PDBe 6gh1

X-ray diffraction
2.1Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Soluble HLA class I histocompatibility antigen, alpha chain E Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 274 amino acids
Theoretical weight: 31.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P13747 (Residues: 22-295; Coverage: 81%)
Gene names: HLA-6.2, HLA-E, HLAE
Sequence domains:
Beta-2-microglobulin Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Enoyl-[acyl-carrier-protein] reductase [NADH] Chains: P, Q, R, Z
Molecule details ›
Chains: P, Q, R, Z
Length: 9 amino acids
Theoretical weight: 980 Da
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Not provided
UniProt:
  • Canonical: P9WGR1 (Residues: 53-61; Coverage: 3%)
Gene names: MTCY277.05, Rv1484, inhA

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P1
Unit cell:
a: 48.38Å b: 76.6Å c: 111.15Å
α: 99.33° β: 99.56° γ: 93.66°
R-values:
R R work R free
0.193 0.191 0.229
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided