EC 2.1.1.367: [Histone H3]-lysine(9) N-methyltransferase
Reaction catalysed:
S-adenosyl-L-methionine + a [histone H3]-L-lysine(9) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(9)
Systematic name:
S-adenosyl-L-methionine:[histone H3]-L-lysine(9) N(6)-methyltransferase
GO terms
Biochemical function:
Biological process:
- regulation of stem cell differentiation
- positive regulation of stem cell population maintenance
- negative regulation of stem cell population maintenance
- positive regulation of DNA-templated transcription
- negative regulation of DNA-templated transcription
- regulation of cell fate specification
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of cell migration
- negative regulation of cell population proliferation
- brain development
- regulation of DNA-templated transcription
- chromatin remodeling
- DNA replication-dependent chromatin assembly
- nucleosome assembly
- chromatin organization
- DNA replication
- negative regulation of transcription by RNA polymerase II
Protein families (Pfam)![The deposited structure of PDB entry 6bw4 contains 10 copies of Pfam domain PF00400 (WD domain, G-beta repeat) in Histone-binding protein RBBP4. Showing 5 copies in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/6bw4_1_A_Pfam_PF00400_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6bw4</span> contains 10 copies of Pfam domain <span class='highlight'>PF00400 (WD domain, G-beta repeat)</span> in <span class='highlight'>Histone-binding protein RBBP4</span>. Showing 5 copies in chain <span class='highlight'>C [auth A]</span>.")
![The deposited structure of PDB entry 6bw4 contains 2 copies of Pfam domain PF12265 (Histone-binding protein RBBP4 or subunit C of CAF1 complex) in Histone-binding protein RBBP4. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/6bw4_1_A_Pfam_PF12265_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6bw4</span> contains 2 copies of Pfam domain <span class='highlight'>PF12265 (Histone-binding protein RBBP4 or subunit C of CAF1 complex)</span> in <span class='highlight'>Histone-binding protein RBBP4</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
InterPro annotations
CATH domain![The deposited structure of PDB entry 6bw4 contains 2 copies of CATH domain 2.130.10.10 (Methylamine Dehydrogenase; Chain H) in Histone-binding protein RBBP4. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/6bw4_1_A_CATH_2.130.10.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6bw4</span> contains 2 copies of CATH domain <span class='highlight'>2.130.10.10 (Methylamine Dehydrogenase; Chain H)</span> in <span class='highlight'>Histone-binding protein RBBP4</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")