-dependent disease.
  Mol Med, 3, 530-543.  
9354468 A.Dessen, C.M.Lawrence, S.Cupo, D.M.Zaller, and D.C.Wiley (1997).
X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II.
  Immunity, 7, 473-481.
PDB code: 2seb
9213257 A.Kamata, M.Chiba, N.Ishii, T.Kudo, Y.Horie, M.Iizuka, and O.Masamune (1997).
Three cases of familial ulcerative colitis--in a mother and two of her sons.
  J Gastroenterol, 32, 401-404.  
9451596 A.M.Boots, G.F.Verheijden, R.Schöningh, C.J.van Staveren, E.Bos, D.Elewaut, Keyser, E.Veys, I.Joosten, and A.W.Rijnders (1997).
Selection of self-reactive peptides within human aggrecan by use of a HLA-DRB1*0401 peptide binding motif.
  J Autoimmun, 10, 569-578.  
9357312 B.Fineschi, and J.Miller (1997).
Endosomal proteases and antigen processing.
  Trends Biochem Sci, 22, 377-382.  
9151902 B.Hemmer, B.T.Fleckenstein, M.Vergelli, G.Jung, H.McFarland, R.Martin, and K.H.Wiesmüller (1997).
Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone.
  J Exp Med, 185, 1651-1659.  
9368599 B.Reizis, D.M.Altmann, and I.R.Cohen (1997).
Biochemical characterization of the human diabetes-associated HLA-DQ8 allelic product: similarity to the major histocompatibility complex class II I-A(g)7 protein of non-obese diabetic mice.
  Eur J Immunol, 27, 2478-2483.  
9243758 C.B.Sanjeevi, C.DeWeese, M.Landin-Olsson, I.Kockum, G.Dahlquist, A.Lernmark, and T.P.Lybrand (1997).
Analysis of critical residues of HLA-DQ6 molecules in insulin-dependent diabetes mellitus.
  Tissue Antigens, 50, 61-65.  
9186677 C.M.Weyand, and J.J.Goronzy (1997).
Correlation between HLA-DR sequence polymorphisms and rheumatoid factor production.
  Ann N Y Acad Sci, 815, 353-356.  
9442878 D.J.Leahy (1997).
Implications of atomic-resolution structures for cell adhesion.
  Annu Rev Cell Dev Biol, 13, 363-393.  
9209477 E.Padovan, T.Bauer, M.M.Tongio, H.Kalbacher, and H.U.Weltzien (1997).
Penicilloyl peptides are recognized as T cell antigenic determinants in penicillin allergy.
  Eur J Immunol, 27, 1303-1307.  
9389315 E.Pareja, R.Tobes, J.Martín, and A.Nieto (1997).
The tetramer model: a new view of class II MHC molecules in antigenic presentation to T cells.
  Tissue Antigens, 50, 421-428.  
9464794 E.Rajnavölgyi, A.Horváth, P.Gogolák, G.K.Tóth, G.Fazekas, M.Fridkin, and I.Pecht (1997).
Characterizing immunodominant and protective influenza hemagglutinin epitopes by functional activity and relative binding to major histocompatibility complex class II sites.
  Eur J Immunol, 27, 3105-3114.  
9039781 E.S.Ward, and A.Qadri (1997).
Biophysical and structural studies of TCRs and ligands: implications for T cell signaling.
  Curr Opin Immunol, 9, 97.  
9039778 E.Y.Jones (1997).
MHC class I and class II structures.
  Curr Opin Immunol, 9, 75-79.  
9360989 G.Aichinger, L.Karlsson, M.R.Jackson, M.Vestberg, J.H.Vaughan, L.Teyton, R.I.Lechler, and P.A.Peterson (1997).
Major histocompatibility complex class II-dependent unfolding, transport, and degradation of endogenous proteins.
  J Biol Chem, 272, 29127-29136.  
9208845 G.Dadaglio, C.A.Nelson, M.B.Deck, S.J.Petzold, and E.R.Unanue (1997).
Characterization and quantitation of peptide-MHC complexes produced from hen egg lysozyme using a monoclonal antibody.
  Immunity, 6, 727-738.  
9182922 G.F.Verheijden, A.W.Rijnders, E.Bos, C.J.Coenen-de Roo, C.J.van Staveren, A.M.Miltenburg, J.H.Meijerink, D.Elewaut, Keyser, E.Veys, and A.M.Boots (1997).
Human cartilage glycoprotein-39 as a candidate autoantigen in rheumatoid arthritis.
  Arthritis Rheum, 40, 1115-1125.  
9396749 G.Ferrari, A.M.Knight, C.Watts, and J.Pieters (1997).
Distinct intracellular compartments involved in invariant chain degradation and antigenic peptide loading of major histocompatibility complex (MHC) class II molecules.
  J Cell Biol, 139, 1433-1446.  
9238041 J.D.Rabinowitz, K.Tate, C.Lee, C.Beeson, and H.M.McConnell (1997).
Specific T cell recognition of kinetic isomers in the binding of peptide to class II major histocompatibility complex.
  Proc Natl Acad Sci U S A, 94, 8702-8707.  
9166421 J.L.Seibel, N.Wilson, H.Kozono, P.Marrack, and J.W.Kappler (1997).
Influence of the NH2-terminal amino acid of the T cell receptor alpha chain on major histocompatibility complex (MHC) class II + peptide recognition.
