PDBe 6f3e

X-ray diffraction
2.67Å resolution

IRAK4 IN COMPLEX WITH inhibitor

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-1 receptor-associated kinase 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 295 amino acids
Theoretical weight: 33.32 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NWZ3 (Residues: 164-458; Coverage: 64%)
Gene name: IRAK4
Sequence domains: Protein tyrosine kinase

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: I222
Unit cell:
a: 87.181Å b: 109.371Å c: 141.544Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.198 0.254
Expression system: Spodoptera frugiperda