PDBe 6m9h

X-ray diffraction
1.79Å resolution

JAK2 JH2 in complex with diaminopyrimidine JAK040

Source organism: Homo sapiens
Entry authors: Puleo DE, Schlessinger J, Jorgensen WL

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein kinase JAK2 Chain: A
Molecule details ›
Chain: A
Length: 289 amino acids
Theoretical weight: 33.12 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: O60674 (Residues: 536-812; Coverage: 25%)
Gene name: JAK2
Sequence domains: Protein tyrosine kinase

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21
Unit cell:
a: 44.298Å b: 57.6Å c: 60.691Å
α: 90° β: 110.17° γ: 90°
R R work R free
0.172 0.171 0.206
Expression system: Spodoptera frugiperda