  J Exp Med, 185, 1919-1927.  
9027964 J.M.Ellis, N.Steiner, J.Wang, T.T.Tang, and C.K.Hurley (1997).
Diversity and evolution of the DRB1*03 family: description of DRB1*03022,*0307,*0308.
  Tissue Antigens, 49, 41-45.  
9039772 J.Pieters (1997).
MHC class II restricted antigen presentation.
  Curr Opin Immunol, 9, 89-96.  
9342218 J.Stöckel, K.Döring, J.Malotka, F.Jähnig, and K.Dornmair (1997).
Pathway of detergent-mediated and peptide ligand-mediated refolding of heterodimeric class II major histocompatibility complex (MHC) molecules.
  Eur J Biochem, 248, 684-691.  
9207120 J.van Bergen, S.P.Schoenberger, F.Verreck, R.Amons, R.Offringa, and F.Koning (1997).
Efficient loading of HLA-DR with a T helper epitope by genetic exchange of CLIP.
  Proc Natl Acad Sci U S A, 94, 7499-7502.  
9209489 K.Bartnes, K.Hannestad, G.Guichard, and J.P.Briand (1997).
A retro-inverso analog mimics the cognate peptide epitope of a CD4+ T cell clone.
  Eur J Immunol, 27, 1387-1391.  
9379075 K.D.Smith, Z.B.Kurago, and C.T.Lutz (1997).
Conformational changes in MHC class I molecules. Antibody, T-cell receptor, and NK cell recognition in an HLA-B7 model system.
  Immunol Res, 16, 243-259.  
9416863 K.Higami, M.Hakoda, Y.Matsuda, H.Ueda, and S.Kashiwazaki (1997).
Lack of association of HLA-DRB1 genotype with radiologic progression in Japanese patients with early rheumatoid arthritis.
  Arthritis Rheum, 40, 2241-2247.  
9276728 K.W.Wucherpfennig, I.Catz, S.Hausmann, J.L.Strominger, L.Steinman, and K.G.Warren (1997).
Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes.
  J Clin Invest, 100, 1114-1122.  
9209501 L.J.Tan, S.Ceman, A.Chervonsky, J.Rodriguez-Paris, T.L.Steck, and A.J.Sant (1997).
Late events in the intracellular sorting of major histocompatibility complex class II molecules are regulated by the 80-82 segment of the class II beta chain.
  Eur J Immunol, 27, 1479-1488.  
9151386 L.K.Gaur, G.T.Nepom, K.E.Snyder, J.Anderson, M.Pandarpurkar, W.Yadock, and E.R.Heise (1997).
MHC-DRB allelic sequences incorporate distinct intragenic trans-specific segments.
  Tissue Antigens, 49, 342-355.  
9316393 M.A.Batalia, and E.J.Collins (1997).
Peptide binding by class I and class II MHC molecules.
  Biopolymers, 43, 281-302.  
8995737 M.Fisher, C.D.Pusey, R.W.Vaughan, and A.J.Rees (1997).
Susceptibility to anti-glomerular basement membrane disease is strongly associated with HLA-DRB1 genes.
  Kidney Int, 51, 222-229.  
9011573 M.S.Lin, S.J.Swartz, A.Lopez, X.Ding, M.A.Fernandez-Vina, P.Stastny, J.A.Fairley, and L.A.Diaz (1997).
Development and characterization of desmoglein-3 specific T cells from patients with pemphigus vulgaris.
  J Clin Invest, 99, 31-40.  
9234492 N.Martínez-Quiles, J.M.Martin-Villa, J.Martínez-Laso, M.Perez-Blas, S.Ferre-Lopez, M.A.Moreno-Pelayo, M.Alvarez-Tejado, and A.Arnaiz-Villena (1997).
Description of two new HLA-DRB alleles (DRB1*0310 and DRB3*01012) found in a Spanish infant.
  Tissue Antigens, 49, 658-661.  
9405666 O.Rötzschke, K.Falk, and J.L.Strominger (1997).
Superactivation of an immune response triggered by oligomerized T cell epitopes.
  Proc Natl Acad Sci U S A, 94, 14642-14647.  
9316394 P.E.Jensen (1997).
Peptide binding and antigen presentation by class II histocompatibility glycoproteins.
  Biopolymers, 43, 303-322.  
9027973 P.Perrier, C.Reveillère, and A.Schuhmacher (1997).
A new DRB1 allele (DRB1*1125) sharing DR11 and DR8 sequence motifs.
  Tissue Antigens, 49, 84-87.  
9312039 P.Stumptner, and P.Benaroch (1997).
Interaction of MHC class II molecules with the invariant chain: role of the invariant chain (81-90) region.
  EMBO J, 16, 5807-5818.  
9324359 R.T.Carson, K.M.Vignali, D.L.Woodland, and D.A.Vignali (1997).
T cell receptor recognition of MHC class II-bound peptide flanking residues enhances immunogenicity and results in altered TCR V region usage.
  Immunity, 7, 387-399.  
9062974 S.Israel, A.G.Smith, K.Miller, A.Marashi, J.A.Hansen, and C.Brautbar (1997).
Two new DR2 alleles: DRB1*1607 identified in an Ashkenazi Jewish family and DRB1*15022 found in a single Caucasian donor.
