PDBe 6f3g

X-ray diffraction
2.37Å resolution

IRAK4 IN COMPLEX WITH inhibitor

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-1 receptor-associated kinase 4 Chain: A
Molecule details ›
Chain: A
Length: 295 amino acids
Theoretical weight: 33.4 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NWZ3 (Residues: 164-458; Coverage: 64%)
Gene name: IRAK4
Sequence domains: Protein tyrosine kinase
Interleukin-1 receptor-associated kinase 4 Chain: B
Molecule details ›
Chain: B
Length: 295 amino acids
Theoretical weight: 33.32 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NWZ3 (Residues: 164-458; Coverage: 64%)
Gene name: IRAK4
Sequence domains: Protein tyrosine kinase

Ligands and Environments

2 bound ligands:

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: I222
Unit cell:
a: 87.512Å b: 110.277Å c: 142.133Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.291 0.29 0.314
Expression system: Spodoptera frugiperda