PDBe 6fgb

X-ray diffraction
2.9Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
IgG receptor FcRn large subunit p51 Chain: A
Molecule details ›
Chain: A
Length: 342 amino acids
Theoretical weight: 37.37 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P55899 (Residues: 24-365; Coverage: 100%)
Gene names: FCGRT, FCRN
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
1519.g57- Light chain Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 23.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
1519.g57- Heavy chain Chain: H
Molecule details ›
Chain: H
Length: 228 amino acids
Theoretical weight: 24.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P3221
Unit cell:
a: 150.1Å b: 150.1Å c: 89.15Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.234 0.232 0.284
Expression systems:
  • Cricetulus griseus
  • Escherichia coli