  Tissue Antigens, 49, 173-175.  
9046437 S.M.Weenink, and A.M.Gautam (1997).
Antigen presentation by MHC class II molecules.
  Immunol Cell Biol, 75, 69-81.  
9379076 S.O.Arndt, A.B.Vogt, G.J.Hämmerling, and H.Kropshofer (1997).
Selection of the MHC class II-associated peptide repertoire by HLA-DM.
  Immunol Res, 16, 261-272.  
9351812 V.L.Murthy, and L.J.Stern (1997).
The class II MHC protein HLA-DR1 in complex with an endogenous peptide: implications for the structural basis of the specificity of peptide binding.
  Structure, 5, 1385-1396.
PDB code: 1aqd
9295029 X.Zhu, S.Bavari, R.Ulrich, S.Sadegh-Nasseri, S.Ferrone, L.McHugh, and M.Mage (1997).
A recombinant single-chain human class II MHC molecule (HLA-DR1) as a covalently linked heterotrimer of alpha chain, beta chain, and antigenic peptide, with immunogenicity in vitro and reduced affinity for bacterial superantigens.
  Eur J Immunol, 27, 1933-1941.  
9342360 Y.Itoh, K.Kajino, K.Ogasawara, A.Takahashi, K.Namba, I.Negishi, N.Matsuki, K.Iwabuchi, M.Kakinuma, R.A.Good, and K.Onoé (1997).
Interaction of pigeon cytochrome c-(43-58) peptide analogs with either T cell antigen receptor or I-Ab molecule.
  Proc Natl Acad Sci U S A, 94, 12047-12052.  
8883301 A.G.Smith, J.L.Nelson, L.Regen, L.A.Guthrie, E.Donadi, E.M.Mickelson, and J.A.Hansen (1996).
Six new DR52-associated DRB1 alleles, three of DR8, two of DR11, and one of DR6, reflect a variety of mechanisms which generate polymorphism in the MHC.
  Tissue Antigens, 48, 118-126.  
8702739 A.Kalandadze, M.Galleno, L.Foncerrada, J.L.Strominger, and K.W.Wucherpfennig (1996).
Expression of recombinant HLA-DR2 molecules. Replacement of the hydrophobic transmembrane region by a leucine zipper dimerization motif allows the assembly and secretion of soluble DR alpha beta heterodimers.
  J Biol Chem, 271, 20156-20162.  
  8782740 A.M.Krensky, and C.Clayberger (1996).
Structure of HLA molecules and immunosuppressive effects of HLA derived peptides.
  Int Rev Immunol, 13, 173-185.  
8851732 B.B.Cizman, S.D.Heron, M.E.McKeen, D.J.Kearns, S.Bassinger, B.B.Griffith, E.G.Argyris, M.Kamoun, C.M.Zmijewski, T.M.Williams, and D.S.Monos (1996).
Identification of DRB1 allele (DRB1*1316) with aspartate at position 86: evolutionary considerations and functional implications.
  Tissue Antigens, 47, 153-154.  
8636413 B.Chauhan, A.Knutsen, P.S.Hutcheson, R.G.Slavin, and C.J.Bellone (1996).
T cell subsets, epitope mapping, and HLA-restriction in patients with allergic bronchopulmonary aspergillosis.
  J Clin Invest, 97, 2324-2331.  
  8797837 B.Fleckenstein, H.Kalbacher, C.P.Muller, D.Stoll, T.Halder, G.Jung, and K.H.Wiesmüller (1996).
New ligands binding to the human leukocyte antigen class II molecule DRB1*0101 based on the activity pattern of an undecapeptide library.
  Eur J Biochem, 240, 71-77.  
8626615 B.Nag, S.Arimilli, P.V.Mukku, and I.Astafieva (1996).
Functionally active recombinant alpha and beta chain-peptide complexes of human major histocompatibility class II molecules.
  J Biol Chem, 271, 10413-10418.  
8692969 B.S.Nepom, G.T.Nepom, M.Coleman, and W.W.Kwok (1996).
Critical contribution of beta chain residue 57 in peptide binding ability of both HLA-DR and -DQ molecules.
  Proc Natl Acad Sci U S A, 93, 7202-7206.  
8872486 C.A.Nelson, N.J.Viner, and E.R.Unanue (1996).
Appreciating the complexity of MHC class II peptide binding: lysozyme peptide and I-Ak.
  Immunol Rev, 151, 81.  
8773316 C.B.Sanjeevi, P.Höök, M.Landin-Olsson, I.Kockum, G.Dahlquist, T.P.Lybrand, and A.Lernmark (1996).
DR4 subtypes and their molecular properties in a population-based study of Swedish childhood diabetes.
  Tissue Antigens, 47, 275-283.  
8760833 C.Beeson, J.Rabinowitz, K.Tate, I.Gütgemann, Y.H.Chien, P.P.Jones, M.M.Davis, and H.M.McConnell (1996).
Early biochemical signals arise from low affinity TCR-ligand reactions at the cell-cell interface.
  J Exp Med, 184, 777-782.  
8612131 D.B.Sant'Angelo, G.Waterbury, P.Preston-Hurlburt, S.T.Yoon, R.Medzhitov, S.C.Hong, and C.A.Janeway (1996).
The specificity and orientation of a TCR to its peptide-MHC class II ligands.
