PDBe 6gu6

X-ray diffraction
2.33Å resolution

CDK1/Cks2 in complex with Dinaciclib

Released:

Function and Biology Details

Reactions catalysed:
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cyclin-dependent kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 302 amino acids
Theoretical weight: 34.55 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06493 (Residues: 1-297; Coverage: 100%)
Gene names: CDC2, CDC28A, CDK1, CDKN1, P34CDC2
Sequence domains: Protein kinase domain
Cyclin-dependent kinases regulatory subunit Chain: B
Molecule details ›
Chain: B
Length: 84 amino acids
Theoretical weight: 10.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: K9J4F7 (Residues: 11-89; Coverage: 89%)
Sequence domains: Cyclin-dependent kinase regulatory subunit

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: I222
Unit cell:
a: 93.704Å b: 97.232Å c: 108.564Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.201 0.246
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli