PDBe 6eny

Electron Microscopy
5.8Å resolution

Structure of the human PLC editing module

Released:
Source organism: Homo sapiens
Related structures: EMD-3906

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Tapasin Chain: C
Molecule details ›
Chain: C
Length: 428 amino acids
Theoretical weight: 45.76 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O15533 (Residues: 21-448; Coverage: 100%)
Gene names: NGS17, TAPA, TAPBP
Sequence domains: Immunoglobulin C1-set domain
Protein disulfide-isomerase A3 Chain: D
Molecule details ›
Chain: D
Length: 481 amino acids
Theoretical weight: 54.34 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P30101 (Residues: 25-505; Coverage: 100%)
Gene names: ERP57, ERP60, GRP58, PDIA3
Sequence domains:
HLA class I histocompatibility antigen, A-3 alpha chain Chain: F
Molecule details ›
Chain: F
Length: 341 amino acids
Theoretical weight: 38.36 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P04439 (Residues: 25-365; Coverage: 100%)
Gene names: HLA-A, HLAA
Sequence domains:
Calreticulin Chain: G
Molecule details ›
Chain: G
Length: 400 amino acids
Theoretical weight: 46.51 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P27797 (Residues: 18-417; Coverage: 100%)
Gene names: CALR, CRTC
Sequence domains: Calreticulin family

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 5.8Å
Relevant EMDB volumes: EMD-3906