PDBe 7pck

X-ray diffraction
3.2Å resolution

CRYSTAL STRUCTURE OF WILD TYPE HUMAN PROCATHEPSIN K

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of wild-type human procathepsin K.
Protein Sci. 8 283-90 (1999)
PMID: 10048321

Function and Biology Details

Reaction catalysed:
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cathepsin K Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 314 amino acids
Theoretical weight: 35.36 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P43235 (Residues: 16-329; Coverage: 100%)
Gene names: CTSK, CTSO, CTSO2
Sequence domains:
Structure domains: Cysteine proteinases

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 58.7Å b: 84.4Å c: 155.6Å
α: 90° β: 90.3° γ: 90°
R-values:
R R work R free
0.194 0.194 0.253