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X-ray structure of human heavy chain ferritin in complex with NAMI A

Source organism: Homo sapiens
Biochemical function: iron ion sequestering activity
Biological process: negative regulation of fibroblast proliferation
Cellular component: ficolin-1-rich granule lumen

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EC 1.16.3.1: Ferroxidase

Reaction catalysed:
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Systematic name:
Fe(II):oxygen oxidoreductase
Alternative Name(s):
  • Caeruloplasmin
  • Ceruloplasmin
  • Ferro:O(2) oxidoreductase
  • Ferroxidase I
  • HEPH
  • Hephaestin
  • Iron II:oxygen oxidoreductase
  • Iron oxidase
  • Iron(II):oxygen oxidoreductase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00210
Domain description: Ferritin-like domain
Occurring in:
  1. Ferritin heavy chain
The deposited structure of PDB entry 6ftv contains 1 copy of Pfam domain PF00210 (Ferritin-like domain) in Ferritin heavy chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR014034
Domain description: Ferritin, conserved site
Occurring in:
  1. Ferritin heavy chain
IPR008331
Domain description: Ferritin/DPS protein domain
Occurring in:
  1. Ferritin heavy chain
IPR009040
Domain description: Ferritin-like diiron domain
Occurring in:
  1. Ferritin heavy chain
IPR009078
Domain description: Ferritin-like superfamily
Occurring in:
  1. Ferritin heavy chain
IPR001519
Domain description: Ferritin
Occurring in:
  1. Ferritin heavy chain
IPR012347
Domain description: Ferritin-like
Occurring in:
  1. Ferritin heavy chain

Structure domain

CATH CATH domain
1.20.1260.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Ferritin
Homology: Ferritin
Occurring in:
  1. Ferritin heavy chain
The deposited structure of PDB entry 6ftv contains 1 copy of CATH domain 1.20.1260.10 (Ferritin) in Ferritin heavy chain. Showing 1 copy in chain A.

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