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Disrupted hydrogen bond network impairs ATPase activity in an Hsc70 cysteine mutant

Source organism: Homo sapiens
Biochemical function: ATP-dependent protein folding chaperone
Biological process: not assigned
Cellular component: not assigned

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EC 3.6.4.10: Non-chaperonin molecular chaperone ATPase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (polypeptide-polymerizing)
Alternative Name(s):
  • Molecular chaperone Hsc70 ATPase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00012
Domain description: Hsp70 protein
Occurring in:
  1. Heat shock cognate 71 kDa protein
The deposited structure of PDB entry 6b1n contains 2 copies of Pfam domain PF00012 (Hsp70 protein) in Heat shock cognate 71 kDa protein. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR018181
Domain description: Heat shock protein 70, conserved site
Occurring in:
  1. Heat shock cognate 71 kDa protein
IPR043129
Domain description: ATPase, nucleotide binding domain
Occurring in:
  1. Heat shock cognate 71 kDa protein
IPR013126
Domain description: Heat shock protein 70 family
Occurring in:
  1. Heat shock cognate 71 kDa protein

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