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Cryo-EM structure of the human CPSF160-WDR33-CPSF30 complex bound to the PAS AAUAAA motif at 3.1 Angstrom resolution

Source organism: Homo sapiens
Biochemical function: RNA binding
Biological process: mRNA 3'-end processing
Cellular component: mRNA cleavage and polyadenylation specificity factor complex

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00400
Domain description: WD domain, G-beta repeat
Occurring in:
  1. pre-mRNA 3' end processing protein WDR33
The deposited structure of PDB entry 6fuw contains 5 copies of Pfam domain PF00400 (WD domain, G-beta repeat) in pre-mRNA 3' end processing protein WDR33. Showing 5 copies in chain B.

PF00642
Domain description: Zinc finger C-x8-C-x5-C-x3-H type (and similar)
Occurring in:
  1. Cleavage and polyadenylation specificity factor subunit 4
The deposited structure of PDB entry 6fuw contains 1 copy of Pfam domain PF00642 (Zinc finger C-x8-C-x5-C-x3-H type (and similar)) in Cleavage and polyadenylation specificity factor subunit 4. Showing 1 copy in chain C (this domain is out of the observed residue ranges!).

PF15663
Domain description: Zinc-finger containing family
Occurring in:
  1. Cleavage and polyadenylation specificity factor subunit 4
The deposited structure of PDB entry 6fuw contains 1 copy of Pfam domain PF15663 (Zinc-finger containing family) in Cleavage and polyadenylation specificity factor subunit 4. Showing 1 copy in chain C.

PF03178
Domain description: CPSF A subunit region
Occurring in:
  1. Cleavage and polyadenylation specificity factor subunit 1
The deposited structure of PDB entry 6fuw contains 1 copy of Pfam domain PF03178 (CPSF A subunit region) in Cleavage and polyadenylation specificity factor subunit 1. Showing 1 copy in chain A.

PF10433
Domain description: Mono-functional DNA-alkylating methyl methanesulfonate N-term
Occurring in:
  1. Cleavage and polyadenylation specificity factor subunit 1
The deposited structure of PDB entry 6fuw contains 1 copy of Pfam domain PF10433 (Mono-functional DNA-alkylating methyl methanesulfonate N-term) in Cleavage and polyadenylation specificity factor subunit 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001680
Domain description: WD40 repeat
Occurring in:
  1. pre-mRNA 3' end processing protein WDR33
IPR000571
Domain description: Zinc finger, CCCH-type
Occurring in:
  1. Cleavage and polyadenylation specificity factor subunit 4
IPR015943
Domain description: WD40/YVTN repeat-like-containing domain superfamily
Occurring in:
  1. Cleavage and polyadenylation specificity factor subunit 1
  2. pre-mRNA 3' end processing protein WDR33
IPR020472
Domain description: G-protein beta WD-40 repeat
Occurring in:
  1. pre-mRNA 3' end processing protein WDR33
IPR036855
Domain description: Zinc finger, CCCH-type superfamily
Occurring in:
  1. Cleavage and polyadenylation specificity factor subunit 4
IPR041686
Domain description: Zinc-finger CCCH domain
Occurring in:
  1. Cleavage and polyadenylation specificity factor subunit 4
IPR045348
Domain description: CPSF complex subunit CPSF4-like
Occurring in:
  1. Cleavage and polyadenylation specificity factor subunit 4
IPR036322
Domain description: WD40-repeat-containing domain superfamily
Occurring in:
  1. pre-mRNA 3' end processing protein WDR33
IPR045245
Domain description: Pre-mRNA 3' end processing protein Pfs2-like
Occurring in:
  1. pre-mRNA 3' end processing protein WDR33
IPR004871
Domain description: Cleavage/polyadenylation specificity factor, A subunit, C-terminal
Occurring in:
  1. Cleavage and polyadenylation specificity factor subunit 1
IPR018846
Domain description: Cleavage/polyadenylation specificity factor, A subunit, N-terminal
Occurring in:
  1. Cleavage and polyadenylation specificity factor subunit 1

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