  Immunity, 4, 367-376.  
8729452 D.H.Fremont, W.A.Rees, and H.Kozono (1996).
Biophysical studies of T-cell receptors and their ligands.
  Curr Opin Immunol, 8, 93.  
8760818 D.J.Loftus, C.Castelli, T.M.Clay, P.Squarcina, F.M.Marincola, M.I.Nishimura, G.Parmiani, E.Appella, and L.Rivoltini (1996).
Identification of epitope mimics recognized by CTL reactive to the melanoma/melanocyte-derived peptide MART-1(27-35).
  J Exp Med, 184, 647-657.  
8879196 D.Plaksin, S.Chacko, P.McPhie, A.Bax, E.A.Padlan, and D.H.Margulies (1996).
A T cell receptor V alpha domain expressed in bacteria: does it dimerize in solution?
  J Exp Med, 184, 1251-1258.  
  8557355 E.J.Wiertz, A.Delvig, E.M.Donders, H.F.Brugghe, L.M.van Unen, H.A.Timmermans, M.Achtman, P.Hoogerhout, and J.T.Poolman (1996).
T-cell responses to outer membrane proteins of Neisseria meningitidis: comparative study of the Opa, Opc, and PorA proteins.
  Infect Immun, 64, 298-304.  
8765038 E.Michaëlsson, J.Broddefalk, A.Engström, J.Kihlberg, and R.Holmdahl (1996).
Antigen processing and presentation of a naturally glycosylated protein elicits major histocompatibility complex class II-restricted, carbohydrate-specific T cells.
  Eur J Immunol, 26, 1906-1910.  
8606061 F.A.Verreck, A.van de Poel, J.W.Drijfhout, R.Amons, J.E.Coligan, and F.Konig (1996).
Natural peptides isolated from Gly86/Val86-containing variants of HLA-DR1, -DR11, -DR13, and -DR52.
  Immunogenetics, 43, 392-397.  
8574855 F.Sanderson, C.Thomas, J.Neefjes, and J.Trowsdale (1996).
Association between HLA-DM and HLA-DR in vivo.
  Immunity, 4, 87-96.  
8921967 F.Vartdal, B.H.Johansen, T.Friede, C.J.Thorpe, S.Stevanović, J.E.Eriksen, K.Sletten, E.Thorsby, H.G.Rammensee, and L.M.Sollid (1996).
The peptide binding motif of the disease associated HLA-DQ (alpha 1* 0501, beta 1* 0201) molecule.
  Eur J Immunol, 26, 2764-2772.  
8855288 G.A.Weiss, R.J.Valentekovich, E.J.Collins, D.N.Garboczi, W.S.Lane, S.L.Schreiber, and D.C.Wiley (1996).
Covalent HLA-B27/peptide complex induced by specific recognition of an aziridine mimic of arginine.
  Proc Natl Acad Sci U S A, 93, 10945-10948.  
8814236 G.Eberl, C.Widmann, and G.Corradin (1996).
The functional half-life of H-2Kd-restricted T cell epitopes on living cells.
  Eur J Immunol, 26, 1993-1999.  
8625994 G.T.Nepom, D.Ou, T.P.Lybrand, C.DeWeese, M.E.Domeier, J.H.Buckner, L.A.Mitchell, and A.J.Tingle (1996).
Recognition of altered self major histocompatibility complex molecules modulated by specific peptide interactions.
  Eur J Immunol, 26, 949-952.  
8551215 H.A.Runnels, J.C.Moore, and P.E.Jensen (1996).
A structural transition in class II major histocompatibility complex proteins at mildly acidic pH.
  J Exp Med, 183, 127-136.  
8621558 H.Chen, and D.F.Mosher (1996).
Formation of sodium dodecyl sulfate-stable fibronectin multimers. Failure to detect products of thiol-disulfide exchange in cyanogen bromide or limited acid digests of stabilized matrix fibronectin.
  J Biol Chem, 271, 9084-9089.  
8781122 H.Kobayashi, T.Kokubo, Y.Abe, K.Sato, S.Kimura, N.Miyokawa, and M.Katagiri (1996).
Analysis of anchor residues in a naturally processed HLA-DR53 ligand.
  Immunogenetics, 44, 366-371.  
  8947036 H.Kropshofer, A.B.Vogt, G.Moldenhauer, J.Hammer, J.S.Blum, and G.J.Hämmerling (1996).
Editing of the HLA-DR-peptide repertoire by HLA-DM.
  EMBO J, 15, 6144-6154.  
  8690461 H.Senpuku, T.Iizima, Y.Yamaguchi, S.Nagata, Y.Ueno, M.Saito, N.Hanada, and T.Nisizawa (1996).
Immunogenicity of peptides coupled with multiple T-cell epitopes of a surface protein antigen of Streptococcus mutans.
  Immunology, 88, 275-283.  
8551214 J.J.Boniface, D.S.Lyons, D.A.Wettstein, N.L.Allbritton, and M.M.Davis (1996).
Evidence for a conformational change in a class II major histocompatibility complex molecule occurring in the same pH range where antigen binding is enhanced.
  J Exp Med, 183, 119-126.  
