PDBe 6jpa

Electron Microscopy
2.6Å resolution

Rabbit Cav1.1-Verapamil Complex

Released:
Source organism: Oryctolagus cuniculus
Entry authors: Zhao Y, Huang G, Wu J, Yan N
Related structures: EMD-9868

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Voltage-dependent L-type calcium channel subunit alpha-1S Chain: A
Molecule details ›
Chain: A
Length: 1506 amino acids
Theoretical weight: 172.15 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P07293 (Residues: 1-1506; Coverage: 80%)
Gene names: CACH1, CACNA1S, CACNL1A3
Sequence domains:
Voltage-dependent calcium channel gamma-1 subunit Chain: E
Molecule details ›
Chain: E
Length: 222 amino acids
Theoretical weight: 25.08 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P19518 (Residues: 1-222; Coverage: 100%)
Gene names: CACNG1, CACNLG
Sequence domains: PMP-22/EMP/MP20/Claudin tight junction
Voltage-dependent L-type calcium channel subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 450 amino acids
Theoretical weight: 49.64 KDa
Source organism: Oryctolagus cuniculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19517 (Residues: 80-524; Coverage: 85%)
Gene names: CACNB1, CACNLB1
Sequence domains: Guanylate kinase
Voltage-dependent L-type calcium channel subunit beta-1 Chain: C
Molecule details ›
Chain: C
Length: 524 amino acids
Theoretical weight: 57.9 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P19517 (Residues: 1-524; Coverage: 100%)
Gene names: CACNB1, CACNLB1
Sequence domains:
Voltage-dependent calcium channel subunit alpha-2/delta-1 Chain: F
Molecule details ›
Chain: F
Length: 1046 amino acids
Theoretical weight: 118.64 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P13806 (Residues: 29-1075; Coverage: 97%)
Gene names: CACNA2D1, CACNL2A, CCHL2A
Sequence domains:

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
Resolution: 2.6Å
Relevant EMDB volumes: EMD-9868
Expression system: Escherichia coli