› 6b3o

Electron Microscopy
4.1Å resolution

Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion

Released:
DOI: 10.2210/pdb6b3o/pdb
PDB entry 6b3o coloured by chain, front view.
PDB entry 6b3o coloured by chain, side view.
PDB entry 6b3o coloured by chain, top view.
Source organism: Murine hepatitis virus strain A59
Primary publication:
Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion.
Walls AC, Tortorici MA, Snijder J, Xiong X, Bosch BJ, Rey FA, Veesler D
Proc Natl Acad Sci U S A 114 11157-11162 (2017)
PMID: 29073020
Related structures: EMD-7040

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145717 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Spike protein S2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 605 amino acids
Theoretical weight: 66.2 KDa
Source organism: Murine hepatitis virus strain A59
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P11224 (Residues: 714-1252; Coverage: 41%)
Gene names: 3, S
Sequence domains: Coronavirus spike glycoprotein S2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.1Å
Relevant EMDB volumes: EMD-7040
Expression system: Drosophila melanogaster

Quick links

Citations

89 review citations

The deadly coronaviruses: The 2003 SARS pandemic and the 2020 novel coronavirus epidemic in China.
Yang et al. (2020)
88 more

22 mentions without citation

Molecular diversity of coronavirus host cell entry receptors.
Millet et al. (2021)
21 more