Bringing Structure to Biology
|01 Nov 2017||
The human genome codes for 20-25,000 proteins. The lab workhorse bacterium, E.coli, codes for around 2,300. Every single one of those proteins is produced by the huge molecular machine shown on our 2017 calendar image for November.
|01 Oct 2017||
Opening a Gate to Human Health
In the 1970s, an exciting discovery of a family of medicines was made by the Japanese scientist Satoshi Ōmura. It is one of these molecules which features in the October image in our 2017 calendar.
|01 Sep 2017||
Thioredoxin - a small protein with a radical role
This month’s featured structure is that of Thioredoxin, a small protein with a vital role in many organisms.
|01 Aug 2017||
The image from our 2017 calendar for August is inspired by a molecular cartwheel which is essential for the mobility of single celled parasites called trypanosomes. Trypanosomes are the causative agents of several potentially fatal human diseases, including Leishmaniasis, Chagas disease and Sleeping Sickness.
|01 Jun 2017||
Focusing on Crystallin
As you read the words on this page, the light enters your eyes and the eye lens focuses it on the retina. From here the image is sent to your brain for processing. The major protein from the eye lens is shown here in June’s featured structure from our 2017 calendar.
|01 May 2017||
Crystallography from the guts of a cockroach
Before obtaining a crystal structure, one must first obtain a crystal, which is not always an easy process. Once in awhile nature saves the scientist potentially decades of work and protein crystals occur in vivo.
|01 Apr 2017||
DHFR- a target for TB drugs?
This month’s featured structure from our 2017 calendar is the enzyme dihydrofolate reductase (DHFR) from the bacterium that causes tuberculosis (TB), Mycobacterium tuberculosis. DHFR is an essential enzyme for life as it reduces dihydrofolate to tetrahydrofolate, a cofactor for several enzymes involved in synthesising amino acids and DNA bases.
|01 Mar 2017||
Giardia kinesin- a model locomotive
The March image in our 2017 calendar is that of the parasite Giardia, responsible for the water-borne disease giardiasis. It is estimated that up to 30% of the population of the developing world may have giardiasis. This image shows the parasite in a water droplet, with two proteins depicted inside the Giardia double nuclei. The protein shown is kinesin 2a which is part of the kinesin family, a group of proteins that function as mini motors within cells, in organisms from Giardia to humans.
|01 Feb 2017||
Zika virus- one year on
First isolated in the Zika Forest of Uganda in 1947, the image in our 2017 calendar for February is that of Zika virus. The capsid, showing the beautiful icosahedral symmetry common to many viruses, is visually stunning, belying the disease it can cause.
|01 Jan 2017||
Ebola GP fusion loop
This featured structure explores the molecule from PDBe’s 2017 calendar for January. The image shows a fragment of a protein from Ebola virus, based on PDB entry 2m5f, which is critical for the virus to infect its host