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Cryo-EM structure of CENP-A nucleosome in complex with kinetochore protein CENP-N

Source organisms:
Biochemical function: protein heterodimerization activity
Biological process: protein localization to CENP-A containing chromatin
Cellular component: CENP-A containing nucleosome

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00125
Domain description: Core histone H2A/H2B/H3/H4
Occurring in:
  1. Histone H3-like centromeric protein A
  2. Histone H2A type 1-B/E
  3. Histone H2B type 1-J
The deposited structure of PDB entry 6buz contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H3-like centromeric protein A. Showing 1 copy in chain A.
The deposited structure of PDB entry 6buz contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2A type 1-B/E. Showing 1 copy in chain C.
The deposited structure of PDB entry 6buz contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2B type 1-J. Showing 1 copy in chain D.

PF16211
Domain description: C-terminus of histone H2A
Occurring in:
  1. Histone H2A type 1-B/E
The deposited structure of PDB entry 6buz contains 2 copies of Pfam domain PF16211 (C-terminus of histone H2A) in Histone H2A type 1-B/E. Showing 1 copy in chain C.

PF15511
Domain description: Centromere kinetochore component CENP-T histone fold
Occurring in:
  1. Histone H4
The deposited structure of PDB entry 6buz contains 2 copies of Pfam domain PF15511 (Centromere kinetochore component CENP-T histone fold) in Histone H4. Showing 1 copy in chain B.

PF05238
Domain description: Kinetochore protein CHL4 like
Occurring in:
  1. Centromere protein N; Maltose/maltodextrin-binding periplasmic protein
The deposited structure of PDB entry 6buz contains 1 copy of Pfam domain PF05238 (Kinetochore protein CHL4 like) in Centromere protein N. Showing 1 copy in chain K [auth N].

PF01547
Domain description: Bacterial extracellular solute-binding protein
Occurring in:
  1. Centromere protein N; Maltose/maltodextrin-binding periplasmic protein
The deposited structure of PDB entry 6buz contains 1 copy of Pfam domain PF01547 (Bacterial extracellular solute-binding protein) in Centromere protein N. Showing 1 copy in chain K [auth N] (this domain is out of the observed residue ranges!).

InterPro InterPro annotations
IPR000558
Domain description: Histone H2B
Occurring in:
  1. Histone H2B type 1-J
IPR002119
Domain description: Histone H2A
Occurring in:
  1. Histone H2A type 1-B/E
IPR001951
Domain description: Histone H4
Occurring in:
  1. Histone H4
IPR009072
Domain description: Histone-fold
Occurring in:
  1. Histone H3-like centromeric protein A
  2. Histone H4
  3. Histone H2A type 1-B/E
  4. Histone H2B type 1-J
IPR000164
Domain description: Histone H3/CENP-A
Occurring in:
  1. Histone H3-like centromeric protein A
IPR006060
Domain description: Maltose/Cyclodextrin ABC transporter, substrate-binding protein
Occurring in:
  1. Centromere protein N; Maltose/maltodextrin-binding periplasmic protein
IPR007125
Domain description: Histone H2A/H2B/H3
Occurring in:
  1. Histone H3-like centromeric protein A
  2. Histone H2A type 1-B/E
  3. Histone H2B type 1-J
IPR032454
Domain description: Histone H2A, C-terminal domain
Occurring in:
  1. Histone H2A type 1-B/E
IPR032458
Domain description: Histone H2A conserved site
Occurring in:
  1. Histone H2A type 1-B/E
IPR035425
Domain description: CENP-T/Histone H4, histone fold
Occurring in:
  1. Histone H4
IPR004823
Domain description: TATA box binding protein associated factor (TAF), histone-like fold domain
Occurring in:
  1. Histone H4
IPR019809
Domain description: Histone H4, conserved site
Occurring in:
  1. Histone H4
IPR007902
Domain description: Centromere protein Chl4/mis15/CENP-N
Occurring in:
  1. Centromere protein N; Maltose/maltodextrin-binding periplasmic protein
IPR006061
Domain description: Solute-binding family 1, conserved site
Occurring in:
  1. Centromere protein N; Maltose/maltodextrin-binding periplasmic protein
IPR006059
Domain description: Bacterial-type extracellular solute-binding protein
Occurring in:
  1. Centromere protein N; Maltose/maltodextrin-binding periplasmic protein

Structure domain

CATH CATH domain
1.10.20.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Histone, subunit A
Homology: Histone, subunit A
Occurring in:
  1. Histone H3-like centromeric protein A
  2. Histone H4
  3. Histone H2A type 1-B/E
  4. Histone H2B type 1-J
The deposited structure of PDB entry 6buz contains 2 copies of CATH domain 1.10.20.10 (Histone, subunit A) in Histone H3-like centromeric protein A. Showing 1 copy in chain A.
The deposited structure of PDB entry 6buz contains 2 copies of CATH domain 1.10.20.10 (Histone, subunit A) in Histone H4. Showing 1 copy in chain B.
The deposited structure of PDB entry 6buz contains 2 copies of CATH domain 1.10.20.10 (Histone, subunit A) in Histone H2A type 1-B/E. Showing 1 copy in chain C.
The deposited structure of PDB entry 6buz contains 2 copies of CATH domain 1.10.20.10 (Histone, subunit A) in Histone H2B type 1-J. Showing 1 copy in chain D.

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