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ADAM10 Extracellular Domain

X-ray diffraction
2.8Å resolution
PDB entry 6be6 coloured by chain, front view.
PDB entry 6be6 coloured by chain, side view.
PDB entry 6be6 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Disintegrin and metalloproteinase domain-containing protein 10
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Multimeric state: monomeric
Accessible surface area: 21426.86 Å2
Buried surface area: 1920.18 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127050
Assembly 2
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Assembly Name: Disintegrin and metalloproteinase domain-containing protein 10
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Multimeric state: monomeric
Accessible surface area: 21852.95 Å2
Buried surface area: 2255.95 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127050
Assembly 3 (preferred)
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Assembly Name: Disintegrin and metalloproteinase domain-containing protein 10
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Multimeric state: monomeric
Accessible surface area: 21746.27 Å2
Buried surface area: 2133.33 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127050
Assembly 4
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Assembly Name: Disintegrin and metalloproteinase domain-containing protein 10
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Multimeric state: monomeric
Accessible surface area: 21759.26 Å2
Buried surface area: 2782.32 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127050

Macromolecules

Disintegrin and metalloproteinase domain-containing protein 10
Chains: A, B, C, D
Length: 449 amino acids
Theoretical weight: 49.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O14672 (Residues: 214-654; Coverage: 61%)
Gene names: ADAM10, KUZ, MADM
Pfam:
InterPro:
Disintegrin and metalloproteinase domain-containing protein 10 in PDB entry 6be6, assembly 3, front view.
Disintegrin and metalloproteinase domain-containing protein 10 in PDB entry 6be6, assembly 3, side view.
Disintegrin and metalloproteinase domain-containing protein 10 in PDB entry 6be6, assembly 3, top view.
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