PDBe 6f3d

X-ray diffraction
2.38Å resolution

IRAK4 IN COMPLEX WITH inhibitor

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-1 receptor-associated kinase 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 295 amino acids
Theoretical weight: 33.32 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NWZ3 (Residues: 164-458; Coverage: 64%)
Gene name: IRAK4
Sequence domains: Protein tyrosine kinase

Ligands and Environments

2 bound ligands:

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: I222
Unit cell:
a: 86.568Å b: 125.278Å c: 142.598Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.198 0.227
Expression system: Spodoptera frugiperda