PDBe 6fzw

X-ray diffraction
2.78Å resolution

Crystal structure of the metalloproteinase enhancer PCPE-1 bound to the procollagen C propeptide trimer (long)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Collagen alpha-1(III) chain Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 293 amino acids
Theoretical weight: 31.96 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: NEW P02461 (Residues: 1185-1466; Coverage: 20%)
Gene name: COL3A1
Sequence domains: Fibrillar collagen C-terminal domain
Procollagen C-endopeptidase enhancer 1 Chain: D
Molecule details ›
Chain: D
Length: 265 amino acids
Theoretical weight: 28.67 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: NEW Q15113 (Residues: 26-278; Coverage: 60%)
Gene names: PCOLCE, PCPE1
Sequence domains: CUB domain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 88.88Å b: 143.65Å c: 156.71Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.249 0.247 0.271
Expression system: Homo sapiens