8642315 J.V.Brawley, and P.Concannon (1996).
Modulation of promiscuous T cell receptor recognition by mutagenesis of CDR2 residues.
  J Exp Med, 183, 2043-2051.  
8702669 J.Zhang, and G.C.Walker (1996).
Identification of elements of the peptide binding site of DnaK by peptide cross-linking.
  J Biol Chem, 271, 19668-19674.  
8625966 K.I.Dawe, P.R.Hutchings, M.Geysen, B.R.Champion, A.Cooke, and I.M.Roitt (1996).
Unique role of thyroxine in T cell recognition of a pathogenic peptide in experimental autoimmune thyroiditis.
  Eur J Immunol, 26, 768-772.  
8625990 L.Fugger, J.B.Rothbard, and G.Sonderstrup-McDevitt (1996).
Specificity of an HLA-DRB1*0401-restricted T cell response to type II collagen.
  Eur J Immunol, 26, 928-933.  
  8726461 L.Fugger, J.Liang, A.Gautam, J.B.Rothbard, and H.O.McDevitt (1996).
Quantitative analysis of peptides from myelin basic protein binding to the MHC class II protein, I-Au, which confers susceptibility to experimental allergic encephalomyelitis.
  Mol Med, 2, 181-188.  
8642287 L.Zerva, B.Cizman, N.K.Mehra, S.K.Alahari, R.Murali, C.M.Zmijewski, M.Kamoun, and D.S.Monos (1996).
Arginine at positions 13 or 70-71 in pocket 4 of HLA-DRB1 alleles is associated with susceptibility to tuberculoid leprosy.
  J Exp Med, 183, 829-836.  
8765027 M.Breloer, S.Ehrlich, B.Fleischer, and A.von Bonin (1996).
A biological function for the XP motif within the N terminus of major histocompatibility complex class II-associated peptides.
  Eur J Immunol, 26, 1825-1829.  
8942634 M.N.Liang, C.Lee, Y.Xia, and H.M.McConnell (1996).
Molecular modeling and design of invariant chain peptides with altered dissociation kinetics from class II MHC.
  Biochemistry, 35, 14734-14742.  
8765035 P.E.Posch, A.E.Hastings, S.Rosen-Bronson, J.R.Richert, and C.K.Hurley (1996).
The relative importance of individual DR binding motif positions as defined by peptide anchor analysis of influenza hemagglutinin peptide 306-318 and human myelin basic protein peptide 152-165 binding to several DR molecules: definition of a common extended DR binding motif.
  Eur J Immunol, 26, 1884-1891.  
8700877 P.I.Neophytou, B.O.Roep, S.D.Arden, E.M.Muir, G.Duinkerken, A.Kallan, Vries, and J.C.Hutton (1996).
T-cell epitope analysis using subtracted expression libraries (TEASEL): application to a 38-kDA autoantigen recognized by T cells from an insulin-dependent diabetic patient.
  Proc Natl Acad Sci U S A, 93, 2014-2018.  
8729446 R.Busch, and E.D.Mellins (1996).
Developing and shedding inhibitions: how MHC class II molecules reach maturity.
  Curr Opin Immunol, 8, 51-58.  
  9003767 R.Lindner, and E.R.Unanue (1996).
Distinct antigen MHC class II complexes generated by separate processing pathways.
  EMBO J, 15, 6910-6920.  
8872483 R.N.German, F.Castellino, R.Han, C.Reis e Sousa, P.Romagnoli, S.Sadegh-Nasseri, and G.M.Zhong (1996).
Processing and presentation of endocytically acquired protein antigens by MHC class II and class I molecules.
  Immunol Rev, 151, 5.  
8799731 S.Alberti (1996).
A high affinity T cell receptor?
  Immunol Cell Biol, 74, 292-297.  
8642290 S.M.Tompkins, J.C.Moore, and P.E.Jensen (1996).
An insulin peptide that binds an alternative site in class II major histocompatibility complex.
  J Exp Med, 183, 857-866.  
8873590 S.Nishimura, J.Sasaki, H.Kandori, T.Matsuda, Y.Fukada, and A.Maeda (1996).
Structural changes in the peptide backbone in complex formation between activated rhodopsin and transducin studied by FTIR spectroscopy.
  Biochemistry, 35, 13267-13271.  
8570625 T.S.Jardetzky, J.H.Brown, J.C.Gorga, L.J.Stern, R.G.Urban, J.L.Strominger, and D.C.Wiley (1996).
Crystallographic analysis of endogenous peptides associated with HLA-DR1 suggests a common, polyproline II-like conformation for bound peptides.
  Proc Natl Acad Sci U S A, 93, 734-738.  
8642268 W.W.Kwok, M.E.Domeier, M.L.Johnson, G.T.Nepom, and D.M.Koelle (1996).
HLA-DQB1 codon 57 is critical for peptide binding and recognition.
  J Exp Med, 183, 1253-1258.  
8613139 W.Walter, M.Loos, and M.J.Maeurer (1996).
H2-M polymorphism in mice susceptible to collagen-induced arthritis involves the peptide binding groove.
  Immunogenetics, 44, 19-26.  
8814061 X.He, W.Zhong, T.G.McCarthy, C.M.Weyand, and J.J.Goronzy (1996).
Increased responsiveness of rheumatoid factor-producing B cells in seronegative and seropositive rheumatoid arthritis.
  Arthritis Rheum, 39, 1499-1506.  
8647211 Y.Itoh, K.Kajino, K.Ogasawara, M.Katoh, K.Namba, K.Takami, K.Iwabuchi, N.S.Braunstein, and K.Onoé (1996).
Determination of the allele-specific antigen-binding site on I-Ak and I-Ab molecules.
  Eur J Immunol, 26, 1314-1321.  
8753854 Y.van de Wal, Y.M.Kooy, J.W.Drijfhout, R.Amons, and F.Koning (1996).
Peptide binding characteristics of the coeliac disease-associated DQ(alpha1*0501, beta1*0201) molecule.
  Immunogenetics, 44, 246-253.  
7816844 A.M.Gautam, C.Pearson, V.Quinn, H.O.McDevitt, and P.J.Milburn (1995).
Binding of an invariant-chain peptide, CLIP, to I-A major histocompatibility complex class II molecules.
  Proc Natl Acad Sci U S A, 92, 335-339.  
7590821 C.G.Drake, S.J.Rozzo, T.J.Vyse, E.Palmer, and B.L.Kotzin (1995).
Genetic contributions to lupus-like disease in (NZB x NZW)F1 mice.
  Immunol Rev, 144, 51-74.  
7667280 C.Lee, and H.M.McConnell (1995).
A general model of invariant chain association with class II major histocompatibility complex proteins.
  Proc Natl Acad Sci U S A, 92, 8269-8273.  
7489760 D.P.Harris, H.M.Vordermeier, M.Singh, C.Moreno, S.Jurcevic, and J.Ivanyi (1995).
Cross-recognition by T cells of an epitope shared by two unrelated mycobacterial antigens.
  Eur J Immunol, 25, 3173-3179.  
7673219 E.A.Nalefski, K.T.Shaw, and A.Rao (1995).
An ion pair in class II major histocompatibility complex heterodimers critical for surface expression and peptide presentation.
  J Biol Chem, 270, 22351-22360.  
9636295 E.A.Whitehorn, E.Tate, S.D.Yanofsky, L.Kochersperger, A.Davis, R.B.Mortensen, S.Yonkovich, K.Bell, W.J.Dower, and R.W.Barrett (1995).
A generic method for expression and use of "tagged" soluble versions of cell surface receptors.
  Biotechnology (N Y), 13, 1215-1219.  
  7650425 E.Dwyer, and R.Winchester (1995).
The role of the trimolecular complex (alpha beta TCR-MHC+peptide) in the pathogenesis of systemic sclerosis.
  Int Rev Immunol, 12, 85-96.  
7697546 E.K.Bikoff, R.N.Germain, and E.J.Robertson (1995).
Allelic differences affecting invariant chain dependency of MHC class II subunit assembly.
  Immunity, 2, 301-310.  
7836904 F.Sinigaglia, and J.Hammer (1995).
Motifs and supermotifs for MHC class II binding peptides.
  J Exp Med, 181, 449-451.  
  7494321 G.A.Cole, T.Tao, T.L.Hogg, K.W.Ryan, and D.L.Woodland (1995).
Binding motifs predict major histocompatibility complex class II-restricted epitopes in the Sendai virus M protein.
  J Virol, 69, 8057-8060.  
7836909 G.Malcherek, V.Gnau, G.Jung, H.G.Rammensee, and A.Melms (1995).
Supermotifs enable natural invariant chain-derived peptides to interact with many major histocompatibility complex-class II molecules.
  J Exp Med, 181, 527-536.  
7540055 G.Siligardi, and A.F.Drake (1995).
The importance of extended conformations and, in particular, the PII conformation for the molecular recognition of peptides.
  Biopolymers, 37, 281-292.  
7772286 H.G.Rammensee (1995).
Chemistry of peptides associated with MHC class I and class II molecules.
  Curr Opin Immunol, 7, 85-96.  
7774629 H.J.Wallny, G.Sollami, and K.Karjalainen (1995).
Soluble mouse major histocompatibility complex class II molecules produced in Drosophila cells.
  Eur J Immunol, 25, 1262-1266.  
7648392 H.Kozono, D.Parker, J.White, P.Marrack, and J.Kappler (1995).
Multiple binding sites for bacterial superantigens on soluble class II MHC molecules.
  Immunity, 3, 187-196.  
7667286 H.Kropshofer, A.B.Vogt, and G.J.Hämmerling (1995).
Structural features of the invariant chain fragment CLIP controlling rapid release from HLA-DR molecules and inhibition of peptide binding.
  Proc Natl Acad Sci U S A, 92, 8313-8317.  
  8528069 J.C.Almagro, E.Vargas-Madrazo, F.Lara-Ochoa, and E.Horjales (1995).
Molecular modeling of a T-cell receptor bound to a major histocompatibility complex molecule: implications for T-cell recognition.
  Protein Sci, 4, 1708-1717.  
7529414 J.Clardy (1995).
The chemistry of signal transduction.
  Proc Natl Acad Sci U S A, 92, 56-61.  
7722459 J.Hammer, F.Gallazzi, E.Bono, R.W.Karr, J.Guenot, P.Valsasnini, Z.A.Nagy, and F.Sinigaglia (1995).
Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association.
  J Exp Med, 181, 1847-1855.  
7546387 J.Hammer (1995).
New methods to predict MHC-binding sequences within protein antigens.
  Curr Opin Immunol, 7, 263-269.  
7667297 J.L.Cornette, H.Margalit, J.A.Berzofsky, and C.DeLisi (1995).
Periodic variation in side-chain polarities of T-cell antigenic peptides correlates with their structure and activity.
  Proc Natl Acad Sci U S A, 92, 8368-8372.  
8564722 J.R.Lamb, A.Faith, J.A.Higgins, A.Verhoef, P.Schneider, H.Yssel, and R.E.O'Hehir (1995).
Clonal analysis of CD4 mediated accessory function on the effector activity of human CD4+ T cell subsets.
  Clin Exp Allergy, 25, 839-847.  
7482505 J.Thonnard, B.Blaimond, M.Heusterspreut, N.Straetmans, and M.Philippe (1995).
A new HLA-DRB1*1116 allele sharing DR13 and DR11 sequence motifs.
  Tissue Antigens, 46, 124-127.  
7545162 K.Jönsson, D.McDevitt, M.H.McGavin, J.M.Patti, and M.Höök (1995).
Staphylococcus aureus expresses a major histocompatibility complex class II analog.
  J Biol Chem, 270, 21457-21460.  
8524878 K.W.Wucherpfennig, B.Yu, K.Bhol, D.S.Monos, E.Argyris, R.W.Karr, A.R.Ahmed, and J.L.Strominger (1995).
Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris.
  Proc Natl Acad Sci U S A, 92, 11935-11939.  
7568039 K.W.Wucherpfennig, D.A.Hafler, and J.L.Strominger (1995).
Structure of human T-cell receptors specific for an immunodominant myelin basic protein peptide: positioning of T-cell receptors on HLA-DR2/peptide complexes.
  Proc Natl Acad Sci U S A, 92, 8896-8900.  
7722439 K.W.Wucherpfennig, and J.L.Strominger (1995).
Selective binding of self peptides to disease-associated major histocompatibility complex (MHC) molecules: a mechanism for MHC-linked susceptibility to human autoimmune diseases.
  J Exp Med, 181, 1597-1601.  
  7769686 K.Zingler, C.Bélanger, R.Peters, E.Agard, and J.A.Young (1995).
Identification and characterization of the viral interaction determinant of the subgroup A avian leukosis virus receptor.
  J Virol, 69, 4261-4266.  
  7542584 L.Abrahmsén, M.Dohlsten, S.Segrén, P.Björk, E.Jonsson, and T.Kalland (1995).
Characterization of two distinct MHC class II binding sites in the superantigen staphylococcal enterotoxin A.
  EMBO J, 14, 2978-2986.  
7540044 L.Otvos, G.R.Krivulka, L.Urge, G.I.Szendrei, L.Nagy, Z.Q.Xiang, and H.C.Ertl (1995).
Comparison of the effects of amino acid substitutions and beta-N- vs. alpha-O-glycosylation on the T-cell stimulatory activity and conformation of an epitope on the rabies virus glycoprotein.
  Biochim Biophys Acta, 1267, 55-64.  
7614994 L.R.Wedderburn, S.J.Searle, A.R.Rees, J.R.Lamb, and M.J.Owen (1995).
Mapping T cell recognition: the identification of a T cell receptor residue critical to the specific interaction with an influenza hemagglutinin peptide.
  Eur J Immunol, 25, 1654-1662.  
7621887 M.W.Nicolle, S.Hawke, N.Willcox, and A.Vincent (1995).
Differences in processing of an autoantigen by DR4:Dw4.2 and DR4:Dw14.2 antigen-presenting cells.
  Eur J Immunol, 25, 2119-2122.  
7697352 P.A.van der Merwe, P.N.McNamee, E.A.Davies, A.N.Barclay, and S.J.Davis (1995).
Topology of the CD2-CD48 cell-adhesion molecule complex: implications for antigen recognition by T cells.
  Curr Biol, 5, 74-84.  
7477400 P.Ghosh, M.Amaya, E.Mellins, and D.C.Wiley (1995).
The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3.
  Nature, 378, 457-462.
PDB code: 1a6a
7645828 P.K.Gregersen, R.Hingorani, and J.Monteiro (1995).
Oligoclonality in the CD8+ T-cell population. Analysis using a multiplex PCR assay for CDR3 length.
  Ann N Y Acad Sci, 756, 19-27.  
7539763 R.D.Gordon, J.A.Young, S.Rayner, R.W.Luke, M.L.Crowther, P.Wordsworth, J.Bell, G.Hassall, J.Evans, and S.A.Hinchliffe (1995).
Purification and characterization of endogenous peptides extracted from HLA-DR isolated from the spleen of a patient with rheumatoid arthritis.
  Eur J Immunol, 25, 1473-1476.  
7773739 R.L.Stanfield, and I.A.Wilson (1995).
Protein-peptide interactions.
  Curr Opin Struct Biol, 5, 103-113.  
8566002 R.Raju, D.Navaneetham, D.Okita, B.Diethelm-Okita, D.McCormick, and B.M.Conti-Fine (1995).
Epitopes for human CD4+ cells on diphtheria toxin: structural features of sequence segments forming epitopes recognized by most subjects.
