PDBe 6eot

X-ray diffraction
3.5Å resolution

DPP8 - SLRFLYEG, space group 19


Function and Biology Details

Reaction catalysed:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Dipeptidyl peptidase 8 Chains: A, B, D, G, I, K
Molecule details ›
Chains: A, B, D, G, I, K
Length: 898 amino acids
Theoretical weight: 103.48 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: NEW Q6V1X1 (Residues: 1-898; Coverage: 100%)
Gene names: DPP8, DPRP1, MSTP097, MSTP135, MSTP141
Sequence domains:
Small ubiquitin-related modifier 1 Chains: C, E, F, H, J, L
Molecule details ›
Chains: C, E, F, H, J, L
Length: 8 amino acids
Theoretical weight: 985 Da
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: NEW P63165 (Residues: 61-68; Coverage: 8%)
Gene names: OK/SW-cl.43, SMT3C, SMT3H3, SUMO1, UBL1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 148.159Å b: 264.675Å c: 268.937Å
α: 90° β: 90° γ: 90°
R R work R free
0.208 0.205 0.262
Expression systems:
  • Spodoptera frugiperda
  • Not provided