  Eur J Immunol, 25, 3207-3214.  
7529765 S.Arimilli, C.Cardoso, P.Mukku, V.Baichwal, and B.Nag (1995).
Refolding and reconstitution of functionally active complexes of human leukocyte antigen DR2 and myelin basic protein peptide from recombinant alpha and beta polypeptide chains.
  J Biol Chem, 270, 971-977.  
  7609057 S.Kodihalli, D.M.Justewicz, L.V.Gubareva, and R.G.Webster (1995).
Selection of a single amino acid substitution in the hemagglutinin molecule by chicken eggs can render influenza A virus (H3) candidate vaccine ineffective.
  J Virol, 69, 4888-4897.  
8849346 S.L.Woulfe, C.P.Bono, M.L.Zacheis, D.A.Kirschmann, T.A.Baudino, C.Swearingen, R.W.Karr, and B.D.Schwartz (1995).
Negatively charged residues interacting with the p4 pocket confer binding specificity to DRB1*0401.
  Arthritis Rheum, 38, 1744-1753.  
7479792 S.Quaratino, C.J.Thorpe, P.J.Travers, and M.Londei (1995).
Similar antigenic surfaces, rather than sequence homology, dictate T-cell epitope molecular mimicry.
  Proc Natl Acad Sci U S A, 92, 10398-10402.  
7536796 S.Shimoda, M.Nakamura, H.Ishibashi, K.Hayashida, and Y.Niho (1995).
HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases.
  J Exp Med, 181, 1835-1845.  
7869051 X.T.Fu, C.P.Bono, S.L.Woulfe, C.Swearingen, N.L.Summers, F.Sinigaglia, A.Sette, B.D.Schwartz, and R.W.Karr (1995).
Pocket 4 of the HLA-DR(alpha,beta 1*0401) molecule is a major determinant of T cells recognition of peptide.
  J Exp Med, 181, 915-926.  
7805754 A.Geluk, X.T.Fu, K.E.van Meijgaarden, Y.Y.Jansen, R.R.De Vries, R.W.Karr, and T.H.Ottenhoff (1994).
T cell receptor and peptide-contacting residues in the HLA-DR17(3) beta 1 chain.
  Eur J Immunol, 24, 3241-3244.  
7664083 A.Musacchio, M.Saraste, and M.Wilmanns (1994).
High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides.
  Nat Struct Biol, 1, 546-551.
PDB codes: 1abo 1abq 1fyn
7855883 B.E.Kemp, M.W.Parker, S.Hu, T.Tiganis, and C.House (1994).
Substrate and pseudosubstrate interactions with protein kinases: determinants of specificity.
  Trends Biochem Sci, 19, 440-444.  
7805744 B.Schoel, U.Zügel, T.Ruppert, and S.H.Kaufmann (1994).
Elongated peptides, not the predicted nonapeptide stimulate a major histocompatibility complex class I-restricted cytotoxic T lymphocyte clone with specificity for a bacterial heat shock protein.
  Eur J Immunol, 24, 3161-3169.  
8090733 C.Beeson, and H.M.McConnell (1994).
Kinetic intermediates in the reactions between peptides and proteins of major histocompatibility complex class II.
  Proc Natl Acad Sci U S A, 91, 8842-8845.  
  7523695 G.A.Cole, J.M.Katz, T.L.Hogg, K.W.Ryan, A.Portner, and D.L.Woodland (1994).
Analysis of the primary T-cell response to Sendai virus infection in C57BL/6 mice: CD4+ T-cell recognition is directed predominantly to the hemagglutinin-neuraminidase glycoprotein.
  J Virol, 68, 6863-6870.  
7536111 I.A.Wilson, and R.L.Stanfield (1994).
Antibody-antigen interactions: new structures and new conformational changes.
  Curr Opin Struct Biol, 4, 857-867.  
7922033 I.A.Wilson (1994).
Covalently linked ligand stabilizes expression of heterodimeric receptor.
  Structure, 2, 561-562.  
7895164 J.Alexander, J.Sidney, S.Southwood, J.Ruppert, C.Oseroff, A.Maewal, K.Snoke, H.M.Serra, R.T.Kubo, and A.Sette (1994).
Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides.
  Immunity, 1, 751-761.  
7953548 J.B.Rothbard (1994).
Antigen presentation. One size fits all.
  Curr Biol, 4, 653-655.  
7964508 J.Hammer, E.Bono, F.Gallazzi, C.Belunis, Z.Nagy, and F.Sinigaglia (1994).
Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning.
  J Exp Med, 180, 2353-2358.  
8078904 J.Kappler, J.White, H.Kozono, J.Clements, and P.Marrack (1994).
Binding of a soluble alpha beta T-cell receptor to superantigen/major histocompatibility complex ligands.
  Proc Natl Acad Sci U S A, 91, 8462-8466.  
8090768 K.L.Hilyard, H.Reyburn, S.Chung, J.I.Bell, and J.L.Strominger (1994).
Binding of soluble natural ligands to a soluble human T-cell receptor fragment produced in Escherichia coli.
  Proc Natl Acad Sci U S A, 91, 9057-9061.  
8087551 L.J.Stern, and D.C.Wiley (1994).
Antigenic peptide binding by class I and class II histocompatibility proteins.
  Structure, 2, 245-251.